Viread 123mg Uses

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What is Viread 123mg?

Darunavir, cobicistat, emtricitabine, and Viread 123mg alafenamide combination is used to treat human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Darunavir, cobicistat, emtricitabine, and Viread 123mg alafenamide is usually given to patients who have yet not received any medicine for HIV infection.

Darunavir, cobicistat, emtricitabine, and Viread 123mg alafenamide combination will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease from occurring. Darunavir, cobicistat, emtricitabine, and Viread 123mg alafenamide will not keep you from spreading HIV to other people. People who receive darunavir, cobicistat, emtricitabine, and Viread 123mg alafenamide may continue to have other problems usually related to AIDS or HIV disease.

Darunavir, cobicistat, emtricitabine, and Viread 123mg alafenamide is available only with your doctor's prescription.

Viread 123mg indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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HIV-1 Infection: Viread 123mg is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 12 years of age and older.

The following points should be considered when initiating therapy with Viread 123mg for the treatment of HIV-1 infection: Viread 123mg should not be used in combination with STRIBILD, TRUVADA or other products containing Viread 123mg disoproxil fumarate.

Chronic Hepatitis B: Viread 123mg is indicated for the treatment of chronic hepatitis B in adults. The following points should be considered when initiating therapy with Viread 123mg for the treatment of HBV infection: The indication in adults is based on safety and efficacy data from treatment of subjects who were nucleoside-treatment-naïve and subjects who were treatment-experienced with documented resistance to lamivudine. Subjects were adults with HBeAg-positive and HBeAg-negative chronic hepatitis B with compensated liver disease.

Viread 123mg was evaluated in a limited number of subjects with chronic hepatitis B and decompensated liver disease..

The numbers of subjects in clinical trials who had adefovir resistance-associated substitutions at baseline were too small to reach conclusions of efficacy.

Viread 123mg is indicated for the treatment of chronic hepatitis B in adolescents 12 to <18 years of age with: Compensated liver disease and evidence of immune active disease, i.e. active viral replication, persistently elevated serum ALT levels and histological evidence of active inflammation and/or fibrosis.

How should I use Viread 123mg?

Use Viread 123mg powder as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Viread 123mg powder. Talk to your pharmacist if you have questions about this information.
  • Take Viread 123mg powder by mouth with food as directed.
  • Only use the dosing scoop that comes with Viread 123mg powder to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Wash and dry your hands immediately before preparing your dose.
  • Mix the prescribed dose of Viread 123mg powder with 1/4 to 1/2 cup (2 to 4 oz) of a soft food that can be swallowed without chewing (eg, applesauce, baby food, yogurt). Do NOT mix Viread 123mg powder with liquid. It may float to the top even after stirring.
  • Stir the mixture with a spoon until it is well mixed. Take your dose right away after mixing to avoid a bad taste.
  • Wash and dry the dosing scoop after each use. Do NOT store it in the bottle.
  • Continue to take Viread 123mg powder even if you feel well. Do not miss any doses.
  • Taking Viread 123mg powder at the same time each day will help you remember to take it.
  • Do not suddenly stop taking Viread 123mg powder without checking with your doctor. This may cause the virus to become less sensitive to this or other medicines. If you have hepatitis B, your condition could become worse if you suddenly stop taking Viread 123mg powder.
  • If you miss a dose of Viread 123mg powder, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Viread 123mg powder.

Uses of Viread 123mg in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Viread 123mg is used in combination with other antiviral drugs in the treatment of human immunodeficiency virus (HIV) infections. It may also be used in very limited cases of long-term infections of liver caused by hepatitis B virus.

Viread 123mg description

Viread 123mg is the brand name for Viread 123mg disoproxil fumarate (a prodrug of Viread 123mg) which is a fumaric acid salt of bis-isopropoxycarbonyloxymethyl ester derivative of Viread 123mg. In vivo Viread 123mg disoproxil fumarate is converted to Viread 123mg, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5'-monophosphate. Viread 123mg exhibits activity against HIV-1 reverse transcriptase.

The chemical name of Viread 123mg disoproxil fumarate is 9-[(R)2[[bis[[(isopropoxycarbonyl)oxy]methoxy]phosphinyl]methoxy]propyl]adenine fumarate (1:1). It has a molecular formula of C19H30N5O10P·C4H4O4 and a molecular weight of 635.52.

