Uospan Uses

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What is Uospan?

Uospan is an anticholinergic medicine. Uospan has many effects in the body including decreasing the secretion of fluids, slowing the stomach and intestines, and dilation of the pupils.

Uospan is used to relieve nausea, vomiting, and dizziness associated with motion sickness and recovery from anesthesia and surgery. Uospan may also be used in the treatment of parkinsonism, spastic muscle states, irritable bowel syndrome, diverticulitis, and other conditions.

Uospan may also be used for purposes other than those listed in this medication guide.

Uospan indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Uospan transdermal system is indicated in adults for the prevention of:

nausea and vomiting associated with motion sickness.
post-operative nausea and vomiting (PONV) associated with recovery from anesthesia and/or opiate analgesia and surgery.

How should I use Uospan?

Use Uospan drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Uospan drops.

Uses of Uospan in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is used to widen the pupils for eye examination or eye surgery. It is also used to decrease pain and swelling from an inflammation of the eye (iridocyclitis). It belongs to a class of drugs known as anticholinergics. Uospan works by blocking the effects of a certain natural chemical (acetylcholine) on certain eye muscles, causing relaxation of these muscles. This effect causes the pupil to widen and the lens to temporarily lose the ability to focus. Uospan decreases pain in eye inflammation by relaxing the eye muscles.

How to use Uospan ophthalmic

If you are using this medication for eye inflammation, apply it to the eye up to 3 or 4 times a day or as directed by your doctor. If you are using this medication to widen the pupil, it is usually applied in the eye 1 hour before the procedure/exam or as directed by your doctor. This medication is for use in the eye only. Do not take by mouth or inject.

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

If you are wearing contact lenses, remove them before using these eye drops. Ask your doctor when you can start wearing your contact lenses again.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place 1 drop into the pouch as directed by your doctor. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure for 2 to 3 minutes. This will prevent the medication from draining away from the eye and will also help reduce side effects. Try not to blink and do not rub your eye. Repeat these steps if your dose is for more than 1 drop or for your other eye if so directed. Wash your hands after applying eye drops.

If you are applying eye drops into a child's eyes, wash your hands and the child's hands afterwards. Be careful not to get any drops in the child's mouth.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), ask your doctor if you should continue to use them with this medication and when you should start them again. Use eye drops before eye ointments to allow the drops to enter the eye.

If you have been directed to use this medicine more than 1 time (e.g., for eye inflammation), use it regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. Continue using it for the full time prescribed.

This medication starts to work in minutes, and its effect usually lasts for several days or sometimes longer. Tell your doctor if you continue to have blurred vision, sensitivity to light, or widened pupils 1 week after your exam. If you are treating inflammation, tell your doctor if your condition does not improve or if it worsens.

Uospan description

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An alkaloid from Solanaceae, especially Datura metel L. and Scopola carniolica. Uospan Hydrobromide Trihydrate and its quaternary derivatives act as antimuscarinics like atropine, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in urinary incontinence, in motion sickness, as an antispasmodic, and as a mydriatic and cycloplegic.

Uospan dosage

Uospan Dosage

Applies to the following strength(s): 1.5 mg; 1 mg/mL; 0.4 mg/mL; 0.4 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Nausea/Vomiting

General antiemetic use: 0.3 to 0.65 mg administered IV, intramuscularly or subcutaneously every 6 to 8 hours as needed.

Post-operative nausea and vomiting use: apply one Uospan 1.5 mg transdermal disc behind the ear the evening before the scheduled surgery. The disc should remain in place for 24 hours after surgery before discarding.

If using Uospan transdermal on an obstetrics patient, apply the disc one hour prior to scheduled Cesarean section to limit exposure to the infant.

Usual Adult Dose for Motion Sickness

Apply one Uospan 1.5 mg transdermal disc behind the ear at least 4 hours prior to exposure every 3 days as needed.

Usual Adult Dose for Parkinsonian Tremor

0.4 to 0.8 mg orally every 8 hours as needed.

Usual Pediatric Dose for Nausea/Vomiting

1 to 12 years: 6 mcg/kg/dose (maximum dose: 0.3 mg/dose) administered IV, IM or subcutaneous every 6 to 8 hours as needed.

Usual Pediatric Dose for Motion Sickness

Greater than 12 years: apply one Uospan 1.5 mg transdermal disc behind the ear at least 4 hours prior to exposure every 3 days as needed.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

As with other anticholinergic agents, Uospan is contraindicated for patients with angle-closure glaucoma, prostatic hypertrophy, and pyloric obstruction. It should not be administered to patients with impaired hepatic or renal function.

Uospan may cause drowsiness, confusion, and disorientation. The elderly may be particularly sensitive to these effects. All patients should be cautioned against engaging in activities which require mental alertness, such as driving or operating dangerous machinery, while using the Uospan transdermal patch. The concomitant use of alcohol or other agents possessing CNS depressant activity should be avoided if possible.

Uospan may aggravate seizures (although this association has been disputed) and psychoses and should be used cautiously in patients with a history of such disorders.

