How long did you take this medication to work?
What is Vyfat?
Vyfat blocks some of the fat that you eat, keeping it from being absorbed by your body.
Vyfat is used together with a reduced-calorie diet and weight maintenance to treat obesity in people with certain risk factors (such as diabetes, high blood pressure, and high cholesterol or triglycerides).
Vyfat may also be used for purposes not listed in this medication guide.
It is dangerous to purchase Vyfat on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of "Vyfat" purchased on the Internet have been found to contain sibutramine (Meridia), a prescription weight loss medication that can have dangerous side effects in certain people. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide.
Vyfat™ (Vyfat 60 mg) is indicated for weight loss in overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet.
Diet and exercise are the starting points for any weight loss program. Try these first before adding Vyfat (Vyfat 60 mg). Check with your doctor before starting any exercise program.
To determine if Vyfat (Vyfat 60 mg) capsules are right for you, find your height on the chart below. You may consider starting with Vyfat (Vyfat 60 mg) if your weight is the same or more than the weight shown for your height.
How should I use Vyfat?
Use Vyfat as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Vyfat. Talk to your pharmacist if you have questions about this information.
- Read the chart on the medicine package. You may consider starting Vyfat if your weight is the same or more than the weight shown for your height. Talk to your doctor or pharmacist if you have any questions.
- Take Vyfat by mouth with each meal. Do not take more than 3 capsules daily.
- If a meal is missed or contains no fat, do not take a dose of Vyfat.
- Vyfat may decrease your absorption of vitamins. Take a multivitamin once a day at bedtime.
- If you also take a thyroid hormone (eg, levothyroxine), do not take it within 4 hours before or after taking Vyfat. Check with your doctor if you have questions.
- If you also take cyclosporine, do not take it within 3 hours before or after taking Vyfat. Check with your doctor if you have questions.
- If you miss a dose of Vyfat, skip the missed dose. Continue to take it as directed by your doctor or on the package label.
Ask your health care provider any questions you may have about how to use Vyfat.
Uses of Vyfat in details
Vyfat is used for weight loss along with an exercise and diet regimen. It is also prescribed by doctors to overweight people who may be suffering from high blood pressure, high cholesterol, diabetes and heart patients. It is also used to stop weight gain after weight reduction.
Vyfat is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Vyfat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
The recommended dose of Vyfat is one 120-mg capsule three times a day with each main meal containing fat (during or up to 1 hour after the meal).
The patient should be on a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat. The daily intake of fat, carbohydrate, and protein should be distributed over three main meals. If a meal is occasionally missed or contains no fat, the dose of Vyfat can be omitted.
Because Vyfat has been shown to reduce the absorption of some fat-soluble vitamins and betacarotene, patients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition. The vitamin supplement should be taken at least 2 hours before or after the administration of Vyfat, such as at bedtime.
For patients receiving both Vyfat and cyclosporine therapy, administer cyclosporine 3 hours after Vyfat.
For patients receiving both Vyfat and levothyroxine therapy, administer levothyroxine and Vyfat at least 4 hours apart. Patients treated concomitantly with Vyfat and levothyroxine should be monitored for changes in thyroid function.
Doses above 120 mg three times a day have not been shown to provide additional benefit.
Based on fecal fat measurements, the effect of Vyfat is seen as soon as 24 to 48 hours after dosing. Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels within 48 to 72 hours.
Dosage Forms And Strengths
Vyfat 120 mg turquoise capsules imprinted with ROCHE and Vyfat 120 in black ink.
Vyfat is a turquoise, hard-gelatin capsule containing pellets of powder.
Vyfat 120 mg Capsules: Turquoise, two-piece, No. 1 opaque hard-gelatin capsule imprinted with ROCHE and Vyfat 120 in black ink - bottle of 90 (NDC 0004-0257-52).
Storage And Handling
Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F). Keep bottle tightly closed.
Vyfat should not be used after the given expiration date.
Distributed by: Genentech USA, Inc., A Member of the Roche Group, 1 DNA Way, South San Francisco, CA 94080-4990. Revised: Aug 2016
What other drugs will affect Vyfat?
Data from a Vyfat and cyclosporine drug interaction study indicate a reduction in cyclosporine plasma levels when Vyfat was coadministered with cyclosporine. Vyfat and cyclosporine should not be simultaneously coadministered. Cyclosporine should be administered 3 hours after the administration of Vyfat.
Fat-soluble Vitamin Supplements And Analogues
Data from a pharmacokinetic interaction study showed that the absorption of beta-carotene supplement is reduced when concomitantly administered with Vyfat. Vyfat inhibited absorption of a vitamin E acetate supplement. The effect of Vyfat on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time.
Hypothyroidism has been reported in patients treated concomitantly with Vyfat and levothyroxine postmarketing. Patients treated concomitantly with Vyfat and levothyroxine should be monitored for changes in thyroid function. Administer levothyroxine and Vyfat at least 4 hours apart.
Anticoagulants Including Warfarin
Vitamin K absorption may be decreased with Vyfat. Reports of decreased prothrombin, increased INR and unbalanced anticoagulant treatment resulting in change of hemostatic parameters have been reported in patients treated concomitantly with Vyfat and anticoagulants. Patients on chronic stable doses of warfarin or other anticoagulants who are prescribed Vyfat should be monitored closely for changes in coagulation parameters.
A pharmacokinetic study, where amiodarone was orally administered during Vyfat treatment, demonstrated a reduction in exposure to amiodarone and its metabolite, desethylamiodarone. A reduced therapeutic effect of amiodarone is possible. The effect of commencing Vyfat treatment in patients on stable amiodarone therapy has not been studied.
Convulsions have been reported in patients treated concomitantly with Vyfat and antiepileptic drugs. Patients should be monitored for possible changes in the frequency and/or severity of convulsions.
