Tinidazole Uses

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What is Tinidazole?

Tinidazole (Tinidazole) is an antibiotic that fights bacteria in the body.

Tinidazole is used to treat certain infections caused by bacteria, such as infection of the intestines or vagina. It is also used to treat certain sexually transmitted infections.

Tinidazole may also be used for purposes other than those listed in this medication guide.

Tinidazole indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Trichomoniasis

Tinidazole is indicated for the treatment of trichomoniasis caused by Trichomonas vaginalis. The organism should be identified by appropriate diagnostic procedures. Because trichomoniasis is a sexually transmitted disease with potentially serious sequelae, partners of infected patients should be treated simultaneously in order to prevent re-infection.

Giardiasis

Tinidazole is indicated for the treatment of giardiasis caused by Giardia duodenalis (also termed G. lamblia) in both adults and pediatric patients older than three years of age.

Amebiasis

Tinidazole is indicated for the treatment of intestinal amebiasis and amebic liver abscess caused by Entamoeba histolytica in both adults and pediatric patients older than three years of age. It is not indicated in the treatment of asymptomatic cyst passage.

Bacterial Vaginosis

Tinidazole is indicated for the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, or anaerobic vaginosis) in non-pregnant women.

Other pathogens commonly associated with vulvovaginitis such as Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans and Herpes simplex virus should be ruled out.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Tinidazole Tablets and other antibacterial drugs, Tinidazole Tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Tinidazole?

Use Tinidazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Tinidazole.

Uses of Tinidazole in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Amebiasis: Treatment of intestinal amebiasis and amebic liver abscess caused by Entamoeba histolytica in adults and pediatric patients older than 3 years.

Limitations of use: Not indicated for the treatment of asymptomatic cyst passage.

Bacterial vaginosis: Treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, or anaerobic vaginosis) in adult women.

Giardiasis: Treatment of giardiasis caused by Giardia duodenalis (also termed Giardia lamblia) in adults and pediatric patients older than 3 years.

Trichomoniasis: Treatment of trichomoniasis caused by Trichomonas vaginalis; treat partners of infected patients simultaneously to prevent reinfection.

Off Label Uses

Helicobacter pylori eradication

Based on the American College of Gastroenterology Clinical Guideline for the Treatment of Helicobacter pylori Infection, Tinidazole is an effective and recommended component of a multiple-drug regimen for the treatment of this condition.

Prophylaxis against sexually transmitted diseases following sexual assault

Based on the Centers for Disease Control and Prevention (CDC) sexually transmitted diseases treatment guidelines, Tinidazole, in combination with ceftriaxone and azithromycin, is a recommended regimen for prophylaxis against sexually transmitted diseases following sexual assault in adolescents and adults.

Urethritis, nongonococcal (persistent and recurrent)

Based on the CDC sexually transmitted diseases treatment guidelines, Tinidazole is effective and recommended as treatment for recurrent and persistent urethritis for men who have sex with women and who live in areas where T. vaginalis is prevalent. Compliance with initial regimen and lack of reexposure to an untreated sex partner should be excluded prior to use. Sex partners should be referred for evaluation and appropriate treatment.

Tinidazole description

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Each vaginal suppository contains tioconazole 100 mg and Tinidazole 150 mg. It also contains witepsol as excipient.

Tinidazole dosage

Tinidazole Dosage

Generic name: Tinidazole 250mg

Dosage form: tablet, film coated

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Dosing Instructions

It is advisable to take Tinidazole with food to minimize the incidence of epigastric discomfort and other gastrointestinal side-effects. Food does not affect the oral bioavailability of Tinidazole.

Alcoholic beverages should be avoided when taking Tinidazole and for 3 days afterwards.

Compounding of the

Oral Suspension

For those unable to swallow tablets, Tinidazole tablets may be crushed in artificial cherry syrup to be taken with food.

Procedure for Extemporaneous Pharmacy Compounding of the

Oral Suspension: Pulverize four 500 mg oral tablets with a mortar and pestle. Add approximately 10 mL of cherry syrup to the powder and mix until smooth. Transfer the suspension to a graduated amber container. Use several small rinses of cherry syrup to transfer any remaining drug in the mortar to the final suspension for a final volume of 30 mL. The suspension of crushed tablets in artificial cherry syrup is stable for 7 days at room temperature. When this suspension is used, it should be shaken well before each administration.

Trichomoniasis

The recommended dose in both females and males is a single 2 g oral dose taken with food. Since trichomoniasis is a sexually transmitted disease, sexual partners should be treated with the same dose and at the same time.

Giardiasis

The recommended dose in adults is a single 2 g dose taken with food. In pediatric patients older than three years of age, the recommended dose is a single dose of 50 mg/kg (up to 2 g) with food.

Amebiasis

Intestinal: The recommended dose in adults is a 2 g dose per day for 3 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3 days with food.

Amebic Liver Abscess: The recommended dose in adults is a 2 g dose per day for 3-5 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3-5 days with food. There are limited pediatric data on durations of therapy exceeding 3 days, although a small number of children were treated for 5 days without additional reported adverse reactions. Children should be closely monitored when treatment durations exceed 3 days.

Bacterial Vaginosis

The recommended dose in non-pregnant females is a 2 g oral dose once daily for 2 days taken with food or a 1 g oral dose once daily for 5 days taken with food. The use of Tinidazole in pregnant patients has not been studied for bacterial vaginosis.

More about Tinidazole (Tinidazole)

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Tinidazole interactions

See also:
What other drugs will affect Tinidazole?

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Although not specifically identified in studies with Tinidazole, the following drug interactions were reported for metronidazole, a chemically-related nitroimidazole. Therefore, these drug interactions may occur with Tinidazole.

Potential Effects Of Tinidazole On Other Drugs

Warfarin And Other

Oral Coumarin Anticoagulants

As with metronidazole, Tinidazole may enhance the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time. The dosage of oral anticoagulants may need to be adjusted during Tinidazole co-administration and up to 8 days after discontinuation.

Alcohols, Disulfiram

Alcoholic beverages and preparations containing ethanol or propylene glycol should be avoided during Tinidazole therapy and for 3 days afterward because abdominal cramps, nausea, vomiting, headaches, and flushing may occur. Psychotic reactions have been reported in alcoholic patients using metronidazole and disulfiram concurrently. Though no similar reactions have been reported with Tinidazole, Tinidazole should not be given to patients who have taken disulfiram within the last two weeks.

Lithium

Metronidazole has been reported to elevate serum lithium levels. It is not known if Tinidazole shares this property with metronidazole, but consideration should be given to measuring serum lithium and creatinine levels after several days of simultaneous lithium and Tinidazole treatment to detect potential lithium intoxication.

Phenytoin, Fosphenytoin

Concomitant administration of oral metronidazole and intravenous phenytoin was reported to result in prolongation of the half-life and reduction in the clearance of phenytoin. Metronidazole did not significantly affect the pharmacokinetics of orally-administered phenytoin.

Cyclosporine, Tacrolimus

There are several case reports suggesting that metronidazole has the potential to increase the levels of cyclosporine and tacrolimus. During Tinidazole co-administration with either of these drugs, the patient should be monitored for signs of calcineurin-inhibitor associated toxicities.

Fluorouracil

Metronidazole was shown to decrease the clearance of fluorouracil, resulting in an increase in side-effects without an increase in therapeutic benefits. If the concomitant use of Tinidazole and fluorouracil cannot be avoided, the patient should be monitored for fluorouracil-associated toxicities.

Potential Effects Of Other Drugs On Tinidazole

CYP3A4 Inducers And Inhibitors

Simultaneous administration of Tinidazole with drugs that induce liver microsomal enzymes, i.e., CYP3A4 inducers such as phenobarbital, rifampin, phenytoin, and fosphenytoin (a pro-drug of phenytoin), may accelerate the elimination of Tinidazole, decreasing the plasma level of Tinidazole. Simultaneous administration of drugs that inhibit the activity of liver microsomal enzymes, i.e., CYP3A4 inhibitors such as cimetidine and ketoconazole, may prolong the half-life and decrease the plasma clearance of Tinidazole, increasing the plasma concentrations of Tinidazole.

Cholestyramine

Cholestyramine was shown to decrease the oral bioavailability of metronidazole by 21%. Thus, it is advisable to separate dosing of cholestyramine and Tinidazole to minimize any potential effect on the oral bioavailability of Tinidazole.

Oxytetracycline

Oxytetracycline was reported to antagonize the therapeutic effect of metronidazole.

Laboratory Test Interactions

Tinidazole, like metronidazole, may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and hexokinase glucose. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide (NAD+↔ NADH). Potential interference is due to the similarity of absorbance peaks of NADH and Tinidazole.

Tinidazole, like metronidazole, may produce transient leukopenia and neutropenia; however, no persistent hematological abnormalities attributable to Tinidazole have been observed in clinical studies. Total and differential leukocyte counts are recommended if re-treatment is necessary.

Tinidazole side effects

See also:
What are the possible side effects of Tinidazole?

Applies to Tinidazole: oral tablet

As well as its needed effects, Tinidazole (the active ingredient contained in Tinidazole) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Tinidazole, check with your doctor immediately:

Rare

Incidence unknown

Minor Side Effects

Some Tinidazole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

Less common: Rare Incidence unknown

Tinidazole contraindications

See also:
What is the most important information I should know about Tinidazole?

Hypersensitivity to Tinidazole, other 5-nitroimidazole derivatives or to any of the excipients of Tinidazole.

As with other drugs of similar structure, Tinidazole is also contraindicated in patients having or with a history of blood dyscrasias, although no persistent hematologic abnormalities have been noted in clinical or animal studies.

Use in pregnancy: Tinidazole crosses the placental barrier. Since the effects of compounds of this class on fetal development are unknown, the use of Tinidazole during the 1st trimester is contraindicated. There is no evidence that Tinidazole is harmful during the latter stages of pregnancy, but its use during the 2nd and 3rd trimesters requires that the potential benefits be weighed against possible hazards to the mother or fetus.

Use in lactation: Tinidazole is distributed in breast milk. Tinidazole may be present in breast milk for >72 hrs after administration. Women should not nurse during and for at least 3 days after having discontinued taking Tinidazole.



Active ingredient matches for Tinidazole:

Tinidazole


Unit description / dosage (Manufacturer)Price, USD
Tablet, Film-Coated; Oral; Tinidazole 500 mg
Tindamax 500 mg tablet$ 9.02
Tinidazole 500 mg tablet$ 4.73
Tindamax 250 mg tablet$ 3.25
Tinidazole / Honten 500 mg
Tinidazole / Yung Shin 500 mg x 1000's
Tinidazole / P.J. 150 mg
Tinidazole / P.J. 500 mg
Tinidazole 300 mg Cyper Tablet$ 0.03
Tinidazole 300 mg Acichem Tablet$ 0.01
Tinidazole 300 mg Tablet$ 0.02
Tinidazole tablet 250 mg/1 (Biocomp Pharma, Inc. (US))
Tinidazole tablet 500 mg/1 (Biocomp Pharma, Inc. (US))
Tinidazole tablet, film coated 250 mg/1 (West Ward Pharmaceuticals Corp. (US))
Tinidazole tablet, film coated 500 mg/1 (West Ward Pharmaceuticals Corp. (US))

List of Tinidazole substitutes (brand and generic names):

TINIDAZOLE 300MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.20
Tinidazole 300mg Tablet (Cadila Pharmaceuticals Ltd)$ 0.01
TINIDAZOLE 500MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.30
Tinidazole Flamingo 500 mg x 1 Box
Tinidazole Polpharma 500 mg x 1 Blister 4 Tablet
Tinidazole Windlas 500 mg x 10 Blister x 10 Tablet
Tinidazole XL 500 mg x 10 Blister x 10 Tablet
200 mg x 100 mL x 400ml (Denis)$ 1.03
Tiniden 200mg x 100mL INF / 400ml (Denis)$ 1.03
TINIDEN infusion 200 mg x 100 mL x 400ml (Denis)$ 1.13
Tiniden 200mg x 100mL INF / 400ml (Denis)$ 1.03
TINIDIN INFUSION 1 bottle / 500 ML infusion each (Denis Chem Lab Ltd)$ 0.53
Tinifas 500mg FC-TAB / 10 (Cipla)$ 0.48
500 mg x 10's (Cipla)$ 0.48
TINIFAS 500MG TABLET 1 strip / 10 tablets each (Cipla)$ 0.50
TINIFAS film-coated tab 500 mg x 10's (Cipla)$ 0.48
Tinifas 500mg Tablet (Cipla)$ 0.05
Tinifas FC 500 mg Tablet (Cipla Limited)$ 0.05
Tinifil 500 mg x 1 Tablet
Tinifur 250+300 Tablet (Vostok & Wilcure Remedies)$ 0.02
Tinigram 300+250 Tablet (Apco Pharma Ltd.)$ 0.05
Tinijing 500 mg
Tinil 300+250 Tablet (Sayona (Zota Healthcare Pvt Ltd))$ 0.04
TINIMA 500MG TABLET 1 strip / 10 tablets each (Morepen Laboratories Ltd)$ 0.89
Tinin 500 mg
Tininor SF 400+600 Tablet (Reliance Formulation Pvt Ltd)$ 0.07
TININOR SF 400MG/600MG TABLET 1 strip / 10 tablets each (Reliance Formulation Pvt Ltd)$ 0.57

References

  1. DailyMed. "TINIDAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "tinidazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "tinidazole". http://www.drugbank.ca/drugs/DB00911 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Tinidazole are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tinidazole. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


3 consumers reported time for results

To what extent do I have to use Tinidazole before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 3 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Tinidazole. To get the time effectiveness of using Tinidazole drug by other patients, please click here.
Users%
3 days1
33.3%
1 day1
33.3%
> 3 month1
33.3%


3 consumers reported age

Users%
16-292
66.7%
6-151
33.3%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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