Tadalafilo La Sante Dosage

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Dosage of Tadalafilo La Sante in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Tadalafilo La Sante Dosage

Generic name: Tadalafilo La Sante 2.5mg

Dosage form: tablet, film coated

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Do not split Tadalafilo La Sante tablets; entire dose should be taken.

Tadalafilo La Sante for Use as Needed for Erectile Dysfunction

Tadalafilo La Sante for Once Daily Use for Erectile Dysfunction

Tadalafilo La Sante for Once Daily Use for Benign Prostatic Hyperplasia

Tadalafilo La Sante for Once Daily Use for Erectile Dysfunction and Benign Prostatic Hyperplasia

The recommended dose of Tadalafilo La Sante for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.

Use with Food

Tadalafilo La Sante may be taken without regard to food.

Use in Specific Populations

Renal Impairment

Tadalafilo La Sante for Use as Needed

Tadalafilo La Sante for Once Daily Use

Erectile Dysfunction

Benign Prostatic Hyperplasia and Erectile Dysfunction/Benign Prostatic Hyperplasia

Hepatic Impairment

Tadalafilo La Sante for Use as Needed

Tadalafilo La Sante for Once Daily Use

Concomitant Medications

Nitrates

Concomitant use of nitrates in any form is contraindicated.

Alpha-Blockers

ED — When Tadalafilo La Sante is coadministered with an alpha-blocker in patients being treated for ED, patients should be stable on alpha-blocker therapy prior to initiating treatment, and Tadalafilo La Sante should be initiated at the lowest recommended dose.

BPH — Tadalafilo La Sante is not recommended for use in combination with alpha-blockers for the treatment of BPH.

CYP3A4 Inhibitors

Tadalafilo La Sante for Use as Needed — For patients taking concomitant potent inhibitors of CYP3A4, such as ketoconazole or ritonavir, the maximum recommended dose of Tadalafilo La Sante is 10 mg, not to exceed once every 72 hours.

Tadalafilo La Sante for Once Daily Use — For patients taking concomitant potent inhibitors of CYP3A4, such as ketoconazole or ritonavir, the maximum recommended dose is 2.5 mg.

More about Tadalafilo La Sante (Tadalafilo La Sante)

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What other drugs will affect Tadalafilo La Sante?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Tadalafilo La Sante, especially:

This list is not complete. Other drugs may interact with Tadalafilo La Sante, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Tadalafilo La Sante interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Tadalafilo La Sante, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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5 mg Film-coated Tablet: Interaction studies were conducted with Tadalafilo La Sante 10 mg and/or 20 mg, as indicated as follows. With regard to those interaction studies where only the Tadalafilo La Sante 10 mg dose was used, clinically relevant interactions at higher doses cannot be completely ruled out.

Effects of Other Substances on Tadalafilo La Sante: Cytochrome P450 Inhibitors: Tadalafilo La Sante is principally metabolized by CYP3A4. A selective inhibitor of CYP3A4, ketoconazole (200 mg daily), increased Tadalafilo La Sante (10 mg) AUC 2-fold and Cmax by 15%, relative to the AUC and Cmax values for Tadalafilo La Sante alone. Ketoconazole (400 mg daily) increased Tadalafilo La Sante (20 mg) AUC 4-fold and Cmax by 22%. Ritonavir, a protease inhibitor (200 mg twice daily), which is an inhibitor of CYP3A4, CYP2C9, CYP2C19, and CYP2D6, increased Tadalafilo La Sante (20 mg) AUC 2-fold with no change in Cmax. Although specific interactions have not been studied, other protease inhibitors such as saquinavir and other CYP3A4 inhibitors eg, erythromycin, clarithromycin, itraconazole and grapefruit juice should be co-administered with caution as they would be expected to increase plasma concentrations of Tadalafilo La Sante.

Consequently the incidence of the adverse reactions might be increased..

Transporters: The role of transporters (for example p-glycoprotein) in the disposition of Tadalafilo La Sante is not known. Therefore, there is the potential of drug interactions mediated by inhibition of transporters.

Cytochrome P450 Inducers: A CYP3A4 inducer, rifampicin, reduced Tadalafilo La Sante AUC by 88%, relative to the AUC values for Tadalafilo La Sante alone (10 mg). This reduced exposure can be anticipated to decrease the efficacy of Tadalafilo La Sante; the magnitude of decreased efficacy is unknown. Other inducers of CYP3A4 such as phenobarbital, phenytoin and carbamazepine, may also decrease plasma concentrations of Tadalafilo La Sante.

Effects of Tadalafilo La Sante on Other Medicinal Products: Nitrates: In clinical studies, Tadalafilo La Sante (5, 10 and 20 mg) was shown to augment the hypotensive effects of nitrates. Therefore, administration of Tadalafilo La Sante to patientswho are using any form of organic nitrate is contraindicated.

Based on the results of a clinical study in which 150 subjects receiving daily doses of Tadalafilo La Sante 20 mg for 7 days and 0.4 mg sublingual nitroglycerin at various times, this interaction lasted for more than 24 hours and was no longer detectable when 48 hours had elapsed after the last Tadalafilo La Sante dose. Thus, in a patient prescribed any dose of Tadalafilo La Sante (2.5 mg-20 mg), where nitrate administration is deemed medically necessary in a life-threatening situation, at least 48 hours should have elapsed after the last dose of Tadalafilo La Sante before nitrate administration is considered. In such circumstances, nitrates should only be administered under close medical supervision with appropriate haemodynamic monitoring.

Antihypertensives (Including Calcium-Channel Blockers): The co-administration of doxazosin (4 and 8 mg daily) and Tadalafilo La Sante (5 mg daily dose and 20 mg as a single dose) increases the blood pressure-lowering effect of this alpha-blocker in a significant manner. This effect lasts at least twelve hours and may be symptomatic, including syncope. Therefore, this combination is not recommended.

In interaction studies performed in a limited number of healthy volunteers, these effects were not reported with alfuzosin or tamsulosin. However, caution should be exercised when using Tadalafilo La Sante in patients treated with any alpha-blockers, and notably in the elderly. Treatments should be initiated at minimal dosage and progressively adjusted.

In clinical pharmacology studies, the potential for Tadalafilo La Sante to augment the hypotensive effects of antihypertensive agents was examined. Major classes of antihypertensive agents were studied, including calcium channel blockers (amlodipine), angiotensin converting enzyme (ACE) inhibitors (enalapril), beta-adrenergic receptor blockers (metoprolol), thiazide diuretics (bendrofluazide), and angiotensin II receptor blockers (various types and doses, alone or in combination with thiazides, calcium channel blockers, beta-blockers, and/or alpha-blockers). Tadalafilo La Sante (10 mg except for studies with angiotensin II receptor blockers and amlodipine in which a 20 mg dose was applied) had no clinically significant interaction with any of these classes. In another clinical pharmacology study Tadalafilo La Sante (20 mg) was studied in combination with up to 4 classes of antihypertensives. In subjects taking multiple antihypertensives, the ambulatory-blood-pressure changes appeared to relate to the degree of blood-pressure control. In this regard, study subjects whose blood pressure was well controlled, the reduction was minimal and similar to that seen in healthy subjects. In study subjects whose blood pressure was not controlled, the reduction was greater although this reduction was not associated with hypotensive symptoms in the majority of subjects. In patients receiving concomitant antihypertensive medications, Tadalafilo La Sante 20 mg may induce a blood pressure decrease, which (with the exception of α-blockers previously mentioned) is, in general, minor and not likely to be clinically relevant. Analysis of phase 3 clinical trial data showed no difference in adverse events in patients taking Tadalafilo La Sante with or without antihypertensive medications. However, appropriate clinical advice should be given to patients regarding a possible decrease in blood pressure when they are treated with antihypertensive medications.

5-Alpha Reductase Inhibitors: In a clinical trial that compared Tadalafilo La Sante 5 mg co-administered with finasteride 5 mg to placebo plus finasteride 5 mg in the relief of BPH symptoms, no new adverse reactions were identified. However, as a formal drug-drug interaction study evaluating the effects of Tadalafilo La Sante and 5-alpha reductase inhibitors (5-ARIs) has not been performed, caution should be exercised when Tadalafilo La Sante is co-administered with 5-ARIs.

CYP1A2 Substrates (e.g. Theophylline): When Tadalafilo La Sante 10 mg was administered with theophylline (a non-selective phosphodiesterase inhibitor) in a clinical pharmacology study, there was no pharmacokinetic interaction. The only pharmacodynamic effect was a small (3.5 bpm) increase in heart rate. Although this effect is minor and was of no clinical significance in this study, it should be considered when co-administering these medications.

Ethinylestradiol and Terbutaline: Tadalafilo La Sante has been demonstrated to produce an increase in the oral bioavailability of ethinylestradiol; a similar increase may be expected with oral administration of terbutaline, although the clinical consequence of this is uncertain.

Alcohol: Alcohol concentrations (mean maximum blood concentration 0.08%) were not affected by co-administration with Tadalafilo La Sante (10 or 20 mg). In addition, no changes in Tadalafilo La Sante concentrations were seen 3 hours after co-administration with alcohol. Alcohol was administered in a manner to maximize the rate of alcohol absorption (overnight fast with no food until 2 hrs after alcohol). Tadalafilo La Sante (20 mg) did not augment the mean blood pressure decrease produced by alcohol [0.7 g/kg or approximately 180 mL of 40% alcohol (vodka) in an 80-kg male] but in some subjects, postural dizziness and orthostatic hypotension were observed. When Tadalafilo La Sante was administered with lower doses of alcohol (0.6 g/kg), hypotension was not observed and dizziness occurred with similar frequency to alcohol alone. The effect of alcohol on cognitive function was not augmented by Tadalafilo La Sante (10 mg).

Cytochrome P450 Metabolized Drugs: Tadalafilo La Sante is not expected to cause clinically significant inhibition or induction of the clearance of drugs metabolized by CYP450 isoforms. Studies have confirmed that Tadalafilo La Sante does not inhibit or induce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9 and CYP2C19.

CYP2C9 Substrates (e.g. R-warfarin): Tadalafilo La Sante (10 and 20 mg) had no clinically significant effect on exposure (AUC) to S-warfarin or R-warfarin (CYP2C9 substrate), nor did Tadalafilo La Sante affect changes in prothrombin time induced by warfarin.

Aspirin: Tadalafilo La Sante (10 and 20 mg) did not potentiate the increase in bleeding time caused by acetylsalicylic acid.

Antidiabetic Medicinal Products: Specific interaction studies with antidiabetic medicinal products were not conducted.

20 mg: Potential for Other Drugs to Affect Tadalafilo La Sante: Tadalafilo La Sante is principally metabolised by CYP3A4. A selective inhibitor of CYP3A4, ketoconazole (400 mg daily), increased Tadalafilo La Sante single-dose exposure (AUC) by 312% and Cmax by 22%, and ketaconazole (200 mg daily), increased Tadalafilo La Sante single-dose exposure (AUC) by 107% and Cmax by 15% relative to the AUC and Cmax values for Tadalafilo La Sante (10 mg) alone.

Ritonavir (200 mg twice daily), an inhibitor of CYP3A4, 2C9, 2C19, and 2D6, increased tadalafi single-dose exposure (AUC) by 124% with no change in Cmax. Although specific interactions have not been studied, other HIV protease inhibitors, such as saquinavir, and other CYP3A4 inhibitors, such as erythromycin, clarithromycin, and itraconazole should be co-administered with caution because they would be expected to increase plasma concentrations of Tadalafilo La Sante.

A selective CYP3A4 inducer, rifampicin (600 mg daily), reduced Tadalafilo La Sante single-dose exposure(AUC) by 88%, and Cmax by 46% relative to the AUC and Cmax values for Tadalafilo La Sante (10 mg) alone. It can be expected that concomitant administration of other CYP3A4 inducers such as phenobarbital, phenytoin and carbamazepine would also decrease plasma concentrations of Tadalafilo La Sante.

Studies with the CYP3A4 probe substrates midazolam with Tadalafilo La Sante 10 mg and lovastatin with Tadalafilo La Sante 20 mg showed little alteration in the kinetics suggesting that Tadalafilo La Sante is unlikely to have interactions with CYP3A4 substrates.

Antacids (Magnesium hydroxide/Aluminium hydroxide): Simultaneous administration of an antacid(magnesium hydroxide/aluminium hydroxide) and Tadalafilo La Sante reduced the apparent rate of absorption of Tadalafilo La Sante without altering exposure (AUC) to Tadalafilo La Sante (10 mg).

H2 Antagonists: An increase in gastric pH resulting from administration of nizatidine had no significant effect on Tadalafilo La Sante (10 mg) pharmacokinetics.


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References

  1. DailyMed. "TADALAFIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. FDA/SPL Indexing Data. "742SXX0ICT: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  3. MeSH. "Vasodilator Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Tadalafilo La Sante are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tadalafilo La Sante. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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