Tadagra Dosage

sponsored
How do you administer this medicine?

Dosage of Tadagra in details

infoThe dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
sponsored

Do not split Tadagra tablets; entire dose should be taken.

Tadagra for Use as Needed for Erectile Dysfunction

  • The recommended starting dose of Tadagra for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity.
  • The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients.
  • Tadagra for use as needed was shown to improve erectile function compared to placebo up to 36 hours following dosing. Therefore, when advising patients on optimal use of Tadagra, this should be taken into consideration.

Tadagra for Once Daily Use for Erectile Dysfunction

  • The recommended starting dose of Tadagra for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.
  • The Tadagra dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.

Tadagra for Once Daily Use for Benign Prostatic Hyperplasia

  • The recommended dose of Tadagra for once daily use is 5 mg, taken at approximately the same time every day.
  • When therapy for BPH is initiated with Tadagra and finasteride, the recommended dose of Tadagra for once daily use is 5 mg, taken at approximately the same time every day for up to 26 weeks.

Tadagra for Once Daily Use for Erectile Dysfunction and Benign Prostatic Hyperplasia

The recommended dose of Tadagra for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.

Use with Food

Tadagra may be taken without regard to food.

Use in Specific Populations

Renal Impairment

Tadagra for Use as Needed

  • Creatinine clearance 30 to 50 mL/min: A starting dose of 5 mg not more than once per day is recommended, and the maximum dose is 10 mg not more than once in every 48 hours.
  • Creatinine clearance less than 30 mL/min or on hemodialysis: The maximum dose is 5 mg not more than once in every 72 hours.

Tadagra for Once Daily Use

Erectile Dysfunction

  • Creatinine clearance less than 30 mL/min or on hemodialysis: Tadagra for once daily use is not recommended.

Benign Prostatic Hyperplasia and Erectile Dysfunction/Benign Prostatic Hyperplasia

  • Creatinine clearance 30 to 50 mL/min: A starting dose of 2.5 mg is recommended. An increase to 5 mg may be considered based on individual response.
  • Creatinine clearance less than 30 mL/min or on hemodialysis: Tadagra for once daily use is not recommended.

Hepatic Impairment

Tadagra for Use as Needed

  • Mild or moderate (Child Pugh Class A or B): The dose should not exceed 10 mg once per day. The use of Tadagra once per day has not been extensively evaluated in patients with hepatic impairment and therefore, caution is advised.
  • Severe (Child Pugh Class C): The use of Tadagra is not recommended.

Tadagra for Once Daily Use

  • Mild or moderate (Child Pugh Class A or B): Tadagra for once daily use has not been extensively evaluated in patients with hepatic impairment. Therefore, caution is advised if Tadagra for once daily use is prescribed to these patients.
  • Severe (Child Pugh Class C): The use of Tadagra is not recommended.

Concomitant Medications

Nitrates

Concomitant use of nitrates in any form is contraindicated.

Alpha-Blockers

ED — When Tadagra is coadministered with an alpha-blocker in patients being treated for ED, patients should be stable on alpha-blocker therapy prior to initiating treatment, and Tadagra should be initiated at the lowest recommended dose.

BPH — Tadagra is not recommended for use in combination with alpha-blockers for the treatment of BPH.

CYP3A4 Inhibitors

Tadagra for Use as Needed — For patients taking concomitant potent inhibitors of CYP3A4, such as ketoconazole or ritonavir, the maximum recommended dose of Tadagra is 10 mg, not to exceed once every 72 hours.

Tadagra for Once Daily Use — For patients taking concomitant potent inhibitors of CYP3A4, such as ketoconazole or ritonavir, the maximum recommended dose is 2.5 mg.

What other drugs will affect Tadagra?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Tadagra, especially:

  • bosentan;

  • imatinib;

  • nefazodone;

  • St. John's wort;

  • an antibiotic--clarithromycin, erythromycin, telithromycin;

  • antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

  • heart or blood pressure medication--amlodipine nicardipine, quinidine;

  • hepatitis C medications--boceprevir, telaprevir;

  • HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;

  • seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or

  • tuberculosis medication--isoniazid, rifabutin, rifampin, rifapentine.

This list is not complete. Other drugs may interact with Tadagra, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Tadagra interactions

infoInteractions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Tadagra, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
sponsored

5 mg Film-coated Tablet: Interaction studies were conducted with Tadagra 10 mg and/or 20 mg, as indicated as follows. With regard to those interaction studies where only the Tadagra 10 mg dose was used, clinically relevant interactions at higher doses cannot be completely ruled out.

Effects of Other Substances on Tadagra: Cytochrome P450 Inhibitors: Tadagra is principally metabolized by CYP3A4. A selective inhibitor of CYP3A4, ketoconazole (200 mg daily), increased Tadagra (10 mg) AUC 2-fold and Cmax by 15%, relative to the AUC and Cmax values for Tadagra alone. Ketoconazole (400 mg daily) increased Tadagra (20 mg) AUC 4-fold and Cmax by 22%. Ritonavir, a protease inhibitor (200 mg twice daily), which is an inhibitor of CYP3A4, CYP2C9, CYP2C19, and CYP2D6, increased Tadagra (20 mg) AUC 2-fold with no change in Cmax. Although specific interactions have not been studied, other protease inhibitors such as saquinavir and other CYP3A4 inhibitors eg, erythromycin, clarithromycin, itraconazole and grapefruit juice should be co-administered with caution as they would be expected to increase plasma concentrations of Tadagra.

Consequently the incidence of the adverse reactions might be increased..

Transporters: The role of transporters (for example p-glycoprotein) in the disposition of Tadagra is not known. Therefore, there is the potential of drug interactions mediated by inhibition of transporters.

Cytochrome P450 Inducers: A CYP3A4 inducer, rifampicin, reduced Tadagra AUC by 88%, relative to the AUC values for Tadagra alone (10 mg). This reduced exposure can be anticipated to decrease the efficacy of Tadagra; the magnitude of decreased efficacy is unknown. Other inducers of CYP3A4 such as phenobarbital, phenytoin and carbamazepine, may also decrease plasma concentrations of Tadagra.

Effects of Tadagra on Other Medicinal Products: Nitrates: In clinical studies, Tadagra (5, 10 and 20 mg) was shown to augment the hypotensive effects of nitrates. Therefore, administration of Tadagra to patientswho are using any form of organic nitrate is contraindicated.

Based on the results of a clinical study in which 150 subjects receiving daily doses of Tadagra 20 mg for 7 days and 0.4 mg sublingual nitroglycerin at various times, this interaction lasted for more than 24 hours and was no longer detectable when 48 hours had elapsed after the last Tadagra dose. Thus, in a patient prescribed any dose of Tadagra (2.5 mg-20 mg), where nitrate administration is deemed medically necessary in a life-threatening situation, at least 48 hours should have elapsed after the last dose of Tadagra before nitrate administration is considered. In such circumstances, nitrates should only be administered under close medical supervision with appropriate haemodynamic monitoring.

Antihypertensives (Including Calcium-Channel Blockers): The co-administration of doxazosin (4 and 8 mg daily) and Tadagra (5 mg daily dose and 20 mg as a single dose) increases the blood pressure-lowering effect of this alpha-blocker in a significant manner. This effect lasts at least twelve hours and may be symptomatic, including syncope. Therefore, this combination is not recommended.

In interaction studies performed in a limited number of healthy volunteers, these effects were not reported with alfuzosin or tamsulosin. However, caution should be exercised when using Tadagra in patients treated with any alpha-blockers, and notably in the elderly. Treatments should be initiated at minimal dosage and progressively adjusted.

In clinical pharmacology studies, the potential for Tadagra to augment the hypotensive effects of antihypertensive agents was examined. Major classes of antihypertensive agents were studied, including calcium channel blockers (amlodipine), angiotensin converting enzyme (ACE) inhibitors (enalapril), beta-adrenergic receptor blockers (metoprolol), thiazide diuretics (bendrofluazide), and angiotensin II receptor blockers (various types and doses, alone or in combination with thiazides, calcium channel blockers, beta-blockers, and/or alpha-blockers). Tadagra (10 mg except for studies with angiotensin II receptor blockers and amlodipine in which a 20 mg dose was applied) had no clinically significant interaction with any of these classes. In another clinical pharmacology study Tadagra (20 mg) was studied in combination with up to 4 classes of antihypertensives. In subjects taking multiple antihypertensives, the ambulatory-blood-pressure changes appeared to relate to the degree of blood-pressure control. In this regard, study subjects whose blood pressure was well controlled, the reduction was minimal and similar to that seen in healthy subjects. In study subjects whose blood pressure was not controlled, the reduction was greater although this reduction was not associated with hypotensive symptoms in the majority of subjects. In patients receiving concomitant antihypertensive medications, Tadagra 20 mg may induce a blood pressure decrease, which (with the exception of α-blockers previously mentioned) is, in general, minor and not likely to be clinically relevant. Analysis of phase 3 clinical trial data showed no difference in adverse events in patients taking Tadagra with or without antihypertensive medications. However, appropriate clinical advice should be given to patients regarding a possible decrease in blood pressure when they are treated with antihypertensive medications.

5-Alpha Reductase Inhibitors: In a clinical trial that compared Tadagra 5 mg co-administered with finasteride 5 mg to placebo plus finasteride 5 mg in the relief of BPH symptoms, no new adverse reactions were identified. However, as a formal drug-drug interaction study evaluating the effects of Tadagra and 5-alpha reductase inhibitors (5-ARIs) has not been performed, caution should be exercised when Tadagra is co-administered with 5-ARIs.

CYP1A2 Substrates (e.g. Theophylline): When Tadagra 10 mg was administered with theophylline (a non-selective phosphodiesterase inhibitor) in a clinical pharmacology study, there was no pharmacokinetic interaction. The only pharmacodynamic effect was a small (3.5 bpm) increase in heart rate. Although this effect is minor and was of no clinical significance in this study, it should be considered when co-administering these medications.

Ethinylestradiol and Terbutaline: Tadagra has been demonstrated to produce an increase in the oral bioavailability of ethinylestradiol; a similar increase may be expected with oral administration of terbutaline, although the clinical consequence of this is uncertain.

Alcohol: Alcohol concentrations (mean maximum blood concentration 0.08%) were not affected by co-administration with Tadagra (10 or 20 mg). In addition, no changes in Tadagra concentrations were seen 3 hours after co-administration with alcohol. Alcohol was administered in a manner to maximize the rate of alcohol absorption (overnight fast with no food until 2 hrs after alcohol). Tadagra (20 mg) did not augment the mean blood pressure decrease produced by alcohol [0.7 g/kg or approximately 180 mL of 40% alcohol (vodka) in an 80-kg male] but in some subjects, postural dizziness and orthostatic hypotension were observed. When Tadagra was administered with lower doses of alcohol (0.6 g/kg), hypotension was not observed and dizziness occurred with similar frequency to alcohol alone. The effect of alcohol on cognitive function was not augmented by Tadagra (10 mg).

Cytochrome P450 Metabolized Drugs: Tadagra is not expected to cause clinically significant inhibition or induction of the clearance of drugs metabolized by CYP450 isoforms. Studies have confirmed that Tadagra does not inhibit or induce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9 and CYP2C19.

CYP2C9 Substrates (e.g. R-warfarin): Tadagra (10 and 20 mg) had no clinically significant effect on exposure (AUC) to S-warfarin or R-warfarin (CYP2C9 substrate), nor did Tadagra affect changes in prothrombin time induced by warfarin.

Aspirin: Tadagra (10 and 20 mg) did not potentiate the increase in bleeding time caused by acetylsalicylic acid.

Antidiabetic Medicinal Products: Specific interaction studies with antidiabetic medicinal products were not conducted.

20 mg: Potential for Other Drugs to Affect Tadagra: Tadagra is principally metabolised by CYP3A4. A selective inhibitor of CYP3A4, ketoconazole (400 mg daily), increased Tadagra single-dose exposure (AUC) by 312% and Cmax by 22%, and ketaconazole (200 mg daily), increased Tadagra single-dose exposure (AUC) by 107% and Cmax by 15% relative to the AUC and Cmax values for Tadagra (10 mg) alone.

Ritonavir (200 mg twice daily), an inhibitor of CYP3A4, 2C9, 2C19, and 2D6, increased tadalafi single-dose exposure (AUC) by 124% with no change in Cmax. Although specific interactions have not been studied, other HIV protease inhibitors, such as saquinavir, and other CYP3A4 inhibitors, such as erythromycin, clarithromycin, and itraconazole should be co-administered with caution because they would be expected to increase plasma concentrations of Tadagra.

A selective CYP3A4 inducer, rifampicin (600 mg daily), reduced Tadagra single-dose exposure(AUC) by 88%, and Cmax by 46% relative to the AUC and Cmax values for Tadagra (10 mg) alone. It can be expected that concomitant administration of other CYP3A4 inducers such as phenobarbital, phenytoin and carbamazepine would also decrease plasma concentrations of Tadagra.

Studies with the CYP3A4 probe substrates midazolam with Tadagra 10 mg and lovastatin with Tadagra 20 mg showed little alteration in the kinetics suggesting that Tadagra is unlikely to have interactions with CYP3A4 substrates.

Antacids (Magnesium hydroxide/Aluminium hydroxide): Simultaneous administration of an antacid(magnesium hydroxide/aluminium hydroxide) and Tadagra reduced the apparent rate of absorption of Tadagra without altering exposure (AUC) to Tadagra (10 mg).

H2 Antagonists: An increase in gastric pH resulting from administration of nizatidine had no significant effect on Tadagra (10 mg) pharmacokinetics.


sponsored

References

  1. DailyMed. "TADALAFIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. FDA/SPL Indexing Data. "742SXX0ICT: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  3. MeSH. "Vasodilator Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Tadagra are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tadagra. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported frequency of use

No survey data has been collected yet


1 consumer reported doses

What doses of Tadagra drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Tadagra drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users%
11-50mg1
100.0%


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 20 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2020 ndrugs.com All Rights Reserved