Trihexyphenidyl Side effects

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• Side effects of Trihexyphenidyl in details
• Trihexyphenidyl contraindications
• Trihexyphenidyl reviews

What are the possible side effects of Trihexyphenidyl?

If you experience any of the following serious side effects, stop taking Trihexyphenidyl and seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• fever;

• fast or irregular heartbeats;

• anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness;

• seizures;

• eye pain; or

• a rash.

Other, less serious side effects may be more likely to occur. Continue to take Trihexyphenidyl and talk to your doctor if you experience

• dryness of the mouth;

• large pupils or blurred vision;

• drowsiness or dizziness;

• difficulty urinating or constipation;

• nervousness or anxiety;

• upset stomach; or

• decreased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Trihexyphenidyl in details

Minor side effects, such as dryness of the mouth, blurred vision, dizziness, mild nausea or nervousness, will be experienced by 30 to 50 percent of all patients. These sensations, however, are much less troublesome with Trihexyphenidyl (Trihexyphenidyl) than with belladonna alkaloids and are usually less disturbing than unallenated parkinsonism. Such reactions tend to become less pronounced, and even to disappear, as treatment continues. Even before these reactions have remitted spontaneously, they may often be controlled by careful adjustment of dosage form, amount of drug, or interval between doses.

Isolated instances of suppurative parotitis secondary to excessive dryness of the mouth, skin rashes, dilatation of the colon, paralytic ileus, and certain psychiatric manifestations such as delusions, hallucinations, and paranoia, all of which may occur with any of the atropine-like drugs, have been reported rarely with Trihexyphenidyl® (Trihexyphenidyl)

Potential side effects associated with the use of any atropine-like drugs, including Trihexyphenidyl (Trihexyphenidyl), include cognitive dysfunctions, including confusion and memory impairment; constipation, drowsiness, urinary hesitancy or retention, tachycardia, dilation of the pupil, increased intraocular pressure, choreiform movements, weakness, vomiting, and headache. Exacerbation of parkinsonism with abrupt treatment withdrawal has been reported. Neuroleptic malignant syndrome with abrupt treatment withdrawal has been reported.

The occurrence of angle-closure glaucoma in patients receiving Trihexyphenidyl HCl has been reported (blindness has been reported in some cases). Paradoxical sinus bradycardia, dry skin, and cycloplegia have been reported.

In addition to adverse events seen in adults, the following adverse events have been reported in the literature in pediatric patients: hyperkinesia, psychosis, forgetfulness, weight loss, restlessness, chorea, and sleep alterations.

Drug Abuse And Dependence

Although Trihexyphenidyl (Trihexyphenidyl) is not classified as a controlled substance, the possibility of abuse should be borne in mind due to its stimulant and euphoriant properties.

What is the most important information I should know about Trihexyphenidyl?

• Trihexyphenidyl may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Trihexyphenidyl with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Trihexyphenidyl may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Do not become overheated in hot weather or while you are being active; heatstroke may occur.
• Lab tests, including eye exams, may be performed while you use Trihexyphenidyl. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Trihexyphenidyl with caution in the ELDERLY, especially patients who may be constipated; they may be more sensitive to its effects.
• Trihexyphenidyl should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Trihexyphenidyl while you are pregnant. It is not known if Trihexyphenidyl is found in breast milk. If you are or will be breast-feeding while you use Trihexyphenidyl, check with your doctor. Discuss any possible risks to your baby.

Trihexyphenidyl contraindications

Dose-dependent side effects are frequent. Particularly geriatric patients may react with confusional states or develop delirium.

* CNS : Drowsiness, vertigo, headache, and dizziness are frequent. With high doses nervousness, agitation, anxiety, delirium, and confusion are noted. Trihexyphenidyl may be abused due to a short acting mood-elevating and euphoriant effect. The normal sleep architecture may be altered (REM sleep depression). Trihexyphenidyl may lower the seizure-threshold.

* Peripheral side effects : Blurred vision, dry mouth, impaired sweating, abdominal discomfort, and obstipation are frequent. Tachycardia may be noted. Allergic skin reactions may occur.

Parenteral use may cause orthostatic hypotension.

* Eyes : Trihexyphenidyl causes mydriasis with or without photophobia. It may precipitate narrow angle glaucoma.

* Tolerance may develop during therapy which requires dose adjustments.

References

1. DTP/NCI. "trihexyphenidyl: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
2. European Chemicals Agency - ECHA. "Trihexyphenidyl: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
3. HSDB. "TRIHEXYPHENIDYL". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology