Tinidazole Yung Shin (Tinidazole Yung Shin) is an antibiotic that fights bacteria in the body.
Tinidazole Yung Shin is used to treat certain infections caused by bacteria, such as infection of the intestines or vagina. It is also used to treat certain sexually transmitted infections.
Tinidazole Yung Shin may also be used for purposes other than those listed in this medication guide.
Tinidazole Yung Shin indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Trichomoniasis
Tinidazole Yung Shin is indicated for the treatment of trichomoniasis caused by Trichomonas vaginalis. The organism should be identified by appropriate diagnostic procedures. Because trichomoniasis is a sexually transmitted disease with potentially serious sequelae, partners of infected patients should be treated simultaneously in order to prevent re-infection.
Giardiasis
Tinidazole Yung Shin is indicated for the treatment of giardiasis caused by Giardia duodenalis (also termed G. lamblia) in both adults and pediatric patients older than three years of age.
Amebiasis
Tinidazole Yung Shin is indicated for the treatment of intestinal amebiasis and amebic liver abscess caused by Entamoeba histolytica in both adults and pediatric patients older than three years of age. It is not indicated in the treatment of asymptomatic cyst passage.
Bacterial Vaginosis
Tinidazole Yung Shin is indicated for the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, or anaerobic vaginosis) in non-pregnant women.
Other pathogens commonly associated with vulvovaginitis such as Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans and Herpes simplex virus should be ruled out.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Tinidazole Yung Shin Tablets and other antibacterial drugs, Tinidazole Yung Shin Tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Tinidazole Yung Shin?
Use Tinidazole Yung Shin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Tinidazole Yung Shin by mouth with food.
If you have trouble swallowing the tablets, check with your doctor or pharmacist.
If you take cholestyramine, do not take it at the same time you take Tinidazole Yung Shin. Talk with your doctor about how you should take cholestyramine with Tinidazole Yung Shin.
If more than one dose of Tinidazole Yung Shin is required, continue using Tinidazole Yung Shin for the full course of treatment in order to clear up your infection completely, even if you feel better in a few days. Do not miss any doses.
If you miss a dose of Tinidazole Yung Shin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Tinidazole Yung Shin.
Uses of Tinidazole Yung Shin in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications
Amebiasis: Treatment of intestinal amebiasis and amebic liver abscess caused by Entamoeba histolytica in adults and pediatric patients older than 3 years.
Limitations of use: Not indicated for the treatment of asymptomatic cyst passage.
Bacterial vaginosis: Treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, or anaerobic vaginosis) in adult women.
Giardiasis: Treatment of giardiasis caused by Giardia duodenalis (also termed Giardia lamblia) in adults and pediatric patients older than 3 years.
Trichomoniasis: Treatment of trichomoniasis caused by Trichomonas vaginalis; treat partners of infected patients simultaneously to prevent reinfection.
Off Label Uses
Helicobacter pylori eradication
Based on the American College of Gastroenterology Clinical Guideline for the Treatment of Helicobacter pylori Infection, Tinidazole Yung Shin is an effective and recommended component of a multiple-drug regimen for the treatment of this condition.
Prophylaxis against sexually transmitted diseases following sexual assault
Based on the Centers for Disease Control and Prevention (CDC) sexually transmitted diseases treatment guidelines, Tinidazole Yung Shin, in combination with ceftriaxone and azithromycin, is a recommended regimen for prophylaxis against sexually transmitted diseases following sexual assault in adolescents and adults.
Urethritis, nongonococcal (persistent and recurrent)
Based on the CDC sexually transmitted diseases treatment guidelines, Tinidazole Yung Shin is effective and recommended as treatment for recurrent and persistent urethritis for men who have sex with women and who live in areas where T. vaginalis is prevalent. Compliance with initial regimen and lack of reexposure to an untreated sex partner should be excluded prior to use. Sex partners should be referred for evaluation and appropriate treatment.
Tinidazole Yung Shin description
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Each vaginal suppository contains tioconazole 100 mg and Tinidazole Yung Shin 150 mg. It also contains witepsol as excipient.
Tinidazole Yung Shin dosage
Tinidazole Yung Shin Dosage
Generic name: Tinidazole Yung Shin 250mg
Dosage form: tablet, film coated
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Dosing Instructions
It is advisable to take Tinidazole Yung Shin with food to minimize the incidence of epigastric discomfort and other gastrointestinal side-effects. Food does not affect the oral bioavailability of Tinidazole Yung Shin.
