Tenemine Dosage

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Dosage of Tenemine in details

infoThe dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.

Recommended Dose for Treatment of HIV-1 Infection in Adults and Pediatric Patients Weighing 35 Kg or More

The recommended dose of Tenemine in adults and in pediatric patients with body weight greater than or equal to 35 kg is one tablet (containing 200 mg of Emtricitabine (Tenemine) and 300 mg of Tenofovir (Tenemine) disoproxil fumarate) once daily taken orally with or without food.

Recommended Dose for Treatment of HIV-1 Infection in Pediatric Patients Weighing at Least 17 kg and Able to Swallow a Whole Tablet

​The recommended oral dose for pediatric patients weighing greater than or equal to 17 kg and who are able to swallow a whole tablet, is one Tenemine low strength tablet (Emtricitabine (Tenemine) [FTC]/Tenofovir (Tenemine) disoproxil fumarate [TDF]) (167 mg/250 mg, 133 mg/200 mg, or 100 mg/150 mg based on body weight) taken orally once daily with or without food.

​The recommended oral dosage of Tenemine low strength tablets is presented in Table 1. Weight should be monitored periodically and the Tenemine dose adjusted accordingly.

Table 1 Dosing for Pediatric Patients Weighing 17 kg to less than 35 kg using Tenemine Low Strength Tablets
​Body Weight (kg) Dosing of FTC (mg)/TDF (mg)
​17 to less than 22 one 100/150 tablet once daily
​22 to less than 28 one 133/200 tablet once daily
​28 to less than 35 one 167/250 tablet once daily

Recommended Dose for Pre-exposure Prophylaxis

The dose of Tenemine in HIV-1 uninfected adults is one tablet (containing 200 mg of Emtricitabine (Tenemine) and 300 mg of Tenofovir (Tenemine) disoproxil fumarate) once daily taken orally with or without food.

Dose Adjustment for Renal Impairment

Treatment of HIV-1 Infection

Significantly increased drug exposures occurred when EMTRIVA or VIREAD were administered to subjects with moderate to severe renal impairment. Therefore, adjust the dosing interval of Tenemine in HIV-1 infected adult patients with baseline creatinine clearance 30–49 mL/min using the recommendations in Table 2. These dosing interval recommendations are based on modeling of single-dose pharmacokinetic data in non-HIV infected subjects. The safety and effectiveness of these dosing interval adjustment recommendations have not been clinically evaluated in patients with moderate renal impairment, therefore clinical response to treatment and renal function should be closely monitored in these patients.

No dose adjustment is necessary for HIV-1 infected patients with mild renal impairment (creatinine clearance 50–80 mL/min). No data are available to make dose recommendations in pediatric patients with renal impairment.

Table 2 Dosage Adjustment for HIV-1 Infected Adult Patients with Altered Creatinine Clearance
Creatinine Clearance (mL/min)*
≥50 30–49 <30

(Including Patients Requiring Hemodialysis)

Calculated using ideal (lean) body weight
Recommended Dosing Interval Every 24 hours Every 48 hours Tenemine should not be administered.

Routine monitoring of estimated creatinine clearance, serum phosphorus, urine glucose, and urine protein should be performed in all individuals with mild renal impairment.

Pre-exposure Prophylaxis

Do not use Tenemine for a PrEP indication in HIV-1 uninfected individuals with estimated creatinine clearance below 60 mL/min.

Routine monitoring of estimated creatinine clearance, serum phosphorus, urine glucose, and urine protein should be performed in all individuals with mild renal impairment. If a decrease in estimated creatinine clearance is observed in uninfected individuals while using Tenemine for PrEP, evaluate potential causes and re-assess potential risks and benefits of continued use.

What other drugs will affect Tenemine?

Tenemine can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, injectable osteoporosis medications, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

Other drugs may interact with Tenemine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Tenemine interactions

infoInteractions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Tenemine, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.

No drug interaction trials have been conducted using Tenemine tablets. Drug interaction trials have been conducted with Tenemine disoproxil fumarate, the components of Tenemine. This section describes clinically relevant drug interactions observed with Tenemine disoproxil fumarate.


