Spasmopan Uses

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How do you administer this medicine?

What is Spasmopan?

Spasmopan is an anticholinergic medicine. Spasmopan has many effects in the body including decreasing the secretion of fluids, slowing the stomach and intestines, and dilation of the pupils.

Spasmopan is used to relieve nausea, vomiting, and dizziness associated with motion sickness and recovery from anesthesia and surgery. Spasmopan may also be used in the treatment of parkinsonism, spastic muscle states, irritable bowel syndrome, diverticulitis, and other conditions.

Spasmopan may also be used for purposes other than those listed in this medication guide.

Spasmopan indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Spasmopan transdermal system is indicated in adults for the prevention of:

nausea and vomiting associated with motion sickness.
post-operative nausea and vomiting (PONV) associated with recovery from anesthesia and/or opiate analgesia and surgery.

How should I use Spasmopan?

Use Spasmopan drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Spasmopan drops is only for the eye. Do not get it in your nose or mouth.
  • To use Spasmopan drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
  • To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
  • If you miss a dose of Spasmopan drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Spasmopan drops.

Uses of Spasmopan in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This medication is used to widen the pupils for eye examination or eye surgery. It is also used to decrease pain and swelling from an inflammation of the eye (iridocyclitis). It belongs to a class of drugs known as anticholinergics. Spasmopan works by blocking the effects of a certain natural chemical (acetylcholine) on certain eye muscles, causing relaxation of these muscles. This effect causes the pupil to widen and the lens to temporarily lose the ability to focus. Spasmopan decreases pain in eye inflammation by relaxing the eye muscles.

How to use Spasmopan ophthalmic

If you are using this medication for eye inflammation, apply it to the eye up to 3 or 4 times a day or as directed by your doctor. If you are using this medication to widen the pupil, it is usually applied in the eye 1 hour before the procedure/exam or as directed by your doctor. This medication is for use in the eye only. Do not take by mouth or inject.

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

If you are wearing contact lenses, remove them before using these eye drops. Ask your doctor when you can start wearing your contact lenses again.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place 1 drop into the pouch as directed by your doctor. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure for 2 to 3 minutes. This will prevent the medication from draining away from the eye and will also help reduce side effects. Try not to blink and do not rub your eye. Repeat these steps if your dose is for more than 1 drop or for your other eye if so directed. Wash your hands after applying eye drops.

If you are applying eye drops into a child's eyes, wash your hands and the child's hands afterwards. Be careful not to get any drops in the child's mouth.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), ask your doctor if you should continue to use them with this medication and when you should start them again. Use eye drops before eye ointments to allow the drops to enter the eye.

If you have been directed to use this medicine more than 1 time (e.g., for eye inflammation), use it regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. Continue using it for the full time prescribed.

This medication starts to work in minutes, and its effect usually lasts for several days or sometimes longer. Tell your doctor if you continue to have blurred vision, sensitivity to light, or widened pupils 1 week after your exam. If you are treating inflammation, tell your doctor if your condition does not improve or if it worsens.

Spasmopan description


Spasmopan is a chiral compound. The racemic mixture can be divided into its optical antipodes: levo- and dextro-amphetamine. Spasmopan is the parent compound of its own structural class, comprising a broad range of psychoactive derivatives, e.g., MDMA (Ecstasy) and the N-methylated form, methamphetamine. Spasmopan is a homologue of phenethylamine.

Spasmopan dosage

Usual Adult Dose for Nausea/Vomiting

General antiemetic use: 0.3 to 0.65 mg administered IV, intramuscularly or subcutaneously every 6 to 8 hours as needed.

Post-operative nausea and vomiting use: apply one Spasmopan 1.5 mg transdermal disc behind the ear the evening before the scheduled surgery. The disc should remain in place for 24 hours after surgery before discarding.

If using Spasmopan transdermal on an obstetrics patient, apply the disc one hour prior to scheduled Cesarean section to limit exposure to the infant.

