Verospiron Uses

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What is Verospiron?

Verospiron is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.

Verospiron is also used to diagnose and treat hyperaldosteronism, a condition in which the adrenal gland produces too much hormone called aldosterone. Verospiron may also be used to treat fluid retention (edema) in patients with congestive heart failure, liver cirrhosis, or a kidney disorder called nephrotic syndrome.

Verospiron is a potassium-sparing diuretic (water pill). It prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Verospiron is also used to treat or prevent hypokalemia (low potassium levels in the blood).

Verospiron is available only with your doctor’s prescription.

Verospiron indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Verospiron (Verospiron) is indicated in the management of:

Primary hyperaldosteronism for:

Establishing the diagnosis of primary hyperaldosteronism by therapeutic trial.

Short-term preoperative treatment of patients with primary hyperaldosteronism.

Long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are judged to be poor operative risks or who decline surgery.

Long-term maintenance therapy for patients with bilateral micro or macronodular adrenal hyperplasia (idiopathic hyperaldosteronism).

Edematous conditions for patients with:

Congestive heart failure

For the management of edema and sodium retention when the patient is only partially responsive to, or is intolerant of, other therapeutic measures. Verospiron is also indicated for patients with congestive heart failure taking digitalis when other therapies are considered inappropriate.

Cirrhosis of the liver accompanied by edema and/or ascites

Aldosterone levels may be exceptionally high in this condition. Verospiron is indicated for maintenance therapy together with bed rest and the restriction of fluid and sodium.

Nephrotic syndrome

For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response.

Essential hypertension

Verospiron is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).

Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.

Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). These considerations may guide selection of therapy.

Usually in combination with other drugs, Verospiron is indicated for patients who cannot be treated adequately with other agents or for whom other agents are considered inappropriate.


For the treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate. Verospiron is also indicated for the prophylaxis of hypokalemia in patients taking digitalis when other measures are considered inadequate or inappropriate.

Severe heart failure (NYHA class III – IV)

To increase survival, and to reduce the need for hospitalization for heart failure when used in addition to standard therapy.

Usage in Pregnancy

The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developing toxemia.

Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy.

Verospiron is indicated in pregnancy when edema is due to pathologic causes just as it is in the absence of pregnancy (however, see Precautions: Pregnancy). Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is unsupported and unnecessary. There is hypervolemia during normal pregnancy which is not harmful to either the fetus or the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema, in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort that is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate.

How should I use Verospiron?

Use Verospiron as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Verospiron by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Verospiron may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Verospiron, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Verospiron.

Uses of Verospiron in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications

Ascites due to cirrhosis: Management of edema in cirrhosis of the liver unresponsive to fluid and sodium restriction.

Heart failure with reduced ejection fraction: To increase survival, manage edema, and reduce need for hospitalization in patients with heart failure with reduced ejection fraction and New York Heart Association class III to IV symptoms; usually administered in conjunction with other heart failure therapies.

Hypertension: Management of hypertension unresponsive to other therapies.

Primary hyperaldosteronism (tablet only): Short-term preoperative treatment of primary hyperaldosteronism; long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are not candidates for surgery; long-term maintenance therapy for bilateral micro- or macronodular adrenal hyperplasia (idiopathic hyperaldosteronism).

Off Label Uses

Acne vulgaris, females

Data from a limited number of patients in a small number of randomized, placebo-controlled trials suggest that Verospiron may be beneficial in the treatment of moderate to severe acne in women.

Post myocardial infarction, complicated by reduced ejection fraction

According to the ACCF/AHA guideline for the management of ST-elevation myocardial infarction and the AHA/ACC guideline for the management of non–ST-elevation acute coronary syndromes, an aldosterone antagonist should be given to post-myocardial infarction patients (without significant renal dysfunction) who are already on an angiotensin-converting enzyme inhibitor and beta-blocker, who have an LVEF ≤40%, and either symptomatic heart failure or diabetes mellitus.

Verospiron description


Verospiron is (1) Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone (7α,17α)-; (2) 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid, γ-lactone acetate.

Its empirical formula is C24H32O4S and molecular weight is 416.57.

Verospiron contains not <97% and not >103% of C24H32O4S, calculated on the dried basis.

Verospiron dosage

Primary Hyperaldosteronism

Verospiron may be employed as an initial diagnostic measure to provide presumptive evidence of primary hyperaldosteronism while patients are on normal diets.

Long Test

Verospiron is administered at a daily dosage of 400 mg for three to four weeks. Correction of hypokalemia and of hypertension provides presumptive evidence for the diagnosis of primary hyperaldosteronism.

Short Test

Verospiron is administered at a daily dosage of 400 mg for four days. If serum potassium increases during Verospiron administration but drops when Verospiron is discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered.

After the diagnosis of hyperaldosteronism has been established by more definitive testing procedures, Verospiron may be administered in doses of 100 to 400 mg daily in preparation for surgery. For patients who are considered unsuitable for surgery, Verospiron may be employed for long-term maintenance therapy at the lowest effective dosage determined for the individual patient.

Edema In Adults (Congestive Heart Failure, Hepatic Cirrhosis, Or Nephrotic Syndrome)

An initial daily dosage of 100 mg of Verospiron administered in either single or divided doses is recommended, but may range from 25 to 200 mg daily. When given as the sole agent for diuresis, Verospiron should be continued for at least five days at the initial dosage level, after which it may be adjusted to the optimal therapeutic or maintenance level administered in either single or divided daily doses. If, after five days, an adequate diuretic response to Verospiron has not occurred, a second diuretic that acts more proximally in the renal tubule may be added to the regimen. Because of the additive effect of Verospiron when administered concurrently with such diuretics, an enhanced diuresis usually begins on the first day of combined treatment; combined therapy is indicated when more rapid diuresis is desired. The dosage of Verospiron should remain unchanged when other diuretic therapy is added.

Essential Hypertension

For adults, an initial daily dosage of 50 to 100 mg of Verospiron administered in either single or divided doses is recommended. Verospiron may also be given with diuretics that act more proximally in the renal tubule or with other antihypertensive agents. Treatment with Verospiron should be continued for at least two weeks since the maximum response may not occur before this time. Subsequently, dosage should be adjusted according to the response of the patient.


Verospiron in a dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia, when oral potassium supplements or other potassium-sparing regimens are considered inappropriate.

Severe Heart Failure In Conjunction With Standard Therapy (NYHA Class III – IV)

Treatment should be initiated with Verospiron 25 mg once daily if the patient's serum potassium is ≤ 5.0 mEq/L and the patient's serum creatinine is ≤ 2.5 mg/dL. Patients who tolerate 25 mg once daily may have their dosage increased to 50 mg once daily as clinically indicated. Patients who do not tolerate 25 mg once daily may have their dosage reduced to 25 mg every other day. See WARNINGS: Hyperkalemia in patients with severe heart failure for advice on monitoring serum potassium and serum creatinine.

How supplied

Verospiron 25 mg tablets are round, light yellow, film-coated, with SEARLE and 1001 debossed on one side and Verospiron and 25 on the other side, supplied as:

NDC Number Size
0025-1001-31 bottle of 100

Verospiron 50 mg tablets are oval, light orange, scored, film-coated, with SEARLE and 1041 debossed on the scored side and Verospiron and 50 on the other side, supplied as:

NDC Number Size
0025-1041-31 bottle of 100

Verospiron 100 mg tablets are round, peach-colored, scored, film-coated, with SEARLE and 1031 debossed on the scored side and Verospiron and 100 on the other side, supplied as:

NDC Number Size
0025-1031-31 bottle of 100

Store below 77°F (25°C).

Distributed by : G.D. Searle, Division of Pfizer Inc., NY, NY 10017. Revised: 2014

Verospiron interactions

See also:
What other drugs will affect Verospiron?


Verospiron has been reported to increase serum digoxin concentration and to interfere with certain serum digoxin assays. In patients receiving digoxin and Verospiron, the digoxin response should be monitored by means other than serum digoxin concentrations, unless the digoxin assay used has been proven not to be affected by Verospiron therapy. If it proves necessary to adjust the dose of digoxin, patients should be carefully monitored for evidence of enhanced or reduced digoxin effect.

Potentiation of the effect of antihypertensive drugs occurs and their dosage may need to be reduced when Verospiron is added to the treatment regimen and then adjusted as necessary. Since ACE inhibitors decrease aldosterone production, they should not routinely be used with Verospiron, particularly in patients with marked renal impairment.

As carbenoxolone may cause sodium retention, and thus, decrease the effectiveness of Verospiron, concurrent use should be avoided.

Non-steroidal anti-inflammatory drugs may attenuate the natriuretic efficacy of diuretics due to inhibition of intrarenal synthesis of prostaglandins.

Verospiron reduces vascular responsiveness to noradrenaline. Caution should be exercised in the management of patients subjected to regional or general anaesthesia while they are being treated with Verospiron.

Concomitant use of Verospiron with other potassium-sparing diuretics, ACE inhibitors, angiotensin II antagonists, aldosterone blockers, potassium supplements, a diet rich in potassium or salt substitutes containing potassium may lead to severe hyperkalaemia.

In fluorimetric assays, Verospiron may interfere with the estimation of compounds with similar fluorescence characteristics.

Verospiron has been shown to increase the half-life of digoxin.

Aspirin, indometacin and mefanamic acid have been shown to attenuate the diuretic effect of Verospiron.

Verospiron enhances the metabolism of antipyrine.

Verospiron can interfere with assays of plasma digoxin concentrations.

Verospiron side effects

See also:
What are the possible side effects of Verospiron?

Applies to Verospiron: oral tablet

In addition to its needed effects, some unwanted effects may be caused by Verospiron (the active ingredient contained in Verospiron). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Verospiron:

Incidence not known:

  • Abdominal or stomach cramping, burning, or tenderness
  • bleeding gums
  • bloody or black, tarry stools
  • bloody urine
  • breast pain
  • chest pain
  • chills
  • clay-colored stools
  • clear or bloody discharge from the nipple
  • cloudy urine
  • coma
  • confusion
  • constipation
  • convulsions
  • cough or hoarseness
  • dark urine
  • decrease in urine output or decrease in urine-concentrating ability
  • diarrhea
  • difficulty with swallowing
  • dimpling of the breast skin
  • dizziness
  • drowsiness
  • fast or irregular heartbeat
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • heartburn
  • hives, itching, or skin rash
  • increased thirst
  • indigestion
  • inverted nipple
  • loss of appetite
  • lower back or side pain
  • lump in the breast or under the arm
  • muscle pain or cramps
  • muscle spasms or twitching
  • nausea and vomiting
  • painful or difficult urination
  • persistent crusting or scaling of the nipple
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness or swelling of the breast
  • severe stomach pain
  • shakiness and unsteady walk
  • sore on the skin of the breast that does not heal
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, fingers, feet, ankles, or lower legs
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • trembling
  • troubled breathing
  • unpleasant breath odor
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weight gain
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking Verospiron, get emergency help immediately:

Symptoms of overdose:

  • Irregular heartbeat
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • rash with flat lesions or small raised lesions on the skin
  • reddened skin
  • weakness or heaviness of the legs

Minor Side Effects

Some of the side effects that can occur with Verospiron may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:

  • Burning feeling in the chest or stomach
  • hair loss or thinning of the hair
  • leg cramps
  • sores, welting, or blisters
  • stomach upset
  • swelling of the breasts or breast soreness in both females and males
  • unusual dullness or feeling of sluggishness

Verospiron contraindications

See also:
What is the most important information I should know about Verospiron?

You should not use Verospiron if you are allergic to it, or if you have kidney disease, high levels of potassium in your blood, or if you are unable to urinate. Do not use potassium supplements or other diuretics while you are taking Verospiron.

