Sydolil Uses

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What is Sydolil?

Caffeine (Sydolil) is a stimulant that causes narrowing of blood vessels (vasoconstriction).

Ergotamine (Sydolil) is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain. Ergotamine (Sydolil) also affects blood flow patterns that are associated with certain types of headaches.

Caffeine (Sydolil) and Ergotamine (Sydolil) is a combination medicine used to treat or prevent a migraine type headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Caffeine (Sydolil) and Ergotamine (Sydolil) should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Caffeine (Sydolil) and Ergotamine (Sydolil) may also be used for purposes not listed in this medication guide.

Sydolil indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Preventing and treating certain kinds of headaches (eg, migraines, migraine variants, "histaminic cephalalgia"). It may also be used for other conditions as determined by your doctor.

Sydolil is a combination of 2 vasoconstrictors. It works by constricting blood vessels in the lining of the brain, which helps to decrease the pain from migraine headaches.

How should I use Sydolil?

Use Sydolil suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Sydolil suppositories.

Uses of Sydolil in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This combination medication is used to treat or prevent certain types of headaches (vascular headaches including migraine and cluster headaches). Headache pain can sometimes be caused by widened blood vessels in the head. Ergotamine (Sydolil) works by narrowing these widened blood vessels. Caffeine (Sydolil) increases the absorption of Ergotamine (Sydolil) and also narrows widened blood vessels.

How to use Sydolil

Take this medication by mouth with or without food as directed by your doctor, usually 2 tablets at the first sign of headache, followed by 1 tablet every half hour until the headache is relieved. Do not take more than 6 tablets per headache attack or 10 tablets in a 7-day period.

If your doctor has prescribed this medication to help prevent certain types of headaches (such as cluster headaches), take this medication exactly as directed by your doctor, usually for short-term treatment (2 to 3 weeks).

The dosage is based on your medical condition and response to treatment. This medication works best if it is taken at the first sign of the headache. If you wait until the headache has worsened, the medication may not work as well.

If you have a higher risk for heart problems, your doctor may perform a heart exam before you start taking this medication. He/she may also direct you to take your first dose of this medication in the office/clinic to monitor for serious side effects (such as chest pain). Talk to your doctor for details.

This medication is usually taken only as needed. It is not meant for long-term daily use.

Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior (addiction). This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction.

Overuse of drugs to treat sudden migraine attacks can sometimes lead to worsening of headache (medication overuse headache) or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. Tell your doctor if you need to use this medication more often, if the medication is not working as well, or if you have more frequent or worse headaches. Your doctor may need to change your medication and/or add another medication to help prevent headaches.

Sydolil description


A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Sydolil&

Sydolil dosage

Sydolil Dosage

Generic name: Ergotamine (Sydolil) tartrate and Caffeine (Sydolil)

Dosage form: Suppositories

See also:

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.


For the best results, dosage should start at the first sign of an attack.

RECTALLY One suppository at start of attack; second suppository

after 1 hour, if needed for full relief

1 hr.

Early Aministration Gives Maximum Effectiveness

Maximum Adult Dosage


Two suppositories is the maximum dose for an individual attack.

Total weekly dosage should not exceed 5 suppositories. Sydolil® (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil)) suppositories should not be used for chronic daily administration.

In carefully selected patients, with due consideration of maximum dosage recommendations, administration of the drug at bedtime may be an appropriate short-term preventive measure.

More about Sydolil (Caffeine (Sydolil) / Ergotamine (Sydolil))

Consumer resources

Professional resources

Related treatment guides

Sydolil interactions

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What other drugs will affect Sydolil?


CYP 3A4 Inhibitors (e.g., Macrolide Antibiotics and Protease Inhibitors): See CONTRAINDICATIONS and WARNINGS.

Sydolil® (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil) tablets, USP) should not be administered with other vasoconstrictors. Use with sympathomimetics (pressor agents) may cause extreme elevation of blood pressure. The beta-blocker Inderal (propranolol) has been reported to potentiate the vasoconstrictive action of Sydolil® (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil) tablets, USP) by blocking the vasodilating property of epinephrine. Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy.

