The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Thromboreductin Dosage
Generic name: Thromboreductin 0.5mg
Dosage form: capsule
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Starting Dose
Adults: The recommended starting dosage of Thromboreductin is 0.5 mg four times daily or 1 mg twice daily.
Pediatric Patients: The recommended starting dosage of Thromboreductin is 0.5 mg daily.
Titration
Continue the starting dose for at least one week and then titrate to reduce and maintain the platelet count below 600,000/µL, and ideally between 150,000/µL and 400,000/µL. The dose increment should not exceed 0.5 mg/day in any one week. Dosage should not exceed 10 mg/day or 2.5 mg in a single dose. Most patients will experience an adequate response at a dose of 1.5 to 3.0 mg/day. Monitor platelet counts weekly during titration then monthly or as necessary.
Dose Modifications for Hepatic Impairment
In patients with moderate hepatic impairment (Child Pugh score 7-9) start Thromboreductin therapy at a dose of 0.5 mg/day and monitor frequently for cardiovascular events. Patients with moderate hepatic impairment who have tolerated Thromboreductin therapy for one week may have their dose increased. The dose increase increment should not exceed 0.5 mg/day in any one week. Avoid use of Thromboreductin in patients with severe hepatic impairment.
Clinical Monitoring
Thromboreductin therapy requires clinical monitoring, including complete blood counts, assessment of hepatic and renal function, and electrolytes.
To prevent the occurrence of thrombocytopenia, monitor platelet counts every two days during the first week of treatment and at least weekly thereafter until the maintenance dosage is reached. Typically, platelet counts begin to respond within 7 to 14 days at the proper dosage. In the clinical trials, the time to complete response, defined as platelet count ≤ 600,000/µL, ranged from 4 to 12 weeks. In the event of dosage interruption or treatment withdrawal, the rebound in platelet count is variable, but platelet counts typically will start to rise within 4 days and return to baseline levels in one to two weeks, possibly rebounding above baseline values. Monitor platelet counts frequently.
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Related treatment guides
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What other drugs will affect Thromboreductin?
Tell your doctor about all other medicines you use, especially:
dasatinib (Sprycel);
deferasirox (Exjade);
fluvoxamine (Luvox);
theophylline (Elixophyllin, Theo-24, Uniphyl);
tipranavir (Aptivus);
tizanidine (Zanaflex);
drugs to treat non-Hodgkin's lymphoma, such as ibritumomab (Zevalin), or iodine I-131 tositumomab (Bexxar);
medication to treat congestive heart failure, such as amrinone (inamrinone, Inocor), enoximone (Perfan), or milrinone (Primacor);
medicines to treat or prevent blood clots, such as dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), or tinzaparin (Innohep); or
other anti-platelet drugs such as abciximab (ReoPro), cilostazol (Pletal), danaparoid (Orgaran), eptifibatide (Integrelin), prasugrel (Effient), rivaroxaban (Xarelto), or tirofiban (Aggrastat).
This list is not complete and other drugs may interact with Thromboreductin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Thromboreductin interactions
Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Thromboreductin, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Limited PK and/or PD studies investigating possible interactions between Thromboreductin and other medicinal products have been conducted. In vivo interaction studies in humans have demonstrated that digoxin and warfarin do not affect the PK properties of Thromboreductin, nor does Thromboreductin affect the PK properties of digoxin or warfarin.
Although additional drug interaction studies have not been conducted, the most common medications used concomitantly with Thromboreductin in clinical trials were aspirin, acetaminophen, furosemide, iron, ranitidine, hydroxyurea, and allopurinol. There is no clinical evidence to suggest that Thromboreductin interacts with any of these compounds.
An in vivo interaction study in humans demonstrated that a single 1mg dose of Thromboreductin administered concomitantly with a single 900 mg dose of aspirin was generally well tolerated. There was no effect on bleeding time, PT or aPTT. No clinically relevant pharmacokinetic interactions between Thromboreductin and acetylsalicylic acid were observed. In that same study, aspirin alone produced a marked inhibition in platelet aggregation ex vivo. Thromboreductin alone had no effect on platelet aggregation, but did slightly enhance the inhibition of platelet aggregation by aspirin.
Thromboreductin is metabolized at least in part by CYP1A2. It is known that CYP1A2 is inhibited by several medicinal products, including fluvoxamine, and such medicinal products could theoretically adversely influence the clearance of Thromboreductin. Thromboreductin demonstrates some limited inhibitory activity towards CYP1A2 which may present a theoretical potential for interaction with other coadministered medicinal products sharing that clearance mechanism e.g. theophylline.
Thromboreductin is an inhibitor of cyclic AMP PDE III. The effects of medicinal products with similar properties such as inotropes milrinone, enoximone, amrinone, olprinone and cilostazol may be exacerbated by Thromboreductin.
There is a single case report, which suggests that sucralfate may interfere with Thromboreductin absorption.
Food has no clinically significant effect on the bioavailability of Thromboreductin.
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References
FDA/SPL Indexing Data. "K9X45X0051: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
PubMed Health. "Anagrelide (By mouth) (Agrylin): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Thromboreductin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Thromboreductin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
8 consumers reported frequency of use
How frequently do I need to take Thromboreductin? It was reported by ndrugs.com website users that Thromboreductin should ideally be taken 3 times in a day as the most common frequency of the Thromboreductin. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Thromboreductin should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Users
%
3 times in a day
4
50.0%
Twice in a day
3
37.5%
Once in a day
1
12.5%
11 consumers reported doses
What doses of Thromboreductin drug you have used? The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Thromboreductin drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users
%
1-5mg
8
72.7%
201-500mg
1
9.1%
11-50mg
1
9.1%
6-10mg
1
9.1%
Consumer reviews
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