Testosterone Enantate P & D Uses

Was this medicine useful for you?
sponsored

What is Testosterone Enantate P & D?

Testosterone Enantate P & D is a naturally occurring sex hormone produced in a man's testicles. Small amounts of Testosterone Enantate P & D are also produced in a woman's ovaries and adrenal system.

Testosterone Enantate P & D is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty, impotence, or other hormonal imbalances. This medicine is not for use in treating low Testosterone Enantate P & D without certain medical conditions or due to getting older.

Testosterone Enantate P & D enanthate is used in women to treat breast cancer that has spread to other parts of the body (metastatic) and cannot be treated with surgery.

Testosterone Enantate P & D will not enhance athletic performance and should not be used for that purpose.

Testosterone Enantate P & D may also be used for purposes not listed in this medication guide.

Testosterone Enantate P & D indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
sponsored

Testosterone Enantate P & D Gel 1% is indicated for replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous Testosterone Enantate P & D:

Limitations of use:

How should I use Testosterone Enantate P & D?

Use Testosterone Enantate P & D solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Testosterone Enantate P & D solution.

Uses of Testosterone Enantate P & D in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
sponsored

Testosterone Enantate P & D is a male hormone primarily used to treat deficiency or absence of naturally produced hormone Testosterone Enantate P & D in men (hypogonadal disorders). The conditions include,

In women, Testosterone Enantate P & D may be used as a treatment to improve quality of life in women with advanced breast cancer.

Testosterone Enantate P & D description

Testosterone Enantate P & D is a steroid sex hormone found in both men and women. In men, Testosterone Enantate P & D is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatogenesis, promote physical and functional maturation of spermatozoa, maintain accessory organs of the male reproductive tract, support development of secondary sexual characteristics, stimulate growth and metabolism throughout the body and influence brain development by stimulating sexual behaviors and sexual drive. In women, Testosterone Enantate P & D is produced by the ovaries (25%), adrenals (25%) and via peripheral conversion from androstenedione (50%). Testerone in women functions to maintain libido and general wellbeing. Testosterone Enantate P & D exerts a negative feedback mechanism on pituitary release of LH and follicle-stimulating hormone (FSH). Testosterone Enantate P & D may be further converted to dihydrotestosterone or estradiol depending on the tissue.

Testosterone Enantate P & D dosage

sponsored

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS

One system is applied at about the same time each day. The adhesive side of the Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS system should be placed on a clean, dry area of skin on the arm, back or upper buttocks immediately upon removal from the protective pouch. DO NOT APPLY TO THE SCROTUM. The area selected should not be oily, damaged, or irritated. The system should be pressed firmly in place with the palm of the hand for about 10 seconds, making sure there is good contact, especially around the edges. In the event that a system should fall off, the same system may be reapplied. If the system comes off after it has been worn for more than 12 hours and it cannot be reapplied, a new system may be applied at the next routine application time. In either case, the daily treatment schedule should be continued. The Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS system should be worn approximately 24 hours and then replaced. To ensure proper dosing, serum Testosterone Enantate P & D concentration may be measured 2-4 hours after an application of Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS. If the serum Testosterone Enantate P & D concentrations are low, the dosing regimen may be increased to 2 systems. Because of variability in analytical values among diagnostic laboratories, all Testosterone Enantate P & D measurements should be performed at the same laboratory.

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE

Patients should start therapy with a 6 mg/d system of either Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) or Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE applied daily; if the scrotal area cannot accommodate a 6 mg/d system, a 4 mg/d Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) system should be used. One Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) or Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE system should be placed on clean, dry, scrotal skin. Scrotal hair should be dry-shaved for optimal skin contact. Chemical depilatories should not be used. Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) or Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE should be worn 22-24 hours.

After 3-4 weeks of daily system use, blood should be drawn 2-4 hours after system application for determination of serum total Testosterone Enantate P & D. Because of variability in analytical values among diagnostic laboratories, this laboratory work and later analyses for assessing the effect of the Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE therapy should be performed at the same laboratory.

If patients have not achieved desired results by the end of 6-8 weeks of treatment with any of the Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) products, another form of Testosterone Enantate P & D replacement therapy should be considered.

