• Dosage of Vitamin B6 in details
• Vitamin B6 interactions
• Vitamin B6 reviews

Dosage of Vitamin B6 in details

Vitamin B6 Dosage

Applies to the following strength(s): 25 mg; 50 mg; 100 mg; 100 mg/mL; (as pyridoxal 5'-phosphate); pyridoxal 5'-phosphate 50 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Drug Induced Vitamin/Mineral Deficiency
• Dietary Supplement
• Anemia
• Nausea/Vomiting

Usual Pediatric Dose for:

• Drug Induced Vitamin/Mineral Deficiency
• Dietary Supplement
• Seizures

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Precautions
• Dialysis
• Other Comments

Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency

Drug Induced Neuritis:

Cycloserine: 100 to 300 mg/day orally in divided doses.

Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.

Oral contraceptives: 25 to 30 mg/day orally.

Acute Intoxication:

Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.

Usual Adult Dose for Dietary Supplement

Vitamin B6 Deficiency:

10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.

Usual Adult Dose for Anemia

Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.

If therapeutic response is not obtained after 1 to 2 months of Vitamin B6 therapy, a different therapy should be considered.

Usual Adult Dose for Nausea/Vomiting

Nausea and vomiting of Pregnancy:

25 mg orally every 8 hours.

Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency

Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :

Treatment: 10 to 50 mg/day.

Prophylaxis: 1 to 2 mg/kg/day

Acute Intoxication:

Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: Acute ingestion of known amount: Initial: A total dose of Vitamin B6 equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining Vitamin B6 over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.

Usual Pediatric Dose for Dietary Supplement

Vitamin B6 Deficiency:

5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.

Usual Pediatric Dose for Seizures

Vitamin B6-dependent seizures:

10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Drug dependence has been reported in patients withdrawn from the drug at doses of 200 mg per day.

Vitamin B6 should not be administered intravenously to patients with heart disease.

Sensory neuropathy with axonal degeneration has been reported following a single large dose of Vitamin B6 (10 g) administered intravenously. It may rarely occur following chronic administration of lower doses.

Dialysis

Data not available

Other Comments

Administer parenteral Vitamin B6 by slow IV push.

When administering large parenteral doses, the patients heart rate, respiratory rate and blood pressure should be monitored closely.

Oral Vitamin B6 may be given with or without food.

Urinary excretion of 4-pyridoxic acid <0.1 mg/24 hours is suggestive of a deficiency.

Vitamin B6 (Vitamin B6) is found in meat, liver, whole-grain breads and cereals, soybeans, vegetables, eggs, peanuts, walnuts, and corn.

Average Adequate Intake (AI) in Adults:

>=19 to 50 years: 1.3 mg/day

>=51 years:

Men: 1.7 mg/day

Women: 1.5 mg/day

Recommended Daily Allowance (RDA) in Pediatrics:

1 to 3 years: 0.5 mg/day

4 to 8 years: 0.6 mg/day

Average Adequate Intake (AI) in Pediatrics:

0 to 6 months: 0.1 mg/day

7 to 12 months: 0.3 mg/day

9 to 13 years: 1 mg/day

Males:

>=14 years: 1.3 mg/day

Female:

>=14 years: 1.2 mg/day

More about Vitamin B6

• Side Effects
• During Pregnancy
• Dosage Information
• Drug Interactions
• Support Group
• En Espanol
• 1 Review - Add your own review/rating

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• Other brands: Vitamin B6, Aminoxin

Professional resources

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Related treatment guides

• Anemia
• Dietary Supplementation
• Drug Induced Vitamin/Mineral Deficiency
• Nausea/Vomiting
• Seizures

What other drugs will affect Vitamin B6?

There may be other drugs that can interact with Vitamin B6. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Vitamin B6 interactions

Food: Vitamin B6 should not be administered with food. Studies have shown that the bioavailability of isoniazid is reduced significantly when administered with food.

Acetaminophen: A report of severe acetaminophen toxicity was reported in a patient receiving Vitamin B6. It is believed that the toxicity may have resulted from a previously unrecognized interaction between isoniazid and acetaminophen and a molecular basis for this interaction has been proposed. However, current evidence suggests that isoniazid does induce P-450IIE1, a mixed-function oxidase enzyme that appears to generate the toxic metabolites, in the liver. Furthermore it has been proposed that isoniazid resulted In induction of P-450IIE1 in the patients liver which, in turn, resulted in a greater proportion of the ingested acetaminophen being converted to the toxic metabolites. Studies have demonstrated that pretreatment with isoniazid potentiates a cetaminophen hepatoxicity in rats.

Carbamazepine: Vitamin B6 is known to slow the metabolism of carbamazepine and increase its serum levels Carbamazepine levels should be determined prior to concurrent administration with isoniazid, signs and symptoms of carbamazepine toxicity should be monitored closely, and appropriate dosage adjustment of the anticonvulsant should be made.

Ketoconazole: Potential interaction of Ketoconazole and Vitamin B6 may exist. When Ketoconazole is given in combination with isoniazid and rifampin the AUC of ketoconazole is decreased by as much as 88% after 5 months of concurrent Vitamin B6 and Rifampin therapy.

Phenytoin: Vitamin B6 may increase serum levels of phenytoin. To avoid phenytoin intoxication, appropriate adjustment of the anticonvulsant should be made.

Therophylline: A recent study has shown that concomitan administration of isoniazid and theophylline may cause elevated plasma levels of theophylline, and in some instances a slight decrease in the elimination of isoniazid. Since the therapeutic range of theophylline is narrow theophylline serum levels should be monitored closely, and appropriate dosage adjustments of theophylline should be made.

Valproate: A recent case study has shown a possible increase in the plasma level of valproate when co administered with isoniazid. Plasma valproate concentration should be monitored when isoniazid and valproate are co administered, and appropriate dosage adjustments of valproate should be made.

References

1. DailyMed. "ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. FDA/SPL Indexing Data. "KV2JZ1BI6Z: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
3. MeSH. "Vitamin B Complex". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Vitamin B6 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Vitamin B6. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology