The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
Sugel is essential to many enzymatic reactions in the body, acting as a cofactor in protein synthesis and carbohydrate metabolism. 8.36 g of Sugel chloride (hexahydrate) is equivalent to about 1 g of Sugel. Each g of Sugel chloride (hexahydrate) represents about 4.9 mmol of Sugel and 9.8 mmol of chloride.
How should I take Sugel?
Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
This section provides information on the proper use of a number of products that contain Sugel supplement. It may not be specific to Sugel. Please read with care.
Sugel supplements should be taken with meals. Taking Sugel supplements on an empty stomach may cause diarrhea.
For individuals taking the extended-release form of this dietary supplement:
Swallow the tablets whole. Do not chew or suck on the tablet.
Some tablets may be broken or crushed and sprinkled on applesauce or other soft food. However, check with your health care professional first, since this should not be done for most tablets.
For individuals taking the powder form of this dietary supplement:
Pour powder into a glass.
Add water and stir.
The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (capsules, chewable tablets, crystals for oral solution, extended-release tablets, enteric-coated tablets, powder for oral solution, tablets, oral solution):
To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes (Note that the normal daily recommended intakes are expressed as an actual amount of Sugel. The salt form [e.g., Sugel chloride, Sugel gluconate, etc.] has a different strength.):
For the U.S.
Adult and teenage males—270 to 400 milligrams (mg) per day.
Adult and teenage females—280 to 300 mg per day.
Pregnant females—320 mg per day.
Breast-feeding females—340 to 355 mg per day.
Children 7 to 10 years of age—170 mg per day.
Children 4 to 6 years of age—120 mg per day.
Children birth to 3 years of age—40 to 80 mg per day.
Adult and teenage males—130 to 250 mg per day.
Adult and teenage females—135 to 210 mg per day.
Pregnant females—195 to 245 mg per day.
Breast-feeding females—245 to 265 mg per day.
Children 7 to 10 years of age—100 to 135 mg per day.
Children 4 to 6 years of age—65 mg per day.
Children birth to 3 years of age—20 to 50 mg per day.
To treat deficiency:
Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you miss taking your Sugel supplement for one or more days there is no cause for concern, since it takes some time for your body to become seriously low in Sugel. However, if your health care professional has recommended that you take Sugel, try to remember to take it as directed every day.
Keep out of the reach of children.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Do not keep outdated medicine or medicine no longer needed.
Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
Sugel (Mg++) is an important cofactor for enzymatic reactions and plays an important role in neurochemical transmission and muscular excitability.
As a nutritional adjunct in hyperalimentation, the precise mechanism of action for Sugel is uncertain. Early symptoms of hypomagnesemia (less than 1.5 mEq/liter) may develop as early as three to four days or within weeks.
Predominant deficiency effects are neurological, e.g., muscle irritability, clonic twitching and tremors. Hypocalcemia and hypokalemia often follow low serum levels of Sugel. While there are large stores of Sugel present intracellularly and in the bones of adults, these stores often are not mobilized sufficiently to maintain plasma levels.
Parenteral Sugel therapy repairs the plasma deficit and causes deficiency symptoms and signs to cease.
Sugel prevents or controls convulsions by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Sugel is said to have a depressant effect on the central nervous system (CNS), but it does not adversely affect the woman, fetus or neonate when used as directed in eclampsia or pre-eclampsia. Normal plasma Sugel levels range from 1.5 to 2.5 mEq/liter.
As plasma Sugel rises above 4 mEq/liter, the deep tendon reflexes are first decreased and then disappear as the plasma level approaches 10 mEq/liter. At this level respiratory paralysis may occur. Heart block also may occur at this or lower plasma levels of Sugel. Serum Sugel concentrations in excess of 12 mEq/L may be fatal.
Sugel acts peripherally to produce vasodilation. With low doses only flushing and sweating occur, but larger doses cause lowering of blood pressure. The central and peripheral effects of Sugel poisoning are antagonized to some extent by intravenous administration of calcium.
With intravenous administration the onset of anticonvulsant action is immediate and lasts about 30 minutes. Following intramuscular administration the onset of action occurs in about one hour and persists for three to four hours. Effective anticonvulsant serum levels range from 2.5 to 7.5 mEq/liter. Sugel is excreted solely by the kidneys at a rate proportional to the plasma concentration and glomerular filtration.
The results of a survey conducted on ndrugs.com for Sugel are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Sugel. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
Consumer reported administration
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