The blood levels of Ergotamine (Sydolil)-containing drugs are reported to be elevated by the concomitant administration of macrolide antibiotics and vasospastic reactions have been reported with therapeutic doses of the Ergotamine (Sydolil)-containing drugs when coadministered with these antibiotics.

Sydolil side effects

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What are the possible side effects of Sydolil?

Cardiovascular: Vasoconstrictive complications of a serious nature may occur at times. These include ischemia, cyanosis, absence of pulse, cold extremities, gangrene, precordial distress and pain, EKG changes and muscle pains. Although these effects occur most commonly with long-term therapy at relatively high doses, they have also been reported with short-term or normal doses. Other cardiovascular adverse effects include transient tachycardia or bradycardia and hypertension.

Gastrointestinal: Nausea and vomiting.

Neurological: paresthesias, numbness, weakness, and vertigo.

Allergic: Localized edema and itching.

Fibrotic Complications


Drug Abuse And Dependence: There have been reports of drug abuse and psychological dependence in patients on Sydolil® (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil)) (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil) tablets, USP) therapy. Due to the chronicity of vascular headaches, it is imperative that patients be advised not to exceed recommended dosages with long-term use to avoid ergotism.

Sydolil contraindications

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What is the most important information I should know about Sydolil?

Coadministration of Ergotamine (Sydolil) with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erthromycin, clarithromycin, and troleandomycin) has been associated with acute ergot toxicity (ergotism) characterized by vasospasm and ischemia of the extremities, with some cases resulting in amputation. There have been rare reports of cerebral ischemia in patients on protease inhibitor therapy when Sydolil® (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil)) (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil) tablets, USP) was coadministered, at least one resulting in death. Because of the increased risk for ergotism and other serious vasospastic adverse events, Ergotamine (Sydolil) use is contraindicated with these drugs and other potent inhibitors of CYP 3A4 (e.g., ketoconazole, itraconazole).

Sydolil® (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil) tablets, USP) may cause fetal harm when administered to pregnant women. Sydolil® (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil)) (Ergotamine (Sydolil) tartrate and Caffeine (Sydolil) tablets, USP) is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy or if the patient becomes pregnant while taking this product, the patient should be apprised of the potential hazard to the fetus.

Peripheral vascular disease, coronary heart disease, hypertension, impaired hepatic or renal function and sepsis.

Hypersensitivity to any of the components.

Active ingredient matches for Sydolil:

Caffeine/Ergotamine in Mexico.

Aspirin/Caffeine/Ergotamine Tartrate

Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Aspirin 400 mg; Caffeine 50 mg; Ergotamine Tartrate 1 mg

List of Sydolil substitutes (brand and generic names):

Dragee; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg
Dragee; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg
Ergocafe 100's
Ergocafe 500's
Ergocafe 1000's
Tablet; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg
Ergoton 100's
Ergoton 500's
Ergoton 1000's
Ericaf 3 x 10's$ 13.95
Tablet; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg
Tablet; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg
Hofergot 20 x 10's
Migana / blister 50 x 10's
Migana / bottle 1, 000's
Suppositories; Rectal; Caffeine 100 mg; Ergotamine Tartrate 2 mg
Poligot-CF 100's
Poligot-CF 10 x 10's
Polygot 1, 000's
Tofago 50 x 10's (T. O. Chemicals)
Tofago tab 50 x 10's (T. O. Chemicals)
Dragee; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg
Suppositories; Rectal; Belladonna 0.1 mg; Caffeine 100 mg; Ergotamine Tartrate 1 mg
Tablet; Oral; Belladonna 0.1 mg; Caffeine 100 mg; Ergotamine Tartrate 1 mg


  1. DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. DailyMed. "ASPIRIN; DIPYRIDAMOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  3. PubChem. "ERGOTAMINE". (accessed September 17, 2018).


The results of a survey conducted on for Sydolil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Sydolil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet

4 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by website users about whether the Sydolil drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Not expensive1

3 consumers reported time for results

To what extent do I have to use Sydolil before I begin to see changes in my health conditions?
As part of the reports released by website users, it takes 2 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Sydolil. To get the time effectiveness of using Sydolil drug by other patients, please click here.
2 days1
1 month1
> 3 month1

14 consumers reported age

> 603

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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