Slimfast Uses

Rating: 3.3 - 9 review(s)
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What is Slimfast?

Slimfast is used together with a reduced-calorie diet to help you lose weight and to help keep the lost weight from returning. It is also used in overweight people who may also have diabetes, high blood pressure, high cholesterol, or heart disease.

Slimfast works by keeping your intestines from absorbing some of the fats from the food that you eat. The undigested fat goes out of your body in your bowel movements.

Slimfast is available both over-the-counter (OTC) and with your doctor's prescription.

Slimfast indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Slimfast is an anti-obesity agent. Slimfast is used to help obese people lose weight and keep this weight off. It does not suppress your appetite or act on the brain. It works in the digestive system, where it blocks about one-third of the fat in the food you eat from being digested. Since fat contains more calories than other components in foods, cutting the fat that is digested by your body is an effective way to limit daily calories and lose weight. It is a potent, specific and long-acting inhibitor of gastrointestinal lipases. The inactivated enzyme is thus unavailable to hydrolyse dietary fat, and this allows about 30% of the fat eaten in the meal to pass through the gut undigested. Your body therefore, cannot use this dietary fat as a source of energy and convert it to fat tissue. This will help you reduce your weight.

Slimfast is indicated in the treatment of obesity in conjunction with a mildly hypocaloric diet.

How should I use Slimfast?

Use Slimfast as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Slimfast. Talk to your pharmacist if you have questions about this information.
  • Take Slimfast by mouth with or up to 1 hour after each main meal that contains fat (up to 3 per day).
  • If a meal is missed or contains no fat, do not take a dose of Slimfast.
  • You should take a multivitamin supplement containing vitamins A, D, E, and K to ensure good nutrition. The supplement should be taken at least 2 hours before or after you take Slimfast, such as at bedtime.
  • If you also take a thyroid hormone (eg, levothyroxine), do not take it within 4 hours before or after taking Slimfast. Check with your doctor if you have questions.
  • If you also take cyclosporine, do not take it within 3 hours before or after taking Slimfast. Check with your doctor if you have questions.
  • If you miss a dose of Slimfast, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Slimfast.

Uses of Slimfast in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Slimfast is used for weight loss along with an exercise and diet regimen. It is also prescribed by doctors to overweight people who may be suffering from high blood pressure, high cholesterol, diabetes and heart patients. It is also used to stop weight gain after weight reduction.

Slimfast description

Slimfast is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Slimfast works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.

Slimfast dosage

Usual Adult Dose for Obesity

120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.

Usual Pediatric Dose for Obesity

12 years or older:

120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

If a meal is occasionally missed or contains no fat, the dose of Slimfast may be skipped.

Precautions

The use of Slimfast is contraindicated in patients with chronic malabsorption syndrome or cholestasis. Organic causes of obesity, such as hypothyroidism, should be excluded before prescribing Slimfast.

Gastrointestinal effects may increase when Slimfast is taken with any one meal high in fat.

Slimfast may reduce the absorption of some fat-soluble vitamins and beta-carotene. In addition, levels of vitamin D and beta-carotene may often be low in obese patients. To ensure adequate nutrition, supplementation with a multivitamin is recommended. The supplement should be taken at least two hours before or after the administration of Slimfast, such as at bedtime.

Elevated levels of urinary oxalate may develop in some patients treated with Slimfast. Cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure have been reported. In patients at risk for renal impairment, it is recommended that renal function be monitored. Caution should be exercised when prescribing Slimfast to patients with a history of hyperoxaluria or calcium oxalate nephrolithiasis.

Improved control of diabetes may accompany the weight-loss seen with Slimfast. A dosage reduction of oral hypoglycemics or insulin may be needed.

There is an increased risk of cholelithiasis with substantial weight loss.

Dialysis

Data not available

Other Comments

Slimfast reduces the absorption of some fat-soluble vitamins, therefore, multivitamin supplementation is necessary. The multivitamin should be administered once a day, at least 2 hours before or after Slimfast is taken.

The patient should be started on a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat. The daily intake of fat, carbohydrate, and protein should be distributed over three main meals.

Dosages greater than 120 mg orally three times a day have not been shown to provide additional benefit.

Slimfast interactions

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Transplant Rejection Medicines (e.g., Ciclosporin): Taking Slimfast and ciclosporin at the same time may decrease the absorption of ciclosporin making it less effective. If the patient take ciclosporin, the patient should check with the doctor before taking Slimfast. The doctor may recommend the patient to take ciclosporin at least three hours before or after Slimfast in order to avoid the interaction.

Medicines Used to Treat Irregular Heart Beat (e.g. Amiodarone): Slimfast may interfere with the absorption of this medicine making it less effective.

Anticoagulants or Medicines that Prevent Blood Clots (e.g., Warfarin): Slimfast can affect the level of vitamin K in the body, which affects the way the patient respond to warfarin. The doctor may need to monitor the patient more closely and adjust the warfarin dosage as necessary if the patient are taking these medicines at the same time.

