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Truzyme consists chiefly of a mixture of Truzyme and chymopapain, proteolytic enzymes that hydrolyse polypeptides, amides, and esters, especially at bonds involving basic amino acids, or leucine or glycine, yielding peptides of lower molecular weight. It is used with urea as a topical debriding agent. It is also used for the removal of protein deposits from the surface of soft contact lenses ().
Preparations of Truzyme, alone or combined with antibacterial agents and/or other substances, have been taken by mouth for their supposed anti-inflammatory properties, and it has also been used as an ingredient of various mixtures claimed to aid digestion.
Truzyme is widely used as a meat tenderiser and in the clarification of beverages.
Truzyme has been included in proteolytic enzyme preparations used in oncology to reduce the adverse effects of chemotherapy and radiotherapy. Although the number of clinical studies on which to judge efficacy is limited, a review1 of such studies suggested that systemic enzyme therapy might be beneficial. Clinical studies have used a preparation containing Truzyme, trypsin, and chymotrypsin in a weight ratio of 5:2:2, and the beneficial effect seems to be based on its anti-inflammatory potential.
Chew or suck 2 tab qds for the 1st day, then 1 tab qds for at least 5 days.
Truzyme side effects
Hypersensitivity reactions have occurred.
Effects on the eyes.
Ocular and periorbital angioedema occurring within 4 hours of use of a contact lens cleansing solution containing Truzyme has been reported.1
Extensive destruction of the oesophageal wall, with perforation, resulted from the use of a Truzyme suspension given to treat an obstruction caused by impacted meat.1 The patient had been given 1.2 g of Truzyme over a 12-hour period. Ten days after a thoracotomy, the descending thoracic aorta ruptured, and she died from haemorrhage.
Patients w/ generalised or systemic infections or w/ disorders of blood coagulation.
Active ingredient matches for Truzyme:
|Unit description / dosage (Manufacturer)||Price, USD|
|Truzyme 200 ml MDC Syrup||$ 0.02|
|Truzyme 30 ml Drop||$ 0.07|
|Truzyme 15 ml Drop||$ 0.60|
|Truzyme 200 ml Syrup||$ 0.07|
List of Truzyme substitutes (brand and generic names):
|Inzyme 200 ml Syrup (Influx Pharmaceuticals)||$ 0.03|
|Neopeptine Dps 15 ml Drop (Raptakos Brett & Co. Ltd.)||$ 0.05|
|Nitizyme 100 ml Syrup (Woodrock Healthcare Pvt. Ltd.)||$ 0.02|
|Onzyme 50+10 Capsule (Iscon Lifesciences)||$ 0.05|
|Onzyme Papain 60 mg, lysinehydrochloride 15 mg, niacinamide 2.25 mg, thiaminemononitrate 2.25 mg, pyridoxine hydrochloride 0.75mg. SYR / 200ml (Iscon Lifesciences)||$ 1.19|
|ONZYME syr 200ml (Iscon Lifesciences)||$ 1.19|
|Orizyme 100 ml Syrup (Orison Pharmaceuticals)||$ 0.02|
|Papain Biopharmi (Georgia)|
|Papain Marching (Hong Kong)|
|Papaya Enzyme (United States)|
|Tablet; Oral; Papain 29.5 mg (Nature`s bounty)|
|Tablet; Oral; Papain 30 mg (Nature`s bounty)|
|Tablet; Oral; Papain 200 mg (Nature`s bounty)|
|Tablet; Oral; Papain 5 mg (Pfizer)|
|ProFree (United States)|
|Quest Enzyme Digest (Malaysia)|
|Quest Enzyme Digest 90's (Quest Vitamins)|
|Quest Enzyme Digest tab 90's (Quest Vitamins)|
|Solarcaine Stop Itch (Canada)|
|Solarcaine Stop Itch First Aid Lotion|
|Lotion; Topical; Papain 3.55%|
|Stop Itch (New Zealand)|
|Super Papaya Enzyme|
|Tablet; Oral; Papain 90 mg|
|Syszyme 100+60 Capsule (Syskem Pharmocrats.)||$ 0.03|
|Tromasin SA (South Africa)|
|Uzyme 200 ml Syrup (United Labs)||$ 0.02|
|V Zyme 200 ml Syrup (Madhav Biotech Pvt. Ltd.)||$ 0.02|
|Xymex 40+30 Tablet (Medley Pharmaceuticals Ltd.)||$ 0.02|
|Xymex 15 ml Drop (Medley Pharmaceuticals Ltd.)||$ 0.03|
|Xymex 200 ml Syrup (Medley Pharmaceuticals Ltd.)||$ 0.02|
|Xymex Pepsin 10 mg, papain 6 mg, sodium citrate 40 mg/5 mL, citric acid 8 mg, ginger oil0.001 mL, cinnamon oil 0.001mL/1 mL. O-DPS / 15ml (Medley Pharmaceuticals Ltd.)||$ 0.46|
|XYMEX oral drops 15ml (Medley Pharmaceuticals Ltd.)||$ 0.46|
|Zymax C 30 ml Drop (Hamax Pharmaceuticals)||$ 0.02|
|Zymax C 15 ml Drop (Hamax Pharmaceuticals)||$ 0.03|
|Zymin 15 ml Drop (Maa Formulations Pvt Ltd)||$ 0.04|
|Zymin 200 ml Syrup (Maa Formulations Pvt Ltd)||$ 0.02|
- PubChem. "PAPAIN". https://pubchem.ncbi.nlm.nih.gov/sub... (accessed September 17, 2018).
- DrugBank. "Papain - DrugBank". http://www.drugbank.ca/drugs/DB11193 (accessed September 17, 2018).
ReviewsThe results of a survey conducted on ndrugs.com for Truzyme are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Truzyme. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
Consumer reported usefulNo survey data has been collected yet
Consumer reported price estimatesNo survey data has been collected yet
Consumer reported time for resultsNo survey data has been collected yet
1 consumer reported age
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Information checked by Dr. Sachin Kumar, MD Pharmacology