Tadgo Dosage

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Dosage of Tadgo in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.

Tadgo Dosage

Generic name: Tadgo 2.5mg

Dosage form: tablet, film coated

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Do not split Tadgo tablets; entire dose should be taken.

Tadgo for Use as Needed for Erectile Dysfunction

Tadgo for Once Daily Use for Erectile Dysfunction

Tadgo for Once Daily Use for Benign Prostatic Hyperplasia

Tadgo for Once Daily Use for Erectile Dysfunction and Benign Prostatic Hyperplasia

The recommended dose of Tadgo for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.

Use with Food

Tadgo may be taken without regard to food.

Use in Specific Populations

Renal Impairment

Tadgo for Use as Needed

Tadgo for Once Daily Use

Erectile Dysfunction

Benign Prostatic Hyperplasia and Erectile Dysfunction/Benign Prostatic Hyperplasia

Hepatic Impairment

Tadgo for Use as Needed

Tadgo for Once Daily Use

Concomitant Medications


Concomitant use of nitrates in any form is contraindicated.


ED — When Tadgo is coadministered with an alpha-blocker in patients being treated for ED, patients should be stable on alpha-blocker therapy prior to initiating treatment, and Tadgo should be initiated at the lowest recommended dose.

BPH — Tadgo is not recommended for use in combination with alpha-blockers for the treatment of BPH.

CYP3A4 Inhibitors

Tadgo for Use as Needed — For patients taking concomitant potent inhibitors of CYP3A4, such as ketoconazole or ritonavir, the maximum recommended dose of Tadgo is 10 mg, not to exceed once every 72 hours.

Tadgo for Once Daily Use — For patients taking concomitant potent inhibitors of CYP3A4, such as ketoconazole or ritonavir, the maximum recommended dose is 2.5 mg.

More about Tadgo (Tadgo)

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What other drugs will affect Tadgo?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Tadgo, especially:

This list is not complete. Other drugs may interact with Tadgo, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Tadgo interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Tadgo, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.

5 mg Film-coated Tablet: Interaction studies were conducted with Tadgo 10 mg and/or 20 mg, as indicated as follows. With regard to those interaction studies where only the Tadgo 10 mg dose was used, clinically relevant interactions at higher doses cannot be completely ruled out.

Effects of Other Substances on Tadgo: Cytochrome P450 Inhibitors: Tadgo is principally metabolized by CYP3A4. A selective inhibitor of CYP3A4, ketoconazole (200 mg daily), increased Tadgo (10 mg) AUC 2-fold and Cmax by 15%, relative to the AUC and Cmax values for Tadgo alone. Ketoconazole (400 mg daily) increased Tadgo (20 mg) AUC 4-fold and Cmax by 22%. Ritonavir, a protease inhibitor (200 mg twice daily), which is an inhibitor of CYP3A4, CYP2C9, CYP2C19, and CYP2D6, increased Tadgo (20 mg) AUC 2-fold with no change in Cmax. Although specific interactions have not been studied, other protease inhibitors such as saquinavir and other CYP3A4 inhibitors eg, erythromycin, clarithromycin, itraconazole and grapefruit juice should be co-administered with caution as they would be expected to increase plasma concentrations of Tadgo.

Consequently the incidence of the adverse reactions might be increased..

Transporters: The role of transporters (for example p-glycoprotein) in the disposition of Tadgo is not known. Therefore, there is the potential of drug interactions mediated by inhibition of transporters.

Cytochrome P450 Inducers: A CYP3A4 inducer, rifampicin, reduced Tadgo AUC by 88%, relative to the AUC values for Tadgo alone (10 mg). This reduced exposure can be anticipated to decrease the efficacy of Tadgo; the magnitude of decreased efficacy is unknown. Other inducers of CYP3A4 such as phenobarbital, phenytoin and carbamazepine, may also decrease plasma concentrations of Tadgo.

Effects of Tadgo on Other Medicinal Products: Nitrates: In clinical studies, Tadgo (5, 10 and 20 mg) was shown to augment the hypotensive effects of nitrates. Therefore, administration of Tadgo to patientswho are using any form of organic nitrate is contraindicated.