Diabetes Medicines: Often, when people with diabetes lose weight, their diabetes medicines need to be adjusted (typically with lower dosages). Make sure that the doctor is aware of the patient's plan for weight loss with Slimfast, as the patient may need to be monitored more closely. As the patient lose weight, the doctor may need to decrease the dose of diabetes medicines accordingly.

Thyroid Medicines (e.g., Liothyronine, levothyroxine): Weight loss can affect how much thyroid medicine the patient need. If the patient take thyroid medicines, make sure to tell the doctor about the weight loss plans. The doctor may choose to monitor the patient more closely while taking Slimfast, adjusting the dose of thyroid medicines if necessary. Take levothyroxine and Slimfast at least 4 hours apart.

Vitamins: Slimfast can decrease the absorption of certain vitamins from the diet, possibly leading to a vitamin deficiency. In particular, this interaction affects fat-soluble vitamins, such as vitamins A, D, E, K and beta-carotene.

Antiepileptic Medicines (e.g., Valproate, lamotrigine): Slimfast may decrease the absorption of antiepileptic medicines which may lead to convulsions. Inform the doctor if there are changes in the frequency and/or severity of convulsions.

Make sure to tell the doctor about all the medicines the patient takes, including prescription and non-prescription medicines, vitamins and herbal supplements.

Slimfast side effects

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Clinical Trials

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in patients.

Commonly Observed (based on first year and second year data)

Gastrointestinal (GI) symptoms were the most commonly observed treatment-emergent adverse events associated with the use of Slimfast in the seven double-blind, placebo-controlled clinical trials and are primarily a manifestation of the mechanism of action. (Commonly observed is defined as an incidence of ≥5% and an incidence in the Slimfast 120 mg group that is at least twice that of placebo.)

In general, the first occurrence of these events was within 3 months of starting therapy. Overall, approximately 50% of all episodes of GI adverse events associated with Slimfast treatment lasted for less than 1 week, and a majority lasted for no more than 4 weeks. However, GI adverse events may occur in some individuals over a period of 6 months or longer.

Discontinuation of Treatment

In controlled clinical trials, 8.8% of patients treated with Slimfast discontinued treatment due to adverse events, compared with 5.0% of placebo-treated patients. For Slimfast, the most common adverse events resulting in discontinuation of treatment were gastrointestinal.

Other Adverse Clinical Events

The following table lists other treatment-emergent adverse events from seven multicenter, double-blind, placebo-controlled clinical trials that occurred at a frequency of ≥2% among patients treated with Slimfast 120 mg three times a day and with an incidence that was greater than placebo during year 1 and year 2, regardless of relationship to study medication.

In the 4-year XENDOS study, the general pattern of adverse events was similar to that reported for the 1- and 2-year studies with the total incidence of gastrointestinal-related adverse events occurring in year 1 decreasing each year over the 4-year period.

In clinical trials in obese diabetic patients, hypoglycemia and abdominal distension were also observed.

Pediatric Patients

In clinical trials with Slimfast in adolescent patients ages 12 to 16 years, the profile of adverse reactions was generally similar to that observed in adults.

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of Slimfast. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to Slimfast exposure.

  • Rare cases of increase in transaminases and in alkaline phosphatase and hepatitis that may be serious have been reported. There have been reports of hepatic failure observed with the use of Slimfast in postmarketing surveillance, with some of these cases resulting in liver transplant or death.
  • Cases of reduced concentrations of cyclosporine have been reported when cyclosporine was co-administered with Slimfast.
  • Rare cases of hypersensitivity have been reported with the use of Slimfast. Signs and symptoms have included pruritus, rash, urticaria, angioedema, bronchospasm and anaphylaxis. Very rare cases of bullous eruption have been reported.
  • Rare cases of leukocytoclastic vasculitis have been reported. Clinical signs include palpable purpura, maculopapular lesions, or bullous eruption.
  • Reports of decreased prothrombin, increased INR and unbalanced anticoagulant treatment resulting in change of hemostatic parameters have been reported in patients treated concomitantly with Slimfast and anticoagulants.
  • Hypothyroidism has been reported in patients treated concomitantly with Slimfast and levothyroxine.
  • Acute oxalate nephropathy after treatment with Slimfast has been reported in patients with or at risk for renal disease.
  • Pancreatitis has been reported with the use of Slimfast in postmarketing surveillance. No causal relationship or physiopathological mechanism between pancreatitis and obesity therapy has been definitively established.
  • Lower gastrointestinal bleeding has been reported in patients treated with Slimfast. Most reports are nonserious; severe or persistent cases should be investigated further.
  • Convulsions have been reported in patients treated concomitantly with Slimfast and antiepileptic drugs.

Slimfast contraindications

Hypersensitivity to Slimfast or to any of the excipients of Slimfast.

Chronic malabsorption syndrome; cholestasis.

Use in lactation: It is not known whether Slimfast is secreted into human milk therefore, it is contraindicated during breastfeeding.

Active ingredient matches for Slimfast:

Orlistat in Bangladesh, India.


