Terfamex Actions

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Actions of Terfamex in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Terfamex is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse. Terfamex (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that Terfamex can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.

How should I take Terfamex?

Take Terfamex only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If you take too much of Terfamex, it may become habit-forming (causing mental or physical dependence).

Terfamex is available in four forms: capsules, disintegrating tablets, extended-release capsules, and tablets. Carefully follow the dosing instructions for the form you are using.

Swallow the extended-release capsule whole. Do not crush, break, or chew it.

Take the disintegrating tablet with or without food. Make sure your hands are dry before touching the tablet. Place the tablet on the top of your tongue right after removing it from the bottle. It should melt quickly. After the tablet has melted, swallow or take a sip of water.

Carefully follow your doctor's instructions for a reduced-calorie diet plan and regular exercise. Talk with your doctor before starting an exercise program.

To avoid trouble with sleeping, take the last dose of the day about 4 to 6 hours before bedtime, unless your doctor tells you otherwise.

Dosing

The dose of Terfamex will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Terfamex. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of Terfamex, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Terfamex administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
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Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Some brands of Terfamex should be taken on an empty stomach before breakfast or within 2 hours after breakfast.

Terfamex disintegrating tablets can be taken with or without food.

Using dry hands, remove the Terfamex tablet from the medicine bottle and place the tablet in your mouth. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

To prevent sleep problems, take this medication early in the day, no later than 6:00pm.

Talk with your doctor if you have increased hunger or if you otherwise think the medication is not working properly. Taking more of this medication will not make it more effective and can cause serious, life-threatening side effects.

Terfamex should be taken only for a short time, such as a few weeks.

Do not stop taking Terfamex suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using Terfamex.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Terfamex is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Terfamex pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
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12.1 Mechanism of Action

Terfamex is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, amphetamine (d- and dll-amphetamine). Drugs of this class used in obesity are commonly known as “anorectics” or “anorexigenics.” It has not been established that the primary action of such drugs in treating obesity is one of appetite suppression since other central nervous system actions, or metabolic effects, may also be involved.

12.2 Pharmacodynamics

Typical actions of amphetamines include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

12.3 Pharmacokinetics

In terms of rate and extent of exposure, Terfamex orally disintegrating tablets are equivalent to Terfamex capsules and tablets administered under fasting conditions.

Following the administration of the oral disintegrating tablet (ODT), Terfamex reaches peak concentrations (Cmax) after 3.0 to 4.4 hours. Swallowing the ODT after disintegration with or without water did not affect the extent (AUC) of Terfamex exposure.

Administration of the ODT after a high fat/high calorie breakfast decreased the Cmax of Terfamex by approximately 5% and the AUC by approximately 12%. Despite the decrease in Cmax and AUC, Terfamex ODT can be administered with or without food.

Swallowing the ODT without prior disintegration decreased the Cmax of Terfamex by approximately 7% and the AUC by approximately 8% compared to swallowing the ODT after disintegration.

Drug Interactions

In a single-dose study comparing the exposures after oral administration of a combination capsule of 15 mg Terfamex and 92 mg topiramate to the exposures after oral administration of a 15 mg Terfamex capsule or a 92 mg topiramate capsule, there is no significant topiramate exposure change in the presence of Terfamex. However in the presence of topiramate, Terfamex Cmax and AUC increase 13% and 42%, respectively.

Specific Populations

Renal Impairment

Terfamex was not studied in patients with renal impairment. The literature reported cumulative urinary excretion of Terfamex under uncontrolled urinary pH conditions is 62%-85%. Exposure increases can be expected in patients with renal impairment. Use caution when administering Terfamex to patients with renal impairment.



References

  1. NCIt. "Phentermine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  2. EPA DSStox. "Phentermine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Terfamex are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Terfamex. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

7 consumers reported administration

When best can I take Terfamex, on an empty stomach, before or after food?
ndrugs.com website users have also released a report stating that Terfamex should be taken Empty stomach. In any case, this may not be the right description on how you ought to take this Terfamex. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Terfamex can be taken.
Users%
Empty stomach3
42.9%
After food3
42.9%
Before food1
14.3%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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