Tonalgen Uses

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What is Tonalgen?

Tonalgen (Tonalgen) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.

Tonalgen is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Tonalgen may also be used for other purposes not listed in this medication guide.

Tonalgen indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Tonalgen® (Tonalgen hydrochloride extended-release capsules) is indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, and limitation of motion.

Limitations of Use:

Tonalgen should be used only for short periods (up to two or three weeks) because adequate evidence of effectiveness for more prolonged use is not available and because muscle spasm associated with acute, painful musculoskeletal conditions is generally of short duration and specific therapy for longer periods is seldom warranted.
Tonalgen has not been found effective in the treatment of spasticity associated with cerebral or spinal cord disease or in children with cerebral palsy.

How should I use Tonalgen?

Use Tonalgen extended-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Tonalgen extended-release capsules.

Uses of Tonalgen in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Tonalgen is used along with physical therapy and rest to relieve pain, stiffness or discomfort caused by muscle injury.

Tonalgen description

Tonalgen is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Tonalgen acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing by only one double bond.

Tonalgen dosage

Tonalgen Dosage

Generic name: Tonalgen HYDROCHLORIDE 15mg

Dosage form: capsule, extended release

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

The recommended adult dose for most patients is one (1) Tonalgen 15 mg capsule taken once daily. Some patients may require up to 30 mg/day, given as one (1) Tonalgen 30 mg capsule taken once daily or as two (2) Tonalgen 15 mg capsules taken once daily.

It is recommended that doses be taken at approximately the same time each day.
Use of Tonalgen for periods longer than two or three weeks is not recommended.

​Instruct patients to swallow Tonalgen capsules intact. Alternatively, the contents of the Tonalgen capsule may be sprinkled over applesauce and then swallowed. This method is appropriate only for patients able to reliably swallow the applesauce without chewing. Other foods have not been tested and should not be substituted for applesauce. Instruct the patient to:

​Sprinkle the contents of the capsule onto a tablespoon of applesauce and consume immediately without chewing.
​Rinse the mouth to ensure all of the contents have been swallowed.
​Discard any unused portion of the Tonalgen capsules after the contents have been sprinkled on applesauce.

More about Tonalgen (Tonalgen)

Consumer resources

Professional resources

Related treatment guides

Tonalgen interactions

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What other drugs will affect Tonalgen?

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Based on its structural similarity to tricyclic antidepressants, Tonalgen may have life-threatening interactions with MAO inhibitors, may enhance the effects of alcohol, barbiturates, and other CNS depressants, may enhance the seizure risk in patients taking tramadol, or may block the antihypertensive action of guanethidine and similarly acting compounds.

Postmarketing cases of serotonin syndrome have been reported during combined use of Tonalgen and other drugs, such as SSRIs, SNRIs, TCAs, tramadol, bupropion, meperidine, verapamil, or MAO inhibitors.

Drug Abuse And Dependence

Dependence

Pharmacologic similarities among the tricyclic drugs require that certain withdrawal symptoms be considered when Tonalgen is administered, even though they have not been reported to occur with this drug. Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise. These are not indicative of addiction.

Tonalgen side effects

See also:
What are the possible side effects of Tonalgen?

Most Common Adverse Reactions in the Tonalgen Clinical Trials

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

The data described below reflect exposure to Tonalgen in 253 patients in 2 clinical trials. Tonalgen was studied in two double-blind, parallel-group, placebo-controlled, active-controlled trials of identical design. The study population was composed of patients with muscle spasms associated with acute painful musculoskeletal conditions. Patients received 15 mg or 30 mg of Tonalgen taken orally once daily, Tonalgen immediate-release (IR) 10 mg three times a day, or placebo for 14 days.

The most common adverse reactions (incidence ≥ 3% in any treatment group and greater than placebo) were dry mouth, dizziness, fatigue, constipation, nausea, dyspepsia, and somnolence.

Table 1: Incidence of the Most Common Adverse Reactions Occurring in ≥ 3% of Patients in any Treatment Group* and Greater Than Placebo in the Two Phase 3, Double-Blind Tonalgen Trials

Placebo

N=128

Tonalgen 15 mg

N=127

Tonalgen 30 mg

N=126

Dry mouth 2% 6% 14%
Dizziness 2% 3% 6%
Fatigue 2% 3% 3%
Constipation 0% 1% 3%
Somnolence 0% 1% 2%
Nausea 1% 3% 3%
Dyspepsia 1% 0% 4%
*Tonalgen 15 mg QD, Tonalgen 30 mg QD, or Tonalgen IR tablets TID

Additional Adverse Reactions from Clinical Studies and Postmarketing Experience

The following adverse reactions have been reported in clinical studies or postmarketing experience with Tonalgen, Tonalgen IR, or tricyclic drugs. Because some of these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

In a postmarketing surveillance program of Tonalgen IR, the adverse reactions reported most frequently were drowsiness, dry mouth, and dizziness and adverse reactions reported in 1% to 3% of the patients were: fatigue/tiredness, asthenia, nausea, constipation, dyspepsia, unpleasant taste, blurred vision, headache, nervousness, and confusion.

The following adverse reactions have been reported in postmarketing experience (Tonalgen or Tonalgen IR), in clinical studies of Tonalgen IR (incidence < 1%), or in postmarketing experience with other tricyclic drugs:

Body as a Whole: Syncope; malaise; chest pain; edema.

Cardiovascular: Tachycardia; arrhythmia; vasodilatation; palpitation; hypotension; hypertension; myocardial infarction; heart block; stroke.

Digestive: Vomiting; anorexia; diarrhea; gastrointestinal pain; gastritis; thirst; flatulence; edema of the tongue; abnormal liver function and rare reports of hepatitis, jaundice, and cholestasis; paralytic ileus, tongue discoloration; stomatitis; parotid swelling.

Endocrine: Inappropriate ADH syndrome.

Hematologic and Lymphatic: Purpura; bone marrow depression; leukopenia; eosinophilia; thrombocytopenia.

Hypersensitivity: Anaphylaxis; angioedema; pruritus; facial edema; urticaria; rash.

Metabolic, Nutritional and Immune: Elevation and lowering of blood sugar levels; weight gain or loss.

Musculoskeletal: Local weakness; myalgia.

Nervous System and Psychiatric: Seizures, ataxia; vertigo; dysarthria; tremors; hypertonia; convulsions; muscle twitching; disorientation; insomnia; depressed mood; abnormal sensations; anxiety; agitation; psychosis, abnormal thinking and dreaming; hallucinations; excitement; paresthesia; diplopia; serotonin syndrome; neuroleptic malignant syndrome; decreased or increased libido; abnormal gait; delusions; aggressive behavior; paranoia; peripheral neuropathy; Bell's palsy; alteration in EEG patterns; extrapyramidal symptoms.

Respiratory: Dyspnea.

Skin: Sweating; photosensitization; alopecia.

Special Senses: Ageusia; tinnitus.

Urogenital: Urinary frequency and/or retention; impaired urination; dilatation of urinary tract; impotence; testicular swelling; gynecomastia; breast enlargement; galactorrhea.

Tonalgen contraindications

See also:
What is the most important information I should know about Tonalgen?

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Do not take Tonalgen if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take Tonalgen before the MAO inhibitor has cleared from your body.

You should not take Tonalgen if you have recently had a heart attack, or if you have a heart rhythm disorder, congestive heart failure, heart block, or an overactive thyroid.

Tonalgen can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol, which can increase some of the side effects of Tonalgen.

Active ingredient matches for Tonalgen:

Cyclobenzaprine in Chile, Peru.

Cyclobenzaprine Hcl


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg

List of Tonalgen substitutes (brand and generic names):

MOBRINE 10 MG TABLET IR 1 strip / 10 tablet irs each (Ranbaxy Laboratories Ltd)$ 1.36
Musgud 5 mg x 500's
Musgud 10 mg x 1000's
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Mylan-cyclobenzaprine tablet 10 mg (Mylan Pharmaceuticals Ulc (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Novo-cycloprine tablet 10 mg (Teva Canada Limited (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
PHL-cyclobenzaprine tablet 10 mg (Pharmel Inc (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Ratio-cyclobenzaprine tablet 10 mg (Ratiopharm Inc Division Of Teva Canada Limited (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 5 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 10 mg
Riva-cyclobenzaprine tablet 10 mg (Laboratoire Riva Inc (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 5 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 5 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Zym-cyclobenzaprine tablet 10 mg (Zymcan Pharmaceuticals Inc (Canada))

References

  1. PubChem. "cyclobenzaprine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "cyclobenzaprine". http://www.drugbank.ca/drugs/DB00924 (accessed September 17, 2018).
  3. MeSH. "Tranquilizing Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Tonalgen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tonalgen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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1 consumer reported age

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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