Salbutamol Uses

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What is Salbutamol?

Salbutamol is used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. Salbutamol is also used to prevent wheezing caused by exercise (exercise-induced bronchospasm).

Salbutamol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

Salbutamol is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Salbutamol is used in certain patients with the following medical condition:

Salbutamol indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Salbutamol is used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. This medicine is also used to prevent exercise-induced bronchospasm.

Salbutamol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor’s prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Salbutamol is used in certain patients with the following medical condition:

Hyperkalemia (too much potassium in the blood)

How should I use Salbutamol?

Use Salbutamol solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Salbutamol solution.

Uses of Salbutamol in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Salbutamol is used to prevent reversible airways obstruction occurring during asthma, infections of airway passages (bronchitis), lung disorder in which the flow of air to the lungs is blocked (emphysema), and other lung diseases.

Salbutamol description

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of Salbutamol. However, the high cost of levalbuterol compared to Salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma.

Salbutamol dosage

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The following dosages of Salbutamol Extended-Release Tablets are expressed in terms of Salbutamol base:

Usual Dosage

Adults and Children Over 12 Years of Age

The usual recommended dosage for adults and pediatric patients over 12 years of age is 8 mg every 12 hours. In some patients, 4 mg every 12 hours may be sufficient.

Children 6 to 12 Years of Age

The usual recommended dosage for children 6 through 12 years of age is 4 mg every 12 hours.

Dosage Adjustment in Adults and Children Over 12 Years of Age

In unusual circumstances, such as adults of low body weight, it may be desirable to use a starting dosage of 4 mg every 12 hours and progress to 8 mg every 12 hours according to response.

If control of reversible airway obstruction is not achieved with the recommended doses in patients on otherwise optimized asthma therapy, the doses may be cautiously increased stepwise under the control of the supervising physician to a maximum dose of 32 mg per day in divided doses (i.e., every 12 hours).

Dosage Adjustment in Children 6 to 12 Years of Age

If control of reversible airway obstruction is not achieved with the recommended doses in patients on otherwise optimized asthma therapy, the doses may be cautiously increased stepwise under the control of the supervising physician to a maximum dose of 24 mg per day in divided doses (i.e., every 12 hours).

Switching From

Oral Salbutamol, USP Products

Patients currently maintained on Salbutamol tablets or Salbutamol sulfate syrup can be switched to Salbutamol Extended-Release Tablets. For example, the administration of one 4 mg Salbutamol extended-release tablet every 12 hours is comparable to one 2 mg Salbutamol tablet every 6 hours. Multiples of this regimen up to the maximum recommended daily dose also apply.

Salbutamol Extended-Release Tablets must be swallowed whole with the aid of liquids. DO NOT CHEW OR CRUSH THESE TABLETS.

Salbutamol interactions

See also:
What other drugs will affect Salbutamol?

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Other short-acting sympathomimetic aerosol bronchodilators should not be used concomitantly with Salbutamol. If additional adrenergic drugs are to be administered by any route, they should be used with caution to avoid deleterious cardiovascular effects.

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants: Salbutamol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of Salbutamol on the vascular system may be potentiated.

Beta-Blockers: Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as VENTOLIN Inhalation Aerosol, but may produce severe bronchospasm in patients with asthma. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.

Diuretics: The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

Digoxin: Mean decreases of 16% to 22% in serum digoxin levels were demonstrated after single-dose intravenous and oral administration of Salbutamol, respectively, to normal volunteers who had received digoxin for 10 days. The clinical significance of these findings for patients with obstructive airway disease who are receiving Salbutamol and digoxin on a chronic basis is unclear. Nevertheless, it would be prudent to carefully evaluate the serum digoxin levels in patients who are currently receiving digoxin and Salbutamol.

Salbutamol side effects

See also:
What are the possible side effects of Salbutamol?

Use of Salbutamol may be associated with the following:

Clinical Trials Experience

A total of 1289 subjects were treated with Salbutamol sulfate inhalation powder (ProAir RespiClick hereafter referred to as Salbutamol sulfate MDPI) during the clinical development program. The most common adverse reactions (≥1% and >placebo) were back pain, pain, gastroenteritis viral, sinus headache, and urinary tract infection. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Adults and Adolescents 12 years of Age and Older: The adverse reaction information presented in Table 1 below concerning Salbutamol sulfate MDPI is derived from the 12-week blinded treatment period of three studies which compared Salbutamol sulfate MDPI 180 mcg four times daily with a double-blinded matched placebo in 653 asthmatic patients 12 to 76 years of age.

Table 1: Adverse Reactions Experienced by Greater Than or Equal to 1.0% of Adult and Adolescent Patients in the Salbutamol sulfate MDPI Group and Greater Than Placebo in three 12-Week Clinical Trials1

Preferred Term

Number (%) of patients

Salbutamol sulfate MDPI 180mcg QID

N=321

Placebo

N=333

Back pain

6 (2%)

4 (1%)

Pain

5 (2%)

2 (<1%)

Gastroenteritis viral

4 (1%)

3 (<1%)

Sinus headache

4 (1%)

3 (<1%)

Urinary tract infection

4 (1%)

3 (<1%)

  1. This table includes all adverse events (whether considered by the investigator drug related or unrelated to drug) which occurred at an incidence rate of greater than or equal to 1.0% in the Salbutamol sulfate MDPI group and greater than placebo.

In a long-term study of 168 patients treated with Salbutamol sulfate MDPI for up to 52 weeks (including a 12-week double-blind period), the most commonly reported adverse events greater than or equal to 5% were upper respiratory infection, nasopharyngitis, sinusitis, bronchitis, cough, oropharyngeal pain, headache, and pyrexia.

In a small cumulative dose study, tremor, palpitations, and headache were the most frequently occurring (≥5%) adverse events.

Pediatric Patients 4 to 11 Years of Age: The adverse reaction information presented in Table 2 below concerning Salbutamol sulfate MDPI is derived from a 3‑week pediatric clinical trial which compared Salbutamol sulfate MDPI 180 mcg four times daily with a double‑blinded matched placebo in 185 asthmatic patients 4 to 11 years of age.

Table 2: Adverse Reactions Experienced by Greater Than or Equal to 2.0% of Patients 4 to 11 Years of Age in the Salbutamol sulfate MDPI Group and Greater Than Placebo in the 3 Week Trial

Preferred Term

Number (%) of patients

Salbutamol sulfate MDPI 180mcg QID

N=93

Placebo

N=92

Nasopharyngitis

2 (2%)

1 (1%)

Oropharyngeal pain

2 (2%)

1 (1%)

Vomiting

3 (3%)

1 (1%)

Postmarketing Experience

In addition to the adverse reactions reported from clinical trials with Salbutamol sulfate MDPI, the following adverse events have been reported during use of other inhaled Salbutamol sulfate products: Urticaria, angioedema, rash, bronchospasm, hoarseness, oropharyngeal edema, and arrhythmias (including atrial fibrillation, supraventricular tachycardia, extrasystoles), rare cases of aggravated bronchospasm, lack of efficacy, asthma exacerbation (potentially fatal), muscle cramps, and various oropharyngeal side-effects such as throat irritation, altered taste, glossitis, tongue ulceration, and gagging. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

In addition, Salbutamol, like other sympathomimetic agents, can cause adverse reactions such as: angina, hypertension or hypotension, palpitations, central nervous system stimulation, insomnia, headache, nervousness, tremor, muscle cramps, drying or irritation of the oropharynx, hypokalemia, hyperglycemia, and metabolic acidosis.

Salbutamol contraindications

See also:
What is the most important information I should know about Salbutamol?

Use of Salbutamol is contraindicated in patients with a history of hypersensitivity to Salbutamol and/or severe hypersensitivity to milk proteins. Rare cases of hypersensitivity reactions, including urticaria, angioedema, and rash have been reported after the use of Salbutamol sulfate. There have been reports of anaphylactic reactions in patients using inhalation therapies containing lactose.

Active ingredient matches for Salbutamol:

Albuterol in Antigua & Barbuda, Argentina, Aruba, Australia, Bahamas, Bangladesh, Barbados, Belgium, Bermuda, Bosnia & Herzegowina, Bulgaria, Canada, Cayman Islands, China, Croatia (Hrvatska), Czech Republic, Ecuador, Estonia, Ethiopia, Georgia, Grenada, Guyana, Hong Kong, Hungary, Iceland, Indonesia, Ireland, Israel, Italy, Jamaica, Latvia, Lithuania, Luxembourg, Malaysia, Malta, Mexico, Myanmar, Netherlands, New Zealand, Oman, Peru, Philippines, Poland, Romania, Russian Federation, Saint Lucia, Serbia, Singapore, Slovakia, Slovenia, South Africa, South Korea, Spain, Switzerland, Taiwan, Thailand, Trinidad & Tobago, Turkey, United Kingdom, Vietnam.

