Trihexyphenidyl Hydrochloride Uses

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What is Trihexyphenidyl Hydrochloride?

Trihexyphenidyl Hydrochloride alters unusual nerve impulses and relaxes stiff muscles.

Trihexyphenidyl Hydrochloride is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.

Trihexyphenidyl Hydrochloride may also be used for purposes other than those listed in this medication guide.

Trihexyphenidyl Hydrochloride indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Trihexyphenidyl Hydrochloride Elixir is indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.

How should I use Trihexyphenidyl Hydrochloride?

Use Trihexyphenidyl Hydrochloride as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Trihexyphenidyl Hydrochloride.

Uses of Trihexyphenidyl Hydrochloride in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Trihexyphenidyl Hydrochloride is used to treat symptoms of Parkinson’s disease (a type of nerve disease that causes movement disorder characterized by slowness of movements, muscle stiffness, uncontrolled shaking and poor balance and co-ordination) and drug-induced extra pyramidal symptoms (movement disorders similar to symptoms of Parkinson’s disease) except tardive dyskinesia (involuntary movement of face and jaw). It is often given along with levodopa (anti-Parkinson drug).

Trihexyphenidyl Hydrochloride description

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Trihexyphenidyl Hydrochloride is administered by various routes, including topically.

Trihexyphenidyl Hydrochloride dosage

Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether Trihexyphenidyl Hydrochloride may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If Trihexyphenidyl Hydrochloride tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water.

Trihexyphenidyl Hydrochloride in Idiopathic Parkinsonism:

As initial therapy for parkinsonism, 1 mg of Trihexyphenidyl Hydrochloride may be administered the first day. The dose may then be increased by 2 mg increments at intervals of three to five days, until a total of 6 to 10 mg is given daily. The total daily dose will depend upon what is found to be the optimal level. Many patients derive maximum benefit from this daily total of 6 to 10 mg, but some patients, chiefly those in the postencephalitic group, may require a total daily dose of 12 to 15 mg.

Trihexyphenidyl Hydrochloride In Drug-Induced Parkinsonism:

The size and frequency of dose of Trihexyphenidyl Hydrochloride needed to control extrapyramidal reactions to commonly employed tranquilizers, notably the phenothiazines, thioxanthenes, and butyrophenones, must be determined empirically. The total daily dosage usually ranges between 5 and 15 mg although, in some cases, these reactions have been satisfactorily controlled on as little as 1 mg daily. It may be advisable to commence therapy with a single 1 mg dose. If the extrapyramidal manifestations are not controlled in a few hours, the subsequent doses may be progressively increased until satisfactory control is achieved. Satisfactory control may sometimes be more rapidly achieved by temporarily reducing the dosage of the tranquilizer on instituting Trihexyphenidyl Hydrochloride therapy and then adjusting dosage of both drugs until the desired ataractic effect is retained without onset of extrapyramidal reactions.

It is sometimes possible to maintain the patient on a reduced Trihexyphenidyl Hydrochloride dosage after the reactions have remained under control for several days. Instances have been reported in which these reactions have remained in remission for long periods after Trihexyphenidyl Hydrochloride therapy was discontinued.

Concomitant Use of Trihexyphenidyl Hydrochloride with Levodopa:

When Trihexyphenidyl Hydrochloride is used concomitantly with levodopa, the usual dose of each may need to be reduced. Careful adjustment is necessary, depending on side effects and degree of symptom control. Trihexyphenidyl Hydrochloride dosage of 3 to 6 mg daily, in divided doses, is usually adequate.

Concomitant Use of Trihexyphenidyl Hydrochloride Elixir with Other Parasympathetic Inhibitors:

Trihexyphenidyl Hydrochloride may be substituted in whole or in part, for other parasympathetic inhibitors. The usual technique is partial substitution initially, with progressive reduction in the other medication as the dose of Trihexyphenidyl Hydrochloride is increased.

The total daily intake of Trihexyphenidyl Hydrochloride is tolerated best if divided into 3 doses and taken at mealtimes. High doses (>10 mg daily) may be divided into 4 parts, with 3 doses administered at mealtimes and the fourth at bedtime.

