Sumamed 250 mg injection is used to treat bacterial infections in many different parts of the body. It is also used to prevent Mycobacterium avium complex (MAC) disease in patients infected with the human immunodeficiency virus (HIV).
Sumamed 250 mg belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, Sumamed 250 mg will not work for colds, flu, or other virus infections. Sumamed 250 mg injection may be used for other problems as determined by your doctor.
Sumamed 250 mg is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Sumamed 250 mg is used in certain patients with the following medical condition:
Sumamed 250 mg indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Sumamed 250 mg extended-release granules are indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of designated microorganisms in the specific conditions listed as follows.
Adults: Acute uncomplicated bacterial sinusitis due to Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.
Mild to moderate community-acquired pneumonia (CAP) due to Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae or Streptococcus pneumoniae.
Pharyngitis/tonsillitis caused by Streptococcus pyogenes as an alternative to first-line therapy in individuals who cannot use first-line therapy. (Penicillin is the usual drug of choice in the treatment of Streptococcus pyogenes pharyngitis. Sumamed 250 mg is often effective in the eradication of susceptible strains of Streptococcus pyogenes from the nasopharynx. Because some strains are resistant to Sumamed 250 mg, susceptibility tests should be performed when patients are treated with Sumamed 250 mg). Data establishing efficacy of Sumamed 250 mg in subsequent prevention of rheumatic fever are not available.
Pediatrics: Mild to moderate community-acquired pneumonia in pediatric patients 6 months of age or older due to Chlamydophila pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae or Streptococcus pneumoniae, in patients appropriate for oral therapy. Pediatric use in this indication is based on extrapolation of adult efficacy.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Sumamed 250 mg and other antibacterial drugs, Sumamed 250 mg should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Appropriate culture and susceptibility tests should be performed before treatment to determine the causative organism and its susceptibility to Sumamed 250 mg. Therapy with Sumamed 250 mg may be initiated before results of these tests are known; once the results become available, antimicrobial therapy should be adjusted accordingly.
How should I use Sumamed 250 mg?
Use Sumamed 250 mg drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with Sumamed 250 mg drops. Talk to your pharmacist if you have questions about this information.
Sumamed 250 mg drops is for use in the eye only. Do not swallow it.
Wash your hands immediately before you use Sumamed 250 mg drops.
To use Sumamed 250 mg drops, turn the bottle upside down and shake once before each use. Remove the cap while the bottle is still upside down. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Gently squeeze the bottle to drop the medicine into the pouch, then gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
If a drop does not come out of the bottle when using your dose, repeat these steps.
To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
Do not wear contact lenses while you are using Sumamed 250 mg drops. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.
To clear up your infection completely, use Sumamed 250 mg drops for the full course of treatment. Keep using it even if you feel better in a few days.
If you miss a dose of Sumamed 250 mg drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Sumamed 250 mg drops.
Uses of Sumamed 250 mg in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
Use: Labeled Indications
Chancroid: Treatment of genital ulcer disease (in men) due to Haemophilus ducreyi (chancroid)
Chronic obstructive pulmonary disease, acute exacerbation: Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease (COPD) due to Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae
Mycobacterium avium complex: Prevention of Mycobacterium avium complex (MAC) in patients with advanced HIV infection; treatment of disseminated MAC (in combination with ethambutol) in patients with advanced HIV infection
Otitis media, acute: Treatment of acute otitis media due to H. influenzae, M. catarrhalis, or S. pneumoniae
Pneumonia, community-acquired: Treatment of community-acquired pneumonia (CAP) due to Chlamydophila pneumoniae, H. influenzae, Legionella pneumophila, M. catarrhalis, Mycoplasma pneumoniae, or S. pneumoniae
Skin and skin structure infection, uncomplicated: Treatment of uncomplicated skin and skin structure infections due to Staphylococcus aureus, Streptococcus pyogenes, or Streptococcus agalactiae
Streptococcal pharyngitis (group A): Treatment of pharyngitis/tonsillitis due to S. pyogenes as an alternative to first-line therapy
Urethritis/cervicitis: Treatment of urethritis and cervicitis due to Chlamydia trachomatis or Neisseria gonorrhoeae
Off Label Uses
Data from controlled trials support the use of Sumamed 250 mg in the treatment of acne vulgaris in adults with moderate to severe acne.
Based on the American Academy of Dermatology guidelines of care for the management of acne vulgaris, Sumamed 250 mg, in combination with topical therapy, may be considered as a treatment option for moderate and severe acne and forms of inflammatory acne that are resistant to topical treatments. However, its use should be limited to patients who cannot receive a tetracycline (ie, pregnant women). Concomitant topical therapy with benzoyl peroxide or a retinoid should be administered with systemic antibiotic therapy (eg, Sumamed 250 mg) and continued for maintenance after the antibiotic course is completed.
Data from a prospective, nonblinded, randomized trial in patients with non-life-threatening babesiosis, support the use of Sumamed 250 mg (in combination with atovaquone) for the treatment of this condition.
Based on the CDC Yellow Book, the ACG guideline for the diagnosis, treatment, and prevention of acute diarrheal infections in adults, and the IDSA practice guidelines for the diagnosis and management of infectious diarrhea, Sumamed 250 mg is effective and recommended treatment for patients with travelers' diarrhea. Due to increased levels of resistance to fluoroquinolones, Sumamed 250 mg may be a recommended first-line treatment, especially in regions with a high prevalence of Campylobacter (eg, Southeast Asia, India) or in geographical areas with suspected fluoroquinolone-resistant pathogens or enterotoxigenic Escherichia coli.
Sumamed 250 mg description
Each capsule contains Azithromycin dihydrate 262.05 mg equivalent to Sumamed 250 mg base 250 mg. It also contains anhydrous lactose, maize starch, magnesium stearate and sodium lauryl sulfate as excipients. The capsule shell contains gelatin, titanium dioxide (E171) and up to 1,000 ppm sulfur dioxide.
Each tablet contains Azithromycin dihydrate 262.05 mg equivalent to Sumamed 250 mg base 250 mg. It also contains pre-gelatinized starch, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate and sodium lauryl sulfate as excipients. The film-coating contains hydroxypropyl cellulose, triacetin and titanium dioxide (E171).
Each 5 mL of powder for oral suspension contains Azithromycin dihydrate 209.64 mg equivalent to Sumamed 250 mg base 200 mg. It also contains sucrose (1.94 g/100 mg dose), anhydrous tribasic sodium phosphate, hydroxypropyl cellulose, xanthan gum, artificial cherry, creme de vanilla and banana flavors as excipients.
Each sachet contains Azithromycin dihydrate 100.16 mg equivalent to Sumamed 250 mg base 100 mg. It also contains sucrose (1.85 g/Sumamed 250 mg 100-mg dose), anhydrous tribasic sodium phosphate, hydroxypropyl cellulose, xanthan gum, artificial cherry, creme de vanilla and banana flavors as excipients. It also contains a dry powder which yields, when added to water, a white to off-white suspension, cherry/banana with a slight vanilla odor.
Each vial contains Azithromycin dihydrate 524.1 mg equivalent to Sumamed 250 mg base 500 mg. It also contains anhydrous citric acid and sodium hydroxide as excipients. It is supplied in lyophilized form under a vacuum in a 10-mL vial for IV administration. Upon reconstitution, Sumamed 250 mg powder yields a solution containing the equivalent of Sumamed 250 mg 100 mg/mL.
Sumamed 250 mg is 9-deoxy-9a-aza-9a-methyl-9a-homoerythromycin A. The molecular weight is 749.
Sumamed 250 mg dosage
Sumamed 250 mg for oral suspension (single dose 1 g packet) can be taken with or without food after constitution. However, increased tolerability has been observed when tablets are taken with food.
Sumamed 250 mg for oral suspension (single dose 1 g packet) is not for pediatric use. For pediatric suspension see the prescribing information for Sumamed 250 mg (Sumamed 250 mg for oral suspension) 100 mg/5 mL and 200 mg/5 mL bottles.
Directions for administration of Sumamed 250 mg for oral suspension in the single dose packet (1 g): The entire contents of the packet should be mixed thoroughly with two ounces (approximately 60 mL) of water. Drink the entire contents immediately; add an additional two ounces of water, mix, and drink to ensure complete consumption of dosage. The single dose packet should not be used to administer doses other than 1000 mg of Sumamed 250 mg.
Sexually Transmitted Diseases
The recommended dose of Sumamed 250 mg for the treatment of non-gonococcal urethritis and cervicitis due to C. trachomatis is a single 1 gram (1000 mg) dose of Sumamed 250 mg. This dose can be administered as one single dose packet (1 g).
Prevention of Disseminated MAC Infections
The recommended dose of Sumamed 250 mg for the prevention of disseminated Mycobacterium avium complex (MAC) disease is: 1200 mg taken once weekly. This dose of Sumamed 250 mg may be combined with the approved dosage regimen of rifabutin.
Treatment of Disseminated MAC Infections
Sumamed 250 mg should be taken at a daily dose of 600 mg, in combination with ethambutol at the recommended daily dose of 15 mg/kg. Other antimycobacterial drugs that have shown in vitro activity against MAC may be added to the regimen of Sumamed 250 mg plus ethambutol at the discretion of the physician or health care provider.
Dosage Forms And Strengths
Sumamed 250 mg 600 mg tablets (engraved on front with “PFIZER” and on back with “308”) are supplied as white, modified oval-shaped, film-coated tablets containing Sumamed 250 mg dihydrate equivalent to 600 mg Sumamed 250 mg. These are packaged in bottles of 30 tablets.
Sumamed 250 mg for oral suspension 1000 mg/5 mL is supplied in single-dose packets containing Sumamed 250 mg dihydrate equivalent to 1 gram of Sumamed 250 mg.
Storage And Handling
Sumamed 250 mg 600 mg tablets (engraved on front with “PFIZER” and on back with “308”) are supplied as white, modified oval-shaped, film-coated tablets containing Sumamed 250 mg dihydrate equivalent to 600 mg Sumamed 250 mg. These are packaged in bottles of 30 tablets. Sumamed 250 mg tablets are supplied as follows:
Bottles of 30 NDC 0069-3080-30
Tablets should be stored at or below 30°C (86°F).
Sumamed 250 mg for oral suspension is supplied in single-dose packets containing Sumamed 250 mg dihydrate equivalent to 1 gram of Sumamed 250 mg as follows:
Boxes of 10 single-dose packets (1 g) NDC 0069-3051-07
Boxes of 3 single-dose packets (1 g) NDC 0069-3051-75
Store single-dose packets between 5° and 30°C (41° and 86°F).
Distributed by: Pfizer Labs Division of Pfizer Inc., NY, NY 10017. Revised: Dec 2015
Antacids: In a pharmacokinetic study investigating the effects of simultaneous administration of antacid with Sumamed 250 mg, no effect on overall bioavailability was seen, although peak serum concentrations were reduced by approximately 24%. In patients receiving both Sumamed 250 mg and antacids, the drugs should not be taken simultaneously. Co-administration of Sumamed 250 mg extended-release granules for oral suspension with a single dose of 20 mL co-magaldrox (aluminum hydroxide and magnesium hydroxide) did not affect the rate and extent of Sumamed 250 mg absorption.
Cetirizine: In healthy volunteers, co-administration of a 5-day regimen of Sumamed 250 mg with 20 mg cetirizine at steady-state resulted in no pharmacokinetic interaction and no significant changes in the QT interval.
Didanosine (Dideoxyinosine): Co-administration of 1,200 mg/day Sumamed 250 mg with 400 mg/day didanosine in six HIV-positive subjects did not appear to affect the steady-state pharmacokinetics of didanosine as compared to placebo.
Digoxin: Concomitant administration of macrolide antibiotics, including Sumamed 250 mg, with P-glycoprotein substrates such as digoxin, has been reported to result in increased serum levels of the P-glycoprotein substrate. Therefore, if Sumamed 250 mg and P-glycoprotein substrates such as digoxin are administered concomitantly, the possibility of elevated serum digoxin concentrations should be considered. Clinical monitoring, and possibly serum digoxin levels, during treatment with Sumamed 250 mg and after its discontinuation are necessary.
Ergot: There is a theoretical possibility of interaction between Sumamed 250 mg and ergot derivatives.
Zidovudine: Single 1,000 mg doses and multiple 1,200 mg or 600 mg doses of Sumamed 250 mg had little effect on the plasma pharmacokinetics or urinary excretion of zidovudine or its glucuronide metabolite. However, administration of Sumamed 250 mg increased the concentrations of phosphorylated zidovudine, the clinically active metabolite, in peripheral blood mononuclear cells. The clinical significance of this finding is unclear, but it may be of benefit to patients.
Sumamed 250 mg does not interact significantly with the hepatic cytochrome P450 system. It is not believed to undergo the pharmacokinetic drug interactions as seen with erythromycin and other macrolides. Hepatic cytochrome P450 induction or inactivation via cytochrome-metabolite complex does not occur with Sumamed 250 mg.
Pharmacokinetic studies have been conducted between Sumamed 250 mg and the following drugs known to undergo significant cytochrome P450-mediated metabolism.
Atorvastatin: Co-administration of atorvastatin (10 mg daily) and Sumamed 250 mg (500 mg daily) did not alter the plasma concentrations of atorvastatin (based on a HMG CoA-reductase inhibition assay). However, post-marketing cases of rhabdomyolysis in patients receiving Sumamed 250 mg with statins have been reported.
