Trifluoperazine Hydrochloride Uses

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What is Trifluoperazine Hydrochloride?

Trifluoperazine Hydrochloride is an anti-psychotic medicine in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Trifluoperazine Hydrochloride is used to treat anxiety or psychotic disorders such as schizophrenia.

Trifluoperazine Hydrochloride may also be used for purposes not listed in this medication guide.

Trifluoperazine Hydrochloride indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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For the management of schizophrenia.

Trifluoperazine Hydrochloride tablets, USP are effective for the short-term treatment of generalized non-psychotic anxiety. However, Trifluoperazine Hydrochloride tablets are not the first drug to be used in therapy for most patients with non-psychotic anxiety because certain risks associated with its use are not shared by common alternative treatments (i.e., benzodiazepines).

When used in the treatment of non-psychotic anxiety, Trifluoperazine Hydrochloride tablets should not be administered at doses of more than 6 mg per day or for longer than 12 weeks because the use of Trifluoperazine Hydrochloride tablets at higher doses or for longer intervals may cause persistent tardive dyskinesia that may prove irreversible.

The effectiveness of Trifluoperazine Hydrochloride tablets as a treatment for non-psychotic anxiety was established in a 4-week clinical multicenter study of outpatients with generalized anxiety disorder (DSM-III). This evidence does not predict that Trifluoperazine Hydrochloride tablets will be useful in patients with other non-psychotic conditions in which anxiety, or signs that mimic anxiety, are found (i.e., physical illness, organic mental conditions, agitated depression, character pathologies, etc.).

Trifluoperazine Hydrochloride tablets have not been shown effective in the management of behavioral complications in patients with mental retardation.

How should I use Trifluoperazine Hydrochloride?

Use Trifluoperazine Hydrochloride as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Trifluoperazine Hydrochloride.

Uses of Trifluoperazine Hydrochloride in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Trifluoperazine Hydrochloride is used for the short-term treatment of anxiety or depression and also for the treatment of nausea and vomiting. Trifluoperazine Hydrochloride may also be used to prevent relapse of schizophrenia (psychiatric disorder with symptoms of emotional instability, detachment from reality, often with delusions and hallucinations, and withdrawal into the self).

Trifluoperazine Hydrochloride description

A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.

Trifluoperazine Hydrochloride dosage

Dosage should be adjusted to the weight of the child and severity of the symptoms. These dosages are for children, ages 6 to 12, who are hospitalized or under close supervision.

Oral

The starting dosage is 1 mg administered once a day or b.i.d. Dosage may be increased gradually until symptoms are controlled or until side effects become troublesome.

While it is usually not necessary to exceed dosages of 15 mg daily, some older children with severe symptoms may require higher dosages.

Trifluoperazine Hydrochloride interactions

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What other drugs will affect Trifluoperazine Hydrochloride?

No information provided.

Trifluoperazine Hydrochloride side effects

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What are the possible side effects of Trifluoperazine Hydrochloride?

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Drowsiness, dizziness, skin reactions, rash, dry mouth, insomnia, amenorrhea, fatigue, muscular weakness, anorexia, lactation, blurred vision and neuromuscular (extrapyramidal) reactions.

Neuromuscular (Extrapyramidal) Reactions

These symptoms are seen in a significant number of hospitalized mental patients. They may be characterized by motor restlessness, be of the dystonic type, or they may resemble parkinsonism.

Depending on the severity of symptoms, dosage should be reduced or discontinued. If therapy is reinstituted, it should be at a lower dosage. Should these symptoms occur in children or pregnant patients, the drug should be stopped and not reinstituted. In most cases, barbiturates by suitable route of administration will suffice. (Or, injectable diphenhydramine hydrochloride may be useful.) In more severe cases, the administration of an antiparkinsonism agent, except levodopa, usually produces rapid reversal of symptoms. Suitable supportive measures such as maintaining a clear airway and adequate hydration should be employed.

Motor Restlessness

Symptoms may include agitation or jitteriness and sometimes insomnia. These symptoms often disappear spontaneously. At times these symptoms may be similar to the original neurotic or psychotic symptoms. Dosage should not be increased until these side effects have subsided.

