Sinarest-AF DPS Uses

How times a day do you take this medicine?

What is Sinarest-AF DPS?

Sinarest-AF DPS (Sinarest-AF DPS) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Sinarest-AF DPS is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes.

Sinarest-AF DPS may also be used for purposes not listed in this medication guide.

Sinarest-AF DPS indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Sinarest-AF DPS Ophthalmic Solution, USP 2.5% and 10%, is indicated to dilate the pupil.

How should I use Sinarest-AF DPS?

Use Sinarest-AF DPS drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Sinarest-AF DPS drops is for use in the eye only. Avoid contact with the nose or mouth.
  • To use Sinarest-AF DPS drops, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
  • To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including your eye. Keep the container tightly closed.
  • Do not wear contact lenses while you are using Sinarest-AF DPS drops. Sterilize contact lenses according to the manufacturer's directions and check with your doctor before using them.
  • Do not use Sinarest-AF DPS drops if it is brown or contains particles.
  • If you miss a dose of Sinarest-AF DPS drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Sinarest-AF DPS drops.

Uses of Sinarest-AF DPS in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications

Hypotension/shock: Treatment of hypotension, vascular failure in shock. Note: Not recommended for routine use in the treatment of septic shock; use should be limited until more evidence demonstrating positive clinical outcomes becomes available (Rhodes 2017).

Guideline recommendations:

Cardiogenic shock: The 2017 American Heart Association (AHA) scientific statement for the Contemporary Management of Cardiogenic Shock recommends Sinarest-AF DPS, if needed, be considered for initial vasoactive management of cardiogenic shock due to aortic stenosis, mitral stenosis, or dynamic left ventricular outflow tract (LVOT) obstruction (AHA [van Diepen 2017]).

Hypotension during anesthesia: As a vasoconstrictor in regional analgesia

Nasal congestion: As a decongestant [OTC]

Off Label Uses

Hypotension in patients with obstructive hypertrophic cardiomyopathy

Sinarest-AF DPS is a pure alpha1 agonist that will increase systemic vascular resistance without increasing heart rate or contractility. This is advantageous in patients with obstructive hypertrophic cardiomyopathy and hypotension since increases in both heart rate and contractility may cause the obstruction to worsen, leading to a decrease in cardiac output. Other vasopressors like dopamine, epinephrine, and norepinephrine may increase contractility and/or heart rate. Additional trials may be necessary to further define the role of Sinarest-AF DPS in this condition.

Based on the American Urological Association guidelines for the management of priapism, due to the low risk of cardiovascular side effects intracavernous injection of Sinarest-AF DPS is recommended for ischemic priapism that persists following aspiration/irrigation.

Sinarest-AF DPS description


Sinarest-AF DPS is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.

Sinarest-AF DPS dosage

General Dosing Recommendations

In patients 1 year of age or greater, apply one drop of either Sinarest-AF DPS ophthalmic solution 2.5% or 10% every 3 to 5 minutes to the conjunctival fornix as required up to a maximum of 3 drops per eye per day.

In order to obtain a greater degree of mydriasis, Sinarest-AF DPS ophthalmic solution 10% may be needed.

Dosing in Pediatric Patients Less Than 1 Year of Age

In pediatric patients less than 1 year of age, one drop of Sinarest-AF DPS ophthalmic solution 2.5% should be instilled at 3 to 5 minute intervals up to a maximum of 3 drops per eye.

Sinarest-AF DPS interactions

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What other drugs will affect Sinarest-AF DPS?



Concurrent use may enhance the pressor effects and induce tachycardia, especially in infants.


Decrease Sinarest-AF DPS’s effect.

Digitalis glycosides, general anesthetics


Furazolidone, MAOIs

May significantly increase pressor response resulting in hypertensive crisis and intracranial hemorrhage.

Guanethidine, methyldopa, reserpine

May increase pressor response of Sinarest-AF DPS; resulting in severe hypertension.

Halogenated hydrocarbon anesthetics

May sensitize myocardium to effects of catecholamines. Use extreme caution to avoid arrhythmias.

Oxytocic drugs

May cause severe persistent hypertension.

Tricyclic antidepressants

May decrease or increase response; use with caution.

Laboratory Test Interactions

Products with potassium guaiacolsulfonate may increase renal Cl for urate and thereby lower serum uric acid levels; may increase urinary 50 hydroxyindoleacetic acid; may falsely elevate VMA test for catecholis.

Sinarest-AF DPS side effects

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What are the possible side effects of Sinarest-AF DPS?

The following serious adverse reactions are described below and elsewhere in the labeling:

  • Cardiovascular Effects
  • Elevation in Blood Pressure

The following adverse reactions have been identified following use of Sinarest-AF DPS ophthalmic solution. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Ocular Adverse Reactions

Eye pain and stinging on instillation, temporary blurred vision and photophobia, and conjunctival sensitization may occur.