Carbamazepine: In a pharmacokinetic interaction study in healthy volunteers, no significant effect was observed on the plasma levels of carbamazepine or its active metabolite in patients receiving concomitant Sumamed 250 mg.
Cimetidine: In a pharmacokinetic study investigating the effects of a single dose of cimetidine, given 2 hours before Sumamed 250 mg, on the pharmacokinetics of Sumamed 250 mg, no alteration of Sumamed 250 mg pharmacokinetics was seen.
In a pharmacokinetic interaction study, Sumamed 250 mg did not alter the anticoagulant effect of a single dose of 15 mg warfarin administered to healthy volunteers. There have been reports received in the post-marketing period of potentiated anticoagulation subsequent to co-administration of Sumamed 250 mg and coumarin-type oral anticoagulants. Although a causal relationship has not been established, consideration should be given to the frequency of monitoring prothrombin time when Sumamed 250 mg is used in patients receiving coumarin-type oral anticoagulants.
Cyclosporin: In a pharmacokinetic study with healthy volunteers who were administered a 500 mg/day oral dose of Sumamed 250 mg for 3 days and were then administered a single 10 mg/kg oral dose of cyclosporin, the resulting cyclosporin Cmax and AUC0-5 were found to be significantly elevated. Consequently, caution should be exercised before considering concurrent administration of these drugs. If co-administration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Efavirenz: Co-administration of a single dose of 600 mg Sumamed 250 mg and 400 mg efavirenz daily for 7 days did not result in any clinically significant pharmacokinetic interactions.
Fluconazole: Co-administration of a single dose of 1,200 mg Sumamed 250 mg did not alter the pharmacokinetics of a single dose of 800 mg fluconazole. Total exposure and half-life of Sumamed 250 mg were unchanged by the co-administration of fluconazole; however, a clinically insignificant decrease in Cmax (18%) of Sumamed 250 mg was observed.
Indinavir: Co-administration of a single dose of 1,200 mg Sumamed 250 mg had no statistically significant effect on the pharmacokinetics of indinavir administered as 800 mg three times daily for 5 days.
Methylprednisolone: In a pharmacokinetic interaction study in healthy volunteers, Sumamed 250 mg had no significant effect on the pharmacokinetics of methylprednisolone.
Midazolam: In healthy volunteers, co-administration of 500 mg/day Sumamed 250 mg for 3 days did not cause clinically significant changes in the pharmacokinetics and pharmacodynamics of a single dose of 15 mg midazolam.
Nelfinavir: Co-administration of Sumamed 250 mg (1,200 mg) and nelfinavir at steady-state (750 mg three times daily) resulted in increased Sumamed 250 mg concentrations. No clinically significant adverse effects were observed and no dose adjustment was required. Although no dosage adjustment of Sumamed 250 mg is recommended when administered with nelfinavir, close monitoring for known side effects of Sumamed 250 mg, such as liver enzyme abnormalities and hearing impairment, is warranted.
Rifabutin: Co-administration of Sumamed 250 mg and rifabutin did not affect the serum concentrations of either drug.
Neutropenia was observed in subjects receiving concomitant treatment of Sumamed 250 mg and rifabutin. Although neutropenia has been associated with the use of rifabutin, a causal relationship to combination with Sumamed 250 mg has not been established.
Sildenafil: In normal healthy male volunteers, there was no evidence of an effect of Sumamed 250 mg (500 mg daily for 3 days) on the AUC and Cmax of sildenafil or its major circulating metabolite.
Terfenadine: Pharmacokinetic studies have reported no evidence of an interaction between Sumamed 250 mg and terfenadine. There have been rare cases reported where the possibility of such an interaction could not be entirely excluded; however, there was no specific evidence that such an interaction had occurred.
Theophylline: There is no evidence of a clinically significant pharmacokinetic interaction when Sumamed 250 mg and theophylline are co-administered to healthy volunteers.
Triazolam: In 14 healthy volunteers, co-administration of 500 mg Sumamed 250 mg on Day 1 and 250 mg on Day 2 with 0.125 mg triazolam on Day 2 had no significant effect on any of the pharmacokinetic variables for triazolam compared to triazolam and placebo.
Trimethoprim/Sulfamethoxazole: Co-administration of trimethoprim/sulfamethoxazole DS (160 mg/800 mg) for 7 days with 1,200 mg Sumamed 250 mg on Day 7 had no significant effect on peak concentrations, total exposure or urinary excretion of either trimethoprim or sulfamethoxazole. Sumamed 250 mg serum concentrations were similar to those seen in other studies.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The data described below reflect exposure to Sumamed 250 mg in 728 adult patients. All patients received a single 2 g oral dose of Sumamed 250 mg. The population studied had community-acquired pneumonia and acute bacterial sinusitis.
