Trifluoperazine Uses

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What is Trifluoperazine?

Trifluoperazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Trifluoperazine is used to treat anxiety or psychotic disorders such as schizophrenia.

Trifluoperazine may also be used for purposes not listed in this medication guide.

Trifluoperazine indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

For the management of schizophrenia.

Trifluoperazine (Trifluoperazine HCl) is effective for the short-term treatment of generalized non-psychotic anxiety. However, Trifluoperazine (Trifluoperazine) is not the first drug to be used in therapy for most patients with non-psychotic anxiety because certain risks associated with its use are not shared by common alternative treatments (i.e., benzodiazepines).

When used in the treatment of non-psychotic anxiety, Trifluoperazine (Trifluoperazine) should not be administered at doses of more than 6 mg per day or for longer than 12 weeks because the use of Trifluoperazine (Trifluoperazine) at higher doses or for longer intervals may cause persistent tardive dyskinesia that may prove irreversible.

The effectiveness of Trifluoperazine (Trifluoperazine) as a treatment for non-psychotic anxiety was established in a 4-week clinical multicenter study of outpatients with generalized anxiety disorder (DSM-III). This evidence does not predict that Trifluoperazine (Trifluoperazine) will be useful in patients with other non-psychotic conditions in which anxiety, or signs that mimic anxiety, are found (i.e., physical illness, organic mental conditions, agitated depression, character pathologies, etc.).

Trifluoperazine (Trifluoperazine HC1) has not been shown effective in the management of behavioral complications in patients with mental retardation.

How should I use Trifluoperazine?

Use Trifluoperazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Trifluoperazine.

Uses of Trifluoperazine in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Trifluoperazine is used for the short-term treatment of anxiety or depression and also for the treatment of nausea and vomiting. Trifluoperazine may also be used to prevent relapse of schizophrenia (psychiatric disorder with symptoms of emotional instability, detachment from reality, often with delusions and hallucinations, and withdrawal into the self).

Trifluoperazine description

A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine.

Trifluoperazine dosage


Dosage should be adjusted to the needs of the individual. The lowest effective dosage should always be used. Dosage should be increased more gradually in debilitated or emaciated patients. When maximum response is achieved, dosage may be reduced gradually to a maintenance level. Because of the inherent long action of the drug, patients may be controlled on convenient b.i.d. administration; some patients may be maintained on once-a-day administration.

When Trifluoperazine (Trifluoperazine HCl) is administered by intramuscular injection, equivalent oral dosage may be substituted once symptoms have been controlled.

Note: Although there is little likelihood of contact dermatitis due to the drug, persons with known sensitivity to phenothiazine drugs should avoid direct contact.

Elderly Patients: In general, dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely. Dosage should be tailored to the individual, response carefully monitored, and dosage adjusted accordingly. Dosage should be increased more gradually in elderly patients.

Non-psychotic Anxiety

Usual dosage is 1 or 2 mg twice daily. Do not administer at doses of more than 6 mg per day or for longer than 12 weeks.



: Usual starting dosage is 2 mg to 5 mg b.i.d. (Small or emaciated patients should always be started on the lower dosage.)

Most patients will show optimum response on 15 mg or 20 mg daily, although a few may require 40 mg a day or more. Optimum therapeutic dosage levels should be reached within 2 or 3 weeks.

When the Concentrate dosage form is to be used, it should be added to 60 mL (2 fl oz) or more of diluent just prior to administration to insure palatability and stability. Vehicles suggested for dilution are: tomato or fruit juice, milk, simple syrup, orange syrup, carbonated beverages, coffee, tea or water. Semisolid foods (soup, puddings, etc.) may also be used.

Intramuscular (for prompt control of severe symptoms)

: Usual dosage is 1 mg to 2 mg (V2 to 1 mL) by deep intramuscular injection q4 to 6h, p.r.n. More than 6 mg within 24 hours is rarely necessary.

Only in very exceptional cases should intramuscular dosage exceed 10 mg within 24 hours. Injections should not be given at intervals of less than 4 hours because of a possible cumulative effect.

Note: Trifluoperazine (Trifluoperazine HCl) Injection has been usually well tolerated and there is little, if any, pain and irritation at the site of injection.

This solution should be protected from light. This is a clear, colorless to pale yellow solution; a slight yellowish discoloration will not alter potency. If markedly discolored, solution should be discarded.

Schizophrenia In Children

Dosage should be adjusted to the weight of the child and severity of the symptoms. These dosages are for children, ages 6 to 12, who are hospitalized or under close supervision.