Systemic Adverse Reactions

A marked increase in blood pressure has been reported particularly, but not limited to low weight premature neonates, infants and hypertensive patients.

Cardiovascular effects which have been seen primarily in hypertensive patients following topical ocular use of Sinarest-AF DPS ophthalmic solution 10% include marked increase in blood pressure, syncope, myocardial infarction, tachycardia, arrhythmia and subarachnoid hemorrhage.

Sinarest-AF DPS contraindications

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What is the most important information I should know about Sinarest-AF DPS?

Cardiac and Endocrine Disease

Sinarest-AF DPS ophthalmic solution 10% is contraindicated in patients with hypertension or thyrotoxicosis. Sinarest-AF DPS ophthalmic solution 2.5% should be used in these patients.

Pediatric Patients Less Than 1 Year of Age

Sinarest-AF DPS ophthalmic solution 10% is contraindicated in pediatric patients less than 1 year of age due to the increased risk of systemic toxicity. Sinarest-AF DPS ophthalmic solution 2.5% should be used in these patients.

Active ingredient matches for Sinarest-AF DPS:

Phenylephrine hydrochloride in India.


Chlorpheniramine maleate in India.

Unit description / dosage (Manufacturer)Price, USD
15ml$ 0.52
Sinarest-Af Dps Phenylephrine hydrochloride2.5 mg, Chlorpheniraminemaleate 1 mg/1 mL. DPS / 15ml$ 0.52
SINAREST-AF DPS oral drops 15ml (Centaur (Shashvatam))$ 0.57
Sinarest-Af Dps Phenylephrine hydrochloride2.5 mg, Chlorpheniraminemaleate 1 mg/1 mL. DPS / 15ml$ 0.52

List of Sinarest-AF DPS substitutes (brand and generic names):

Sinarest Tablet (Samruddhi (Centaur Pharmaceuticals))$ 0.07
Sinarest-PD Syr Paracetamol 125 mg, phenylephrine hydrochloride2.5 mg, chlorpheniraminemaleate 1 mg, sodium citrate60 mg, menthol 0.5 mg/5 mL. SYR / 60ml (Centaur)$ 0.49
SINAREST-PD SYR syr 60ml (Centaur)$ 0.49
Sinex DMR 100 ml Suspension (Zee Laboratories Ltd)$ 0.03
Sino Plus Tab Tablet (Entod Pharmaceuticals Ltd)$ 0.03
Sinoclear Cough 60 ml Syrup (Liva (Zydus Cadila Healthcare Ltd.))$ 0.03
Sinucold Cetirizine 5 mg, paracetamol325 mg, phenylephrine 5 mg. TAB / 10 (Intecare)$ 0.67
Sinucold Cetirizine 2.5 mg, paracetamol12.5 mg, phenylephrine 5 mg. O-SUSP / 60ml (Intecare)$ 0.56
SINUCOLD tab 10's (Intecare)$ 0.67
SINUCOLD oral susp 60ml (Intecare)$ 0.56
Sinurhon Tablet (Leben Laboratories Pvt. Ltd.)$ 0.53
Solicon 60 ml Syrup (Unicure (India) Pvt.Ltd.)$ 0.01
Spa DMR 100 ml Syrup (Spa Biological Labs)$ 0.04
Spa DMR 60 ml Syrup (Spa Biological Labs)$ 0.05
Spray; Nasal; Phenylephrine (Spirig)
Sudafed PE Congestion tablet 10 mg/1 (Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division (US))
Tablet; Oral; Phenylephrine Hydrochloride 10 mg
Sudafed PE Extra Strength tablet 10 mg (Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc (Canada))
Sudicin 400 B 400+30+4 Tablet (Terrace Pharmaceuticals (P) Ltd)$ 0.02
Sudogest PE tablet, film coated 10 mg/1 (Major Pharmaceuticals (US))
Sudohist P 500+60+4 Tablet (Hamax Pharmaceuticals)$ 0.02
Sudophen 60 ml Syrup (Kentreck Labs Pvt Ltd.)$ 0.04
Sunepherine Eye 2.5% Drop (Sunways India Pvt. Ltd.)$ 0.02
Sunepherine Eye 10% Drop (Sunways India Pvt. Ltd.)$ 0.09
Sunepherine Eye 5% Drop (Sunways India Pvt. Ltd.)$ 0.03
SUNEPHRINE EYE DROP 1 packet / 5 ML eye drop each (Sunways India Pvt Ltd)$ 0.42
Sunephrine-H Phenylephrine 5 %, atropine 1%. EYE-DPS / 5ml (Sunways)$ 0.52


  1. DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "phenylephrine". (accessed September 17, 2018).
  3. PubChem. "chlorpheniramine". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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