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Telebrix N 30 G Side effects |
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Intravascular use
Side effects in association with the use of iodinated contrast media are usually mild to moderate and transient in nature. However, severe and life-threatening reactions as well as deaths have been reported. The prevalence of adverse drug reactions in patients receiving ionic contrast media is reported to be over 12% compared to over 3% for non-ionics.
Nausea, vomiting, a sensation of pain and a general feeling of warmth are the most frequently recorded reactions.
Anaphylactoid reactions/hypersensitivity
Angioedema, conjunctivitis, coughing, pruritus, rhinitis, sneezing and urticaria have been reported commonly. These reactions which can occur irrespective of the amount administered and the mode of administration, may be the first signs of an incipient state of shock. Administration of the contrast medium must be discontinued immediately and –if necessary –specific therapy instituted via a venous access.
Severe reactions requiring emergency treatment can occur in the form of a circulatory reaction accompanied by peripheral vasodilatation and subsequent hypotension, reflex tachycardia, dyspnoea, agitation, confusion and cyanosis possibly leading to unconsciousness.
Hypotension, bronchospasm and laryngeal spasm or oedema occur uncommonly.
Delayed contrast medium reactions are rare.
Body as a whole
Heat sensations and headache have been reported as being common. Malaise, chills or sweating and vasovagal reactions are uncommon.
In rare cases alterations in body temperature and swelling of salivary glands are possible.
Respiratory
Transient disturbance in respiratory rate, dyspnoea and respiratory distress and coughing are common.
Respiratory arrest and pulmonary oedema are rare reactions.
Cardiovascular
Clinically relevant transient disturbance in heart rate, blood pressure, disturbance in cardiac rhythm or function and cardiac arrest are uncommon.
Severe reactions requiring emergency treatment can occur in the form of a circulatory reaction accompanied by peripheral vasodilatation and subsequent hypotension, reflex tachycardia, dyspnoea, agitation, confusion and cyanosis possibly leading to unconsciousness.
Serious thromboembolic events causing myocardial infarction have been reported in rare cases.
Gastrointestinal
Nausea and vomiting are common reactions. Abdominal pain has been reported as being uncommon.
Cerebrovascular
Cerebral angiography and other procedures in which the contrast medium reaches the brain in high concentrations with the arterial blood can be accompanied by transient neurological complications such as: dizziness, headache, agitation or confusion, amnesia, disturbed speech, vision, hearing, convulsions, tremor, paresis/paralysis, photophobia, temporary blindness, coma, and somnolence are uncommon.
Serious, in isolated cases fatal, thromboembolic events causing stroke have been reported on rare occasions.
Renal
In rare cases renal impairment or failure have been reported.
Skin
Mild angioedema, flush reaction with vasodilatation, urticaria, pruritus and erythema have been commonly observed.
Toxic skin reactions such as the mucocutaneous syndrome (eg Stevens-Johnson
Hypersensitivity to antihistamines,
History of agranulocytosis,
Risk of urinary retention due to disorders - Risk of glaucoma angle closure.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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