Viread 123mg disoproxil fumarate is a white to off-white crystalline powder with a solubility of 13.4 mg/mL in distilled water at 25°C. It has an octanol/phosphate buffer (pH 6.5) partition coefficient (log p) of 1.25 at 25°C.

Viread 123mg tablets are for oral administration. Each tablet contains 300 mg of Viread 123mg disoproxil fumarate, which is equivalent to 245 mg of Viread 123mg disoproxil.

Excipients/Inactive Ingredients: Croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and pregelatinized starch. The tablets are coated with Opadry II Y–30–10671–A, which contains FD&C blue #2 aluminum lake, hypromellose 2910, lactose monohydrate, titanium dioxide, and triacetin.

In this insert, all dosages are expressed in terms of Viread 123mg disoproxil fumarate except where otherwise noted.

Viread 123mg dosage

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Recommended Dose In Adults And Pediatric Patients 12 Years Of Age And Older (35 kg or more)

For the treatment of HIV-1 or chronic hepatitis B: The dose is one 300 mg Viread 123mg tablet once daily taken orally, without regard to food.

For patients unable to swallow Viread 123mg tablets, the oral powder formulation (7.5 scoops) may be used.

In the treatment of chronic hepatitis B, the optimal duration of treatment is unknown. Safety and efficacy in pediatric patients with chronic hepatitis B weighing less than 35 kg have not been established.

Recommended Dose In Pediatric Patients 2 Years To Less Than 12 Years Of Age

HIV-1 Infection

For the treatment of HIV-1 in pediatric patients 2 years of age and older, the recommended oral dose of Viread 123mg is 8 mg of Viread 123mg disoproxil fumarate per kilogram of body weight (up to a maximum of 300 mg) once daily administered as oral powder or tablets.

Viread 123mg oral powder should be measured only with the supplied dosing scoop. One level scoop delivers 1 g of powder which contains 40 mg of Viread 123mg disoproxil fumarate. Viread 123mg oral powder should be mixed in a container with 2 to 4 ounces of soft food not requiring chewing (e.g., applesauce, baby food, yogurt). The entire mixture should be ingested immediately to avoid a bitter taste. Do not administer Viread 123mg oral powder in a liquid as the powder may float on top of the liquid even after stirring. Further patient instructions on how to administer Viread 123mg oral powder with the supplied dosing scoop are provided in the FDA-approved patient labeling (Patient Information).

Viread 123mg is also available as tablets in 150, 200, 250 and 300 mg strengths for pediatric patients who weigh greater than or equal to 17 kg and who are able to reliably swallow intact tablets. The dose is one tablet once daily taken orally, without regard to food.

Tables 1 and 2 contain dosing recommendations for Viread 123mg oral powder and tablets based on body weight. Weight should be monitored periodically and the Viread 123mg dose adjusted accordingly.

Table 1 : Dosing Recommendations for Pediatric Patients ≥ 2 Years of Age Using

Body Weight Kilogram (kg)

Oral Powder Once Daily

Scoops of Powder

10 to < 12 2
12 to < 14 2.5
14 to < 17 3
17 to < 19 3.5
19 to < 22 4
22 to < 24 4.5
24 to < 27 5
27 to < 29 5.5
29 to < 32 6
32 to < 34 6.5
34 to < 35 7
≥ 35 7.5

Table 2: Dosing Recommendations for Pediatric Patients ≥ 2 Years of Age and Weighing ≥ 17 kg Using Viread 123mg Tablets

Body Weight Kilogram (kg) Tablets Once Daily
17 to < 22 150 mg
22 to < 28 200 mg
28 to < 35 250 mg
≥ 35 300 mg

Chronic Hepatitis B

Safety and efficacy of Viread 123mg in patients younger than 12 years of age have not been established.

