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Trazine LS Actions |
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Description: Trazine LS inhibits dopamine D2 receptors in the brain. It has weak anticholinergic and sedative effects but strong extrapyramidal and antiemetic effects. It controls severely disturbed, agitated or violent behaviour but may also be used for nonpsychotic anxiety.
Pharmacokinetics:
Absorption: Readily absorbed from GI tract. Peak plasma concentrations: 1.5-6 hr. Bioavailability: subject to interindividual variation.
Distribution: Protein binding: highly bound. Distributed into breast milk.
Excretion: Terminal half life: 22 hr.
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Call your doctor if your symptoms do not improve, or if they get worse while using Trazine LS.
Do not stop using Trazine LS suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Trazine LS.
Store at room temperature away from moisture, heat, and light.
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Call your doctor if your symptoms do not improve, or if they get worse while taking Trazine LS.
If you need to have an x-ray or CT scan of your spinal column using a dye that is injected into a vein, you may need to temporarily stop taking Trazine LS. Be sure the doctor knows ahead of time that you are using this medication.
Do not stop using Trazine LS suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using Trazine LS.
Store at room temperature away from moisture, heat, and light.
Trazine LS is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron leading to an increase in the release of these monoamines into the extraneuronal space. Dopamine integrates incoming sensory stimuli, initiates and controls fine movement (nigro-neostriatal pathway), controls emotional behavior (midbrain mesolimbic-forebrain system) and controls hypothalamic-pituitary endocrine system (tubero-infundibular system). It is this latter effect on the tubero-infundibular systm that seems to lead to reduced food intake. Trazine LS also acts as a monoamine oxidase inhibitor.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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