Actions of Selenase T in details
Selenase T is a trace element that is essential in small amounts in the body. Selenase T is important in the functioning of Selenase T dependent chemical (enzymes) in the body called as selanoproteins. Selenase T is an integral part of glutathione peroxidases (GPx) that act as potent antioxidant (substance that protects against cell damage) by neutralizing the free radicals (waste products formed in the body during energy production) such as reactive oxygen and nitrogen species. Thus Selenase T participates in vital redox reactions of the body. Also, a selenoprotein (iodothyronine deiodinases) is essential for the conversion of thyroxine (T4) to the biologically active thyroid hormone triiodothyronine (T3) thereby indicating the importance of Selenase T in thyroid hormone functioning.
How should I take Selenase T?
When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. If you choose to use Selenase T, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider.
Long-term use of Selenase T in doses greater than 400 micrograms (mcg) per day can lead to serious medical problems or death. Do not use more of this product than is recommended on the label.
The recommended dietary allowance of Selenase T increases with age. Follow your healthcare provider's instructions. You may also consult the National Academy of Sciences "Dietary Reference Intake" or the U.S. Department of Agriculture's "Dietary Reference Intake" (formerly "Recommended Daily Allowances" or RDA) listings for more information.
If you need surgery, tell the surgeon ahead of time that you are using Selenase T. You may need to stop using this product for at least 2 weeks before your surgery.
This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Selenase T.
Store at room temperature away from moisture and heat.
Selenase T administration
Oral: Bariatric surgery: Tablet, extended release: Some institutions may have specific protocols that conflict with these recommendations; refer to institutional protocols as appropriate. ER tablets should be swallowed whole. Do not break, crush, or chew. IR tablet, capsule, oral solution, and injectable formulations are available. If safety and efficacy can be effectively monitored, no change in formulation or administration is required after bariatric surgery. Bariatric vitamin supplementation is recommended on a lifelong basis after surgery; may consider integration of daily Selenase T regimen into the bariatric vitamin regimen.
Selenase T pharmacology
Selenase T is part of glutathione peroxidase which protects cell components from oxidative damage due to peroxides produced in cellular metabolism.
Prolonged TPN support in humans has resulted in Selenase T deficiency symptoms which include muscle pain and tenderness. The symptoms have been reported to respond to supplementation of TPN solutions with Selenase T.
Pediatric conditions, Keshan disease, and Kwashiorkor, have been associated with low dietary intake of Selenase T. The conditions are endemic to geographical areas with low Selenase T soil content. Dietary supplementation with Selenase T salts has been reported to reduce the incidence of the conditions among affected children.
Normal blood levels of Selenase T in different human populations have been found to vary and depend on the Selenase T content of the food consumed. Results of surveys carried out in some countries are tabulated below:
| COUNTRY | Number of Samples | Selenase T (mcg/100 mL) (a) | ||
| Whole Blood | Blood Cells | Plasma/ Serum | ||
| (a) Mean values with or without standard deviation in parentheses, all other ranges. | ||||
| (b) Age group unknown. | ||||
| (c) Three children recovered from Kwashiorkor and the other six under treatment for other diseases. | ||||
| (d) Low Selenase T-content soil area. | ||||
| (e) Well nourished children, three recovered from Kwashiorkor and the other six under treatment for other diseases. | ||||
| (f) Mean values from seven subjects. | ||||
| Canada | 254 Adults | (37.9 ± 7.8) | (23.6 ± 6.0) | (14.4 ± 2.9) |
| England | 8 (b) | 26-37 (32) | —— | —— |
| Guatemala & Southern USA | 10 Adults 9 Children (c) | 19-28 (22) (23 ± 5) | —— (36 ± 12) | —— (15 ± 5) |
| New Zealand (d) | 113 Adults | (5.4 ± 0.1) | (6.6 ± 0.3) | (4.3 ± 0.1) |
| Thailand | 3 Adults 9 Children (e) | 14.4-20.2 (12.0 ± 3.6) (f) | 17.8-35.8 (19.5 ± 8.2) | 8.1-12.5 (8.3 ± 2.2) |
| USA | 210 Adults | 15.7-25.6 (20.6) | —— | —— |
Plasma Selenase T levels of 0.3 and 0.9 mcg/100 mL have been reported to produce deficiency symptoms in humans.
Selenase T is eliminated primarily in urine. However, significant endogenous losses through feces also occur. The rate of excretion and the relative importance of two routes varies with the chemical form of Selenase T used in supplementation. Ancillary routes of elimination are lungs and skin.
Reviews
The results of a survey conducted on ndrugs.com for Selenase T are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Selenase T. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
