V-Penum Dosage

How times a day do you take this medicine?
sponsored

Dosage of V-Penum in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
sponsored

V-Penum Dosage

Generic name: V-Penum 1g in 30mL

Dosage form: injection

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Adult Patients

The recommended dose of V-Penum I.V. is 500 mg given every 8 hours for skin and skin structure infections and 1 gram given every 8 hours for intra-abdominal infections. When treating complicated skin and skin structure infections caused by P.aeruginosa, a dose of 1 gram every 8 hours is recommended.

V-Penum I.V. should be administered by intravenous infusion over approximately 15 minutes to 30 minutes. Doses of 1 gram may also be administered as an intravenous bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes.

Use in Adult Patients with Renal Impairment

Dosage should be reduced in patients with creatinine clearance of 50 mL/min or less.

When only serum creatinine is available, the following formula (Cockcroft and Gault equation)5 may be used to estimate creatinine clearance.

Males: Creatinine Clearance (mL/min) =

Weight (kg) x (140 - age)

72 x serum creatinine (mg/dL)

Females: 0.85 x above value

Recommended V-Penum I.V. Dosage Schedule for Adult Patients with Renal Impairment

Creatinine Clearance (mL/min)

Dose (dependent on type of infection)

Dosing Interval

Greater than 50

Recommended dose (500 mg cSSSI and 1 gram Intra-abdominal)

Every 8 hours

Greater than 25-50

Recommended dose

Every 12 hours

10-25

One-half recommended dose

Every 12 hours

Less than 10

One-half recommended dose

Every 24 hours

There is inadequate information regarding the use of V-Penum I.V. in patients on hemodialysis or peritoneal dialysis.

Use in Pediatric Patients

Pediatric Patients 3 Months of Age and Older

For pediatric patients 3 months of age and older, the V-Penum I.V. dose is 10 mg/kg, 20 mg/kg or 40 mg/kg every 8 hours (maximum dose is 2 grams every 8 hours), depending on the type of infection (complicated skin and skin structure, intra-abdominal or meningitis). See dosing table below. Pediatric patients weighing over 50 kg should be administered V-Penum I.V. at a dose of 500 mg every 8 hours for complicated skin and skin structure infections, 1 gram every 8 hours for intra-abdominal infections and 2 grams every 8 hours for meningitis. V-Penum I.V. should be given as intravenous infusion over approximately 15 minutes to 30 minutes or as an intravenous bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes.

There is limited safety data available to support the administration of a 40 mg/kg (up to a maximum of 2 grams) bolus dose.

Recommended V-Penum I.V. Dosage Schedule for Pediatric Patients 3 Months of Age and Older with Normal Renal Function

Type of Infection

Dose (mg/kg)

Up to a Maximum Dose

Dosing Interval

Complicated skin and skin structure

10

500 mg

Every 8 hours

Intra-abdominal

20

1 gram

Every 8 hours

Meningitis

40

2 grams

Every 8 hours

There is no experience in pediatric patients with renal impairment.

When treating complicated skin and skin structure infections caused by P. aeruginosa, a dose of 20 mg/kg (or 1 gram for pediatric patients weighing over 50 kg) every 8 hours is recommended.

Pediatric Patients Less Than 3 Months of Age

For pediatric patients (with normal renal function) less than 3 months of age, with intra-abdominal infections, the V-Penum I.V. dose is based on gestational age (GA) and postnatal age (PNA). See dosing table below. V-Penum I.V. should be given as intravenous infusion over 30 minutes.

Recommended V-Penum I.V. Dosage Schedule for Pediatric Patients Less than 3 Months of Age with Complicated Intra-Abdominal Infections and Normal Renal Function

Age Group

Dose (mg/kg)

Dose Interval

Infants less than 32 weeks GA and PNA less than 2 weeks

20

Every 12 hours

Infants less than 32 weeks GA and PNA 2 weeks and older

20

Every 8 hours

Infants 32 weeks and older GA and PNA less than 2 weeks

20

Every 8 hours

Infants 32 weeks and older GA and PNA 2 weeks and older

30

Every 8 hours

There is no experience in pediatric patients with renal impairment.

Preparation of Solution

For

Intravenous Bolus Administration

Constitute injection vials (500 mg and 1 gram) with sterile Water for Injection. Shake to dissolve and let stand until clear.