Salbutamol in Romania.


Unit description / dosage (Manufacturer)Price, USD
Liquid; Inhalation; Albuterol Sulfate 1 mg / ml
Aerosol, Metered-Dose; Inhalation; Albuterol 100 mcg / dose
Syrup; Oral; Albuterol 2 mg / 5 ml
Tablet; Oral; Albuterol 4 mg
Syrup; Oral; Albuterol Sulfate 2 mg / 5 ml
Solution; Irrigation; Albuterol Sulfate 0.5%
Solution; Inhalation; Albuterol
Solution; Inhalation; Albuterol Sulfate 1 mg / ml
Solution; Inhalation; Albuterol Sulfate 2 mg / ml
Aerosol, Metered-Dose; Inhalation; Albuterol Sulfate 100 mcg / dose
Solution; Oral; Albuterol Sulfate 2 mg / 5 ml
Suspension; Inhalation; Albuterol Sulfate 100 mcg / dose
Injectable; Injection; Albuterol Sulfate 1 mg / ml
Aerosol, Metered-Dose; Inhalation; Albuterol
Tablet, Retard; Oral; Albuterol 8 mg
Tablet; Oral; Albuterol 2 mg
Xopenex 0.63 mg/3 ml solution$ 64.20
Proventil HFA 108 / 90 Basemcg/act Aerosol 6.7 gm Inhaler$ 55.09
Xopenex HFA 45 mcg/act Aerosol 15 gm Inhaler$ 53.84
AccuNeb 0.63 mg/3ml Neb. Solution 1 Box= 25 Vials$ 53.14
AccuNeb 1.25 mg/3ml Neb. Solution 1 Box= 25 Vials$ 53.14
ProAir HFA 108 / 90 Basemcg/act Aerosol 8.5 gm Inhaler$ 45.99
Ventolin HFA 108 / 90 Basemcg/act Aerosol 18 gm Inhaler$ 39.99
Proair hfa 90 mcg inhaler$ 12.62
Proventil hfa 90 mcg inhaler$ 8.07
Xopenex hfa 45 mcg inhaler$ 6.12
Xopenex 0.31 mg/3ml / 1 Box = 24, 3ml Vials$ 4.87
Xopenex 1.25 mg/3ml / 1 Box = 24, 3ml Vials$ 4.87
Xopenex 0.63 mg/3ml / 1 Box = 24, 3ml Vials$ 4.71
Xopenex 1.25 mg/3 ml solution$ 2.96
Ventolin hfa 90 mcg inhaler$ 2.01
Xopenex 0.31 mg/3 ml solution$ 1.56
Ventolin 5 mg/ml Solution$ 1.13
Ventolin Nebules P.F. 2 mg/ml Unit Dose Solution$ 0.88
Accuneb 0.63 mg/3 ml inh solution$ 0.68
Accuneb 1.25 mg/3 ml inh solution$ 0.68
Mylan-Salbutamol 5 mg/ml Solution$ 0.62
Pms-Salbutamol 5 mg/ml Solution$ 0.62
Ratio-Salbutamol 5 mg/ml Solution$ 0.62
Sandoz Salbutamol 5 mg/ml Solution$ 0.62
Mylan-Salbutamol Sterinebs P.F. 2 mg/ml Unit Dose Solution$ 0.48
Pms-Salbutamol Polyneb 2 mg/ml Unit Dose Solution$ 0.48
Ratio-Salbutamol Uni Dose P.F. 2 mg/ml Unit Dose Solution$ 0.48
Ventolin Nebules P.F. 1 mg/ml Solution$ 0.47
Mylan-Salbutamol Sterinebs P.F. 1 mg/ml Solution$ 0.25
Pms-Salbutamol 1 mg/ml Solution$ 0.25
Ratio-Salbutamol Sulf U.D.P.F. 1 mg/ml Solution$ 0.25
Apo-Salvent 4 mg Tablet$ 0.22
Pms-Salbutamol 0.5 mg/ml Solution$ 0.16
Ratio-Salbutamol Unit Dose P.F 0.5 mg/ml Solution$ 0.16
Apo-Salvent 2 mg Tablet$ 0.13
Pms-Salbutamol 400 mcg/ml Liquid$ 0.05
Ratio-Salbutamol Hfa 100 mcg/dose Metered Dose Aerosol$ 0.04
Airomir Cfc-Free 100 mcg/dose Metered Dose Aerosol$ 0.03
Apo-Salvent Cfc Free 100 mcg/dose Metered Dose Aerosol$ 0.03
Ventolin Hfa 100 mcg/dose Metered Dose Aerosol$ 0.03
Salbutamol - RESP-SOLN / 10ml$ 0.21
Salbutamol 20mg MDI / 200$ 1.32
Salbutamol / Prince 2 mg
Salbutamol / Y.S. 4 mg
20 mg x 200's$ 1.32
10ml$ 0.21
Salbutamol / C.H. 0.4 mg/1 mL x 1 mL
Salbutamol / C.H. 0.4 mg/1 mL x 60 mL
Salbutamol / Update 4 mg
Salbutamol / F.Y. 4 mg
Salbutamol / F.Y. 4 mg x 84's
Salbutamol / Honten 4 mg
Salbutamol / C.S. 2 mg
Salbutamol / M.T 4.82 mg
Salbutamol / Yung Shin 4 mg
Salbutamol / Yung Shin 0.5 mg/1 mL x 1 mL
Tablets; Oral; Albuterol 4 mg
Tablets, Retard; Oral; Albuterol 8 mg
Tablets; Oral; Albuterol 2 mg
Salbutamol 4 mg Tablet$ 0.00
Salbutamol 20 mg Inhaler$ 0.01
Salbutamol 2 mg Tablet$ 0.00
Salbutamol 2 mg Acichem Labs Tablet$ 0.00
Salbutamol 4 mg LOCOST Tablet$ 0.01
Salbutamol 2 mg Tosc International Tablet$ 0.00
Salbutamol 100 ml Syrup$ 0.02
Salbutamol 4 mg Acichem Labs Tablet$ 0.00
Salbutamol 2 mg Wings Pharma Tablet$ 0.00
SALBUTAMOL RESPIRATOR SOLUTION 1 bottle / 10 ML solution each (Cipla Ltd)$ 0.21
SALBUTAMOL / GSK MDI 100 mcg x 1 puff x 200md (GSK)$ 1.32
SALBUTAMOL / GSK inhalation soln 10ml (GSK)$ 0.21
Salbutamol NA Solution (Cipla Ltd)$ 0.21

