Trifed Uses

Rating: 5 - 2 review(s)
How long did you take this medication to work?

What is Trifed?

Triprolidine (Trifed) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine (Trifed) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of Trifed is used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Trifed may also be used for purposes not listed in this medication guide.

Trifed indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

This medicine is indicated as adjuvant therapy for patients with abnormal, viscid, or inspissated mucous secretions in such conditions as:

Chronic bronchopulmonary disease (chronic emphysema, emphysema with bronchitis, chronic asthmatic bronchitis, tuberculosis, bronchiectasis and primary amyloidosis of the lung)

Acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis)

Pulmonary complications of cystic fibrosis

Tracheostomy care

Pulmonary complications associated with surgery

Use during anesthesia

Post-traumatic chest conditions

Atelectasis due to mucous obstruction

Diagnostic bronchial studies (bronchograms, bronchospirometry, and bronchial wedge catheterization)

How should I use Trifed?

Use Trifed liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Trifed liquid.

Uses of Trifed in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This combination medication is used to temporarily relieve symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis). Antihistamines help relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Decongestants help to relieve stuffy nose and ear congestion symptoms.

If you are self-treating with this medication, carefully read the package instructions to be sure it is right for you before you start using this product. Some products have similar brand names but different active ingredients with different uses. Taking the wrong product could harm you. Ask your pharmacist if you have any questions about your product or its use.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (including some long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely. Do not use this product to make a child sleepy.

These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use Trifed

Take this medication by mouth as directed by your doctor. If you are self-treating, follow all directions on the product package. If you are uncertain about any of the information, ask your doctor or pharmacist.

This medication may be taken with food if stomach upset occurs. Drink plenty of fluids unless otherwise directed by your doctor.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

Do not crush or chew extended-release tablets or capsules. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are using chewable tablets, chew each tablet thoroughly before swallowing.

If you are using a product made to dissolve in the mouth (tablets/strips), dry your hands before handling the medication. Place each dose on the tongue and allow to dissolve completely, then swallow it with saliva or with water.

Dosage is based on the product you are taking and your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed without your doctor's approval. Improper use (abuse) of this medication may result in serious harm (such as hallucinations, seizure, death).

If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Tell your doctor if your condition persists for more than 1 week, if it worsens, or if it occurs with fever, rash, or persistent headache. These may be symptoms of a serious medical problem and should be checked by a doctor.

Trifed description


Trifed is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists.

Trifed dosage

Trifed Dosage

Generic name: Triprolidine (Trifed) Hydrochloride 1.25mg in 5mL, Pseudoephedrine (Trifed) Hydrochloride 45mg in 5mL

Dosage form: oral liquid

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Adults and children over 12 years of age

1-2 teaspoonfuls every 4 to 6 hours (Do not exceed 240 mg of Pseudoephedrine (Trifed) HCI in 24 hours).

Children 6 to 12 years

½-1 teaspoonful every 4 to 6 hours (Do not exceed 120 mg of Pseudoephedrine (Trifed) HCI in 24 hours). This product is not indicated for use in children under 6 years of age.

More about Trifed (Pseudoephedrine (Trifed) / Triprolidine (Trifed))

Consumer resources

Professional resources

Other formulations

Related treatment guides

Trifed interactions

See also:
What other drugs will affect Trifed?


Simultaneous administration of Trifed Zentis Drugs with:

  • drugs providing a depressing effect on the CNS or with ethanol may increase the CNS depressant effects of tramadol;
  • MAO inhibitors are likely development of serotonin syndrome;
  • serotonin reuptake inhibitors, tricyclic antidepressants, antipsychotics, other means of reducing the threshold of convulsive readiness, increases the risk of seizures;
  • warfarin and phenprocoumon increase anticoagulant effect;
  • carbamazepine reduced the concentration of tramadol in plasma and its analgesic effect;
  • paroxetine describes cases of serotonin syndrome, seizures;
  • sertraline, fluoxetine describes cases of serotonin syndrome;
  • opioid analgesics is likely to reduce the analgesic action. Prolonged use of opioid analgesics or barbiturates stimulates the development of cross-tolerance;
  • naloxone activates respiration, eliminating analgesia after opioid analgesics.

    Trifed side effects

    See also:
    What are the possible side effects of Trifed?

    Drowsiness, dizziness, dry mouth/nose/throat, headache, upset stomach, constipation, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

    If your doctor has directed you to use this product, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using the product do not have serious side effects.

    Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (such as confusion, hallucinations), ringing in the ears, difficulty urinating, vision changes (such as blurred/double vision).

