Testoviron Depot 100 Dosage

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Dosage of Testoviron Depot 100 in details

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Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS

One system is applied at about the same time each day. The adhesive side of the Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS system should be placed on a clean, dry area of skin on the arm, back or upper buttocks immediately upon removal from the protective pouch. DO NOT APPLY TO THE SCROTUM. The area selected should not be oily, damaged, or irritated. The system should be pressed firmly in place with the palm of the hand for about 10 seconds, making sure there is good contact, especially around the edges. In the event that a system should fall off, the same system may be reapplied. If the system comes off after it has been worn for more than 12 hours and it cannot be reapplied, a new system may be applied at the next routine application time. In either case, the daily treatment schedule should be continued. The Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS system should be worn approximately 24 hours and then replaced. To ensure proper dosing, serum Testoviron Depot 100 concentration may be measured 2-4 hours after an application of Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS. If the serum Testoviron Depot 100 concentrations are low, the dosing regimen may be increased to 2 systems. Because of variability in analytical values among diagnostic laboratories, all Testoviron Depot 100 measurements should be performed at the same laboratory.

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) and Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE

Patients should start therapy with a 6 mg/d system of either Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) or Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE applied daily; if the scrotal area cannot accommodate a 6 mg/d system, a 4 mg/d Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) system should be used. One Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) or Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE system should be placed on clean, dry, scrotal skin. Scrotal hair should be dry-shaved for optimal skin contact. Chemical depilatories should not be used. Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) or Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE should be worn 22-24 hours.

After 3-4 weeks of daily system use, blood should be drawn 2-4 hours after system application for determination of serum total Testoviron Depot 100. Because of variability in analytical values among diagnostic laboratories, this laboratory work and later analyses for assessing the effect of the Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) and Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE therapy should be performed at the same laboratory.

If patients have not achieved desired results by the end of 6-8 weeks of treatment with any of the Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) products, another form of Testoviron Depot 100 replacement therapy should be considered.

How supplied

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS, Testoviron Depot 100 (Testoviron Depot 100 (transdermal)), and Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE Testoviron Depot 100 transdermal systems contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS systems are supplied as individually pouched systems, 30 per carton. Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS 5 mg/d (Testoviron Depot 100 Transdermal System) -- each 60 cm2 system contains 328 mg Testoviron Depot 100 USP for nominal dose of 5 mg/day

Carton of 30 Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS 5 mg/d systemsNDC 17314-4717-3

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) and Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) and Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE systems are supplied as individually pouched systems, 30 per carton.

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) 4 mg/d (Testoviron Depot 100 Transdermal System) -- each 40 cm2 system contains 10 mg Testoviron Depot 100 USP for nominal delivery of 4 mg for one day.

Carton of 30 Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) 4 mg/d systems. NDC 17314-4608-3

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) and Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE

6 mg/d (Testoviron Depot 100 Transdermal System) -- each 60 cm2 system contains 15 mg Testoviron Depot 100 USP for nominal delivery of 6 mg for one day.

Carton of 30 Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) 6 mg/d systems. NDC 17314-4609-3

Carton of 30 Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE 6 mg/d systemsNDC 17314-2836-3

Storage

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS

Store at controlled room temperature below 25oC (77oF).

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) and Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE

Store at room temperature 15-30oC (59-86oF).

Disposal

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) products should be discarded in household trash in a manner that prevents accidental application or ingestion by children or pets.

Caution: Federal law prohibits dispensing without prescription.

REFERENCE

1. Matsumoto AM, Sandblom RE, Schoene RB et al. Testoviron Depot 100 replacement in hypogonadal men: Effects on obstructive sleep apnoea, respiratory drives, and sleep. Clin Endocrinol (1985) 22: 713-721.

2. Schneider BK, Pickett CK, Zwillich CW et al. Influence of Testoviron Depot 100 on breathing during sleep. J Appl Physiol (1986) 61: 618-623.

3. Matsumoto AM. Hormonal therapy of male hypogonadism. Endocrinol Metab Clin North Am. (1994) 23: 857-875.

4. Bardin CW, Swerdloff RS, Santen RJ. Androgens: Risks and benefits. J Clin Endocinol Metab (1991) 73: 4-7.

5. Nieschlag E, Wang CCL. Guidelines for the use of androgens in men. Geneva: World Health Organization (1992); 1-16.

6. Walle T, Walle UK, Mathur RS et al. Propranolol metabolism in normal subjects: Association with sex steroid hormones. Curr Pharmacol Ther (1994) 56:127-132.

7. Physicians Generic Rx: The Complete Drug Reference. (1996); II-1972

What other drugs will affect Testoviron Depot 100?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Testoviron Depot 100, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Testoviron Depot 100 drug interactions (in more detail)

Testoviron Depot 100 interactions

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Drug Interactions

Anticoagulants: C-17 substituted derivatives of Testoviron Depot 100, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. Patients receiving oral anticoagulant therapy require close monitoring, especially when androgens are started or stopped.

Oxyphenbutazone: Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

Insulin: In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.

Propranolol: In a published pharmacokinetic study of an injectable Testoviron Depot 100 product, administration of Testoviron Depot 100 cypionate led to an increased clearance of propranolol in the majority of men tested.6

Corticosteroids: The concurrent administration of Testoviron Depot 100 with ACTH or corticosteroids may enhance edema formation; thus these drugs should be administered cautiously, particularly in patients with cardiac or hepatic disease.7

Drug/Laboratory Test Interactions

Androgens may decrease levels of thyroxin-binding globulin, resulting in decreased total T. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

The Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) products contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) TTS is designed for application to arm, back or upper buttocks skin.

Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) and Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE are designed for application to scrotal skin only. Because scrotal skin is at least five times more permeable to Testoviron Depot 100 than other skin sites, Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) or Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) WITH ADHESIVE will not produce adequate serum Testoviron Depot 100 concentrations if applied to non-scrotal skin.

Ingestion of Testoviron Depot 100, or the contents of any of the Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) products will not result in clinically significant serum Testoviron Depot 100 concentrations due to extensive first-pass metabolism. In addition, an intramuscular injection of Testoviron Depot 100 from any of the Testoviron Depot 100 (Testoviron Depot 100 (transdermal)) products will not produce adequate serum Testoviron Depot 100 levels due to its short half-life (about 10 minutes).


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References

  1. DailyMed. "TESTOSTERONE PROPIONATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "TESTOSTERONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. FDA/SPL Indexing Data. "WI93Z9138A: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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