Trihexyphenidyl Hydrochloride interactions

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What other drugs will affect Trihexyphenidyl Hydrochloride?


Cannabinoids, barbiturates, opiates, and alcohol may have additive effects with PMS Trihexyphenidyl Hydrochloride, and thus, an abuse potential exists.

Concurrent use of alcohol or other CNS depressants with PMS Trihexyphenidyl Hydrochloride may cause increased sedative effects.

Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications

Prophylactic administration of anticholinergic agents, such as Trihexyphenidyl Hydrochloride, as a prevention of drug-induced parkinsonism during neuroleptic therapy is not recommended. There may be an increased risk for the development of tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics.

The usual dose of either Trihexyphenidyl Hydrochloride or levodopa may need to be reduced during concomitant therapy, since concomitant administration may increase drug-induced involuntary movements

Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when PMS Trihexyphenidyl Hydrochloride is administered to a nursing woman. As with other anticholinergics, Trihexyphenidyl Hydrochloride may cause suppression of lactation. Therefore, Trihexyphenidyl Hydrochloride should only be used if the expected benefit to the mother outweighs the potential risk to the infant

Pediatric Use Safety and effectiveness in pediatric patients have not been established.

Trihexyphenidyl Hydrochloride side effects

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What are the possible side effects of Trihexyphenidyl Hydrochloride?


Minor side effects, such as dryness of the mouth, blurring of vision, dizziness, mild nausea or nervousness, will be experienced by 30 to 50 percent of all patients. These sensations, however, are much less troublesome with Trihexyphenidyl Hydrochloride than with belladonna alkaloids and are usually less disturbing than unalleviated parkinsonism. Such reactions tend to become less pronounced, and even to disappear, as treatment continues. Even before these reactions have remitted spontaneously, they may often be controlled by careful adjustment of dosage form, amount of drug, or interval between doses.

Isolated instances of suppurative parotitis secondary to excessive dryness of the mouth, skin rashes, dilatation of the colon, paralytic ileus, and certain psychiatric manifestations such as delusions and hallucinations, plus one doubtful case of paranoia all of which may occur with any of the atropine-like drugs, have been reported rarely with Trihexyphenidyl Hydrochloride.

Patients with arteriosclerosis or with a history of idiosyncrasy to other drugs may exhibit reactions of mental confusion, agitation, disturbed behavior, or nausea and vomiting. Such patients should be allowed to develop a tolerance through the initial administration of a small dose and gradual increase in dose until an effective level is reached. If a severe reaction should occur, administration of the drug should be discontinued for a few days and then resumed at a lower dosage. Psychiatric disturbances can result from indiscriminate use (leading to overdosage) to sustain continued euphoria.

Potential side effects associated with the use of any atropine-like drugs include constipation, drowsiness, urinary hesitancy or retention, tachycardia, dilation of the pupil, increased intraocular tension, weakness, vomiting, and headache.

The occurrence of angle-closure glaucoma due to long-term treatment with Trihexyphenidyl Hydrochloride has been reported.

Trihexyphenidyl Hydrochloride contraindications

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What is the most important information I should know about Trihexyphenidyl Hydrochloride?

Dose-dependent side effects are frequent. Particularly geriatric patients may react with confusional states or develop delirium.

* CNS : Drowsiness, vertigo, headache, and dizziness are frequent. With high doses nervousness, agitation, anxiety, delirium, and confusion are noted. Trihexyphenidyl Hydrochloride may be abused due to a short acting mood-elevating and euphoriant effect. The normal sleep architecture may be altered (REM sleep depression). Trihexyphenidyl Hydrochloride may lower the seizure-threshold.

* Peripheral side effects : Blurred vision, dry mouth, impaired sweating, abdominal discomfort, and obstipation are frequent. Tachycardia may be noted. Allergic skin reactions may occur.

Parenteral use may cause orthostatic hypotension.

* Eyes : Trihexyphenidyl Hydrochloride causes mydriasis with or without photophobia. It may precipitate narrow angle glaucoma.

* Tolerance may develop during therapy which requires dose adjustments.