Alcoholic beverages should be avoided when taking Tinidazole Yung Shin and for 3 days afterwards.
Compounding of the
Oral Suspension
For those unable to swallow tablets, Tinidazole Yung Shin tablets may be crushed in artificial cherry syrup to be taken with food.
Procedure for Extemporaneous Pharmacy Compounding of the
Oral Suspension: Pulverize four 500 mg oral tablets with a mortar and pestle. Add approximately 10 mL of cherry syrup to the powder and mix until smooth. Transfer the suspension to a graduated amber container. Use several small rinses of cherry syrup to transfer any remaining drug in the mortar to the final suspension for a final volume of 30 mL. The suspension of crushed tablets in artificial cherry syrup is stable for 7 days at room temperature. When this suspension is used, it should be shaken well before each administration.
Trichomoniasis
The recommended dose in both females and males is a single 2 g oral dose taken with food. Since trichomoniasis is a sexually transmitted disease, sexual partners should be treated with the same dose and at the same time.
Giardiasis
The recommended dose in adults is a single 2 g dose taken with food. In pediatric patients older than three years of age, the recommended dose is a single dose of 50 mg/kg (up to 2 g) with food.
Amebiasis
Intestinal: The recommended dose in adults is a 2 g dose per day for 3 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3 days with food.
Amebic Liver Abscess: The recommended dose in adults is a 2 g dose per day for 3-5 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3-5 days with food. There are limited pediatric data on durations of therapy exceeding 3 days, although a small number of children were treated for 5 days without additional reported adverse reactions. Children should be closely monitored when treatment durations exceed 3 days.
Bacterial Vaginosis
The recommended dose in non-pregnant females is a 2 g oral dose once daily for 2 days taken with food or a 1 g oral dose once daily for 5 days taken with food. The use of Tinidazole Yung Shin in pregnant patients has not been studied for bacterial vaginosis.
More about Tinidazole Yung Shin (Tinidazole Yung Shin)
Although not specifically identified in studies with Tinidazole Yung Shin, the following drug interactions were reported for metronidazole, a chemically-related nitroimidazole. Therefore, these drug interactions may occur with Tinidazole Yung Shin.
Potential Effects Of Tinidazole Yung Shin On Other Drugs
Warfarin And Other
Oral Coumarin Anticoagulants
As with metronidazole, Tinidazole Yung Shin may enhance the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time. The dosage of oral anticoagulants may need to be adjusted during Tinidazole Yung Shin co-administration and up to 8 days after discontinuation.
Alcohols, Disulfiram
Alcoholic beverages and preparations containing ethanol or propylene glycol should be avoided during Tinidazole Yung Shin therapy and for 3 days afterward because abdominal cramps, nausea, vomiting, headaches, and flushing may occur. Psychotic reactions have been reported in alcoholic patients using metronidazole and disulfiram concurrently. Though no similar reactions have been reported with Tinidazole Yung Shin, Tinidazole Yung Shin should not be given to patients who have taken disulfiram within the last two weeks.
Lithium
Metronidazole has been reported to elevate serum lithium levels. It is not known if Tinidazole Yung Shin shares this property with metronidazole, but consideration should be given to measuring serum lithium and creatinine levels after several days of simultaneous lithium and Tinidazole Yung Shin treatment to detect potential lithium intoxication.
Phenytoin, Fosphenytoin
Concomitant administration of oral metronidazole and intravenous phenytoin was reported to result in prolongation of the half-life and reduction in the clearance of phenytoin. Metronidazole did not significantly affect the pharmacokinetics of orally-administered phenytoin.
Cyclosporine, Tacrolimus
There are several case reports suggesting that metronidazole has the potential to increase the levels of cyclosporine and tacrolimus. During Tinidazole Yung Shin co-administration with either of these drugs, the patient should be monitored for signs of calcineurin-inhibitor associated toxicities.
Fluorouracil
Metronidazole was shown to decrease the clearance of fluorouracil, resulting in an increase in side-effects without an increase in therapeutic benefits. If the concomitant use of Tinidazole Yung Shin and fluorouracil cannot be avoided, the patient should be monitored for fluorouracil-associated toxicities.
Potential Effects Of Other Drugs On Tinidazole Yung Shin
CYP3A4 Inducers And Inhibitors
Simultaneous administration of Tinidazole Yung Shin with drugs that induce liver microsomal enzymes, i.e., CYP3A4 inducers such as phenobarbital, rifampin, phenytoin, and fosphenytoin (a pro-drug of phenytoin), may accelerate the elimination of Tinidazole Yung Shin, decreasing the plasma level of Tinidazole Yung Shin. Simultaneous administration of drugs that inhibit the activity of liver microsomal enzymes, i.e., CYP3A4 inhibitors such as cimetidine and ketoconazole, may prolong the half-life and decrease the plasma clearance of Tinidazole Yung Shin, increasing the plasma concentrations of Tinidazole Yung Shin.
Cholestyramine
Cholestyramine was shown to decrease the oral bioavailability of metronidazole by 21%. Thus, it is advisable to separate dosing of cholestyramine and Tinidazole Yung Shin to minimize any potential effect on the oral bioavailability of Tinidazole Yung Shin.
Oxytetracycline
Oxytetracycline was reported to antagonize the therapeutic effect of metronidazole.
Laboratory Test Interactions
Tinidazole Yung Shin, like metronidazole, may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and hexokinase glucose. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide (NAD+↔ NADH). Potential interference is due to the similarity of absorbance peaks of NADH and Tinidazole Yung Shin.
Tinidazole Yung Shin, like metronidazole, may produce transient leukopenia and neutropenia; however, no persistent hematological abnormalities attributable to Tinidazole Yung Shin have been observed in clinical studies. Total and differential leukocyte counts are recommended if re-treatment is necessary.
As well as its needed effects, Tinidazole Yung Shin (the active ingredient contained in Tinidazole Yung Shin) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking Tinidazole Yung Shin, check with your doctor immediately:
Rare
Change in consciousness
cough
difficulty breathing
loss of consciousness
noisy breathing
shortness of breath
tightness in chest
wheezing
Incidence unknown
Black, tarry stools
bleeding gums
blood in urine or stools
burning, numbness, tingling, or painful sensations
chest pain
chills
difficulty swallowing
fast, irregular, pounding, or racing heartbeat or pulse
fever
hives
increased transaminase levels
large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
lower back or side pain
nausea
painful or difficult urination
pale skin
pinpoint red spots on skin
reddening of the skin, especially around ears
seizures
sore throat
sores, ulcers, or white spots on lips or in mouth
swelling of eyes, face, or inside of nose
swollen glands
ulcers
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
weakness in arms, hands, legs, or feet
Minor Side Effects
Some Tinidazole Yung Shin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
More common:
Bitter taste
metallic taste
Less common:
Acid or sour stomach
belching
cramps
difficulty having a bowel movement (stool)
dizziness
general feeling of discomfort or illness
headache
heartburn
indigestion
loss of appetite
pain or discomfort in chest, upper stomach, or throat
vomiting
weight loss
Rare
Body aches or pain
coating on tongue
congestion
depression
dryness or soreness of throat
hoarseness
mood or mental changes
runny nose
tender, swollen glands in neck
voice changes
Incidence unknown
Abnormal liver
darkened urine
diarrhea
difficulty in moving
feeling of constant movement of self or surroundings
giddiness
lightheadedness
muscle pain or stiffness
pain, swelling, or redness in joints
sensation of spinning
shakiness and unsteady walk
sleepiness
sleeplessness
swelling or inflammation of the mouth
tongue discoloration
trembling, or other problems with muscle control or coordination
trouble sleeping
unable to sleep
white or brownish vaginal discharge
white patches in the mouth or throat or on the tongue
Hypersensitivity to Tinidazole Yung Shin, other 5-nitroimidazole derivatives or to any of the excipients of Tinidazole Yung Shin.
As with other drugs of similar structure, Tinidazole Yung Shin is also contraindicated in patients having or with a history of blood dyscrasias, although no persistent hematologic abnormalities have been noted in clinical or animal studies.
Use in pregnancy: Tinidazole Yung Shin crosses the placental barrier. Since the effects of compounds of this class on fetal development are unknown, the use of Tinidazole Yung Shin during the 1st trimester is contraindicated. There is no evidence that Tinidazole Yung Shin is harmful during the latter stages of pregnancy, but its use during the 2nd and 3rd trimesters requires that the potential benefits be weighed against possible hazards to the mother or fetus.
Use in lactation: Tinidazole Yung Shin is distributed in breast milk. Tinidazole Yung Shin may be present in breast milk for >72 hrs after administration. Women should not nurse during and for at least 3 days after having discontinued taking Tinidazole Yung Shin.
Active ingredient matches for Tinidazole Yung Shin:
DailyMed. "TINIDAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
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