Dose Adjustment For Renal Impairment In Adults

Significantly increased drug exposures occurred when Viread 123mg was administered to subjects with moderate to severe renal impairment. Therefore, the dosing interval of Viread 123mg tablets 300 mg should be adjusted in patients with baseline creatinine clearance below 50 mL/min using the recommendations in Table 3. These dosing interval recommendations are based on modeling of single-dose pharmacokinetic data in non-HIV and non-HBV infected subjects with varying degrees of renal impairment, including end-stage renal disease requiring hemodialysis. The safety and effectiveness of these dosing interval adjustment recommendations have not been clinically evaluated in patients with moderate or severe renal impairment, therefore clinical response to treatment and renal function should be closely monitored in these patients. There are no data to recommend use of Viread 123mg tablets 150, 200 or 250 mg or Viread 123mg oral powder in patients with renal impairment.

No dose adjustment of Viread 123mg tablets 300 mg is necessary for patients with mild renal impairment (creatinine clearance 50–80 mL/min). Routine monitoring of estimated creatinine clearance, serum phosphorus, urine glucose, and urine protein should be performed in patients with mild renal impairment.

Table 3 : Dosage Adjustment for Patients with Altered Creatinine Clearance

Creatinine Clearance (mL/min) Generally once weekly assuming three hemodialysis sessions a week of approximately 4 hours duration. Viread 123mg should be administered following completion of dialysis.

The pharmacokinetics of Viread 123mg have not been evaluated in non-hemodialysis patients with creatinine clearance below 10 mL/min; therefore, no dosing recommendation is available for these patients.

No data are available to make dose recommendations in pediatric patients with renal impairment.

How supplied

Dosage Forms And Strengths

Viread 123mg is available as tablets or as an oral powder.

Viread 123mg tablets 150 mg contain 150 mg of Viread 123mg disoproxil fumarate, which is equivalent to 123 mg of Viread 123mg disoproxil. The tablets are triangle-shaped, white, film-coated, and debossed with “GSI” on one side and “150” on the other side.

Viread 123mg tablets 200 mg contain 200 mg of Viread 123mg disoproxil fumarate, which is equivalent to 163 mg of Viread 123mg disoproxil. The tablets are round-shaped, white, film-coated, and debossed with “GSI” on one side and “200” on the other side.

Viread 123mg tablets 250 mg contain 250 mg of Viread 123mg disoproxil fumarate, which is equivalent to 204 mg of Viread 123mg disoproxil. The tablets are capsule-shaped, white, film-coated, and debossed with “GSI” on one side and “250” on the other side.

Viread 123mg tablets 300 mg contain 300 mg of Viread 123mg disoproxil fumarate, which is equivalent to 245 mg of Viread 123mg disoproxil. The tablets are almond-shaped, light blue, film-coated, and debossed with “GILEAD” and “4331” on one side and with “300” on the other side.

The oral powder consists of white, taste-masked, coated granules containing 40 mg of Viread 123mg disoproxil fumarate, which is equivalent to 33 mg of Viread 123mg disoproxil, per level scoop. Each level scoop contains 1 gram of oral powder.

Storage And Handling

Tablets

Viread 123mg tablets, 150 mg, are triangle-shaped, white, film-coated tablets containing 150 mg of Viread 123mg disoproxil fumarate, which is equivalent to 123 mg of Viread 123mg disoproxil, are debossed with “GSI” on one side and with “150” on the other side. Each bottle contains 30 tablets, a desiccant (silica gel canister or sachet), and closed with a child-resistant closure. (NDC 61958-0404-1)

Viread 123mg tablets, 200 mg, are round-shaped, white, film-coated tablets containing 200 mg of Viread 123mg disoproxil fumarate, which is equivalent to 163 mg of Viread 123mg disoproxil, are debossed with “GSI” on one side and with “200” on the other side. Each bottle contains 30 tablets, a desiccant (silica gel canister or sachet), and closed with a child-resistant closure. (NDC 61958-0405-1)

Viread 123mg tablets, 250 mg, are capsule-shaped, white, film-coated tablets containing 250 mg of Viread 123mg disoproxil fumarate, which is equivalent to 204 mg of Viread 123mg disoproxil, are debossed with “GSI” on one side and with “250” on the other side. Each bottle contains 30 tablets, a desiccant (silica gel canister or sachet), and closed with a child-resistant closure. (NDC 61958-0406-1)

