Consists of Naphazoline, Sulfathiazole
Actions of Naphazoline (Sulfarinol) in details
Naphazoline (Sulfarinol) is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activates the adrenal system to yield systemic vasoconstrction. In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and consequently decreased nasal congestion. The vasoconstriction means that there is less pressure in the capillaries and less water can filter out, thus less discharge is made.
How should I take Naphazoline (Sulfarinol)?
Do not use Naphazoline (Sulfarinol) ophthalmic solution if it becomes cloudy or changes color.
Naphazoline (Sulfarinol) should not be used in infants and children. It may cause severe slowing down of the central nervous system (CNS), which may lead to unconsciousness. It may also cause a severe decrease in body temperature.
Use Naphazoline (Sulfarinol) only as directed. Do not use more of it, do not use it more often, and do not use it for more than 72 hours, unless otherwise directed by your doctor. To do so may make your eye redness and irritation worse and may also increase the chance of side effects.
To use:
- First, wash your hands. With the middle finger, apply pressure to the inside corner of the eye (and continue to apply pressure for 1 or 2 minutes after the medicine has been placed in the eye). Tilt the head back and with the index finger of the same hand, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close the eyes. Do not blink. Keep the eyes closed for 1 or 2 minutes to allow the medicine to be absorbed.
- To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.
Dosing
The dose of Naphazoline (Sulfarinol) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Naphazoline (Sulfarinol). If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For ophthalmic solution (eye drop) dosage form:
- For eye redness:
- Adults—Use one drop not more often than every four hours.
- Children—Use is not recommended.
- For eye redness:
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Naphazoline (Sulfarinol) pharmacology
Naphazoline (Sulfarinol) is a direct acting sympathomimetic adrenergic alpha-agonist used to induce systemic vasoconstriction, thereby decreasing nasal congestion and inducing constriction around the conjunctiva. The sympathomimetic action of Naphazoline (Sulfarinol) constricts the smaller arterioles of the nasal passages, producing a decongesting effect. Naphazoline (Sulfarinol) ophthalmic causes constriction of blood vessels in the eyes. It also decreases itching and irritation of the eyes. aphazoline constricts the vascular system of the conjunctiva. It is presumed that this effect is due to direct stimulation action of the drug upon the alpha adrenergic receptors in the arterioles of the conjunctiva resulting in decreased conjunctival congestion. Naphazoline (Sulfarinol) belongs to the imidazoline class of sympathomimetics.
Actions of Sulfathiazole (Sulfarinol) in details
Description: Sulfathiazole (Sulfarinol) interferes with nucleic acid synthesis in microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. It has properties similar to sulfamethoxazole. It is a short-acting sulfonamide, now rarely used systemically due to its toxicity.
References
- NCIt. "Sulfathiazole: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- NCIt. "Naphazoline: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Sulfathiazole: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Sulfarinol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Sulfarinol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
