Vistadrox DT Uses

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What is Vistadrox DT?

Vistadrox DT is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, Vistadrox DT will not work for colds, flu, or other virus infections.

Vistadrox DT is available only with your doctor's prescription.

Vistadrox DT indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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To reduce the development of drug-resistant bacteria and maintain the effectiveness of Vistadrox DT (Vistadrox DT hemihydrate) Tablets and Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) Capsules and other antibacterial drugs, Vistadrox DT (Vistadrox DT hemihydrate) Tablets and Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) is indicated for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:

Urinary tract infections caused by E. coli, P. mirabilis, and Klebsiella species.

Skin and skin structure infections caused by staphylococci and/or streptococci.

Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (Group A beta-hemolytic Streptococci).

Note: Only penicillin by the intramuscular route of administration has been shown to be effective in the prophylaxis of rheumatic fever. Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) is generally effective in the eradication of streptococci from the oropharynx. However, data establishing the efficacy of Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) for the prophylaxis of subsequent rheumatic fever are not available.

Note: Culture and susceptibility tests should be initiated prior to and during therapy.

Renal function studies should be performed when indicated.

How should I use Vistadrox DT?

Use Vistadrox DT suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Vistadrox DT suspension.

Uses of Vistadrox DT in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Pharyngitis and/or tonsillitis: Treatment of pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (group A beta-hemolytic streptococci).

Skin and skin structure infections: Treatment of skin and skin structure infections caused by staphylococci and/or streptococci.

Urinary tract infection: Treatment of urinary tract infections caused by Escherichia coli, Proteus mirabilis, and Klebsiella species.

Off Label Uses

Prosthetic joint infection with Staphylococci (oxacillin-susceptible)

Based on the Infectious Diseases Society of America (IDSA) guidelines for the management of prosthetic joint infection, Vistadrox DT is an effective and recommended agent for chronic oral antimicrobial suppression of prosthetic joint infection with Staphylococci (oxacillin-susceptible) after completion of parenteral therapy.

Vistadrox DT description

Vistadrox DT (Vistadrox DT monohydrate) is a semisynthetic cephalosporin antibiotic intended for oral administration. It is a white to yellowish-white crystalline powder. It is soluble in water and it is acid-stable.

It is 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[amino(4-hydroxy-phenyl)acetyl]amino]-3-methyl-8-oxo-,monohydrate, [6R-[6(α),7(β)(R*)]. It has the formula C16H17N3O5S·H2O and a molecular weight of 381.40.

Vistadrox DT dosage

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Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) is acid-stable and may be administered orally without regard to meals. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.

Adults

Urinary Tract Infections: For uncomplicated lower urinary tract infections (i.e., cystitis) the usual dosage is 1 or 2 g per day in single (q.d.) or divided doses (b.i.d).

For all other urinary tract infections the usual dosage is 2 g per day in divided doses (b.i.d).

Skin and Skin Structure Infections: For skin and skin structure infections the usual dosage is 1 g per day in single (q.d.) or divided doses (b.i.d).

Pharyngitis and Tonsillitis: Treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis - 1 g per day in single (q.d.) or divided doses (b.i.d) for 10 days.

Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) oral suspension may be more suitable for pediatric patients

Children

For urinary tract infections, the recommended daily dosage for children is 30 mg/kg/day in divided doses every 12 hours. For pharyngitis, tonsillitis, and impetigo, the recommended daily dosage for children is 30 mg/kg/day in a single dose or in equally divided doses every 12 hours. For other skin and skin structure infections, the recommended daily dosage is 30 mg/kg/day in equally divided doses every 12 hours. In the treatment of beta-hemolytic streptococcal infections, a therapeutic dosage of Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) should be administered for at least 10 days.

Renal Impairment

In patients with renal impairment, the dosage of Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) should be adjusted according to creatinine clearance rates to prevent drug accumulation. The following schedule is suggested. In adults, the initial dose is 1000 mg of Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) and the maintenance dose (based on the creatinine clearance rate [mL/min/1.73 M]) is 500 mg at the time intervals listed below.

Creatinine Clearances Dosage Interval
0 to 10 mL/min 36 hours
10 to 25 mL/min 24 hours
25 to 50 mL/min 12 hours

Patients with creatinine clearance rates over 50 mL/min may be treated as if they were patients having normal renal function

How supplied

Vistadrox DT tablets contain Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) hemihydrate equivalent to 1 gram of Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) and are supplied as follows:

Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) 1 gram Tablets: white, oblong, biconvex film-coated tablets, debossed on one side with ‘CF 512’ and scored on the other side.

(50s) NDC 63304-512-50

(100s) NDC 63304-512-01

(unit-dose 100s) NDC 63304-512-80

Vistadrox DT capsules contain Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) hemihydrate equivalent to 500 mg of Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) and are supplied as follows:

Vistadrox DT (Vistadrox DT (Vistadrox DT hemihydrate) hemihydrate) 500 mg Capsules: white opaque body and brown opaque cap imprinted with ‘C’ on the cap and ‘582’ on the body.

(50s) NDC 63304-582-50

(100s) NDC 63304-582-01

Dispense in a tight container as defined in the USP.

Store at 20 - 25° C (68 - 77° F)..Manufactured for: Ranbaxy Pharmaceuticals Inc. Jacksonville, FL 32216 USA by: Ranbaxy Laboratories Ltd. New Delhi - 110 019, India March 2007

FDA rev date: 3/2007

Vistadrox DT interactions

See also:
What other drugs will affect Vistadrox DT?

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Positive direct Coombs' tests have been reported during treatment with the cephalosporin antibiotics. In hematologic studies or in transfusion cross-matching procedures when antiglobulin tests are performed on the minor side or in Coombs' testing of newborns whose mothers have received cephalosporin antibiotics before parturition, it should be recognized that a positive Coombs' test may be due to Vistadrox DT.