In controlled clinical trials with Sumamed 250 mg, the majority of the reported treatment-related adverse reactions were gastrointestinal in nature and mild to moderate in severity.
Overall, the most common treatment-related adverse reactions in adult patients receiving a single 2 g dose of Sumamed 250 mg were diarrhea/loose stools (12%), nausea (4%), abdominal pain (3%), headache (1%), and vomiting (1%). The incidence of treatment-related gastrointestinal adverse reactions was 17% for Sumamed 250 mg and 10% for pooled comparators.
Treatment-related adverse reactions following Sumamed 250 mg treatment that occurred with a frequency of <1% included the following:
The data described below reflect exposure to Sumamed 250 mg in 907 pediatric patients. The population was 3 months to 12 years of age. All patients received a single 60 mg/kg oral dose of Sumamed 250 mg.
As in adults, the most common treatment-related adverse reactions in pediatric subjects were gastrointestinal in nature. The pediatric subjects all received a single 60 mg/kg dose (equivalent to 27 mg/lb) of Sumamed 250 mg.
In a trial with 450 pediatric subjects (ages 3 months to 48 months), vomiting (11%), diarrhea (10%) loose stools (9%), and abdominal pain (2%) were the most frequently reported treatment-related gastrointestinal adverse reactions. Many treatment related gastrointestinal adverse reactions with an incidence greater than 1% began on the day of dosing in these subjects [43% (68/160)] and most [53% (84/160)] resolved within 48 hr of onset. Treatment-related adverse events that were not gastrointestinal, occurring with a frequency ≥ 1% were: rash (5%), anorexia (2%), fever (2%), and dermatitis (2%).
In a second trial of 337 pediatric subjects, ages 2 years to 12 years, the most frequently reported treatment-related adverse reactions also included vomiting (14%), diarrhea (7%), loose stools (2%), nausea (4%) and abdominal pain (4%).
A third trial investigated the tolerability of two different concentrations of Sumamed 250 mg oral suspension in 120 pediatric subjects (ages 3 months to 48 months), all of whom were treated with Sumamed 250 mg. The study evaluated the hypothesis that a more dilute, less viscous formulation (the recommended 27 mg/mL concentration of Sumamed 250 mg) is less likely to induce vomiting in young children than a more concentrated suspension used in other pediatric studies. The vomiting rate for subjects taking the dilute concentration Sumamed 250 mg was 3% (2/61). The rate was numerically lower but not statistically different from the vomiting for the more concentrated suspension Across both treatment arms, the only treatment-related adverse events with a frequency of ≥ 1% were vomiting (6%, 7/120) and diarrhea (2%, 2/120).
Treatment-related adverse reactions with a frequency of < 1% following Sumamed 250 mg treatment in all 907 pediatric subjects in the Phase 3 studies were:
Body as a whole: Chills, fever, flu syndrome, headache;
Skin/appendages: Pruritus, rash, photosensitivity, serious skin reactions including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, and DRESS.
Special senses: Hearing disturbances including hearing loss, deafness and/or tinnitus and reports of taste/smell perversion and/or loss
In subjects with normal baseline values, the following clinically significant laboratory abnormalities (irrespective of drug relationship) were reported in Sumamed 250 mg clinical trials in adults and pediatric patients:
Laboratory abnormalities with an incidence of greater than or equal to 1%: reduced lymphocytes and increased eosinophils; reduced bicarbonate. Laboratory abnormalities with an incidence of less than 1%: leukopenia, neutropenia, elevated bilirubin, AST, ALT, BUN, creatinine, alterations in potassium. Where follow-up was provided, changes in laboratory tests appeared to be reversible.
Laboratory abnormalities with an incidence of greater than or equal to 1%: elevated eosinophils, BUN, and potassium; decreased lymphocytes; and alterations in neutrophils; with an incidence of less than 1%: elevated SGOT, SGPT and creatinine; decreased potassium; and alterations in sodium and glucose.
You should not use this medication if you have ever had jaundice or liver problems caused by taking Sumamed 250 mg. You should not use Sumamed 250 mg if you are allergic to it or to similar drugs such as erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), clarithromycin (Biaxin), telithromycin (Ketek), or troleandomycin (Tao).
There are many other medicines that can interact with Sumamed 250 mg. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Sumamed 250 mg will not treat a viral infection such as the common cold or flu.
Avoid taking an antacid within 2 hours before or after you take Sumamed 250 mg. Some antacids can make it harder for your body to absorb Sumamed 250 mg.
DailyMed. "AZITHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
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