Use with caution in patients with cardiac disease and in the elderly.

The safety and efficacy of Uospan in children have not been determined.

Dialysis

Data not available

Other Comments

Uospan transdermal patches contain residual drug when removed after being applied for 72 hours. Patients should wash their hands well with soap and water to prevent accidental transfer of Uospan to eyes or mucosal surfaces. Once removed, the patch should be folded against itself such that the adhesive side containing residual drug is not accessible.

Only one transdermal patch should be on the patient at any given time during therapy; remove the used disc prior to placing a fresh disc on the skin.

More about Uospan

Consumer resources

Professional resources

Related treatment guides

Uospan interactions

See also:
What other drugs will affect Uospan?

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The absorption of oral medications may be decreased during the concurrent use of Uospan because of decreased gastric motility and delayed gastric emptying.

Uospan Hydrobromide Trihydrate should be used with care in patients taking other drugs that are capable of causing CNS effects such as sedatives, tranquilizers, or alcohol. Special attention should be paid to potential interactions with drugs having anticholinergic properties; e.g., other belladonna alkaloids, antihistamines (including meclizine), tricyclic antidepressants, and muscle relaxants.

Laboratory Test Interactions

Uospan Hydrobromide Trihydrate will interfere with the gastric secretion test.

Uospan side effects

See also:
What are the possible side effects of Uospan?

Applies to Uospan: transdermal patch extended release

In addition to its needed effects, some unwanted effects may be caused by Uospan (the active ingredient contained in Uospan). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Uospan:

Incidence not known:

If any of the following symptoms of overdose occur while taking Uospan, get emergency help immediately:

Symptoms of overdose:

Uospan contraindications

See also:
What is the most important information I should know about Uospan?

Hypersensitivity to Uospan, belladonna alkaloids or derivatives, or any other ingredients of Uospan.

Tablet: Patients with glaucoma, toxic megacolon (a very enlarged bowel), myasthenia gravis (a rare muscle wasting disease), obstructive prostatic hyperthropy (enlarged and blocked prostate), porphyria (hereditary blood disorder).

Patients who are pregnant, likely to become pregnant or breastfeeding, and children <6 years should not take Uospan.

Injection: Patients with porphyria, untreated angle-closure glaucoma, prostatic enlargement, myasthenia gravis, and severe ulcerative colitis, or toxic megacolon, tachycardia; acute hemorrhage whose cardiovascular status is unstable; stomach or bowel obstruction, or in conditions where there is reduced bowel activity (eg, pyloroduodenal stenosis, achalasia), paralytic ileus or intestinal atony.

Uospan injection should not be given IM in patients being treated with anticoagulant therapy. Subcutaneous or IV routes may be used in these patients instead.



Active ingredient matches for Uospan:

Scopolamine in Thailand.

Hyoscine-N-butylbromide in Thailand.


Unit description / dosage (Manufacturer)Price, USD
Uospan 10 mg x 50 x 10's
Uospan 10 mg x 1, 000's

List of Uospan substitutes (brand and generic names):

Tablet; Oral; Scopolamine Hydrobromide 0.3 mg (Boots)
U-Oscine Injection 20 mg/1 mL x 1 mL x 50's
U-Oscine 10 mg x 100 x 10's
U-Oscine 10 mg x 1, 000's
Unimed Buscosin 20 mg/2 mL x 10 tube
Vacopan 10 mg x 500's (Atlantic Lab)
Vacopan 20 mg/1 mL x 50's (Atlantic Lab)
Vacopan 20 mg/1 mL x 10's (Atlantic Lab)
Vacopan 20 mg/1 mL x 1 mL x 50's (Atlantic Lab)
Vacopan inj 20 mg/mL 50 x 1's (Atlantic Lab)
Vacopan tab 10 mg 500's (Atlantic Lab)
Vellios / amp 20 mg/1 mL x 5's$ 7.75
Vesuton 10 mg x 1000's
Vesuton 10 mg x 100 x 10's
Vhesyn / amp 20 mg/1 mL x 1 mL x 10's
We-Wang 2 mg
Weiernin 2 mg
Weilin 2 mg
XSPAS Injection / 20mg per ml / 1ml units (Neon Laboratories Ltd)$ 0.11
Xspas 20mg INJ / 1ml (Neon Laboratories Ltd)$ 0.11
20 mg x 1ml (Neon Laboratories Ltd)$ 0.11
Xspas 20 mg Injection (Neon Laboratories Ltd)$ 0.16
Xspas 250 mg Injection (Neon Laboratories Ltd)$ 1.89
XSPAS inj 20 mg x 1ml (Neon Laboratories Ltd)$ 0.11
Xspas 20mg INJ / 1ml (Neon Laboratories Ltd)$ 0.11
Xspas 10mg Tablet (Neon Laboratories Ltd)$ 0.05
Xspas Tablet 10 mg x 100's

References

  1. DailyMed. "SCOPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "scopolamine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "scopolamine". http://www.drugbank.ca/drugs/DB00747 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Uospan are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Uospan. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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1 consumer reported age

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100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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