Vistadrox DT side effects

See also:
What are the possible side effects of Vistadrox DT?

Applies to Vistadrox DT: oral capsule, oral powder for suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by Vistadrox DT (the active ingredient contained in Vistadrox DT). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Vistadrox DT:

Rare

Incidence not known:

Minor Side Effects

Some of the side effects that can occur with Vistadrox DT may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Rare

Incidence not known:

Vistadrox DT contraindications

See also:
What is the most important information I should know about Vistadrox DT?

Do not take this medication if you are allergic to Vistadrox DT, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others.

Before taking this medication, tell your doctor if you are allergic to any drugs (especially penicillin). Also tell your doctor if you have kidney disease or a history of intestinal problems.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Vistadrox DT will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Active ingredient matches for Vistadrox DT:

Cefadroxil


Unit description / dosage (Manufacturer)Price, USD
Vistadrox DT 250 mg Tablet$ 0.03
Vistadrox DT 125 mg Tablet$ 0.03
Vistadrox DT 500 mg Tablet$ 0.05

List of Vistadrox DT substitutes (brand and generic names):

Vistadrox 500mg Tablet (Cadila Pharmaceuticals Ltd.)$ 0.79
Vocefa 500 mg x 3 x 10's$ 31.62
Vocefa 125 mg/5 mL x 60 mL x 1's$ 4.65
Vocefa Forte 250 mg/5 mL x 60 mL x 1's$ 7.13
Vroxil 500 mg x 3 x 10's (Promed)$ 29.76
Vroxil 125 mg/5 mL x 60 mL x 1's (Promed)$ 4.34
Vroxil 250 mg/5 mL x 60 mL x 1's (Promed)$ 6.20
WALADROX Dispersible Tablet / 250mg / 10 units (Wallace Pharmaceuticals Ltd.)$ 0.34
WALADROX Capsule/ Tablet / 500mg / 4 units (Wallace Pharmaceuticals Ltd.)$ 0.95
WALADROX Liquid / 125mg per 5ml / 30ml units (Wallace Pharmaceuticals Ltd.)$ 0.26
WALADROX Dispersible Tablet / 125mg / 10 units (Wallace Pharmaceuticals Ltd.)$ 0.17
250 mg x 10's (Wallace Pharmaceuticals Ltd.)$ 0.56
500 mg x 10's (Wallace Pharmaceuticals Ltd.)$ 0.90
125 mg x 5 mL x 30ml (Wallace Pharmaceuticals Ltd.)$ 0.32
Waladrox 250mg DT-TAB / 10 (Wallace Pharmaceuticals Ltd.)$ 0.56
Waladrox 500mg TAB / 10 (Wallace Pharmaceuticals Ltd.)$ 0.90
Waladrox 125mg/5mL SUSP / 30ml (Wallace Pharmaceuticals Ltd.)$ 0.32
Waladrox 30 ml Suspension (Wallace Pharmaceuticals Ltd.)$ 0.05
Waladrox 500 mg Tablet (Wallace Pharmaceuticals Ltd.)$ 0.11
WALADROX 125MG SUSPENSION 1 bottle / 30 ML suspension each (Wallace Pharmaceuticals Ltd.)$ 0.27
WALADROX 125MG TABLET 1 strip / 10 tablets each (Wallace Pharmaceuticals Ltd.)$ 0.16
WALADROX 250MG TABLET 1 strip / 10 tablets each (Wallace Pharmaceuticals Ltd.)$ 0.31
WALADROX 500MG TABLET 1 strip / 10 tablets each (Wallace Pharmaceuticals Ltd.)$ 0.59
WALADROX KID 125MG TABLET 1 strip / 4 tablets each (Wallace Pharmaceuticals Ltd.)$ 0.17
WALADROX dispertab 250 mg x 10's (Wallace Pharmaceuticals Ltd.)$ 0.56
WALADROX tab 500 mg x 10's (Wallace Pharmaceuticals Ltd.)$ 0.90
WALADROX oral susp 125 mg x 5 mL x 30ml (Wallace Pharmaceuticals Ltd.)$ 0.32
Waladrox 250mg DT-TAB / 10 (Wallace Pharmaceuticals Ltd.)$ 0.56
Waladrox 500mg TAB / 10 (Wallace Pharmaceuticals Ltd.)$ 0.90
Waladrox 125mg/5mL SUSP / 30ml (Wallace Pharmaceuticals Ltd.)$ 0.32
Waladrox 125mg Suspension (Wallace Pharmaceuticals Ltd.)$ 0.27
Waladrox 125mg Tablet (Wallace Pharmaceuticals Ltd.)$ 0.04
Waladrox 250mg Tablet (Wallace Pharmaceuticals Ltd.)$ 0.03
Waladrox 500mg Tablet (Wallace Pharmaceuticals Ltd.)$ 0.06
Waladrox DT 250 mg Tablet (Wallace Pharmaceuticals Ltd.)$ 0.06
Widrox 500 mg x 3 x 10's (Landson)$ 30.47
Wincef 500 mg (Ambic Aayurchem)
Wincef 250 mg Tablet (Ambic Aayurchem)$ 0.40
Wincef 500 mg Tablet (Ambic Aayurchem)$ 0.56
Wincocef 500 mg x 10 Blister x 10 Tablet
Wydrox 500 mg Tablet (Vostok & Wilcure Remedies)$ 0.13

References

  1. DailyMed. "CEFADROXIL/CEFADROXIL HEMIHYDRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "cefadroxil". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "cefadroxil". http://www.drugbank.ca/drugs/DB01140 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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