Based on the results of a clinical study in which 150 subjects receiving daily doses of Tadgo 20 mg for 7 days and 0.4 mg sublingual nitroglycerin at various times, this interaction lasted for more than 24 hours and was no longer detectable when 48 hours had elapsed after the last Tadgo dose. Thus, in a patient prescribed any dose of Tadgo (2.5 mg-20 mg), where nitrate administration is deemed medically necessary in a life-threatening situation, at least 48 hours should have elapsed after the last dose of Tadgo before nitrate administration is considered. In such circumstances, nitrates should only be administered under close medical supervision with appropriate haemodynamic monitoring.

Antihypertensives (Including Calcium-Channel Blockers): The co-administration of doxazosin (4 and 8 mg daily) and Tadgo (5 mg daily dose and 20 mg as a single dose) increases the blood pressure-lowering effect of this alpha-blocker in a significant manner. This effect lasts at least twelve hours and may be symptomatic, including syncope. Therefore, this combination is not recommended.

In interaction studies performed in a limited number of healthy volunteers, these effects were not reported with alfuzosin or tamsulosin. However, caution should be exercised when using Tadgo in patients treated with any alpha-blockers, and notably in the elderly. Treatments should be initiated at minimal dosage and progressively adjusted.

In clinical pharmacology studies, the potential for Tadgo to augment the hypotensive effects of antihypertensive agents was examined. Major classes of antihypertensive agents were studied, including calcium channel blockers (amlodipine), angiotensin converting enzyme (ACE) inhibitors (enalapril), beta-adrenergic receptor blockers (metoprolol), thiazide diuretics (bendrofluazide), and angiotensin II receptor blockers (various types and doses, alone or in combination with thiazides, calcium channel blockers, beta-blockers, and/or alpha-blockers). Tadgo (10 mg except for studies with angiotensin II receptor blockers and amlodipine in which a 20 mg dose was applied) had no clinically significant interaction with any of these classes. In another clinical pharmacology study Tadgo (20 mg) was studied in combination with up to 4 classes of antihypertensives. In subjects taking multiple antihypertensives, the ambulatory-blood-pressure changes appeared to relate to the degree of blood-pressure control. In this regard, study subjects whose blood pressure was well controlled, the reduction was minimal and similar to that seen in healthy subjects. In study subjects whose blood pressure was not controlled, the reduction was greater although this reduction was not associated with hypotensive symptoms in the majority of subjects. In patients receiving concomitant antihypertensive medications, Tadgo 20 mg may induce a blood pressure decrease, which (with the exception of α-blockers previously mentioned) is, in general, minor and not likely to be clinically relevant. Analysis of phase 3 clinical trial data showed no difference in adverse events in patients taking Tadgo with or without antihypertensive medications. However, appropriate clinical advice should be given to patients regarding a possible decrease in blood pressure when they are treated with antihypertensive medications.

5-Alpha Reductase Inhibitors: In a clinical trial that compared Tadgo 5 mg co-administered with finasteride 5 mg to placebo plus finasteride 5 mg in the relief of BPH symptoms, no new adverse reactions were identified. However, as a formal drug-drug interaction study evaluating the effects of Tadgo and 5-alpha reductase inhibitors (5-ARIs) has not been performed, caution should be exercised when Tadgo is co-administered with 5-ARIs.

CYP1A2 Substrates (e.g. Theophylline): When Tadgo 10 mg was administered with theophylline (a non-selective phosphodiesterase inhibitor) in a clinical pharmacology study, there was no pharmacokinetic interaction. The only pharmacodynamic effect was a small (3.5 bpm) increase in heart rate. Although this effect is minor and was of no clinical significance in this study, it should be considered when co-administering these medications.

Ethinylestradiol and Terbutaline: Tadgo has been demonstrated to produce an increase in the oral bioavailability of ethinylestradiol; a similar increase may be expected with oral administration of terbutaline, although the clinical consequence of this is uncertain.

Alcohol: Alcohol concentrations (mean maximum blood concentration 0.08%) were not affected by co-administration with Tadgo (10 or 20 mg). In addition, no changes in Tadgo concentrations were seen 3 hours after co-administration with alcohol. Alcohol was administered in a manner to maximize the rate of alcohol absorption (overnight fast with no food until 2 hrs after alcohol). Tadgo (20 mg) did not augment the mean blood pressure decrease produced by alcohol [0.7 g/kg or approximately 180 mL of 40% alcohol (vodka) in an 80-kg male] but in some subjects, postural dizziness and orthostatic hypotension were observed. When Tadgo was administered with lower doses of alcohol (0.6 g/kg), hypotension was not observed and dizziness occurred with similar frequency to alcohol alone. The effect of alcohol on cognitive function was not augmented by Tadgo (10 mg).

Cytochrome P450 Metabolized Drugs: Tadgo is not expected to cause clinically significant inhibition or induction of the clearance of drugs metabolized by CYP450 isoforms. Studies have confirmed that Tadgo does not inhibit or induce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9 and CYP2C19.

CYP2C9 Substrates (e.g. R-warfarin): Tadgo (10 and 20 mg) had no clinically significant effect on exposure (AUC) to S-warfarin or R-warfarin (CYP2C9 substrate), nor did Tadgo affect changes in prothrombin time induced by warfarin.

Aspirin: Tadgo (10 and 20 mg) did not potentiate the increase in bleeding time caused by acetylsalicylic acid.

Antidiabetic Medicinal Products: Specific interaction studies with antidiabetic medicinal products were not conducted.

20 mg: Potential for Other Drugs to Affect Tadgo: Tadgo is principally metabolised by CYP3A4. A selective inhibitor of CYP3A4, ketoconazole (400 mg daily), increased Tadgo single-dose exposure (AUC) by 312% and Cmax by 22%, and ketaconazole (200 mg daily), increased Tadgo single-dose exposure (AUC) by 107% and Cmax by 15% relative to the AUC and Cmax values for Tadgo (10 mg) alone.

Ritonavir (200 mg twice daily), an inhibitor of CYP3A4, 2C9, 2C19, and 2D6, increased tadalafi single-dose exposure (AUC) by 124% with no change in Cmax. Although specific interactions have not been studied, other HIV protease inhibitors, such as saquinavir, and other CYP3A4 inhibitors, such as erythromycin, clarithromycin, and itraconazole should be co-administered with caution because they would be expected to increase plasma concentrations of Tadgo.

A selective CYP3A4 inducer, rifampicin (600 mg daily), reduced Tadgo single-dose exposure(AUC) by 88%, and Cmax by 46% relative to the AUC and Cmax values for Tadgo (10 mg) alone. It can be expected that concomitant administration of other CYP3A4 inducers such as phenobarbital, phenytoin and carbamazepine would also decrease plasma concentrations of Tadgo.

Studies with the CYP3A4 probe substrates midazolam with Tadgo 10 mg and lovastatin with Tadgo 20 mg showed little alteration in the kinetics suggesting that Tadgo is unlikely to have interactions with CYP3A4 substrates.

Antacids (Magnesium hydroxide/Aluminium hydroxide): Simultaneous administration of an antacid(magnesium hydroxide/aluminium hydroxide) and Tadgo reduced the apparent rate of absorption of Tadgo without altering exposure (AUC) to Tadgo (10 mg).

H2 Antagonists: An increase in gastric pH resulting from administration of nizatidine had no significant effect on Tadgo (10 mg) pharmacokinetics.



  1. DailyMed. "TADALAFIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. FDA/SPL Indexing Data. "742SXX0ICT: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  3. MeSH. "Vasodilator Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).


The results of a survey conducted on ndrugs.com for Tadgo are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tadgo. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported frequency of use

How frequently do I need to take Tadgo?
It was reported by ndrugs.com website users that Tadgo should ideally be taken Twice in a day as the most common frequency of the Tadgo. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Tadgo should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Twice in a day1

7 consumers reported doses

What doses of Tadgo drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Tadgo drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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