What happens if I overdose Sinapdin?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately. Symptoms may include dilated pupils; flushing; hallucinations; overexcitement; seizures; severe drowsiness; severe dry mouth; vomiting.
Proper storage of Sinapdin:
Store Sinapdin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sinapdin out of the reach of children and away from pets.
Overdose of Sinapdin in details
Antihistamine overdosage reactions may vary from central nervous system depression to stimulation especially in children. Also, atropine-like signs and symptoms (dry mouth; fixed, dilated pupils; flushing, etc.) as well as gastrointestinal symptoms may occur.
If vomiting has not occurred spontaneously, the patient should be induced to vomit with syrup of ipecac.
If the patient is unable to vomit, perform gastric lavage followed by activated charcoal. Isotonic or 1/2 isotonic saline is the lavage of choice. Precautions against aspiration must be taken especially in infants and children.
When life threatening CNS signs and symptoms are present, intravenous physostigmine salicylate may be considered. Dosage and frequency of administration are dependent on age, clinical response and recurrence after response.
Saline cathartics, as milk of magnesia, by osmosis draw water into the bowel and, therefore, are valuable for their action in rapid dilution of bowel content.
Stimulants should not be used.
Vasopressors may be used to treat hypotension.
The oral LD50 of Sinapdin is 123 mg/kg, and 295 mg/kg in the mouse and rat, respectively.
What should I avoid while taking Sinapdin?
Sinapdin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Drinking alcohol can increase some of the side effects of Sinapdin.
Sinapdin warnings
Children
Overdosage of antihistamines, particularly in infants and children, may produce hallucinations, central nervous system depression, convulsions and death.
Antihistamines may diminish mental alertness; conversely, particularly in the young child, they may occasionally produce excitation.
CNS Depressants
Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.
Activities Requiring Mental Alertness
Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.
Antihistamines are more likely to cause dizziness, sedation and hypotension in elderly patients.
What should I discuss with my healthcare provider before taking Sinapdin?
Some medical conditions may interact with Sinapdin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of asthma; bladder, stomach, or bowel blockage; glaucoma or increased pressure in the eye; difficulty urinating; prostate problems; kidney problems; overactive thyroid; heart problems; high blood pressure; or seizures
Some MEDICINES MAY INTERACT with Sinapdin. Tell your health care provider if you are taking any other medicines, especially any of the following:
- MAOIs (eg, phenelzine) because they may increase the risk of Sinapdin's side effects
- Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because their effectiveness may be decreased by Sinapdin
This may not be a complete list of all interactions that may occur. Ask your health care provider if Sinapdin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Sinapdin precautions
General
Sinapdin has an atropine-like action and, therefore, should be used with caution in patients with:
History of bronchial asthma
Increased intraocular pressure
Hyperthyroidism
Cardiovascular disease
Hypertension
Information for Patients
Antihistamines may diminish mental alertness; conversely, particularly in the young child, they may occasionally produce excitation.
Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.
Drug Interactions
MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.
Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, anti-anxiety agents.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term carcinogenic studies have not been done with Sinapdin.
Sinapdin had no effect on fertility in a two-litter study in rats or a two generation study in mice at about 10 times the human dose.
Sinapdin did not produce chromosome damage in human lymphocytes or fibroblasts in vitro; high doses (10-4M) were cytotoxic. Sinapdin did not have any mutagenic effect in the Ames microbial mutagen test; concentrations of above 500 mcg/plate inhibited bacterial growth.
Pregnancy
Pregnancy Category BReproduction studies have been performed in rabbits, mice and rats at oral or subcutaneous doses up to 32 times the maximum recommended human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to Sinapdin. Sinapdin has been shown to be fetotoxic in rats when given by intraperitoneal injection in doses four times the maximum recommended human oral dose. Two studies in pregnant women, however, have not shown that Sinapdin increases the risk of abnormalities when administered during the first, second and third trimesters of pregnancy. No teratogenic effects were observed in any of the newborns. Nevertheless, because the studies in humans cannot rule out the possibility of harm, Sinapdin should be used during pregnancy only if clearly needed.
Nursing Mothers
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from Sinapdin, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use
Safety and effectiveness in pediatric patients below the age of two years have not been established..
What happens if I miss a dose of Sinapdin?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DrugBank. "CYPROHEPTADINE". http://www.drugbank.ca/drugs/DB00434 (accessed September 17, 2018).
- MeSH. "Serotonin Antagonists". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