How supplied

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS, Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)), and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE Testosterone Enantate P & D transdermal systems contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS systems are supplied as individually pouched systems, 30 per carton. Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS 5 mg/d (Testosterone Enantate P & D Transdermal System) -- each 60 cm2 system contains 328 mg Testosterone Enantate P & D USP for nominal dose of 5 mg/day

Carton of 30 Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS 5 mg/d systemsNDC 17314-4717-3

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE systems are supplied as individually pouched systems, 30 per carton.

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) 4 mg/d (Testosterone Enantate P & D Transdermal System) -- each 40 cm2 system contains 10 mg Testosterone Enantate P & D USP for nominal delivery of 4 mg for one day.

Carton of 30 Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) 4 mg/d systems. NDC 17314-4608-3

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE

6 mg/d (Testosterone Enantate P & D Transdermal System) -- each 60 cm2 system contains 15 mg Testosterone Enantate P & D USP for nominal delivery of 6 mg for one day.

Carton of 30 Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) 6 mg/d systems. NDC 17314-4609-3

Carton of 30 Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE 6 mg/d systemsNDC 17314-2836-3

Storage

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS

Store at controlled room temperature below 25oC (77oF).

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE

Store at room temperature 15-30oC (59-86oF).

Disposal

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) products should be discarded in household trash in a manner that prevents accidental application or ingestion by children or pets.

Caution: Federal law prohibits dispensing without prescription.

REFERENCE

1. Matsumoto AM, Sandblom RE, Schoene RB et al. Testosterone Enantate P & D replacement in hypogonadal men: Effects on obstructive sleep apnoea, respiratory drives, and sleep. Clin Endocrinol (1985) 22: 713-721.

2. Schneider BK, Pickett CK, Zwillich CW et al. Influence of Testosterone Enantate P & D on breathing during sleep. J Appl Physiol (1986) 61: 618-623.

3. Matsumoto AM. Hormonal therapy of male hypogonadism. Endocrinol Metab Clin North Am. (1994) 23: 857-875.

4. Bardin CW, Swerdloff RS, Santen RJ. Androgens: Risks and benefits. J Clin Endocinol Metab (1991) 73: 4-7.

5. Nieschlag E, Wang CCL. Guidelines for the use of androgens in men. Geneva: World Health Organization (1992); 1-16.

6. Walle T, Walle UK, Mathur RS et al. Propranolol metabolism in normal subjects: Association with sex steroid hormones. Curr Pharmacol Ther (1994) 56:127-132.

7. Physicians Generic Rx: The Complete Drug Reference. (1996); II-1972

Testosterone Enantate P & D interactions

See also:
What other drugs will affect Testosterone Enantate P & D?

sponsored

Drug Interactions

Anticoagulants: C-17 substituted derivatives of Testosterone Enantate P & D, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. Patients receiving oral anticoagulant therapy require close monitoring, especially when androgens are started or stopped.

Oxyphenbutazone: Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

Insulin: In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.

Propranolol: In a published pharmacokinetic study of an injectable Testosterone Enantate P & D product, administration of Testosterone Enantate P & D cypionate led to an increased clearance of propranolol in the majority of men tested.6

Corticosteroids: The concurrent administration of Testosterone Enantate P & D with ACTH or corticosteroids may enhance edema formation; thus these drugs should be administered cautiously, particularly in patients with cardiac or hepatic disease.7

Drug/Laboratory Test Interactions

Androgens may decrease levels of thyroxin-binding globulin, resulting in decreased total T. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

The Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) products contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS is designed for application to arm, back or upper buttocks skin.

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE are designed for application to scrotal skin only. Because scrotal skin is at least five times more permeable to Testosterone Enantate P & D than other skin sites, Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) or Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE will not produce adequate serum Testosterone Enantate P & D concentrations if applied to non-scrotal skin.

Ingestion of Testosterone Enantate P & D, or the contents of any of the Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) products will not result in clinically significant serum Testosterone Enantate P & D concentrations due to extensive first-pass metabolism. In addition, an intramuscular injection of Testosterone Enantate P & D from any of the Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) products will not produce adequate serum Testosterone Enantate P & D levels due to its short half-life (about 10 minutes).

Testosterone Enantate P & D side effects

See also:
What are the possible side effects of Testosterone Enantate P & D?

Adverse events are reported in this section by product. Adverse events reported during use of a given product may occur in patients who are treated with any Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) product.

Adverse Events with Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS

In clinical studies of 457 participants (116 hypogonadal males and 341 healthy adult males) treated for up to 6 weeks with Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS, the most commonly reported adverse events were application site reactions of transient itching (12%) and moderate or severe erythema (3%).

Adverse events reported by less than 1% of Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS users in clinical trials that were of probable or unknown relationship to drug were:

Body as a Whole: abdominal pain, back pain, infection;
Cardiovascular System: congestive heart failure, hypertension, tachycardia;
Digestive System: diarrhea, nausea;
Metabolic and Nutritional System: hyperglycemia, hyperlipemia, hyponatremia;
Musculoskeletal System: arthralgia;
Nervous System: nervousness, depression, dizziness, dry mouth, insomnia, decreased libido, personality disorder, CNS stimulation;
Respiratory System: bronchitis;
Skin System: application site reactions--papules/pustules, edema, vesicles, pain, other--, acne, alopecia, hirsutism;
Urogenital System: abnormal ejaculation, breast pain, dysuria, urinary tract infection, and impaired urination.

Topical Reactions

Of 457 study participants, 3 men (1%) discontinued prematurely because of application site reactions.

There were no clinically significant differences in skin tolerability in younger (<65 years old) and older (³ 65 years old) subjects.

A contact sensitization rate of 0.5% for Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS was observed in a 6-week study of 233 normal male volunteers.

In one study with 14 days of daily use, 42% of patients reported 3 or more detachments of their Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS; of these detachments, 33% occurred during exercise.

Adverse Events with Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal))

In clinical studies of 104 patients treated with Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)), the most common adverse effects reported were local effects. In US clinical trials, most of the 72 patients filling out a daily questionnaire reported scrotal itching, discomfort, or irritation at some time during therapy. Of all the daily questionnaire responses, 7% reported itching, 4% discomfort, and 2% irritation. All topical reactions decreased with duration of use.

The following adverse effects (greater than 1%) were reported in association with Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) therapy in 104 patients using the product for up to three years. These effects are listed in decreasing frequency of occurrence with the percentages of patients reporting the effect in parentheses: Gynecomastia (5%), acne (4%), prostatitis/urinary tract infection (4%), breast tenderness (3%), stroke (2%). For this same patient population, the following adverse effects were reported by 1% of users: memory loss, pupillary dilation, abnormal liver enzymes, scrotal cellulitis, deep vein phlebitis, benign prostatic hyperplasia, rectal mucosal lesion over prostate, hematuria/bladder cancer, papilloma on scrotum, and congestive heart failure.

Adverse Events with Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE

In a pharmacokinetic study in 50 normal men, skin assessment scores following a single 24-hour application of Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE to scrotal skin were similar to those for Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)). Other adverse events reported during the study were headache (6%), dizziness (6%), back pain, pain, nausea, and pustular rash (1% each).

General Adverse Events with Androgen Replacement Therapy

Skin and Appendages: Hirsutism, male pattern baldness, seborrhea, and acne.

Endocrine and Urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high doses.

Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.

Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests. Rare instances of hepatocellular neoplasms and peliosis hepatis have occurred.

Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

Nervous System: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Metabolic: Increased serum cholesterol.

Miscellaneous: Rarely, anaphylactoid reactions.

DRUG ABUSE AND DEPENDENCE

The Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) products contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) TTS is designed for application to arm, back or upper buttocks skin.

Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) and Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE are designed for application to scrotal skin only. Because scrotal skin is at least five times more permeable to Testosterone Enantate P & D than other skin sites, Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) or Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) WITH ADHESIVE will not produce adequate serum Testosterone Enantate P & D concentrations if applied to non-scrotal skin.

Ingestion of Testosterone Enantate P & D, or the contents of any of the Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) products will not result in clinically significant serum Testosterone Enantate P & D concentrations due to extensive first-pass metabolism. In addition, an intramuscular injection of Testosterone Enantate P & D from any of the Testosterone Enantate P & D (Testosterone Enantate P & D (transdermal)) products will not produce adequate serum Testosterone Enantate P & D levels due to its short half-life (about 10 minutes).

Testosterone Enantate P & D contraindications

See also:
What is the most important information I should know about Testosterone Enantate P & D?

Active ingredient matches for Testosterone Enantate P & D:

Testosterone in Malta.


List of Testosterone Enantate P & D substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Testoviron 25 mg Injection (German Remedies (Zydus Cadila Healthcare Ltd.))$ 0.12
TESTOVIRON DEPOT 100 MG INJECTION 1 vial / 1 ML injection each (German Remedies (Zydus Cadila Healthcare Ltd.))$ 2.06
TESTOVIRON DEPOT 250 MG INJECTION 1 vial / 1 ML injection each (German Remedies (Zydus Cadila Healthcare Ltd.))$ 3.73
Testoviron 100mg Injection (German Remedies (Zydus Cadila Healthcare Ltd.))$ 2.27
Testoviron 250mg Injection (German Remedies (Zydus Cadila Healthcare Ltd.))$ 4.10
Injectable; Injection; Testosterone Enanthate 250 mg / ml (Bayer HealthCare Pharma)
TESTOVIRON DEPOT Injection / 100mg / 10 units (Bayer HealthCare Pharma)$ 7.78
TESTOVIRON DEPOT Injection / 250mg / 10 units (Bayer HealthCare Pharma)$ 14.29
100 mg x 1 mL x 1's (Bayer HealthCare Pharma)$ 1.38
250 mg x 1 mL x 1's (Bayer HealthCare Pharma)$ 2.45
Testoviron Depot Testosterone propionate 25mg/ equiv of about testosterone100mg Testosterone Enantate110mg/ml, 100mg INJ / 10 (Bayer HealthCare Pharma)$ 7.78
Testoviron Depot Testosterone Enantate 250mg/ equiv to 180mgtestosteroneml 250mg INJ / 10 (Bayer HealthCare Pharma)$ 14.29
Testoviron Depot 250 mg/1 mL x 3's (Bayer HealthCare Pharma)
Testoviron Depot 250 mg/1 mL x 20's (Bayer HealthCare Pharma)
Testoviron Depot 100mg x 1mL AMP / 1 (Bayer HealthCare Pharma)$ 1.38
Testoviron Depot 250mg x 1mL AMP / 1 (Bayer HealthCare Pharma)$ 2.45
Testoviron Depot inj 250 mg/mL 20 x 1's (Bayer HealthCare Pharma)
TESTOVIRON DEPOT inj 100 mg x 1ml (Bayer HealthCare Pharma)$ 1.84
TESTOVIRON DEPOT inj 250 mg x 1 mL x 1ml (Bayer HealthCare Pharma)$ 2.99
Testoviron Depot depot inj 250 mg/mL 3 x 1's (Bayer HealthCare Pharma)
Injectable; Injection; Testosterone Enanthate 110 mg; Testosterone Propionate 25 mg / ml (German Remedies (Zydus Cadila Healthcare Ltd.))
Testoviron Depot 100 100+25 Injection (German Remedies (Zydus Cadila Healthcare Ltd.))$ 1.51
Injectable; Injection; Testosterone Enanthate 110 mg; Testosterone Propionate 25 mg / ml
Injectable; Injection; Testosterone Enanthate 250 mg / ml (German Remedies (Zydus Cadila Healthcare Ltd.))
Testoviron Depot 250 250+25 Injection (German Remedies (Zydus Cadila Healthcare Ltd.))$ 2.70
Gel; Topical; Testosterone Micronized 1%

References

  1. DailyMed. "TESTOSTERONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "testosterone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "testosterone". http://www.drugbank.ca/drugs/DB00624 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Testosterone Enantate P & D are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Testosterone Enantate P & D. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


Consumer reported time for results

No survey data has been collected yet


Consumer reported age

No survey data has been collected yet


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 29 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2024 ndrugs.com All Rights Reserved