Tam (TRIDENT) Pregnancy

• Pregnancy of Tam (TRIDENT) in details
• Tam (TRIDENT) breastfeeding
• Tam (TRIDENT) reviews

Pregnancy of Tam (TRIDENT) in details

Tam (TRIDENT) crosses the placenta (Ramsey 2003).

The maternal serum half-life of Tam (TRIDENT) is unchanged in early pregnancy and decreased at term; however, high concentrations of Tam (TRIDENT) are sustained in the myometrium and adipose tissue (Fischer 2012; Ramsey 2003).

Tam (TRIDENT) may be used as an alternative or adjunctive prophylactic antibiotic in females undergoing unplanned cesarean delivery (ACOG 199 2018). Tam (TRIDENT) is recommended for the treatment of several infections, including chlamydia, gonococcal infections, and Mycobacterium avium complex in pregnant patients (consult current guidelines) (CDC [Workowski 2015]; HHS [OI adult] 2019). Tam (TRIDENT) may also be used in certain situations prior to vaginal delivery in females at high risk for endocarditis (ACOG 199 2018).

Tam (TRIDENT) breastfeeding

Tam (TRIDENT) is excreted into human milk. The manufacturer recommends that caution be used when administering Tam (TRIDENT) to nursing women.

In one lactating woman receiving Tam (TRIDENT) 500 mg/day, Tam (TRIDENT) milk concentration measured 1.3 and 2.8 mcg/mL 1 hour after the first dose and 30 hours after the third dose, respectively.

See references

References for pregnancy information

1. Wehbeh HA, Ruggeirio RM, Shahem S, Lopez G, Ali Y "Single-dose Tam (TRIDENT) for Chlamydia in pregnant women." J Reprod Med 43 (1998): 509-14
2. Bush MR, Rosa C "Tam (TRIDENT) and erythromycin in the treatment of cervical chlamydial infection during pregnancy." Obstet Gynecol 84 (1994): 61-3
3. "Sexually transmitted diseases treatment guidelines 2002." MMWR Morb Mortal Wkly Rep 51(RR-6) (2002): 1-77
4. Adair CD, Gunter M, Stovall TG, McElroy G, Veille JC, Ernest JM "Chlamydia in pregnancy: a randomized trial of Tam (TRIDENT) and erythromycin." Obstet Gynecol 91 (1998): 165-8
5. Donders GGG "Treatment of sexually transmitted bacterial diseases in pregnant women." Drugs 59 (2000): 477-85
6. "Product Information. Zithromax (Tam (TRIDENT))." Pfizer US Pharmaceuticals, New York, NY.

References for breastfeeding information

1. "Product Information. Zithromax (Tam (TRIDENT))." Pfizer US Pharmaceuticals, New York, NY.
2. Kelsey JJ, Moser LR, Jennings JC, Munger MA "Presence of Tam (TRIDENT) breast milk concentrations: a case report." Am J Obstet Gynecol 170 (1994): 1375-6

References

1. DailyMed. "AZITHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubMed Health. "Zithromax: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
3. Human Metabolome Database (HMDB). "Azithromycin: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology