Trimidex Uses

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What is Trimidex?

Trimidex is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Trimidex is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Trimidex is also used to treat skin hives and itching in people with chronic skin reactions.

Trimidex may also be used for purposes not listed in this medication guide.

Trimidex indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Treatment of seasonal allergic rhinitis, perennial rhinitis, urticaria, allergic dermatologic disorders, angioedema and conjunctivitis. Trimidex is generally considered to be ineffective in asthma.

Acute anaphylaxis should be treated with adrenaline; Trimidex and corticosteroids are given to prevent relapse.

Trimidex is also used to control the pruritus associated with skin disorders eg, atopic eczema.

How should I use Trimidex?

Use Trimidex orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Trimidex orally disintegrating tablets.

Uses of Trimidex in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This medication is an antihistamine that treats symptoms such as itching, runny nose, watery eyes, and sneezing from "hay fever" and other allergies. It is also used to relieve itching from hives.

Trimidex does not prevent hives or prevent/treat a serious allergic reaction (e.g., anaphylaxis). Therefore, if your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use Trimidex in place of your epinephrine.

If you are self-treating with this medication, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist.

Do not use this medication in children younger than 6 years unless directed by the doctor.

How to use Trimidex

If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor or the product package, usually once or twice a day. Remove the tablet from its foil pack immediately before taking and place the tablet on the tongue. It will dissolve quickly. You may swallow the dissolved medication with or without water. Dosage is based on your age, condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.

Tell your doctor if your allergy symptoms do not improve after 3 days of treatment or if your hives last more than 6 weeks. Seek immediate medical attention if your condition worsens or you think you have a serious medical problem (e.g., very serious allergic reaction/anaphylaxis).

Trimidex description


Trimidex competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. Trimidex's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease.

Trimidex dosage

Trimidex Dosage

Applies to the following strength(s): 10 mg; 5 mg/5 mL; 5 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Allergic Rhinitis

10 mg orally once a day

Usual Adult Dose for Urticaria

10 mg orally once a day

Usual Pediatric Dose for Allergic Rhinitis

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)

Usual Pediatric Dose for Urticaria

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)

Renal Dose Adjustments

CrCl less than 30 mL/min: administer dosage every other day initially

Liver Dose Adjustments

Liver failure: administer dosage every other day initially


Trimidex is not significantly removed by hemodialysis, thus supplementary dosing is not required following hemodialysis.

More about Trimidex

Consumer resources

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Related treatment guides

Trimidex interactions

See also:
What other drugs will affect Trimidex?


Trimidex (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of Trimidex and/or descarboethoxyloratadine were observed following coadministration of Trimidex with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of Trimidex, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of Trimidex relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.

TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Trimidex and Descarboethoxyloratadine After 10 Days of Coadministration (Trimidex 10 mg) in Normal Volunteers
Trimidex Descarboethoxyloratadine
Erythromycin (500 mg q8h) + 40% +46%
Cimetidine (300 mg qid) +103% + 6%
Ketoconazole (200 mg q12h) +307% +73%

Trimidex side effects

See also:
What are the possible side effects of Trimidex?

Applies to Trimidex: oral fixed-combination tablets, oral orally disintegrating tablets, oral solution, oral tablets

Side effects include:

Children 2–5 years of age receiving oral solution: Diarrhea, epistaxis, pharyngitis, flu-like symptoms, fatigue, stomatitis, tooth disorder, earache, viral infection, rash.

Children 6–12 years of age receiving oral solution: Nervousness, wheezing, fatigue, hyperkinesia, abdominal pain, conjunctivitis, dysphonia, upper respiratory tract infection.

Adults and children ≥12 years of age receiving conventional or orally disintegrating tablets: Headache, somnolence, fatigue, dry mouth.

Fixed combination Trimidex (the active ingredient contained in Trimidex Reditab) pseudoephedrine sulfate preparations: Insomnia, dry mouth, headache, somnolence, nervousness, dizziness, fatigue.

Trimidex contraindications

See also:
What is the most important information I should know about Trimidex?

Do NOT use Trimidex if:

you are allergic to any ingredient in Trimidex

Contact your doctor or health care provider right away if any of these apply to you.

Active ingredient matches for Trimidex:

Loratadine in Mexico.

Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Loratadine 10 mg

List of Trimidex substitutes (brand and generic names):

U Chu Loratadine 10 mg x 20 Tablet
Ubitlor 10 mg Tablet (Ubit Pharmaceuticals Pvt Ltd)$ 0.04
Uradine 10 mg x 3 Blister x 10 Tablet
Urtilar 10 mg x 50's$ 21.08
Vaco Loratadine 10 mg x 10 Blister x 10 Tablet
Vaco Loratadine 10 mg x 1 Bottle 100 Tablet
Drops; Oral; Loratadine 1 mg / ml (Rayere)
Solution; Oral; Loratadine 5 mg / 5 ml (Rayere)
Tablet; Oral; Loratadine 10 mg (Rayere)
Tablet; Oral; Loratadine (Mann)
Winatin 10 mg x 10 x 10's (Ifars)$ 9.90
WINDLORA 10MG TABLET 1 strip / 10 tablets each (Windlas Biotech Ltd)$ 0.46
WINDLORA 5MG SYRUP 1 bottle / 30 ML syrup each (Windlas Biotech Ltd)$ 0.29
Windlora 5mg Syrup (Windlas Biotech Ltd)$ 0.29
10 mg x 100's (Arlak Biotech Pvt Ltd)$ 0.71
Wylor 10 mg Tablet (Arlak Biotech Pvt Ltd)$ 0.07
Wylor 10mg TAB / 100 (Arlak Biotech Pvt Ltd)$ 0.71
WYLOR tab 10 mg x 10's (Arlak Biotech Pvt Ltd)$ 0.71
Wylor 10mg TAB / 100 (Arlak Biotech Pvt Ltd)$ 0.71
Xepalodin 10 mg x 5 x 10's
Xepalodin 5 mg/5 mL x 60 mL x 1's


  1. DailyMed. "LORATADINE; PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "loratadine". (accessed September 17, 2018).
  3. DrugBank. "loratadine". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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