Vitamin B2 Uses

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What is Vitamin B2?

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Vitamin B2 (vitamin B 2) is needed to help break down carbohydrates, proteins, and fats. It also makes it possible for oxygen to be used by your body.

Lack of Vitamin B2 may lead to itching and burning eyes, sensitivity of eyes to light, sore tongue, itching and peeling skin on the nose and scrotum, and sores in the mouth. Your doctor may treat this condition by prescribing Vitamin B2 for you.

Some conditions may increase your need for Vitamin B2. These include:

In addition, Vitamin B2 may be given to infants with high blood levels of bilirubin (hyperbilirubinemia).

Increased need for Vitamin B2 should be determined by your health care professional.

Claims that Vitamin B2 is effective for treatment of acne, some kinds of anemia (weak blood), migraine headaches, and muscle cramps have not been proven.

Oral forms of Vitamin B2 are available without a prescription.

Vitamin B2 indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.


Prophylaxis of Vitamin B2 deficiency

Adult: 1-2 mg daily.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.


Vitamin B2 deficiency

Adult: Up to 30 mg daily in divided doses.

Child: 3-10 mg daily.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.


Microcytic anaemia

Adult: Associated with splenomegaly and glutathione reductase deficiency: 10 mg daily for 10 days.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Uses of Vitamin B2 in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Vitamin B2 (Vitamin B2) supplementation is used to prevent and treat Vitamin B2 deficiency. Vitamin B2 may prevent migraine headaches at high doses and be useful for prevention of eye conditions such as cataract, glaucoma and tired eyes (fatigue). Vitamin B2 is also used for boosting of immune system, and maintenance of healthy hair, skin, nails and mucous membranes.

Vitamin B2 description


Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]

Vitamin B2 dosage

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.



B-2-400: 400 mg

Generic: 50 mg



Generic: 25 mg, 50 mg, 100 mg

Dosing: Adult

Dietary supplement:

Oral: 100 mg once or twice daily

Prevention of migraine headache (off-label use):

Oral: 400 mg once daily (Rahimdel 2015; Schoenen 1998)

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Dietary supplement: Infants, Children, and Adolescents: A multivitamin preparation is most commonly used for the provision of Vitamin B2 supplementation in pediatric patients; the use of a single-ingredient Vitamin B2 product as a daily supplement for the prevention of deficiency in pediatric patients is very rare. If single-ingredient Vitamin B2 supplement is necessary, consult product labeling for appropriateness of product in infants and young children in particular.

Migraine headache, prevention: Limited data available, efficacy results variable: Children ≥ 8 years and Adolescents:

Oral: 200 to 400 mg once daily; dosing based on a retrospective study of 41 patients (ages 8 to 18 years) who received 200 mg/day (n=21) or 400 mg/day (n=20) as prophylaxis for migraine and migraine-type headaches; results showed significant reduction in primary endpoint of frequency of headache attack; 68.4% of patients had a ≥50% decrease in headache frequency during treatment (Condò 2009). However, in a prospective, placebo-controlled study of 48 patients (ages 5 to 15 years), patients received 200 mg/day (n=27) or placebo (n=21) and in the treatment group (Vitamin B2) no benefit compared to placebo for migraine frequency or intensity was observed; a high placebo responder rate was also reported (MacLennan 2008).

Vitamin B2 interactions

See also:
What other drugs will affect Vitamin B2?


Interactions for Vitamin B2 (Vitamin B2)

Alcohol - impairs the intestinal absorption of riboflavi

Antidepressants (tricyclics or phenothiazines) - requirements for Vitamin B2 may be increased in patients receiving these medications

Probenecid - concurrent use decreases gastrointestinal absorption of Vitamin B2; requirements for Vitamin B2 may be increased in patients receiving probenecid.

Vitamin B2 side effects

See also:
What are the possible side effects of Vitamin B2?

Adverse Reactions

Frequency not defined: Genitourinary: Urine discoloration (yellow-orange)

Vitamin B2 contraindications

See also:
What is the most important information I should know about Vitamin B2?

None well documented.

Active ingredient matches for Vitamin B2:

Riboflavin in Latvia, Lithuania.

Unit description / dosage (Manufacturer)Price, USD
Dragee; Oral; Vitamin B2 / Riboflavin 10 mg
Injectable; Injection; Vitamin B2 / Riboflavin Sodium Phosphate 5 mg / ml
Tablet; Oral; Vitamin B2 / Riboflavin 100 mg
Tablet; Oral; Vitamin B2 100 mg
Tablet; Oral; Vitamin B2 4 mg
Capsule; Oral; Vitamin B2 / Riboflavin 100 mg
Tablet, Extended Release; Oral; Vitamin B2 200 mg
Capsule; Oral; Vitamin B2 / Riboflavin 5'-Phosphate 100 mg
Tablet; Oral; Vitamin B2 / Riboflavin 25 mg
Tablet; Oral; Vitamin B2 / Riboflavin 50 mg
Vitamin B2 / Shinlon 10 mg x 1000's
Vitamin B2 / F.Y. 5 mg x 1000's
Vitamin B2 / Chin Teng 10 mg x 100's, 1000's
Vitamin B2 / Johnson 10 mg x 1000's

List of Vitamin B2 substitutes (brand and generic names):

Riboflavin Chew Brothers 10 mg x 500's
Riboflavin Chew Brothers 10 mg x 1000's
Savent Plus Tablet (Saviour Drugs)$ 0.13
Tebovin 25 mg x 1000's
Vitabee-2-25 25 mg x 1000's
Vitamin B2 Beacons 5 mg x 1000's
Vitamin B2 SSP 10 mg x 1000's
Vitone Capsule (Cosmas Pharmacls)$ 0.04


  1. DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "riboflavin". (accessed September 17, 2018).
  3. DrugBank. "riboflavin". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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