What happens if I overdose Sinifev?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe nausea or stomach pain; slow or troubled breathing; unusual bleeding or bruising; vomit that looks like coffee grounds.
Proper storage of Sinifev capsules:
Store Sinifev capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Avoid temperatures above 104 degrees F (40 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sinifev capsules out of the reach of children and away from pets.
Overdose of Sinifev in details
The toxicity of Sinifev overdose is dependent upon the amount of drug ingested and the time elapsed since ingestion, though individual response may vary, which makes it necessary to evaluate each case individually. Although uncommon, serious toxicity and death have been reported in the medical literature with Sinifev overdosage. The most frequently reported symptoms of Sinifev overdose include abdominal pain, nausea, vomiting, lethargy and drowsiness. Other central nervous system symptoms include headache, tinnitus, CNS depression and seizures. Metabolic acidosis, coma, acute renal failure and apnea (primarily in very young children) may rarely occur. Cardiovascular toxicity, including hypotension, bradycardia, tachycardia and atrial fibrillation, also have been reported.
The treatment of acute Sinifev overdose is primarily supportive. Management of hypotension, acidosis and gastrointestinal bleeding may be necessary. In cases of acute overdose, the stomach should be emptied through ipecac-induced emesis or lavage. Emesis is most effective if initiated within 30 minutes of ingestion.
Orally administered activated charcoal may help in reducing the absorption and reabsorption of Sinifev.
In children, the estimated amount of Sinifev ingested per body weight may be helpful to predict the potential for development of toxicity although each case must be evaluated. Ingestion of less than 100 mg/kg is unlikely to produce toxicity. Children ingesting 100 to 200 mg/kg may be managed with induced emesis and a minimal observation time of four hours. Children ingesting 200 to 400 mg/kg of Sinifev should have immediate gastric emptying and at least four hours observation in a health care facility. Children ingesting greater than 400 mg/kg require immediate medical referral, careful observation and appropriate supportive therapy. Ipecac-induced emesis is not recommended in overdoses greater than 400 mg/kg because of the risk for convulsions and the potential for aspiration of gastric contents.
In adult patients the history of the dose reportedly ingested does not appear to be predictive of toxicity. The need for referral and follow-up must be judged by the circumstances at the time of the overdose ingestion. Symptomatic adults should be carefully evaluated, observed and supported.
What should I avoid while taking Sinifev?
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Avoid taking aspirin while you are taking Sinifev.
Avoid taking Sinifev if you are taking aspirin to prevent stroke or heart attack. Sinifev can make aspirin less effective in protecting your heart and blood vessels. If you must use both medications, take the Sinifev at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form).
Ask a doctor or pharmacist before using any cold, allergy, or pain medicine. Many medicines available over the counter contain aspirin or other medicines similar to Sinifev. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, Sinifev, ketoprofen, or naproxen.
Sinifev warnings
Junior Strength Sinifev is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, reduce fever, and treat osteoarthritis, rheumatoid arthritis, and menstrual cramps. Inform your physician if you are pregnant or nursing. Junior Strength Sinifev should not be taken during the last three months of pregnancy. Inform your physician if you use alcohol chronically. Junior Strength Sinifev should not be taken with aspirin products. This medication should be taken with food, milk or antacids if stomach upset occurs. Junior Strength Sinifev may cause dizziness and drowsiness; use caution while driving or operating hazardous machinery. Junior Strength Sinifev may cause increased sensitivity to sunlight. Use sunscreens and wear protective clothing until degree of sensitivity is determined. Notify your physician if you develop stomach pain, bloody vomit, bloody or black tarry stools, cloudy urine, trouble breathing, rash or hives.
What should I discuss with my healthcare provider before taking Sinifev?
- If you are allergic to Sinifev (Sinifev suspension); any part of Sinifev (Sinifev suspension); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have an allergy to aspirin or NSAIDs.
- If you have ever had asthma caused by a salicylate drug like aspirin or a drug like this one like NSAIDs.
- If you have any of these health problems: GI (gastrointestinal) bleeding or kidney problems.
- If you have heart failure (weak heart).
- If you have had a recent heart attack.
- If you are taking any other NSAID, a salicylate drug like aspirin, or pemetrexed.
- If you are having trouble getting pregnant or you are having your fertility checked.
- If you are pregnant or may be pregnant. Do not take Sinifev (Sinifev suspension) if you are in the third trimester of pregnancy. You may also need to avoid Sinifev (Sinifev suspension) at other times during pregnancy. Talk with your doctor to see when you need to avoid taking Sinifev (Sinifev suspension) during pregnancy.
This is not a list of all drugs or health problems that interact with Sinifev (Sinifev suspension).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Sinifev (Sinifev suspension) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Sinifev precautions
5.1 General
There are no long-term evaluations of the infants treated with Sinifev at durations greater than the 36 weeks post-conceptual age observation period. Sinifev’s effects on neurodevelopmental outcome and growth as well as disease processes associated with prematurity (such as retinopathy of prematurity and chronic lung disease) have not been assessed.
5.2 Infection
Sinifev Lysine may alter the usual signs of infection. The physician must be continually on the alert and should use the drug with extra care in the presence of controlled infection and in infants at risk of infection.
5.3 Platelet Aggregation
Sinifev Lysine, like other non-steroidal anti-inflammatory agents, can inhibit platelet aggregation. Preterm infants should be observed for signs of bleeding. Sinifev has been shown to prolong bleeding time (but within the normal range) in normal adult subjects. This effect may be exaggerated in patients with underlying hemostatic defects.
5.4 Bilirubin Displacement
Sinifev has been shown to displace bilirubin from albumin binding-sites; therefore, it should be used with caution in patients with elevated total bilirubin.
5.5 Administration
Sinifev Lysine should be administered carefully to avoid extravascular injection or leakage, as solution may be irritating to tissue.
What happens if I miss a dose of Sinifev?
Since Sinifev is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DailyMed. "IBUPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "ibuprofen". http://www.drugbank.ca/drugs/DB01050 (accessed September 17, 2018).
- MeSH. "Cyclooxygenase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