If this phase becomes too troublesome, the symptoms can usually be controlled by a reduction of dosage or change of drug. Treatment with antiparkinsonism agents, benzodiazepines or propranolol may be helpful.

Dystonia

Class Effect

Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.

Pseudoparkinsonism

Symptoms may include: mask-like facies; drooling; tremors; pill-rolling motion; cogwheel rigidity; and shuffling gait. Reassurance and sedation are important. In most cases these symptoms are readily controlled when an antiparkinsonism agent is administered concomitantly. Antiparkinsonism agents should be used only when required. Generally, therapy of a few weeks to 2 or 3 months will suffice. After this time, patients should be evaluated to determine their need for continued treatment. (Note: Levodopa has not been found effective in pseudoparkinsonism.) Occasionally it is necessary to lower the dosage of Trifluoperazine Hydrochloride or to discontinue the drug.

Tardive Dyskinesia

As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. The syndrome can also develop, although much less frequently, after relatively brief treatment periods at low doses. This syndrome appears in all age groups. Although its prevalence appears to be highest among elderly patients, especially elderly women, it is impossible to rely upon prevalence estimates to predict at the inception of antipsychotic treatment which patients are likely to develop the syndrome. The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw (e.g., protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements). Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia. A variant of tardive dyskinesia, tardive dystonia, has also been described.

There is no known effective treatment for tardive dyskinesia; antiparkinsonism agents do not alleviate the symptoms of this syndrome. If clinically feasible, it is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked.

It has been reported that fine vermicular movements of the tongue may be an early sign of the syndrome and if the medication is stopped at that time the syndrome may not develop.

Adverse Reactions Reported with Trifluoperazine Hydrochloride or Other Phenothiazine Derivatives

Adverse effects with different phenothiazines vary in type, frequency, and mechanism of occurrence, i.e., some are dose related, while others involve individual patient sensitivity. Some adverse effects may be more likely to occur, or occur with greater intensity, in patients with special medical problems, e.g., patients with mitral insufficiency or pheochromocytoma have experienced severe hypotension following recommended doses of certain phenothiazines.

Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs.

Not all of the following adverse reactions have been observed with every phenothiazine derivative, but they have been reported with one or more and should be borne in mind when drugs of this class are administered: extrapyramidal symptoms (opisthotonos, oculogyric crisis, hyperreflexia, dystonia, akathisia, dyskinesia, parkinsonism) some of which have lasted months and even years–particularly in elderly patients with previous brain damage; grand mal and petit mal convulsions, particularly in patients with EEG abnormalities or history of such disorders; altered cerebrospinal fluid proteins; cerebral edema; intensification and prolongation of the action of central nervous system depressants (opiates, analgesics, antihistamines, barbiturates, alcohol), atropine, heat, organophosphorus insecticides; autonomic reactions (dryness of mouth, nasal congestion, headache, nausea, constipation, obstipation, adynamic ileus, ejaculatory disorders/impotence, priapism, atonic colon, urinary retention, miosis and mydriasis); reactivation of psychotic processes, catatonic-like states; hypotension (sometimes fatal); cardiac arrest; blood dyscrasias (pancytopenia, thrombocytopenic purpura, leukopenia, agranulocytosis, eosinophilia, hemolytic anemia, aplastic anemia); liver damage (jaundice, biliary stasis); endocrine disturbances (hyperglycemia, hypoglycemia, glycosuria, lactation, galactorrhea, gynecomastia, menstrual irregularities, false-positive pregnancy tests); skin disorders (photosensitivity, itching, erythema, urticaria, eczema up to exfoliative dermatitis); other allergic reactions (asthma, laryngeal edema, angioneurotic edema, anaphylactoid reactions); peripheral edema; reversed epinephrine effect; hyperpyrexia; increased appetite; increased weight; a systemic lupus erythematosus-like syndrome; pigmentary retinopathy; with prolonged administration of substantial doses, skin pigmentation, epithelial keratopathy, and lenticular and corneal deposits.

EKG changes-particularly nonspecific, usually reversible Q and T wave distortions-have been observed in some patients receiving phenothiazine antipsychotics. Although phenothiazines cause neither psychic nor physical dependence, sudden discontinuance in long-term psychiatric patients may cause temporary symptoms, e.g., nausea and vomiting, dizziness, tremulousness.

