Ve IC Dosage
Adult: Combined with cilastatin: (as anhydrous Ve IC) 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 min, and doses of 750 mg or 1 g over 40-60 min. Max: 4 g/day or 50 mg/kg.
Child: >40 kg: same as adult dose. Child >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Doses up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr. Max: >40 kg: 4 g/day or 50 mg/kg; <40 kg: 2 g/day.
Renal impairment: Max doses based on CrCl.
|CrCl (ml/min)||Dosage Recommendation|
|31-70||500 mg every 6-8 hr.|
|21-30||500 mg every 8-12 hr.|
|6-20||250 mg or 3.5 mg/kg (whichever is lower) every 12 hr.|
|≤5||Only give if haemodialysis is started within 48 hr.|
Prophylaxis of surgical infections
Adult: 1 g may be given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.
Mild to moderate susceptible infections
Adult: 500 or 750 mg every 12 hr.
Adult: 500 mg as a single dose.
Increased risk of seizures when used with ganciclovir. Ciclosporin may increase neurotoxicity of ifosfamide; ifosfamide may also raise serum levels of ciclosporin. Serum levels may be increased by uricosuric agents. May reduce efficacy of valproic acid; monitor.
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Information checked by Dr. Sachin Kumar, MD Pharmacology