Viread 123mg tablets, 300 mg, are almond-shaped, light blue, film-coated tablets containing 300 mg of Viread 123mg disoproxil fumarate, which is equivalent to 245 mg of Viread 123mg disoproxil, are debossed with “GILEAD” and “4331” on one side and with “300” on the other side. Each bottle contains 30 tablets, a desiccant (silica gel canister or sachet), and closed with a child-resistant closure. (NDC 61958-0401-1)

Oral Powder

Viread 123mg oral powder consists of white, coated granules containing 40 mg of Viread 123mg disoproxil fumarate, which is equivalent to 33 mg of Viread 123mg disoproxil, per gram of powder and is available in multi-use bottles containing 60 grams of oral powder, closed with a child-resistant closure, and co-packaged with a dosing scoop. (NDC 61958-04031)

Store Viread 123mg tablets and oral powder at 25 °C (77 °F), excursions permitted to 1530 °C (59-86 °F).

Keep the bottle tightly closed. Dispense only in original container. Do not use if seal over bottle opening is broken or missing.

Manufactured for and distributed by: Gilead Sciences, Inc. Foster City, CA 94404. Revised: February 2016

Viread 123mg interactions

See also:
What other drugs will affect Viread 123mg?

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This section describes clinically relevant drug interactions with Viread 123mg. Drug interactions trials are described elsewhere in the labeling.

Didanosine

Coadministration of Viread 123mg and didanosine should be undertaken with caution and patients receiving this combination should be monitored closely for didanosineassociated adverse reactions. Didanosine should be discontinued in patients who develop didanosine-associated adverse reactions.

When administered with Viread 123mg, Cmax and AUC of didanosine increased significantly. The mechanism of this interaction is unknown. Higher didanosine concentrations could potentiate didanosine-associated adverse reactions, including pancreatitis and neuropathy. Suppression of CD4cell counts has been observed in patients receiving Viread 123mg with didanosine 400 mg daily.

In patients weighing greater than 60 kg, the didanosine dose should be reduced to 250 mg once daily when it is coadministered with Viread 123mg. In patients weighing less than 60 kg, the didanosine dose should be reduced to 200 mg once daily when it is coadministered with Viread 123mg. When coadministered, Viread 123mg and didanosine EC may be taken under fasted conditions or with a light meal (less than 400 kcal, 20% fat). For additional information on coadministration of Viread 123mg and didanosine, please refer to the full prescribing information for didanosine.

HIV-1 Protease Inhibitors

Viread 123mg decreases the AUC and Cmin of atazanavir. When coadministered with Viread 123mg, it is recommended that atazanavir 300 mg is given with ritonavir 100 mg. Viread 123mg should not be coadministered with atazanavir without ritonavir.

Lopinavir/ritonavir, atazanavir coadministered with ritonavir, and darunavir coadministered with ritonavir have been shown to increase Viread 123mg concentrations. Viread 123mg disoproxil fumarate is a substrate of Pglycoprotein (Pgp) and breast cancer resistance protein (BCRP) transporters. When Viread 123mg disoproxil fumarate is coadministered with an inhibitor of these transporters, an increase in absorption may be observed. Patients receiving Viread 123mg concomitantly with lopinavir/ritonavir, ritonavir-boosted atazanavir, or ritonavir-boosted darunavir should be monitored for Viread 123mg-associated adverse reactions. Viread 123mg should be discontinued in patients who develop Viread 123mg-associated adverse reactions.

Hepatitis C Antiviral Agents

Coadministration of Viread 123mg disoproxil fumarate and HARVONI (ledipasvir/sofosbuvir) has been shown to increase Viread 123mg exposure.

In patients receiving Viread 123mg concomitantly with HARVONI without an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination, monitor for adverse reactions associated with Viread 123mg disoproxil fumarate.

In patients receiving Viread 123mg concomitantly with HARVONI and an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination, consider an alternative HCV or antiretroviral therapy, as the safety of increased Viread 123mg concentrations in this setting has not been established. If coadministration is necessary, monitor for adverse reactions associated with Viread 123mg disoproxil fumarate.

Drugs Affecting Renal Function

Since Viread 123mg is primarily eliminated by the kidneys, coadministration of Viread 123mg with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of Viread 123mg and/or increase the concentrations of other renally eliminated drugs. Some examples include, but are not limited to, cidofovir, acyclovir, valacyclovir, ganciclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs.

In the treatment of chronic hepatitis B, Viread 123mg should not be administered in combination with HEPSERA (adefovir dipivoxil).

Viread 123mg side effects

See also:
What are the possible side effects of Viread 123mg?

The following adverse reactions are discussed in other sections of the labeling:

  • Lactic Acidosis/Severe Hepatomegaly with Steatosis
  • Severe Acute Exacerbation of Hepatitis B
  • New Onset or Worsening of Renal Impairment

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Adverse Reactions in Adult Subjects with Chronic Hepatitis B and Compensated Liver Disease

The safety assessment of Viread 123mg was based on pooled data through the Week 48 data analysis from 1298 subjects in two randomized, double-blind, active-controlled trials, Study 108 and Study 110, in adult subjects with chronic hepatitis B and compensated liver disease. A total of 866 subjects received Viread 123mg 25 mg once daily.

The proportion of subjects who discontinued treatment with Viread 123mg or Viread 123mg disoproxil fumarate due to adverse reactions of any severity was 1.0% and 1.2%, respectively. Table 1 displays the frequency of the adverse reaction (all Grades) greater than or equal to 5% in the Viread 123mg group.

Table 1 Adverse Reactions* (All Grades) Reported in ≥5% of Subjects with Chronic HBV Infection and Compensated Liver Disease in Studies 108 and 110 (Week 48 analysis)
Viread 123mg

(N=866)

Viread 123mg Disoproxil Fumarate

(N=432)

*
Frequencies of adverse reactions are based on all treatment-emergent adverse events, regardless of relationship to study drug.
Headache 9% 8%
Abdominal pain 7% 6%
Fatigue 6% 5%
Cough 6% 6%
Nausea 5% 5%
Back pain 5% 4%

Renal Laboratory Tests

In a pooled analysis of Studies 108 and 110 in adult subjects with chronic hepatitis B and a median baseline eGFR of 106 and 105 mL per minute (for the Viread 123mg and Viread 123mg disoproxil fumarate [TDF] groups, respectively), mean serum creatinine increased by less than 0.1 mg/dL and median serum phosphorus decreased by 0.1 mg/ dL in both treatment groups. Median change from baseline in eGFR was -1.2 mL per minute in the Viread 123mg group and -5.4 mL per minute in those receiving TDF. The long-term clinical significance of these renal laboratory changes on adverse reaction frequencies between Viread 123mg and TDF is not known.

Decrease in Bone Mineral Density

In a pooled analysis of Studies 108 and 110, the mean percentage change in bone mineral density (BMD) from baseline to Week 48 as assessed by dual-energy X-ray absorptiometry (DXA) was -0.6% with Viread 123mg compared to -2.4% with TDF at the lumbar spine and -0.2% compared to -1.9% at the total hip. BMD declines of 5% or greater at the lumbar spine were experienced by 6% of Viread 123mg subjects and 20% of TDF subjects. BMD declines of 7% or greater at the femoral neck were experienced by 3% of Viread 123mg subjects and 6% of TDF subjects. The long-term clinical significance of these BMD changes is not known.

Laboratory Abnormalities

The frequency of laboratory abnormalities (Grades 3–4) occurring in at least 2% of subjects receiving Viread 123mg in Studies 108 and 110 are presented in Table 2.

Table 2 Laboratory Abnormalities (Grades 3–4) Reported in ≥2% of Subjects with Chronic HBV Infection and Compensated Liver Disease in Studies 108 and 110 (Week 48 analysis)
Laboratory Parameter Abnormality* Viread 123mg

(N=866)

Viread 123mg Disoproxil Fumarate

(N=432)

*
Frequencies are based on treatment-emergent laboratory abnormalities.
ALT (>5 × ULN) 8% 9%
Glycosuria (≥3+) 5% 1%
LDL-cholesterol (fasted) (>190 mg/dL) 4% <1%
AST (>5 × ULN) 3% 5%
Creatine Kinase (≥10 × ULN) 3% 3%
Serum Amylase (>2.0 × ULN) 3% 2%

Amylase and Lipase Elevations and Pancreatitis

In Studies 108 and 110, seven subjects treated with Viread 123mg with elevated amylase levels had associated symptoms, such as nausea, low back pain, abdominal tenderness, biliary pancreatitis and pancreatitis. Of these seven, two subjects discontinued Viread 123mg due to elevated amylase and/or lipase; one subject experienced recurrence of adverse events when Viread 123mg was restarted. No subject treated with Viread 123mg disoproxil fumarate had associated symptoms or discontinued treatment.

Serum Lipids

Changes from baseline in total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and total cholesterol to HDL ratio among subjects treated with Viread 123mg and Viread 123mg disoproxil fumarate are presented in Table 3.

Table 3 Lipid Abnormalities: Mean Change from Baseline in Lipid Parameters in Patients with Chronic HBV Infection and Compensated Liver Disease in Studies 108 and 110 (Week 48 Analysis)
Viread 123mg

(N=866)

Viread 123mg Disoproxil Fumarate

(N=432)

Baseline Week 48 Baseline Week 48
mg/dL Change* mg/dL Change*
*
The change from baseline is the mean of within-subject changes from baseline for subjects with both baseline and Week 48 values.
Total Cholesterol (fasted) 188 [n=835] 0 [n=772] 193 [n=423] -25 [n=394]
HDL-Cholesterol (fasted) 60 [n=835] -4 [n=771] 61 [n=423] -10 [n=394]
LDL-Cholesterol (fasted) 116 [n=835] +6 [n=772] 120 [n=423] -11 [n=394]
Triglycerides (fasted) 102 [n=836] +11 [n=773] 102 [n=423] -10 [n=394]
Total Cholesterol to HDL ratio 3 [n=835] 0 [n=771] 3 [n=423] 0 [n=394]

Viread 123mg contraindications

See also:
What is the most important information I should know about Viread 123mg?

Do not take Viread 123mg together with adefovir (Hepsera), or with combination medicines that contain Viread 123mg (Atripla, Complera, or Truvada).

Viread 123mg should not be given to a child with HIV who is younger than 2 years old. Viread 123mg should not be used to treat hepatitis B in anyone younger than 18 years old.

Some people develop lactic acidosis while taking Viread 123mg. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.

Viread 123mg can also cause severe or life-threatening effects on your liver. Call your doctor at once if you have any of these symptoms while taking Viread 123mg: nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

If you have hepatitis B you may develop liver symptoms after you stop taking this medication, even months after stopping. Your doctor may want to check your liver function for several months after you stop using Viread 123mg. Visit your doctor regularly.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.



Active ingredient matches for Viread 123mg:

Tenofovir in Austria, Germany.


List of Viread 123mg substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Tolak cream .04 g/g (Hill Dermaceuticals, Inc. (US))
Valten 300mg Tablet (Wockhardt Ltd)$ 0.76
VALTEN 300 MG TABLET 1 strip / 30 tablets each (Wockhardt Ltd)$ 22.68
Tablet, Film-Coated; Oral; Tenofovir Disoproxil Fumarate 245 mg (Abbott)
Tablet; Oral; Tenofovir Disoproxil Fumarate 245 mg (Abbott)
Tablet; Oral; Tenofovir Disoproxil Fumarate 300 mg (Abbott)
Viread 300 mg x 1000's (Abbott)
30 tablet in 1 bottle, plastic (Abbott)
Viread 300 mg x 30's (Abbott)
Viread 300 mg x 1 Bottle 30 Tablet (Abbott)
VIREAD 300 MG TABLET 1 strip / 30 tablets each (Abbott)$ 37.79
VIREAD tab 300 mg x 30's (Abbott)$ 39.68
Viread FC tab 300 mg 30's (Abbott)
Viread tablet 300 mg (Abbott)
Viread tablet, coated 300 mg/1 (Abbott)
Viread tablet, coated 200 mg/1 (Abbott)
Viread tablet, coated 250 mg/1 (Abbott)
Viread powder 40 mg/g (Abbott)
Viread tablet, coated 150 mg/1 (Abbott)
Viread 300mg Tablet (Abbott)$ 1.26
Virkil 300 mg x 1 Blister x 10 Tablet
Virkil 300 mg x 3 Blister x 10 Tablet
Zifam Tenovir FC tab 300 mg 6 x 10's (Zifam India)

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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