: The starting dosage is 1 mg administered once a day or b.i.d. Dosage may be increased gradually until symptoms are controlled or until side effects become troublesome.

While it is usually not necessary to exceed dosages of 15 mg daily, some older children with severe symptoms may require higher dosages.


: There has been little experience with the use of Trifluoperazine (Trifluoperazine HCl) Injection in children. However, if it is necessary to achieve rapid control of severe symptoms, 1 mg (V2 mL) of the drug may be administered intramuscularly once or twice a day.

How supplied

Tablets, 1 mg, 2 mg, 5 mg and 10 mg in bottles of 100.

1 mg 100's: NDC 0108-4903-20

2 mg 100's: NDC 0108-4904-20

5 mg 100's: NDC 0108-4906-20

10 mg 100's: NDC 0108-4907-20

Multi-Dose Vials, 10 mL (2 mg/mL), in 1's: NDC 0108-4902-01

Concentrate (for institutional use), 10 mg/mL, in 2 fl oz bottles and in cartons of 12 bottles.

The Concentrate form is light-sensitive. For this reason, it should be protected from light and dispensed in amber bottles. Refrigeration is not required.

10 mg/mL 2 fl oz (carton of 12): NDC 0108-4901-42

Store all Trifluoperazine (Trifluoperazine HCl) formulations between 15° and 30°C (59° and 86°F).

Date Of Issuance Mar.. 2002. GlaxoSmithKline., Research Triangle Park, NC 27709

Trifluoperazine interactions

See also:
What other drugs will affect Trifluoperazine?


Phenothiazines may diminish the effect of oral anticoagulants.

Concomitant administration of propranolol with phenothiazines results in increased plasma levels of both drugs.

Phenothiazines may lower the convulsive threshold; dosage adjustment of anticonvulsants may be necessary. Potentiation of anticonvulsant effects does not occur. However, it has been reported that phenothiazines may interfere with the metabolism of phenytoin and thus precipitate phenytoin toxicity.

Drugs which lower the seizure threshold, including phenothiazine derivatives, should not be used with metrizamide. As with other phenothiazine derivatives, Trifluoperazine should be discontinued at least 48 hours before myelography, should not be resumed for at least 24 hours post procedure, and should not be used for the control of nausea and vomiting occurring either prior to myelography or post procedure

Trifluoperazine side effects

See also:
What are the possible side effects of Trifluoperazine?

Drowsiness, dizziness, skin reactions, rash, dry mouth, insomnia, amenorrhea, fatigue, muscular weakness, anorexia, lactation, blurred vision and neuromuscular (extrapyramidal) reactions.

Neuromuscular (Extrapyramidal) Reactions

These symptoms are seen in a significant number of hospitalized mental patients. They may be characterized by motor restlessness, be of the dystonic type, or they may resemble parkinsonism.

Depending on the severity of symptoms, dosage should be reduced or discontinued. If therapy is reinstituted, it should be at a lower dosage. Should these symptoms occur in children or pregnant patients, the drug should be stopped and not reinstituted. In most cases barbiturates by suitable route of administration will suffice. (Or, injectable Benadryl®" may be useful.) In more severe cases, the administration of an anti-parkinsonism agent, except levodopa, usually produces rapid reversal of symptoms. Suitable supportive measures such as maintaining a clear airway and adequate hydration should be employed.

Motor Restlessness: Symptoms may include agitation or jitteriness and sometimes insomnia. These symptoms often disappear spontaneously. At times these symptoms may be similar to the original neurotic or psychotic symptoms. Dosage should not be increased until these side effects have subsided.

If this phase becomes too troublesome, the symptoms can usually be controlled by a reduction of dosage or change of drug. Treatment with anti-parkinsonian agents, benzodiazepines or propranolol may be helpful.

Dystonias: Symptoms may include: spasm of the neck muscles, sometimes progressing to torticollis; extensor rigidity of back muscles, sometimes progressing to opisthotonos; carpopedal spasm, trismus, swallowing difficulty, oculogyric crisis and protrusion of the tongue.

These usually subside within a few hours, and almost always within 24 to 48 hours, after the drug has been discontinued.

In mild cases, reassurance or a barbiturate is often sufficient. In moderate cases, barbiturates will usually bring rapid relief. In more severe adult cases, the administration of an anti-parkinsonism agent, except levodopa, usually produces rapid reversal of symptoms. Also, intravenous caffeine with sodium benzoate seems to be effective. In children, reassurance and barbiturates will usually control symptoms. (Or, injectable Benadryl may be useful.) Note: See Benadryl prescribing information for appropriate children's dosage. If appropriate treatment with anti-parkinsonism agents or Benadryl fails to reverse the signs and symptoms, the diagnosis should be reevaluated.

