Tremin Dosage

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Dosage of Tremin in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether Tremin® (Tremin HCl) may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If Tremin (Tremin) tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water.

Abrupt withdrawal of treatment for parkinsonism may result in acute exacerbation of parkinsonism symptoms; therefore, abrupt withdrawal should be avoided.

Abrupt withdrawal of treatment may result in neuroleptic malignant syndrome (NMS)

Idiopathic Parkinsonism

As initial therapy for parkinsonism, 1 mg of Tremin (Tremin) in tablet or elixir form may be administered the first day. The dose may then be increased by 2 mg increments at intervals of three to five days, until a total of 6 to 10 mg is given daily. The total daily dose will depend upon what is found to be the optimal level. Many patients derive maximum benefit from this daily total of 6 to 10 mg, but some patients, chiefly those in the postencephalitic group, may require a total daily dose of 12 to 15 mg.

Drug-Induced Parkinsonism

The size and frequency of the Tremin (Tremin) dose needed to control extrapyramidal reactions to commonly employed tranquilizers, notably the phenothiazines, thioxanthenes, and butyrophenones, must be determined empirically. The total daily dosage usually ranges between 5 and 15 mg although, in some cases, these reactions have been satisfactorily controlled with as little as 1 mg daily. It may be advisable to commence therapy with a single 1 mg dose. If the extrapyramidal manifestations are not controlled in a few hours, the subsequent doses may be progressively increased until satisfactory control is achieved. Satisfactory control may sometimes be more rapidly achieved by temporarily reducing the dosage of the tranquilizer when instituting Tremin (Tremin) therapy and then adjusting the dosage of both drugs until the desired ataractic effect is retained without onset of extrapyramidal reactions.

It is sometimes possible to maintain the patient on a reduced Tremin (Tremin) dosage after the reactions have remained under control for several days. Instances have been reported in which these reactions have remained in remission for long periods after Tremin (Tremin) therapy was discontinued.

Concomitant Use with Levodopa

When Tremin (Tremin) is used concomitantly with levodopa, the usual dose of each may need to be reduced. Careful adjustment is necessary, depending on side effects and degree of symptom control. An Tremin (Tremin) dosage of 3 to 6 mg daily, in divided doses, is usually adequate.

Concomitant Use with Other Parasympathetic Inhibitors

Tremin (Tremin) may be substituted, in whole or in part, for other parasympathetic inhibitors. The usual technique is partial substitution initially, with progressive reduction in the other medication as the dose of Tremin HCl is increased.

Tremin (Tremin) TABLETS and ELIXIR - The total daily intake of Tremin (Tremin) tablets or elixir is tolerated best if divided into 3 doses and taken at mealtimes. High doses ( > 10 mg daily) may be divided into 4 parts, with 3 doses administered at mealtimes and the fourth at bedtime.

How supplied

Tremin® (Tremin HCl) Tablets are available as follows:

2 mg - round, flat, scored, white tablets; engraved “Tremin (Tremin) ” above “2” on one side and “LL” above “A11” below the score on the other side, supplied as follows:

NDC 0005-4434-23 - Bottle of 100

NDC 0005-4434-34 - Bottle of 1000

5 mg - round, flat, scored, white tablets; engraved “Tremin (Tremin) ” above “5” on one side and “LL” above “A12” below the score on the other side, supplied as follows:

NDC 0005-4436-23 - Bottle of 100

NDC 0005-4436-34 - Bottle of 1000

Store at controlled room temperature 20° to 25°C (68° to 77°F).

Dispense in tight containers as defined in the USP.

ALSO AVAILABLE

Tremin (Tremin) is available in Elixir as follows:

2 mg/5 mL - NDC 0005-4440-65 - Bottle of 16 fl oz

Store at controlled room temperature 20° to 25°C (68° to 77°F).

DO NOT FREEZE.

Dispense in tight containers as defined in the USP.

Lederle Pharmaceutical Division of American Cyanamid Company, Pearl River, NY 10965. Rev 03/03.

What other drugs will affect Tremin?

Before taking this medication, tell your doctor if you are taking any of the following medicines:

You may not be able to take Tremin or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with Tremin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Tremin interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Tremin, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Cannabinoids, barbiturates, opiates, and alcohol may have additive effects with PMS Tremin, and thus, an abuse potential exists.

Concurrent use of alcohol or other CNS depressants with PMS Tremin may cause increased sedative effects.

Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications

Prophylactic administration of anticholinergic agents, such as Tremin, as a prevention of drug-induced parkinsonism during neuroleptic therapy is not recommended. There may be an increased risk for the development of tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics.

The usual dose of either Tremin or levodopa may need to be reduced during concomitant therapy, since concomitant administration may increase drug-induced involuntary movements

Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when PMS Tremin is administered to a nursing woman. As with other anticholinergics, Tremin may cause suppression of lactation. Therefore, Tremin should only be used if the expected benefit to the mother outweighs the potential risk to the infant

Pediatric Use Safety and effectiveness in pediatric patients have not been established.


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References

  1. MeSH. "Muscarinic Antagonists". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
  2. European Chemicals Agency - ECHA. "Trihexyphenidyl: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
  3. PubMed Health. "Artane: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Tremin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tremin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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