Unit description / dosage (Manufacturer)Price, USD
SlimFast - 30 Capsule$ 24.95
SlimFast - 90 Capsule$ 54.95
SLIMFAST cap 60 mg x 10's (Intra (Intra Life))$ 3.97
SLIMFAST cap 120 mg x 10's (Intra (Intra Life))$ 7.14

List of Slimfast substitutes (brand and generic names):

SLIMREX cap 120 mg x 10's (Pax Healthcare)$ 8.41
Capsule; Oral; Ginkgo Biloba Extract 60 mg (Medichemie)
Capsule; Oral; Orlistat 120 mg (Medichemie)
Troyslim 120mg CAP / 10 (Troikaa Pharmaceuticals Ltd.)$ 6.05
Troyslim 120 mg Capsule (Troikaa Pharmaceuticals Ltd.)$ 0.67
TROYSLIM 120MG CAPSULE 1 strip / 10 capsules each (Troikaa Pharmaceuticals Ltd.)$ 7.14
TROYSLIM cap 120 mg x 10's (Troikaa Pharmaceuticals Ltd.)$ 6.05
ULTISLIM 120 MG TABLET 1 strip / 10 tablets each (Akumentis Healthcare Ltd)$ 6.17
ULTISLIM 60 MG TABLET 1 strip / 10 tablets each (Akumentis Healthcare Ltd)$ 3.97
Ultislim 120mg Tablet (Akumentis Healthcare Ltd)$ 0.62
Ultislim 60mg Tablet (Akumentis Healthcare Ltd)$ 0.40
Capsule; Oral; Orlistat 120 mg
Capsule; Oral; Orlistat 120 mg
Capsule; Oral; Orlistat 120 mg (K2 pharmacare)
Viplena 120 120 mg x 2 Blister x 10 Tablet
Vyfat 120mg CAP / 10 (Intas Pharmaceuticals Ltd.)$ 6.11
120 mg x 10's (Intas Pharmaceuticals Ltd.)$ 5.56
Vyfat 120 mg Capsule (Intas Pharmaceuticals Ltd.)$ 0.61
Vyfat 60 mg Capsule (Intas Pharmaceuticals Ltd.)$ 0.32
VYFAT 120 MG CAPSULE 1 strip / 10 capsules each (Intas Pharmaceuticals Ltd.)$ 7.62
VYFAT cap 120 mg x 10's (Intas Pharmaceuticals Ltd.)$ 6.11
Vyfat 120mg Capsule (Intas Pharmaceuticals Ltd.)$ 0.83
WONLISTAT tab 60 mg x 10's (Wonder (Xtra))
WONLISTAT tab 120 mg x 10's (Wonder (Xtra))
Capsule; Oral; Orlistat 120 mg (USV-Corvette (US Vitamins Ltd))
Generic Xenical 120mg - 42 Capsule (USV-Corvette (US Vitamins Ltd))$ 114.95
Generic Xenical 120mg - 84 Capsule (USV-Corvette (US Vitamins Ltd))$ 199.95
Xenical 120 mg - 21 Tablets (USV-Corvette (US Vitamins Ltd))$ 57.20
Xenical 120 mg x 4 x 21's (USV-Corvette (US Vitamins Ltd))
Xenical 120 mg x 21's (USV-Corvette (US Vitamins Ltd))$ 22.81
Xenical 120 mg x 84's (USV-Corvette (US Vitamins Ltd))
Xenical 120 mg x 21 Tablet (USV-Corvette (US Vitamins Ltd))
Xenical 120 mg x 42's (USV-Corvette (US Vitamins Ltd))
Xenical 120 mg x 4 Blister x 21 Tablet (USV-Corvette (US Vitamins Ltd))
Xenical 120 mg Capsule (USV-Corvette (US Vitamins Ltd))$ 0.83
XENICAL 120 MG CAPSULE 1 strip / 21 capsules each (USV-Corvette (US Vitamins Ltd))$ 17.59
XENICAL cap 120 mg x 10's (USV-Corvette (US Vitamins Ltd))$ 7.62

References

  1. DailyMed. "ORLISTAT: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailymed/se... (accessed September 18, 2017).
  2. PubChem. "orlistat". https://pubchem.ncbi.nlm.nih.gov/compoun... (accessed September 18, 2017).

Reviews

The results of a survey conducted on ndrugs.com for Slimfast are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Slimfast. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

3 consumers reported useful

Was the Slimfast drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful3
100.0%

4 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Slimfast drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Expensive3
75.0%
Not expensive1
25.0%

13 consumers reported time for results

To what extent do I have to use Slimfast before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 2 weeks and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Slimfast. To get the time effectiveness of using Slimfast drug by other patients, please click here.
Users%
2 weeks3
23.1%
1 month3
23.1%
1 day3
23.1%
5 days2
15.4%
3 month2
15.4%

21 consumers reported age

Users%
16-2917
81.0%
30-452
9.5%
> 601
4.8%
46-601
4.8%

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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