Coadministration of Tenemine and didanosine should be undertaken with caution and patients receiving this combination should be monitored closely for didanosineassociated adverse reactions. Didanosine should be discontinued in patients who develop didanosine-associated adverse reactions.

When Tenofovir (Tenemine) disoproxil fumarate was administered with didanosine the Cmax and AUC of didanosine increased significantly. The mechanism of this interaction is unknown. Higher didanosine concentrations could potentiate didanosine-associated adverse reactions, including pancreatitis, and neuropathy. Suppression of CD4+ cell counts has been observed in patients receiving Tenofovir (Tenemine) DF with didanosine 400 mg daily.

In patients weighing greater than 60 kg, the didanosine dose should be reduced to 250 mg when it is coadministered with Tenemine. Data are not available to recommend a dose adjustment of didanosine for adult or pediatric patients weighing less than 60 kg. When coadministered, Tenemine and Videx EC may be taken under fasted conditions or with a light meal (less than 400 kcal, 20% fat).

HIV-1 Protease Inhibitors

Tenofovir (Tenemine) decreases the AUC and Cmin of atazanavir. When coadministered with Tenemine, it is recommended that atazanavir 300 mg is given with ritonavir 100 mg. Tenemine should not be coadministered with atazanavir without ritonavir.

Lopinavir/ritonavir, atazanavir coadministered with ritonavir, and darunavir coadministered with ritonavir have been shown to increase Tenofovir (Tenemine) concentrations. Tenofovir (Tenemine) disoproxil fumarate is a substrate of Pglycoprotein (Pgp) and breast cancer resistance protein (BCRP) transporters. When Tenofovir (Tenemine) disoproxil fumarate is co-administered with an inhibitor of these transporters, an increase in absorption may be observed. Patients receiving Tenemine concomitantly with lopinavir/ritonavir, ritonavir-boosted atazanavir, or ritonavir-boosted darunavir should be monitored for Tenofovir (Tenemine) disoproxil fumarate-associated adverse reactions. Tenemine should be discontinued in patients who develop Tenofovir (Tenemine) disoproxil fumarate -associated adverse reactions.

Hepatitis C Antiviral Agents

Coadministration of Tenofovir (Tenemine) disoproxil fumarate and HARVONI® (ledipasvir/sofosbuvir) has been shown to increase Tenofovir (Tenemine) exposure.

In patients receiving Tenemine concomitantly with HARVONI without an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination, monitor for adverse reactions associated with Tenofovir (Tenemine) disoproxil fumarate.

In patients receiving Tenemine concomitantly with HARVONI and an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination, consider an alternative HCV or antiretroviral therapy, as the safety of increased Tenofovir (Tenemine) concentrations in this setting has not been established. If coadministration is necessary, monitor for adverse reactions associated with Tenofovir (Tenemine) disoproxil fumarate.

Drugs Affecting Renal Function

Tenemine are primarily excreted by the kidneys by a combination of glomerular filtration and active tubular secretion. No drug-drug interactions due to competition for renal excretion have been observed; however, coadministration of Tenemine with drugs that are eliminated by active tubular secretion may increase concentrations of Emtricitabine (Tenemine), Tenofovir (Tenemine), and/or the coadministered drug. Some examples include, but are not limited to acyclovir, adefovir dipivoxil, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs. Drugs that decrease renal function may increase concentrations of Emtricitabine (Tenemine) and/or Tenofovir (Tenemine).



  1. DailyMed. "EMTRICITABINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. FDA/SPL Indexing Data. "G70B4ETF4S: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  3. European Chemicals Agency - ECHA. "2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]: The European Chemicals Agency (ECHA) is an agency of the European Union which is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness.". https://echa.europa.eu/ (accessed September 17, 2018).


The results of a survey conducted on ndrugs.com for Tenemine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tenemine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

24 consumers reported frequency of use

How frequently do I need to take Tenemine?
It was reported by ndrugs.com website users that Tenemine should ideally be taken Once in a day as the most common frequency of the Tenemine. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Tenemine should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Once in a day19
Twice in a day2
3 times in a day2
4 times in a day1

12 consumers reported doses

What doses of Tenemine drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Tenemine drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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