Sinlerg Pregnancy

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Consists of Chlorphenamine, Ibuprofen, Pseudoephedrine

Pregnancy of Chlorphenamine (Sinlerg) in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Contraindicated in pregnancy (safety and efficacy in women during pregnancy has not been established); ciprofloxacin crosses the placenta, excreted in breast milk.

In experimental studies found that it causes arthropathy. In experiments on rats and mice treated with ciprofloxacin in doses exceeding the usual daily dose for a person 6 times, adverse effects on the fetus is not revealed. In experiments on rabbits treated with oral dose of ciprofloxacin 30 and 100 mg / kg, it is shown that the drug causes disruption of the gastrointestinal tract, leading to loss of body weight in females and increase the number of miscarriages but teratogenicity not found. When IV introduction to the doses of 20 mg / kg ciprofloxacin did not exert toxic effects on the mother and embryo, showed no teratogenicity. The use of local forms of ciprofloxacin in pregnancy is possible if the anticipated benefits exceed the potential risk to the fetus.

Category of the fetus by FDA - C.

Ciprofloxacin is excreted in breast milk, so the period of lactation should decide, stop taking ciprofloxacin or breastfeeding based on the degree of importance of the use of drugs for the mother.

With careful use of local forms of ciprofloxacin in breast-feeding (not known whether ciprofloxacin is excreted in breast milk when applied topically).

Pregnancy of Ibuprofen (Sinlerg) in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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During pregnancy patients should avoid prolonged use of Dol P.C. India Pharma because the risk of addiction in the fetus and the occurrence of withdrawal in the neonatal period.

If necessary using in lactation (breastfeeding) should be aware that tramadol in small amounts excreted in breast milk. In the case of long-term treatment can not been excluded the possibility of drug dependence.

Dol P.C. India Pharma is not recommended for treatment of withdrawal syndrome drugs.

Patients need to avoid combination with MAO inhibitors.

During the period of treatment with Dol P.C. India Pharma you should avoid to take alcohol.

Tramadol in the form of long-acting formulations should not be used in children under the age of 14 years.

During the period of tramadol using is not recommended to engage in activities that require special attention, speed of psychomotor reactions.

Ibuprofen (Sinlerg) breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Due to low levels in breast milk, short half-life, and therapeutic administration directly to infants at doses much higher than those excreted in breast milk, use is considered acceptable in nursing mothers; however, according to some manufacturers, use is not recommended. Limited published reports indicate that following oral administration, this drug is present in human milk at relative infant doses of 0.06% to 0.6% of the maternal weight-adjusted daily dose.

AU: Use is not recommended. UK and US: Caution is recommended. Excreted into human milk: Yes (in small amounts) Comments: This drug has been used without apparent harmful effects in the nursing infant.

See references

References for pregnancy information

  1. "Product Information. Caldolor (Ibuprofen (Sinlerg))." Cumberland Pharmaceuticals Inc, Nashville, TN.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. "Product Information. NeoProfen (Ibuprofen (Sinlerg))." Ovation Pharmaceuticals Inc, Deerfield, IL.
  4. Cerner Multum, Inc. "Australian Product Information." O 0
  5. "Product Information. Ibuprofen (Sinlerg)." Par Pharmaceutical Inc, Spring Valley, NY.
  6. "Product Information. Motrin (Ibuprofen (Sinlerg))." Pharmacia and Upjohn, Kalamazoo, MI.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  2. "Product Information. NeoProfen (Ibuprofen (Sinlerg))." Ovation Pharmaceuticals Inc, Deerfield, IL.
  3. "Product Information. Motrin (Ibuprofen (Sinlerg))." Pharmacia and Upjohn, Kalamazoo, MI.
  4. "Product Information. Caldolor (Ibuprofen (Sinlerg))." Cumberland Pharmaceuticals Inc, Nashville, TN.
  5. Cerner Multum, Inc. "Australian Product Information." O 0
  6. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  7. "Product Information. Ibuprofen (Sinlerg)." Par Pharmaceutical Inc, Spring Valley, NY.

Pregnancy of Pseudoephedrine (Sinlerg) in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Use of Pseudoephedrine (Sinlerg) during the first trimester may be associated with a possible risk of gastroschisis, small intestinal atresia, and hemifacial microsomia due to Pseudoephedrine (Sinlerg)'s vasoconstrictive effects; additional studies are needed to define the magnitude of risk. Single doses of Pseudoephedrine (Sinlerg) were not found to adversely affect the fetus during the third trimester of pregnancy (limited data); however, fetal tachycardia was noted in a case report following maternal use of an extended release product for multiple days. Decongestants are not the preferred agents for the treatment of rhinitis during pregnancy.

Oral Pseudoephedrine (Sinlerg) should be avoided during the first trimester.

Pseudoephedrine (Sinlerg) breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Based on limited data, it has been estimated that 0.5% to 0.7% of the mother's dose is excreted into breast milk over 24 hours. In 1 study, irritability was reported in up to 20% of infants. A 24% mean decrease in milk production was observed after a single 60 mg dose in 8 nursing mothers.

Caution is recommended Excreted into human milk: Yes Comments: -Single doses are unlikely to harm a nursing infant, but may cause irritability or disturbed sleep. -Repeated doses may interfere with lactation in mothers who are having difficulties producing sufficient milk or in those whose lactation is not well established.

See references

References for pregnancy information

  1. Werler MM, Mitchell AA, Shapiro S "First trimester maternal medication use in relation to gastroschisis." Teratology 45 (1992): 361-7
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
  4. Cerner Multum, Inc. "Australian Product Information." O 0
  5. Smith CV, Rayburn WF, Anderson JC, Duckworth AF, Appel LL "Effect of a single dose of oral Pseudoephedrine (Sinlerg) on uterine and fetal Doppler blood flow." Obstet Gynecol 76 (1990): 803-6

References for breastfeeding information

  1. Cerner Multum, Inc. "Australian Product Information." O 0
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):



References

  1. DailyMed. "PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "IBUPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubMed Health. "Pseudoephedrine (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).

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