Actions of Vicks Sinex Nasal Spray in details
Onset of Action
Intranasal: ≤2 minutes (Chua 1989)
How should I take Vicks Sinex Nasal Spray?
This section provides information on the proper use of a number of products that contain phenylephrine. It may not be specific to Vicks Sinex Nasal Spray. Please read with care.
To use the nose drops:
- Blow your nose gently. Tilt the head back while standing or sitting up, or lie down on a bed and hang head over the side. Place the drops into each nostril and keep the head tilted back for a few minutes to allow the medicine to spread throughout the nose.
- Rinse the dropper with hot water and dry with a clean tissue. Replace the cap right after use.
- To avoid spreading the infection, do not use the container for more than one person.
To use the nose spray:
- Blow your nose gently. With the head upright, spray the medicine into each nostril. Sniff briskly while squeezing the bottle quickly and firmly. For best results, spray once or twice into each nostril and wait 3 to 5 minutes to allow the medicine to work. Then, blow your nose gently and thoroughly. Repeat until the complete dose is used.
- Rinse the tip of the spray bottle with hot water, taking care not to suck water into the bottle, and dry with a clean tissue. Replace the cap right after use.
- To avoid spreading the infection, do not use the container for more than one person.
To use the nose jelly:
- Blow your nose gently. Wash your hands before applying the medicine. With your finger, place a small amount of jelly (about the size of a pea) up each nostril. Sniff it well back into the nose.
- Wipe the tip of the tube with a clean, damp tissue and replace the cap right after use.
Use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for longer than 3 days without first checking with your doctor. To do so may make your runny or stuffy nose worse and may also increase the chance of side effects.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For stuffy nose:
- For nose jelly dosage form:
- Adults—Use a small amount in the nose every three or four hours as needed.
- Children—Use is not recommended.
- For nose drops dosage form:
- Adults and children 12 years of age and older—Use two or three drops of a 0.25 to 0.5% solution in the nose every four hours as needed.
- Children 6 to 12 years of age—Use two or three drops of a 0.25% solution in the nose every four hours as needed.
- Children 4 to 6 years of age—Use two or three drops of a 0.125 or 0.16% solution in the nose every four hours as needed.
- Children and infants up to 4 years of age—Use is not recommended.
- For nose spray dosage form:
- Adults and children 12 years of age and older—Use two or three sprays of a 0.25 to 0.5% solution in the nose every four hours as needed.
- Children 6 to 12 years of age—Use two or three sprays of a 0.25% solution in the nose every four hours as needed.
- Children 4 to 6 years of age—Use and dose must be determined by your doctor.
- Children and infants up to 4 years of age—Use is not recommended.
- For nose jelly dosage form:
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Vicks Sinex Nasal Spray administration
Use phenylephrine eyedrops exactly as directed by your doctor, or follow the directions that accompany the package. If you do not understand these instructions, ask your doctor, pharmacist, or nurse to explain them to you.
Wash your hands before and after using the eyedrops.
If you wear contact lenses, remove them before applying phenylephrine ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Phenylephrine ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.
To apply the eyedrops:
- Tilt the head back slightly and pull down on the lower eyelid. Position the dropper above the eye. Look up and away from the dropper. Squeeze out a drop and close the eye. Apply gentle pressure to the inside corner of the eye (near the nose) for about 1 minute to prevent the liquid from draining down the tear duct. Repeat the process in the other eye if needed.
Do not use phenylephrine ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen.
Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.
Do not use any eyedrop that is discolored or has particles in it.
Store phenylephrine ophthalmic at room temperature away from moisture and heat. Keep the bottle properly capped.
Vicks Sinex Nasal Spray pharmacology
Vicks Sinex Nasal Spray (phenylephrine hydrochloride ophthalmic solution) possesses predominantly α-adrenergic effects. In the eye, phenylephrine acts locally as a potent vasoconstrictor and mydriatic, by constricting ophthalmic blood vessels and the radial muscle of the iris.
The ophthalmologic usefulness of Vicks Sinex Nasal Spray (phenylephrine hydrochloride ophthalmic solution) hydrochloride is due to its rapid effect and moderately prolonged action, as well as to the fact that it produces no compensatory vasodilatation.
The action of different concentrations of ophthalmic solutions of Vicks Sinex Nasal Spray (phenylephrine hydrochloride ophthalmic solution) hydrochloride is shown in the following table:
| Strength of solution (%) | Mydriasis | Paralysis of accomodation | |
| Maximal (minutes) | Recovery time (hours) | ||
| 2.5 | 15-60 | 3 | trace |
| 10 | 10-60 | 6 | slight |
Although rare, systemic absorption of sufficient quantities of phenylephrine may lead to systemic α-adrenergic effects, such as rise in blood pressure which may be accompanied by a reflex atropine-sensitive bradycardia.
References
- NCIt. "Phenylephrine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Phenylephrine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
- EPA Chemicals under the TSCA. "Benzenemethanol, 3-hydroxy-.alpha.-[(methylamino)methyl]- , hydrochloride (1:1), (.alpha.R)-: The Chemical Data Reporting under the Toxic Substances Control Act (TSCA) contains chemical physical description and chemical use categories.". http://www.epa.gov/chemical-data-rep... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