Active ingredient matches for Trihexyphenidyl Hydrochloride:

Trihexyphenidyl Hydrochloride

Unit description / dosage (Manufacturer)Price, USD
Trihexyphenidyl Hydrochloride tablet 5 mg/1 (REMEDYREPACK INC. (US))
Trihexyphenidyl Hydrochloride solution 2 mg/5mL (Pharmaceutical Associates, Inc. (US))
Trihexyphenidyl Hydrochloride tablet 2 mg/1 (State of Florida DOH Central Pharmacy (US))
Trihexyphenidyl Hydrochloride syrup 2 mg/5mL (Versa Pharm Incorporated (US))

List of Trihexyphenidyl Hydrochloride substitutes (brand and generic names):

MANOHEXY inj 2 mg x 1's (Orchid (Psychiatry))$ 0.24
Manohexy 2mg Tablet (Orchid (Psychiatry))$ 0.02
Manohexy 5mg Tablet (Orchid (Psychiatry))$ 0.04
Manohexy 2mg Injection (Orchid (Psychiatry))$ 0.26
Parales 2mg TAB / 100 (Psycorem)$ 1.71
Parales 5mg TAB / 100 (Psycorem)$ 2.57
2 mg x 100's (Psycorem)$ 1.71
5 mg x 100's (Psycorem)$ 2.57
PARALES 2 MG TABLET 1 strip / 10 tablets each (Psycorem)$ 0.24
PARALES tab 2 mg x 10's (Psycorem)$ 0.17
PARALES tab 5 mg x 10's (Psycorem)$ 0.26
Parales 2mg Tablet (Psycorem)$ 0.02
Parkitane 2mg TAB / 10 (Sun)$ 0.16
2 mg x 10's (Sun)$ 0.16
PARKITANE 2 MG TABLET 1 strip / 10 tablets each (Sun)$ 1.22
PARKITANE tab 2 mg x 10's (Sun)$ 0.16
Parkitane 2mg Tablet (Sun)$ 0.12
2 mg x 100's (Acme Pharma)$ 3.17
Parkure 2mg TAB / 100 (Acme Pharma)$ 3.17
PARKURE tab 2 mg x 10's (Acme Pharma)$ 0.32
Parkure 2mg TAB / 100 (Acme Pharma)$ 3.17
Peradyl Forte Trihexyphenidyl HCI 2mg, Trifluooperazine HCI 5mg, Chlorpromazine HCI 50mg FC-TAB (Psycorem)
Peradyl Forte Trihexyphenidyl hydrochloride2 mg, Trifluoperazinehydrochloride 5 mg, Chlorpromazine hydrochloride50 mg. FC-TAB (Psycorem)
Peradyl Forte Trihexyphenidyl hydrochloride2 mg, trifluoperazinehydrochloride 5 mg, chlorpromazine hydrochloride50 mg. FC-TAB / 10 (Psycorem)
PERADYL FORTE TABLET 1 strip / 10 tablets each (Psycorem)$ 0.21
PERADYL FORTE film-coated tab 10's (Psycorem)$ 0.21
Peradyl Forte Tablet (Psycorem)$ 0.02
Seretane 2mg DT-TAB / 10 (RPG LS)$ 0.25
2 mg x 10's (RPG LS)$ 0.25
SERETANE 2MG TABLET DT 1 strip / 10 tablet dts each (RPG LS)$ 0.26
SERETANE dispertab 2 mg x 10's (RPG LS)$ 0.25
Texy 2mg TAB / 10 (Triton (Calyx))
2 mg x 10's (Triton (Calyx))
TEXY TABLET 1 strip / 10 tablets each (Triton (Calyx))$ 0.25
TEXY tab 2 mg x 10's (Triton (Calyx))$ 0.19
Texy 2mg Tablet (Triton (Calyx))$ 0.02
2 mg x 10's (Esma)$ 0.19
Trexy 2mg TAB / 10 (Esma)$ 0.19
TREXY tab 2 mg x 10's (Esma)$ 0.19
Trexy 2mg TAB / 10 (Esma)$ 0.19


  1. PubChem. "trihexyphenidyl". (accessed September 17, 2018).
  2. DrugBank. "trihexyphenidyl". (accessed September 17, 2018).
  3. DTP/NCI. "trihexyphenidyl: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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