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Actions of Stugeron-Richter in details
Stugeron-Richter inhibits contractions of vascular smooth muscle cells by blocking calcium channels. In addition to this direct calcium antagonism, Stugeron-Richter decreases the contractile activity of vasoactive substances eg, norepinephrine and serotonin, by blocking receptor-operated calcium channels. Blockade of the cellular influx of calcium is tissue-selective and results in antivasoconstrictor properties without effect on blood pressure and heart rate.
Stugeron-Richter may further improve deficient microcirculation by increasing erythrocyte deformability and decreasing blood viscosity. Cellular resistance to hypoxia is increased.
Stugeron-Richter inhibits stimulation of the vestibular system which results in suppression of nystagmus and other autonomic disturbances. Acute episodes of vertigo can be prevented or reduced by Stugeron-Richter.
Pharmacokinetics: The peak plasma levels of Stugeron-Richter are obtained 1-3 hrs after intake. It disappears from plasma with an initial half-life of 4 hrs. It is thoroughly metabolized. The elimination of these metabolites occurs for about 1/3 in the urine and for 2/3 with the faeces.
The plasma protein-binding of Stugeron-Richter is 91%.
How should I take Stugeron-Richter?
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole.
Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.
Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
Store at room temperature away from moisture and heat.
Should be taken with food.
Stugeron-Richter is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Stugeron-Richter also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Stugeron-Richter through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
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Information checked by Dr. Sachin Kumar, MD Pharmacology