List of Salbutamol substitutes (brand and generic names):

Salbutamo 4 mg
SALBUTAMOL 2 MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.04
SALBUTAMOL 2MG SYRUP 1 bottle / 100 ML syrup each (Jan Aushadhi)$ 0.22
SALBUTAMOL 4MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.04
Salbutamol Actavis 2 mg x 500's (Actavis)
Salbutamol Actavis 4 mg x 500's (Actavis)
Salbutamol Actavis tab 2 mg 500's (Actavis)
Salbutamol Actavis tab 4 mg 500's (Actavis)
Salbutamol Alpine 4 mg x 10 Blister x 10 Tablet
Salbutamol Bidiphar 2 mg x 1 Bottle 500 Tablet
Salbutamol Bidiphar 4 mg x 10 Blister x 10 Tablet
Salbutamol Bidiphar 4 mg x 1 Bottle 100 Tablet
Salbutamol Bidiphar 0.5 mg/1 mL x 6 tube x 1mL

References

  1. DailyMed. "ALBUTEROL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "Salbutamol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "Salbutamol". http://www.drugbank.ca/drugs/DB01001 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Salbutamol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Salbutamol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Salbutamol drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful1
100.0%


1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Salbutamol drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Not expensive1
100.0%


3 consumers reported time for results

To what extent do I have to use Salbutamol before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Salbutamol. To get the time effectiveness of using Salbutamol drug by other patients, please click here.
Users%
1 day2
66.7%
3 days1
33.3%


5 consumers reported age

Users%
6-151
20.0%
> 601
20.0%
30-451
20.0%
16-291
20.0%
46-601
20.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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