Pregnancy of Chlorpheniramine maleate (Tuzalos) in details
Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Chlorpheniramine maleate (Tuzalos) breastfeeding
When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!
There are no data on the excretion of Chlorpheniramine maleate (Tuzalos) into human milk. However, because other antihistamines are excreted into human milk in low concentrations, the manufacturer recommends that caution be used when administering Chlorpheniramine maleate (Tuzalos) to nursing women.
See references
References for pregnancy information
"Product Information. Chlortrimeton (Chlorpheniramine maleate (Tuzalos))." Schering-Plough, Liberty Corner, NJ.
Black RA, Hill DA "Over-the-counter medications in pregnancy." Am Fam Physician 67 (2003): 2517-24
Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
Nelson MA, Forfar JO "Associations between drugs administered during pregnancy and congenital abnormalities of the fetus." Br Med J 1 (1971): 523-7
References for breastfeeding information
"Product Information. Chlortrimeton (Chlorpheniramine maleate (Tuzalos))." Schering-Plough, Liberty Corner, NJ.
Pregnancy of Dextromethorphan HBr (Tuzalos) in details
Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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During pregnancy (especially in the I trimester) and lactation (breastfeeding) Dextromethorphan HBr (Tuzalos) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.
Dextromethorphan HBr (Tuzalos) breastfeeding
When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!
There are no data on the excretion of Dextromethorphan HBr (Tuzalos) into human milk.
Based on the low molecular weight of Dextromethorphan HBr (Tuzalos) some passage into breast milk probably occurs. However, maternal use of Dextromethorphan HBr (Tuzalos) products that do not contain alcohol are probably safe to use during breast-feeding.
See references
References for pregnancy information
Debus O, Kurlemann G, Gehrmann J, Krasemann T "Dextromethorphan HBr (Tuzalos) in pregnancy." Chest 120 (2001): 1038-40
Andaloro VJ, Monaghan DT, Rosenquist TH "Dextromethorphan HBr (Tuzalos) and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model." Pediatr Res 43 (1998): 1-7
Einarson A, Lyszkiewicz D, Koren G "The safety of Dextromethorphan HBr (Tuzalos) in pregnancy - Results of a controlled study." Chest 119 (2001): 466-9
Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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During pregnancy patients should avoid prolonged use of Paracetamol (Tuzalos) Zodley Pharmaceuticals because the risk of addiction in the fetus and the occurrence of withdrawal in the neonatal period.
If necessary using in lactation (breastfeeding) should be aware that tramadol in small amounts excreted in breast milk. In the case of long-term treatment can not been excluded the possibility of drug dependence.
Paracetamol (Tuzalos) Zodley Pharmaceuticals is not recommended for treatment of withdrawal syndrome drugs.
Patients need to avoid combination with MAO inhibitors.
During the period of treatment with Paracetamol (Tuzalos) Zodley Pharmaceuticals you should avoid to take alcohol.
Tramadol in the form of long-acting formulations should not be used in children under the age of 14 years.
During the period of tramadol using is not recommended to engage in activities that require special attention, speed of psychomotor reactions.
Pregnancy of Phenylpropanolamine HCl (Tuzalos) in details
Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
In a review of deliveries to Michigan Medicaid patients during 1980 to 1983, 1489 exposures to Phenylpropanolamine HCl (Tuzalos) any time during pregnancy were recorded. A total of 128 birth defects were reported (91 expected). An association was seen between Phenylpropanolamine HCl (Tuzalos) and laryngotracheal anomalies, pyloric stenosis, intestinal fixation anomalies, upper limb defects, skull/face anomalies, and musculoskeletal defects. The statistical significance of these associations is not known. (written communication, Franz Rosa, MD, Food and Drug Administration, 1994). The Collaborative Perinatal Project monitored 50,282 mother-child pairs and recorded 726 first-trimester exposures and 2489 exposures to Phenylpropanolamine HCl (Tuzalos) anytime during pregnancy. Possible associations between Phenylpropanolamine HCl (Tuzalos) and first trimester use and Phenylpropanolamine HCl (Tuzalos) include hypospadias (4), eye and ear abnormalities (7, statistically significant), polydactyly (6), cataract (3), and pectus excavatum (7). For use anytime during pregnancy a possible association was noted between Phenylpropanolamine HCl (Tuzalos) use and congenital dislocation of hip (12).
Phenylpropanolamine HCl (Tuzalos) has been assigned to pregnancy category C. There are no controlled data in human pregnancy. Phenylpropanolamine HCl (Tuzalos) should only be used during pregnancy when benefit outweighs the risk to the fetus.
See references
Phenylpropanolamine HCl (Tuzalos) breastfeeding
When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!
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There are no data on the excretion of Phenylpropanolamine HCl (Tuzalos) into human milk.
See references
References for pregnancy information
Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
References for breastfeeding information
"Product Information. Dexatrim (Phenylpropanolamine HCl (Tuzalos))." Thompson Medical Company Inc, West Palm Beach, FL.
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References
DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
DailyMed. "DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
PubMed Health. "Vicks 44 Cough Relief: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
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