    Seek immediate medical attention if any of these rare but very serious side effects occur: fast/irregular heartbeat, seizure.

    A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

    This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

    In the US -

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

    In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

    Trifed contraindications

    See also:
    What is the most important information I should know about Trifed?

    this medicine is contraindicated in individuals who have previously exhibited intolerance to it or to Pseudoephedrine (Trifed) or Triprolidine (Trifed).

    this medicine is contraindicated in patients who are taking or have taken monoamine oxidase inhibitors within the preceding two weeks. The concomitant use of Pseudoephedrine (Trifed) and this type of product may occasionally cause a rise in blood pressure.

    this medicine is contraindicated in patients with severe hypertension or severe coronary artery disease.

    The antibacterial agent furazolidone, is known to cause a dose-related inhibition of monoamine oxidase. Although there are no reports of hypertensive crises caused by the concurrent administration of Multi-Action Trifed Tablets and furazolidone they should not be taken together.

    Active ingredient matches for Trifed:

    Pseudoephedrine/Triprolidine in Georgia, Indonesia, Slovakia, Thailand.

    Guaifenesin/Pseudoephedrine/Triprolidine in Oman.

    Pseudoephedrine HCl/Triprolidine HCl in Indonesia.

    Unit description / dosage (Manufacturer)Price, USD
    Trifed 50's$ 4.65
    Trifed 60 mL$ 1.61
    Trifed 250's
    Trifed 50 x 10's
    Trifed 60+2.5 Tablet$ 0.01

    List of Trifed substitutes (brand and generic names):

    Trifedrin 3 x 10's$ 2.98
    Trifedrin 60 mL x 1's$ 1.49
    Syrup; Oral; Pseudoephedrine Hydrochloride 30 mg; Triprolidine Hydrochloride 1.25 mg / 5 ml
    Tablet; Oral; Pseudoephedrine Hydrochloride 60 mg; Triprolidine Hydrochloride 2.5 mg
    Triofed 1, 000's
    Triofed 100 x 10's
    Triofed 60 mL
    Triofed 1 gal
    Tablet; Oral; Pseudoephedrine Hydrochloride 60 mg; Triprolidine Hydrochloride 2.5 mg
    Tripo 60 mL
    Triprodrine 1, 000's$ 18.18
    Triprodrine 30 mL$ 0.24
    Triprodrine 60 mL$ 0.36
    Triprodrine 1 L$ 4.55
    Triprodrine 1 gal$ 18.18
    Tablet; Oral; Pseudoephedrine Hydrochloride 60 mg; Triprolidine Hydrochloride 2.5 mg
    Tablet; Oral; Pseudoephedrine Hydrochloride 60 mg; Triprolidine Hydrochloride 2.5 mg
    Capsule, Extended Release; Oral; 120 mg; 5 mg
    Tablet, Extended Release; Oral; 120 mg; 5 mg
    Tablet; Oral; Pseudoephedrine Hydrochloride 60 mg; Triprolidine Hydrochloride 2.5 mg
    Trisodine 50 x 10's
    Trisodine 1000's
    Trisodine 60 mL x 12's
    Syrup; Oral; Pseudoephedrine Hydrochloride; Triprolidine Hydrochloride
    Valved 10 x 10's (Global Multi Pharmalab (GMP))$ 6.82
    Valved 60 mL x 1's (Global Multi Pharmalab (GMP))$ 1.24
    Vefed 1, 000's
    Vesprolid HCl 50 x 10's
    Vesprolid HCl 500's


    1. DailyMed. "PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
    2. DailyMed. "GUAIFENESIN; HYDROCODONE BITARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
    3. PubChem. "PSEUDOEPHEDRINE". (accessed September 17, 2018).


    The results of a survey conducted on for Trifed are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Trifed. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

    User reports

    Consumer reported useful

    No survey data has been collected yet

    1 consumer reported price estimates

    Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
    The below mentioned numbers have been reported by website users about whether the Trifed drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
    Not expensive1

    2 consumers reported time for results

    To what extent do I have to use Trifed before I begin to see changes in my health conditions?
    As part of the reports released by website users, it takes 3 month and a few days before you notice an improvement in your health conditions.
    Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Trifed. To get the time effectiveness of using Trifed drug by other patients, please click here.
    3 month1
    1 day1

    30 consumers reported age

    < 18
    > 601

    Consumer reviews

    There are no reviews yet. Be the first to write one!

    Your name: 
    Spam protection:  < Type 24 here

    Information checked by Dr. Sachin Kumar, MD Pharmacology

  • | Privacy Policy
    This site does not supply any medicines. It contains prices for information purposes only.
    © 2003 - 2022 All Rights Reserved