Consists of Loratadine, Paracetamol, Pseudoephedrine
Pregnancy of Loratadine (Trimed Flu) in details
Loratadine (Trimed Flu) has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Loratadine (Trimed Flu) is only recommended for use during pregnancy when benefit outweighs risk.
See references
Loratadine (Trimed Flu) breastfeeding
Loratadine (Trimed Flu) concentrations in human milk approximate that found in the serum of the mother. Approximately 0.029% of the administered dose was excreted in human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
See references
References for pregnancy information
- "Product Information. Claritin (Loratadine (Trimed Flu))." Schering Laboratories, Kenilworth, NJ.
References for breastfeeding information
- "Product Information. Claritin (Loratadine (Trimed Flu))." Schering Laboratories, Kenilworth, NJ.
- Hilbert J, Radwanski E, Affrime MB, Perentesis G, Symchowicz S, Zampaglione N "Excretion of Loratadine (Trimed Flu) in human breast milk." J Clin Pharmacol 28 (1988): 234-9
Pregnancy of Paracetamol (Trimed Flu) in details
During pregnancy patients should avoid prolonged use of Paracetamol (Trimed Flu) Zodley Pharmaceuticals because the risk of addiction in the fetus and the occurrence of withdrawal in the neonatal period.
If necessary using in lactation (breastfeeding) should be aware that tramadol in small amounts excreted in breast milk. In the case of long-term treatment can not been excluded the possibility of drug dependence.
Paracetamol (Trimed Flu) Zodley Pharmaceuticals is not recommended for treatment of withdrawal syndrome drugs.
Patients need to avoid combination with MAO inhibitors.
During the period of treatment with Paracetamol (Trimed Flu) Zodley Pharmaceuticals you should avoid to take alcohol.
Tramadol in the form of long-acting formulations should not be used in children under the age of 14 years.
During the period of tramadol using is not recommended to engage in activities that require special attention, speed of psychomotor reactions.
Pregnancy of Pseudoephedrine (Trimed Flu) in details
Use of Pseudoephedrine (Trimed Flu) during the first trimester may be associated with a possible risk of gastroschisis, small intestinal atresia, and hemifacial microsomia due to Pseudoephedrine (Trimed Flu)'s vasoconstrictive effects; additional studies are needed to define the magnitude of risk. Single doses of Pseudoephedrine (Trimed Flu) were not found to adversely affect the fetus during the third trimester of pregnancy (limited data); however, fetal tachycardia was noted in a case report following maternal use of an extended release product for multiple days. Decongestants are not the preferred agents for the treatment of rhinitis during pregnancy.
Oral Pseudoephedrine (Trimed Flu) should be avoided during the first trimester.
Pseudoephedrine (Trimed Flu) breastfeeding
Based on limited data, it has been estimated that 0.5% to 0.7% of the mother's dose is excreted into breast milk over 24 hours. In 1 study, irritability was reported in up to 20% of infants. A 24% mean decrease in milk production was observed after a single 60 mg dose in 8 nursing mothers.
Caution is recommended Excreted into human milk: Yes Comments: -Single doses are unlikely to harm a nursing infant, but may cause irritability or disturbed sleep. -Repeated doses may interfere with lactation in mothers who are having difficulties producing sufficient milk or in those whose lactation is not well established.
See references
References for pregnancy information
- Werler MM, Mitchell AA, Shapiro S "First trimester maternal medication use in relation to gastroschisis." Teratology 45 (1992): 361-7
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
- Cerner Multum, Inc. "Australian Product Information." O 0
- Smith CV, Rayburn WF, Anderson JC, Duckworth AF, Appel LL "Effect of a single dose of oral Pseudoephedrine (Trimed Flu) on uterine and fetal Doppler blood flow." Obstet Gynecol 76 (1990): 803-6
References for breastfeeding information
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
References
- DailyMed. "PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "LORATADINE; PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Pseudoephedrine (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