Usual Adult Dose for Motion Sickness

Apply one Spasmopan 1.5 mg transdermal disc behind the ear at least 4 hours prior to exposure every 3 days as needed.

Usual Adult Dose for Parkinsonian Tremor

0.4 to 0.8 mg orally every 8 hours as needed.

Usual Pediatric Dose for Nausea/Vomiting

1 to 12 years: 6 mcg/kg/dose (maximum dose: 0.3 mg/dose) administered IV, IM or subcutaneous every 6 to 8 hours as needed.

Usual Pediatric Dose for Motion Sickness

Greater than 12 years: apply one Spasmopan 1.5 mg transdermal disc behind the ear at least 4 hours prior to exposure every 3 days as needed.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


As with other anticholinergic agents, Spasmopan is contraindicated for patients with angle-closure glaucoma, prostatic hypertrophy, and pyloric obstruction. It should not be administered to patients with impaired hepatic or renal function.

Spasmopan may cause drowsiness, confusion, and disorientation. The elderly may be particularly sensitive to these effects. All patients should be cautioned against engaging in activities which require mental alertness, such as driving or operating dangerous machinery, while using the Spasmopan transdermal patch. The concomitant use of alcohol or other agents possessing CNS depressant activity should be avoided if possible.

Spasmopan may aggravate seizures (although this association has been disputed) and psychoses and should be used cautiously in patients with a history of such disorders.

Use with caution in patients with cardiac disease and in the elderly.

The safety and efficacy of Spasmopan in children have not been determined.


Data not available

Other Comments

Spasmopan transdermal patches contain residual drug when removed after being applied for 72 hours. Patients should wash their hands well with soap and water to prevent accidental transfer of Spasmopan to eyes or mucosal surfaces. Once removed, the patch should be folded against itself such that the adhesive side containing residual drug is not accessible.

Only one transdermal patch should be on the patient at any given time during therapy; remove the used disc prior to placing a fresh disc on the skin.

Spasmopan interactions

See also:
What other drugs will affect Spasmopan?


The absorption of oral medications may be decreased during the concurrent use of Spasmopan because of decreased gastric motility and delayed gastric emptying.

Spasmopan Hydrobromide Trihydrate should be used with care in patients taking other drugs that are capable of causing CNS effects such as sedatives, tranquilizers, or alcohol. Special attention should be paid to potential interactions with drugs having anticholinergic properties; e.g., other belladonna alkaloids, antihistamines (including meclizine), tricyclic antidepressants, and muscle relaxants.

Laboratory Test Interactions

Spasmopan Hydrobromide Trihydrate will interfere with the gastric secretion test.

Spasmopan side effects

See also:
What are the possible side effects of Spasmopan?

Applies to Spasmopan: transdermal patch extended release

In addition to its needed effects, some unwanted effects may be caused by Spasmopan (the active ingredient contained in Spasmopan). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Spasmopan:

Incidence not known:

  • Blurred vision
  • chest pain or discomfort
  • difficulty with urinating
  • dilation of the pupils
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • eye pain
  • flushing or redness of the skin
  • mood or mental changes
  • muscle weakness
  • nausea or vomiting
  • rash
  • redness of the white part of the eyes
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • shortness of breath
  • slow or irregular heartbeat
  • sweating
  • unusual tiredness
  • unusually warm skin

If any of the following symptoms of overdose occur while taking Spasmopan, get emergency help immediately:

Symptoms of overdose:

  • Anxiety
  • blurred or loss of vision
  • change in consciousness
  • decrease in frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • disturbed color perception
  • double vision
  • dry mouth
  • dry, flushed skin
  • fast, pounding, or irregular heartbeat or pulse
  • halos around lights
  • headache
  • hyperventilation
  • irritability
  • loss of consciousness
  • nervousness
  • night blindness
  • overbright appearance of lights
  • painful urination
  • pounding in the ears
  • seizures
  • shaking
  • sleepiness
  • trouble with sleeping
  • tunnel vision
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Spasmopan contraindications

See also:
What is the most important information I should know about Spasmopan?

Hypersensitivity to hyoscine-N-butylbromide, belladonna alkaloids or derivatives, or any other ingredients of Spasmopan.

Tablet: Patients with glaucoma, toxic megacolon (a very enlarged bowel), myasthenia gravis (a rare muscle wasting disease), obstructive prostatic hyperthropy (enlarged and blocked prostate), porphyria (hereditary blood disorder).

Patients who are pregnant, likely to become pregnant or breastfeeding, and children <6 years should not take hyoscine-N-butylbromide.

Injection: Patients with porphyria, untreated angle-closure glaucoma, prostatic enlargement, myasthenia gravis, and severe ulcerative colitis, or toxic megacolon, tachycardia; acute hemorrhage whose cardiovascular status is unstable; stomach or bowel obstruction, or in conditions where there is reduced bowel activity (eg, pyloroduodenal stenosis, achalasia), paralytic ileus or intestinal atony.

Spasmopan injection should not be given IM in patients being treated with anticoagulant therapy. Subcutaneous or IV routes may be used in these patients instead.

Active ingredient matches for Spasmopan:

Scopolamine in Bahrain, Iraq, Japan, Jordan, Kuwait, Lebanon, Libya, Nigeria, Oman, Qatar, Saudi Arabia, Sudan, Syria, Tunisia, United Arab Emirates, Yemen.

Acetaminophen/Codeine Phosphate/Fenpiverinium Bromide/Pitofenone Hcl

Hyoscine Butylbromide

List of Spasmopan substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Spasmonil Tablet (Cipla Limited)$ 0.03
Spasmosan 20 mg/1 mL x 100's (Scanpharm)
Spasmoson inj 20 mg/mL 1 mL x 10 x 1's (Jayson Pharma)
Spoline 10 mg
Stomex 20 mg x 2 Blister x 8 Tablet
Stomica 10 mg x 3 x 10's (Pharos)$ 4.46
Stomica / amp 20 mg/1 mL x 1 mL x 5's (Pharos)$ 7.75
Sucopanlin 10 mg
Suspan 10 mg
Suspan 10 mg x Blister pk
Thinthin 10 mg
Disc, Sustained Release; Transdermal; Scopolamine 1.5 mg (Novartis)
Tablet; Oral; Scopolamine Hydrobromide 0.3 mg (Boots)
U-Oscine Injection 20 mg/1 mL x 1 mL x 50's
U-Oscine 10 mg x 100 x 10's
U-Oscine 10 mg x 1, 000's
Ulcipan 10 mg x 100's
ULCIPAN 40MG TABLET 1 strip / 10 tablets each (Lancer Health Care Pvt Ltd)$ 0.78
Ulcipan 40mg Tablet (Lancer Health Care Pvt Ltd)$ 0.08
Uospan 10 mg x 50 x 10's
Uospan 10 mg x 1, 000's
Vacopan 10 mg x 500's (Atlantic Lab)
Vacopan 20 mg/1 mL x 50's (Atlantic Lab)
Vacopan 20 mg/1 mL x 10's (Atlantic Lab)
Vacopan 20 mg/1 mL x 1 mL x 50's (Atlantic Lab)
Vacopan inj 20 mg/mL 50 x 1's (Atlantic Lab)
Vacopan tab 10 mg 500's (Atlantic Lab)


  1. DailyMed. "SCOPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. DailyMed. "CODEINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  3. DailyMed. "ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).


The results of a survey conducted on for Spasmopan are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Spasmopan. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

2 consumers reported useful

Was the Spasmopan drug useful in terms of decreasing the symptom or the disease?
According to the reports released by website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Not useful1

Consumer reported price estimates

No survey data has been collected yet

3 consumers reported time for results

To what extent do I have to use Spasmopan before I begin to see changes in my health conditions?
As part of the reports released by website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Spasmopan. To get the time effectiveness of using Spasmopan drug by other patients, please click here.
1 day1
2 days1
1 week1

8 consumers reported age

> 602

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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