Pseudo-parkinsonism: Symptoms may include: mask-like facies; drooling; tremors; pill-rolling motion; cogwheel rigidity; and shuffling gait. Reassurance and sedation are important. In most cases these symptoms are readily controlled when an anti-parkinsonism agent is administered concomitantly. Anti-parkinsonism agents should be used only when required. Generally, therapy of a few weeks to 2 to 3 months will suffice. After this time patients should be evaluated to determine their need for continued treatment. (Note: Levodopa has not been found effective in pseudo-parkinsonism.) Occasionally it is necessary to lower the dosage of Trifluoperazine (Trifluoperazine HCl) or to discontinue the drug.

Tardive Dyskinesia: As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. The syndrome can also develop, although much less frequently, after relatively brief treatment periods at low doses. This syndrome appears in all age groups. Although its prevalence appears to be highest among elderly patients, especially elderly women, it is impossible to rely upon prevalence estimates to predict at the inception of antipsychotic treatment which patients are likely to develop the syndrome. The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw (e.g., protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements). Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia. A variant of tardive dyskinesia, tardive dystonia, has also been described.

There is no known effective treatment for tardive dyskinesia; anti-parkinsonism agents do not alleviate the symptoms of this syndrome. If clinically feasible, it is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked.

It has been reported that fine vermicular movements of the tongue may be an early sign of the syndrome and if the medication is stopped at that time the syndrome may not develop.

Adverse Reactions Reported with Trifluoperazine (Trifluoperazine HCl) or Other Phenothiazine Derivatives: Adverse effects with different phenothiazines vary in type, frequency, and mechanism of occurrence, i.e., some are dose-related, while others involve individual patient sensitivity. Some adverse effects may be more likely to occur, or occur with greater intensity, in patients with special medical problems, e.g., patients with mitral insufficiency or pheochromocytoma have experienced severe hypotension following recommended doses of certain phenothiazines.

Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs.

Not all of the following adverse reactions have been observed with every phenothiazine derivative, but they have been reported with one or more and should be borne in mind when drugs of this class are administered: extrapyramidal symptoms (opisthotonos, oculogyric crisis, hyperreflexia, dystonia, akathisia, dyskinesia, parkinsonism) some of which have lasted months and even years-particularly in elderly patients with previous brain damage; grand mal and petit mal convulsions, particularly in patients with EEG abnormalities or history of such disorders; altered cerebrospinal fluid proteins; cerebral edema; intensification and prolongation of the action of central nervous system depressants (opiates, analgesics, antihistamines, barbiturates, alcohol), atropine, heat, organophosphorus insecticides; autonomic reactions (dryness of mouth, nasal congestion, headache, nausea, constipation, obstipation, adynamic ileus, ejaculatory disorders/impotence, priapism, atonic colon, urinary retention, miosis and mydriasis); reactivation of psychotic processes, catatonic-like states; hypotension (sometimes fatal); cardiac arrest; blood dyscrasias (pancytopenia, thrombocytopenic purpura, leukopenia, agranulocytosis, eosinophilia, hemolytic anemia, aplastic anemia); liver damage (jaundice, biliary stasis); endocrine disturbances (hyperglycemia, hypoglycemia, glycosuria, lactation, galactorrhea, gynecomastia, menstrual irregularities, false-positive pregnancy tests); skin disorders (photosensitivity, itching, erythema, urticaria, eczema up to exfoliative dermatitis); other allergic reactions (asthma, laryngeal edema, angioneurotic edema, anaphylactoid reactions); peripheral edema; reversed epinephrine effect; hyperpyrexia; mild fever after large I.M. doses; increased appetite; increased weight; a systemic lupus erythematosus-like syndrome; pigmentary retinopathy; with prolonged administration of substantial doses, skin pigmentation, epithelial keratopathy, and lenticular and corneal deposits.

EKG changes-particularly nonspecific, usually reversible Q and T wave distortions-have been observed in some patients receiving phenothiazine antipsychotics. Although phenothiazines cause neither psychic nor physical dependence, sudden discontinuance in long-term psychiatric patients may cause temporary symptoms, e.g., nausea and vomiting, dizziness, tremulousness.

Note: There have been occasional reports of sudden death in patients receiving phenothiazines. In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex.

Trifluoperazine contraindications

See also:
What is the most important information I should know about Trifluoperazine?


Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Trifluoperazine is not for use in psychotic conditions related to dementia. Trifluoperazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Do not use Trifluoperazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder (such as low platelets or low red or white blood cell counts), or if you are also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to Trifluoperazine or other phenothiazines.

Before you take Trifluoperazine, tell your doctor about all of your medical conditions, and if you have ever had a serious side effect while using Trifluoperazine or similar medicines. Also, tell your doctor about all other medications you use.

Active ingredient matches for Trifluoperazine:


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Trifluoperazine Hydrochloride 1 mg
Tablet; Oral; Trifluoperazine Hydrochloride 2 mg
Tablet; Oral; Trifluoperazine Hydrochloride 5 mg
Tablet; Oral; Trifluoperazine Hydrochloride 10 mg
Tablet; Oral; Trifluoperazine Hydrochloride 20 mg
Solution; Oral; Trifluoperazine Hydrochloride 5 mg / 5 ml
Concentrate; Oral; Trifluoperazine Hydrochloride 10 mg / ml
Injectable; Injection; Trifluoperazine Hydrochloride 2 mg / ml
Trifluoperazine HCl 10 mg tablet$ 1.70
Trifluoperazine 10 mg tablet$ 1.63
Trifluoperazine HCl 5 mg tablet$ 1.09
Trifluoperazine 5 mg tablet$ 1.08
Trifluoperazine HCl 2 mg tablet$ 0.89
Trifluoperazine 2 mg tablet$ 0.86
Trifluoperazine HCl 1 mg tablet$ 0.59
Trifluoperazine 1 mg tablet$ 0.58
Apo-Trifluoperazine 20 mg Tablet$ 0.58
Apo-Trifluoperazine 10 mg Tablet$ 0.29
Apo-Trifluoperazine 5 mg Tablet$ 0.24
Apo-Trifluoperazine 2 mg Tablet$ 0.18
Apo-Trifluoperazine 1 mg Tablet$ 0.14
Trifluoperazine / S.C. 1 mg
Trifluoperazine tablet 5 mg (Aa Pharma Inc (Canada))
Trifluoperazine tablet 20 mg (Aa Pharma Inc (Canada))
Trifluoperazine tablet 2 mg (Aa Pharma Inc (Canada))
Trifluoperazine tablet 10 mg (Aa Pharma Inc (Canada))
Trifluoperazine tablet 1 mg (Aa Pharma Inc (Canada))
Trifluoperazine tablet, film coated 2 mg/1 (STAT Rx USA LLC (US))

List of Trifluoperazine substitutes (brand and generic names):

TRIKOZIN 5MG TABLET 1 strip / 10 tablets each (Triko Pharmaceuticals)$ 0.16
TRINICALM Capsule/ Tablet / 5mg / 10 units (Torrent Pharmaceuticals Ltd.)$ 0.09
Trinicalm 5 mg Tablet (Torrent Pharmaceuticals Ltd.)$ 0.01
Triozine 1 mg x 1, 000's (Pharmasant)
Triozine 5 mg x 1, 000's (Pharmasant)
Triphenazin 10+2 Tablet (Sun Pharmaceutical Industries Ltd.)$ 0.01
Injectable; Injection; Trifluoperazine 2 mg / ml
Tablet, Film-Coated; Oral; Trifluoperazine Hydrochloride 5 mg
Tablet, Film-Coated; Oral; Trifluoperazine Hydrochloride 10 mg
Trirazine 2 mg
Trofaz Forte 5+50+2 Tablet (Olcare Laboratories)$ 0.01
Trofaz Plus 5+2 Tablet (Olcare Laboratories)$ 0.01
Trofaz Plus Trifluoperazine 5 mg, trihexyphenidyl 2 mg. TAB / 10 (Olcare Laboratories)$ 0.19
TROFAZ PLUS 5MG/2MG TABLET 1 strip / 20 tablets each (Olcare Laboratories)$ 0.20
TROFAZ PLUS tab 10's (Olcare Laboratories)$ 0.19


  1. DailyMed. "TRIFLUOPERAZINE HYDROCHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "trifluoperazine". (accessed September 17, 2018).
  3. DrugBank. "trifluoperazine". (accessed September 17, 2018).


The results of a survey conducted on for Trifluoperazine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Trifluoperazine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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1 consumer reported time for results

To what extent do I have to use Trifluoperazine before I begin to see changes in my health conditions?
As part of the reports released by website users, it takes 1 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Trifluoperazine. To get the time effectiveness of using Trifluoperazine drug by other patients, please click here.
1 month1

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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