Vial Size

Amount of Diluent Added (mL)

Approximate Withdrawable Volume

(mL)

Approximate Average Concentration (mg/mL)

500 mg

10

10

50

1 gram

20

20

50

For Infusion

Infusion vials (500 mg and 1 gram) may be directly constituted with a compatible infusion fluid. Alternatively, an injection vial may be constituted, then the resulting solution added to an intravenous container and further diluted with an appropriate infusion fluid.

WARNING: Do not use flexible container in series connections.

Compatibility

Compatibility of V-Penum I.V. with other drugs has not been established. V-Penum I.V. should not be mixed with or physically added to solutions containing other drugs.

Stability and Storage

Freshly prepared solutions of V-Penum I.V. should be used. However, constituted solutions of V-Penum I.V. maintain satisfactory potency under the conditions described below. Solutions of intravenous V-Penum I.V. should not be frozen.

Intravenous Bolus Administration

V-Penum I.V. injection vials constituted with sterile Water for Injection for bolus administration (up to 50 mg/mL of V-Penum I.V.) may be stored for up to 3 hours at up to 25oC (77oF) or for 13 hours at up to 5oC (41oF).

Intravenous Infusion Administration

Solutions prepared for infusion (V-Penum I.V. concentrations ranging from 1 mg/mL to 20 mg/mL) constituted with Sodium Chloride Injection 0.9% may be stored for 1 hour at up to 25oC (77oF) or 15 hours at up to 5oC (41oF).

Solutions prepared for infusion (V-Penum I.V. concentrations ranging from 1 mg/mL to 20 mg/mL) constituted with Dextrose Injection 5% should be used immediately.

NOTE:

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

More about V-Penum (V-Penum)

Consumer resources

Professional resources

Related treatment guides

What other drugs will affect V-Penum?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with V-Penum, especially:

This list is not complete. Other drugs may interact with V-Penum, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

V-Penum interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug V-Penum, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
sponsored

Probenecid competes with V-Penum for active tubular secretion and thus inhibits the renal excretion, with the effect of increasing the elimination half-life and plasma concentration of V-Penum. As the potency and duration of action of V-Penum dosed without probenecid are adequate, the co-administration of probenecid with V-Penum is not recommended.

The potential effect of V-Penum on the protein-binding of other drugs or metabolism has not been studied. The protein binding of V-Penum is low (approximately 2%) and, therefore, no interactions with other compounds based on displacement from plasma proteins would be expected.

V-Penum may reduce serum valproic acid levels. Subtherapeutic levels may be reached in some patients.

V-Penum has been administered concomitantly with other medications without adverse pharmacological interactions. However, no specific data regarding potential drug interactions is available (apart from probenecid as previous;y mentioned).

Decreases in blood levels of valproic acid have been reported when it is co-administered with carbapenem agents resulting in a 60-100% decrease in valproic acid levels in about 2 days. Due to the rapid onset and the extent of the decrease, co-administration of V-Penum in patients stabilised on valproic acid is not considered to be manageable and therefore should be avoided.

Oral Anticoagulants:

Simultaneous administration of antibiotics with warfarin may augment its anticoagulant effects. There have been many reports of increases in the anticoagulant effects of orally administered anticoagulant agents, including warfarin in patients who are concomitantly receiving antibacterial agents. The risk may vary with the underlying infection, age and general status of the patient so that the contribution of the antibiotic to the increase in international normalised ratio (INR) is difficult to assess. It is recommended that the INR should be monitored frequently during and shortly after co-administration of antibiotics with an oral anticoagulant agent.

Incompatibilities: V-Penum must not be mixed with other medicinal products except those mentioned in Cautions for Usage.


sponsored

References

  1. DailyMed. "CILASTATIN SODIUM; IMIPENEM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "MEROPENEM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. DailyMed. "CILASTATIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for V-Penum are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking V-Penum. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported frequency of use

How frequently do I need to take V-Penum?
It was reported by ndrugs.com website users that V-Penum should ideally be taken Twice in a day as the most common frequency of the V-Penum. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this V-Penum should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Users%
Twice in a day1
100.0%


Consumer reported doses

No survey data has been collected yet


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 30 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2022 ndrugs.com All Rights Reserved