Rxone Uses

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What is Rxone?

Rxone is used to treat bacterial infections in many different parts of the body. Rxone is also given before certain types of surgery to prevent infections.

Rxone belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, Rxone will not work for colds, flu, or other virus infections.

Rxone is available only with your doctor's prescription.

Rxone indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician. The below description contains indications of Rxone drug.

Before instituting treatment with Rxone, appropriate specimens should be obtained for isolation of the causative organism and for determination of its susceptibility to the drug. Therapy may be instituted prior to obtaining results of susceptibility testing.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Rxone for injection USP and other antibacterial drugs, Rxone for injection USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Rxone for injection USP is indicated for the treatment of the following infections when caused by susceptible organisms:

Lower Respiratory Tract Infections

caused by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis or Serratia marcescens.

Acute Bacterial Otitis Media

caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains) or Moraxella catarrhalis (including beta-lactamase producing strains).

NOTE: In one study lower clinical cure rates were observed with a single dose of Rxone for injection USP compared to 10 days of oral therapy. In a second study comparable cure rates were observed between single dose Rxone for injection USP and the comparator. The potentially lower clinical cure rate of Rxone for injection USP should be balanced against the potential advantages of parenteral therapy.

Skin and Skin Structure Infections

caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii*, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis* or Peptostreptococcus species.

Urinary Tract Infections (complicated and uncomplicated)

caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii or Klebsiella pneumoniae.

Uncomplicated Gonorrhea (cervical/urethral and rectal)

caused by Neisseria gonorrhoeae, including both penicillinase- and nonpenicillinase-producing strains, and pharyngeal gonorrhea caused by nonpenicillinase-producing strains of Neisseria gonorrhoeae.

Pelvic Inflammatory Disease

caused by Neisseria gonorrhoeae. Rxone sodium, like other cephalosporins, has no activity against Chlamydia trachomatis. Therefore, when cephalosporins are used in the treatment of patients with pelvic inflammatory disease and Chlamydia trachomatis is one of the suspected pathogens, appropriate antichlamydial coverage should be added.

Bacterial Septicemia

caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae or Klebsiella pneumoniae.

Bone and Joint Infections

caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae or Enterobacter species.

Intra-Abdominal Infections

caused by Escherichia coli, Klebsiella pneumoniae, Bacteroides fragilis, Clostridium species (Note: most strains of Clostridium difficile are resistant) or Peptostreptococcus species.

Meningitis

caused by Haemophilus influenzae, Neisseria meningitidis or Streptococcus pneumoniae. Rxone for injection USP has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis* and Escherichia coli.*

*Efficacy for this organism in this organ system was studied in fewer than ten infections.

Surgical Prophylaxis

The preoperative administration of a single 1 g dose of Rxone for injection USP may reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated or potentially contaminated (e.g., vaginal or abdominal hysterectomy or cholecystectomy for chronic calculous cholecystitis in high-risk patients, such as those over 70 years of age, with acute cholecystitis not requiring therapeutic antimicrobials, obstructive jaundice or common duct bile stones) and in surgical patients for whom infection at the operative site would present serious risk (e.g., during coronary artery bypass surgery). Although Rxone for injection USP has been shown to have been as effective as cefazolin in the prevention of infection following coronary artery bypass surgery, no placebo-controlled trials have been conducted to evaluate any cephalosporin antibiotic in the prevention of infection following coronary artery bypass surgery.

When administered prior to surgical procedures for which it is indicated, a single 1 g dose of Rxone for injection USP provides protection from most infections due to susceptible organisms throughout the course of the procedure.

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How should I use Rxone?

Use Rxone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Rxone is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Rxone at home, a health care provider will teach you how to use it. Be sure you understand how to use Rxone. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Rxone is light yellow to amber in color. Do not use Rxone if it contains particles, is cloudy or discolored, or if the vial or container is cracked or damaged in any way.
  • To clear up your infection completely, use Rxone for the full course of treatment. Keep using it even if you feel better in a few days.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Rxone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rxone.

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Uses of Rxone in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it. The below information contains the uses of Rxone drug.

Rxone is used to treat bacterial infections of the brain respiratory tract ear abdomen abdominal wall, urinary tract and kidney, bones, joints, and skin or soft tissues. It is also used in the management of fever with low white blood cells (neutropenia), surgical site infections, joint pain caused by parasite ticks (Lyme disease), typhoid, paratyphoid and sexually transmitted infections (gonorrhea, syphilis).

Rxone description

infoPharmacology is a crucial part of medicine wherein various medications are used to advance the well-being of an individual. Some drugs cure the infection or a disease; few prevent the occurrence of a symptom or a disease, and few are used in long-term treatment of the disease. Drugs are obtained from the plants as well as they can be synthesized organically. The drugs are used in various combinations or a single drug by the pharmaceutical industry during its preparation. The half-life of each medicine is different, and the dosage of the drug depends on the half-life of the drug. The below information gives the detailed description of Rxone drug.

Rxone is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy.

Rxone is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis. In pediatrics, it is commonly used in febrile infants between 4 and 8 weeks of age who are admitted to the hospital to exclude sepsis. The dosage for acute ear infection in the very young is 50 mg/Kg IM, one dose only. It has also been used in the treatment of Lyme disease, typhoid fever and gonorrhea.

Intravenous dosages may be adjusted for body mass in younger patients and is administered every 12–24 hours, at a dose that depends on the type and severity of the infection.

For the treatment of gonorrhoea, a single intramuscular injection is usually given. Treatment for chlamydia infection is also recommended (usually with azithromycin) unless it is specifically ruled out.

It must not be mixed or administered simultaneously (within 48 hours) with calcium-containing solutions or products, even via different infusion lines (rare fatal cases of calcium-Rxone precipitates in lung and kidneys in neonates have been described).

To reduce the pain of intramuscular injection, Rxone may be reconstituted with 1% lidocaine.

Rxone has also been investigated for efficacy in preventing relapse to cocaine addicition.

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Active ingredient matches for Rxone:

Ceftriaxone in India.


Unit description / dosage (Manufacturer)Price, USD
Rxone 1000mg INJ / 1$ 1.35
1000 mg x 1's$ 1.35

List of Rxone substitutes (brand and generic names):

Safecare 1g VIAL / 1 (Medico Health Care)$ 1.14
Safecare 250mg VIAL / 1 (Medico Health Care)$ 0.56
Safecare 500mg VIAL / 1 (Medico Health Care)$ 0.79
1 g x 1's (Medico Health Care)$ 1.14
250 mg x 1's (Medico Health Care)$ 0.56
500 mg x 1's (Medico Health Care)$ 0.79
Safecare 500 mg Injection (Medico Health Care)$ 0.79
Safecare 250 mg Injection (Medico Health Care)$ 0.56
Safecare 1000 mg Injection (Medico Health Care)$ 1.24
Safegard 1g VIAL / 15ml (Kalpataru Formulations Pvt. Ltd.)$ 0.71
Safegard 250mg VIAL / 5ml (Kalpataru Formulations Pvt. Ltd.)$ 0.32
Safegard 500mg VIAL / 5ml (Kalpataru Formulations Pvt. Ltd.)$ 0.48
1 g x 15ml (Kalpataru Formulations Pvt. Ltd.)$ 0.71
250 mg x 5ml (Kalpataru Formulations Pvt. Ltd.)$ 0.32
500 mg x 5ml (Kalpataru Formulations Pvt. Ltd.)$ 0.48
Safegard 250 mg Injection (Kalpataru Formulations Pvt. Ltd.)$ 0.32
Safegard 1000 mg Injection (Kalpataru Formulations Pvt. Ltd.)$ 0.71
Safegard 500 mg Injection (Kalpataru Formulations Pvt. Ltd.)$ 0.48
SAFETRI Injection / 250mg / 1 vial units (Allure Remedies)$ 0.68
SAFETRI Injection / 1gm / 1 vial units (Allure Remedies)$ 1.56
SAFEZONE PLUS INJECTION 1 vial / 25 ML injection each (Maan Pharmaceuticals Ltd)$ 1.68
Safta 1000 mg Injection (Profic Organic Ltd.)$ 0.95
Saftak 1000 mg Injection (Safetech Formulation)$ 1.24
Saftak 500 mg Injection (Safetech Formulation)$ 0.95
Saftak 250 mg Injection (Safetech Formulation)$ 0.48
Saftak 125 mg Injection (Safetech Formulation)$ 0.38
Saibact 250 mg Injection (Novakind Bio Sciences)$ 0.52
Sal P 1000+500 Injection (Prism Pharma)$ 2.06
SAL P OINTMENT 1 tube / 15 GM ointment each (Prism Pharma)$ 0.80
Sal P Ointment (Prism Pharma)$ 0.05
1 g x 1's (Salvus)
125 mg x 1's (Salvus)
250 mg x 1's (Salvus)
500 mg x 1's (Salvus)
Salvacef 1g INJ / 1 (Salvus)
Salvacef 125mg INJ / 1 (Salvus)
Salvacef 250mg INJ / 1 (Salvus)
Salvacef 500mg INJ / 1 (Salvus)
Salvacef 1g INJ / 1 (Salvus)
Salvacef 125mg INJ / 1 (Salvus)
Salvacef 250mg INJ / 1 (Salvus)

References

  1. DailyMed. "CEFTRIAXONE SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailymed/se... (accessed September 18, 2017).
  2. Wikipedia. "ceftriaxone: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Ceftriaxon... (accessed September 18, 2017).
  3. PubChem. "ceftriaxone". https://pubchem.ncbi.nlm.nih.gov/compoun... (accessed September 18, 2017).
  4. FDA Orange Book. "CEFTRIAXONE SODIUM; LIDOCAINE: The publication, Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book), identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act).". https://www.fda.gov/Drugs/InformationOnD... (accessed September 18, 2017).

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