Note: There have been occasional reports of sudden death in patients receiving phenothiazines. In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex.

Trifluoperazine Hydrochloride contraindications

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What is the most important information I should know about Trifluoperazine Hydrochloride?

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A known hypersensitivity to phenothiazines, comatose or greatly depressed states due to central nervous system depressants and, in cases of existing blood dyscrasias, bone marrow depression and pre-existing liver damage.

Active ingredient matches for Trifluoperazine Hydrochloride:

Trifluoperazine Hydrochloride


Unit description / dosage (Manufacturer)Price, USD
10 tablet in 1 blister pack
100 tablet in 1 bottle
1000 tablet in 1 bottle
500 tablet in 1 bottle
Trifluoperazine Hydrochloride tablet, film coated 2 mg/1 (REMEDYREPACK INC. (US))
Trifluoperazine Hydrochloride tablet, film coated 10 mg/1 (Sandoz Inc (US))
Trifluoperazine Hydrochloride tablet, film coated 1 mg/1 (Mylan Institutional Inc. (US))
Trifluoperazine Hydrochloride tablet, film coated 5 mg/1 (Mylan Institutional Inc. (US))
Trifluoperazine Hydrochloride tablet 1 mg/1 (REMEDYREPACK INC. (US))

List of Trifluoperazine Hydrochloride substitutes (brand and generic names):

TRIKOZIN 5MG TABLET 1 strip / 10 tablets each (Triko Pharmaceuticals)$ 0.16
TRINICALM Capsule/ Tablet / 5mg / 10 units (Torrent Pharmaceuticals Ltd.)$ 0.09
Trinicalm 5 mg Tablet (Torrent Pharmaceuticals Ltd.)$ 0.01
Triozine 1 mg x 1, 000's (Pharmasant)
Triozine 5 mg x 1, 000's (Pharmasant)
Triphenazin 10+2 Tablet (Sun Pharmaceutical Industries Ltd.)$ 0.01
Injectable; Injection; Trifluoperazine 2 mg / ml
Tablet, Film-Coated; Oral; Trifluoperazine Hydrochloride 5 mg
Tablet, Film-Coated; Oral; Trifluoperazine Hydrochloride 10 mg
Trirazine 2 mg
Trofaz Forte 5+50+2 Tablet (Olcare Laboratories)$ 0.01
Trofaz Plus 5+2 Tablet (Olcare Laboratories)$ 0.01
Trofaz Plus Trifluoperazine 5 mg, trihexyphenidyl 2 mg. TAB / 10 (Olcare Laboratories)$ 0.19
TROFAZ PLUS 5MG/2MG TABLET 1 strip / 20 tablets each (Olcare Laboratories)$ 0.20
TROFAZ PLUS tab 10's (Olcare Laboratories)$ 0.19
Trofaz Plus 5 mg/2 mg Tablet (Olcare Laboratories)$ 0.01
Trycalm Forte 5+50+2 Tablet (S.P.Pharmaceuticals)$ 0.02
TRYCALM FORTE 50MG/2MG/5MG TABLET 1 strip / 10 tablets each (S.P.Pharmaceuticals)$ 0.31
Trycalm Forte 50 mg/2 mg/5 mg Tablet (S.P.Pharmaceuticals)$ 0.03
Trycalm Plus 5+2 Tablet (S.P.Pharmaceuticals)$ 0.01
TRYCALM PLUS 5MG/2MG TABLET 1 strip / 10 tablets each (S.P.Pharmaceuticals)$ 0.18
Trycalm Plus 5 mg/2 mg Tablet (S.P.Pharmaceuticals)$ 0.02
Trycalm SF 5+25+2 Tablet (S.P.Pharmaceuticals)$ 0.02
TRYCALM SF 25MG/2MG/5MG TABLET 1 strip / 10 tablets each (S.P.Pharmaceuticals)$ 0.31

References

  1. DailyMed. "TRIFLUOPERAZINE HYDROCHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "trifluoperazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "trifluoperazine". http://www.drugbank.ca/drugs/DB00831 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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