Before using this medication, tell your doctor if you have liver disease, or if you use a steroid or another diuretic.

Drinking alcohol can increase certain side effects of Verospiron.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking Verospiron.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Active ingredient matches for Verospiron:

Spironolactone in Bulgaria, Czech Republic, Estonia, Ethiopia, Georgia, Germany, Hungary, Latvia, Lithuania, Poland, Romania, Russian Federation, Slovakia, Vietnam.

Unit description / dosage (Manufacturer)Price, USD
Capsule; Oral; Spironolactone 100 mg
Capsule; Oral; Spironolactone 50 mg
Tablet; Oral; Spironolactone 100 mg
Tablet; Oral; Spironolactone 25 mg
Tablet; Oral; Spironolactone 50 mg
Verospiron 50 mg - 30 Capsule$ 10.40
Spirinolactone - 30 Tablets$ 18.80
Spirinolactone 25mg - 50 Tablets$ 20.80
Verospiron 25 mg x 1 Blister x 20 Tablet
Verospiron 50 mg x 3 Blister x 10 Tablet
Capsules; Oral; Spironolactone 100 mg
Capsules; Oral; Spironolactone 50 mg
Tablets; Oral; Spironolactone 100 mg
Tablets; Oral; Spironolactone 25 mg
Tablets; Oral; Spironolactone 50 mg

List of Verospiron substitutes (brand and generic names):

Torsid Plus 50+10 Tablet (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 0.07
Upha Spironolactone 25 mg x 50 x 10's (CCM Pharmaceuticals)
Upha Spironolactone tab 25 mg 50 x 10's (CCM Pharmaceuticals)
Uractonum 25 mg x 250's (Medochemie)
Tablets; Oral; Spironolactone 25 mg (Medochemie)
Uractonum tab 25 mg 100 x 10's (Medochemie)
Tablet; Oral; Spironolactone 25 mg
Tablets; Oral; Spironolactone 25 mg
Tablet; Oral; Spironolactone 25 mg
Tablets; Oral; Spironolactone 25 mg
Capsule; Oral; Spironolactone 100 mg
Capsule; Oral; Spironolactone 50 mg
Tablet; Oral; Spironolactone 25 mg
Capsules; Oral; Spironolactone 100 mg
Capsules; Oral; Spironolactone 50 mg
Tablets; Oral; Spironolactone 25 mg
Tablet; Oral; Spironolactone 100 mg (Armstrong)
Tablet; Oral; Spironolactone 25 mg (Armstrong)
Tablets; Oral; Spironolactone 100 mg (Armstrong)
Tablets; Oral; Spironolactone 25 mg (Armstrong)
Tablet, Film-Coated; Oral; Spironolactone 150 mg
Tablet, Film-Coated; Oral; Spironolactone 50 mg
Tablets, Film-Coated; Oral; Spironolactone 150 mg
Tablets, Film-Coated; Oral; Spironolactone 50 mg
Tablet, Film-Coated; Oral; Spironolactone 150 mg (Mepha)
Tablet, Film-Coated; Oral; Spironolactone 50 mg (Mepha)
Tablets, Film-Coated; Oral; Spironolactone 150 mg (Mepha)
Tablets, Film-Coated; Oral; Spironolactone 50 mg (Mepha)


  1. DailyMed. "HYDROCHLOROTHIAZIDE; SPIRONOLACTONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "spironolactone". (accessed September 17, 2018).
  3. DrugBank. "spironolactone". (accessed September 17, 2018).


The results of a survey conducted on for Verospiron are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Verospiron. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Verospiron drug useful in terms of decreasing the symptom or the disease?
According to the reports released by website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.

1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by website users about whether the Verospiron drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Not expensive1

2 consumers reported time for results

To what extent do I have to use Verospiron before I begin to see changes in my health conditions?
As part of the reports released by website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Verospiron. To get the time effectiveness of using Verospiron drug by other patients, please click here.
5 days1
> 3 month1

4 consumers reported age

> 602

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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