Loss of virological control has been reported in HIV-infected patients taking Vyfat concomitantly with antiretroviral drugs such as atazanavir, ritonavir, tenofovir disoproxil fumarate, emtricitabine, and with the combinations lopinavir/ritonavir and emtricitabine/efavirenz/tenofovir disoproxil fumarate. The exact mechanism for this is unclear, but may include a drug-drug interaction that inhibits systemic absorption of the antiretroviral drug. HIV RNA levels should be frequently monitored in patients who take Vyfat while being treated for HIV infection. If there is a confirmed increase in HIV viral load, Vyfat should be discontinued.
Drug Abuse And Dependence
As with any weight-loss agent, the potential exists for abuse of Vyfat in inappropriate patient populations (e.g., patients with anorexia nervosa or bulimia). See INDICATIONS AND USAGE for recommended prescribing guidelines.
Vyfat side effects
Some people on Vyfat™ (Vyfat 60 mg) will experience GI side effects, which is expected since Vyfat (Vyfat 60 mg) works by inhibiting about 25% of dietary fat. Vyfat (Vyfat 60 mg) is half the strength of prescription Vyfat® (Vyfat 120 mg), and, as a result, has fewer GI events overall than Vyfat®. In clinical trials, subjects on 120 mg withdrew due to GI adverse events at a rate of 5.4%-and at 60 mg it was only 3.2%.
The main treatment effect occurs when an individual eats a meal with too much fat while taking Vyfat (Vyfat 60 mg). Treatment effects may include:
- Loose or more frequent stools that may be hard to control
- An urgent need to go to the bathroom
- Gas with oily spotting
- While excess fat that is excreted is not harmful, patients could be distressed by the experience. Treatment effects can be lessened if an individual sticks with reduced-calorie, low-fat meals that average 15 grams of fat per meal (or 30% fat or less). Diets may vary from 1,200 calories to 1,800 calories per day, so 15 grams is an average. Individuals need to be aware of hidden fat in food, so that they can lower the chance of having treatment effects.
Not all individuals will experience treatment effects, but those that do can reduce the likelihood of these effects by taking Vyfat (Vyfat 60 mg) as directed and sticking with a reduced-calorie, low-fat diet. The Vyfat (Vyfat 60 mg) starter pack includes portable reference guides and online support at myalli (Vyfat 60 mg).com to help patients follow the program accurately. Some patients may experience treatment effects as they begin therapy until they learn to adjust their diet.
Do not take Vyfat if you are pregnant. Weight loss is not recommended during pregnancy, even if you are overweight or obese.
You should not take this medication if you are allergic to Vyfat, if you are pregnant, or if you have gallbladder problems or chronic malabsorption syndrome (an inability to absorb food and nutrients properly).
Before taking Vyfat, tell your doctor if you have an underactive thyroid, a history of gallstones or pancreatitis, type 1 or type 2 diabetes, an eating disorder, liver or kidney disease, or if you take other weight-loss medications (prescription or over-the-counter).
Do not give over-the-counter Vyfat to a child younger than 18 years old. Prescription Vyfat should not be used by anyone age 12 to 18 without the advice of a doctor.
Vyfat should be used only by the person for whom it was prescribed. Never share Vyfat with another person, especially someone who has a history of eating disorder. Keep the medication in a place where others cannot get to it.
Vyfat is only part of a complete program of treatment that also includes diet, exercise, and weight control. Your daily intake of fat, protein, and carbohydrates should be evenly divided over all of your daily meals. Follow your diet, medication, and exercise routines very closely.
Avoid a diet that is high in fat. High-fat meals taken in combination with Vyfat can increase your risk of unpleasant side effects on your stomach or intestines.
Active ingredient matches for Vyfat:
Orlistat in India.
|Unit description / dosage (Manufacturer)||Price, USD|
|Vyfat 120mg CAP / 10||$ 6.11|
|120 mg x 10's||$ 5.56|
|Vyfat 120 mg Capsule||$ 0.61|
|Vyfat 60 mg Capsule||$ 0.32|
|VYFAT 120 MG CAPSULE 1 strip / 10 capsules each (Intas Pharmaceuticals Ltd)||$ 7.62|
|VYFAT cap 120 mg x 10's (Intas)||$ 6.11|
|Vyfat 120mg Capsule (Intas Pharmaceuticals Ltd)||$ 0.83|
List of Vyfat substitutes (brand and generic names):
|Viplena 120 (Vietnam)|
|Viplena 120 120 mg x 2 Blister x 10 Tablet|
|WONLISTAT tab 60 mg x 10's (Wonder (Xtra))|
|WONLISTAT tab 120 mg x 10's (Wonder (Xtra))|
|Xenical (Argentina, Armenia, Aruba, Australia, Austria, Bangladesh, Belarus, Belgium, Bolivia, Bosnia & Herzegowina, Botswana, Brazil, Brunei Darussalam, Cambodia, Canada, Chile, China, Colombia, Croatia (Hrvatska), Cuba, Cyprus, Czech Republic, Denmark, Ecuador, Estonia, Finland, France, Georgia, Germany, Ghana, Greece, Hong Kong, Hungary, Iceland, Indonesia, Ireland, Israel, Italy, Jamaica, Jordan, Kazakhstan, Kenya, Kuwait, Laos, Lebanon, Lithuania, Luxembourg, Macedonia, Malawi, Malaysia, Mexico, Morocco, Namibia, Netherlands, New Zealand, Nigeria, Norway, Oman, Pakistan, Paraguay, Peru, Philippines, Poland, Portugal, Qatar, Romania, Russian Federation, Saudi Arabia, Serbia, Singapore, Slovakia, Slovenia, South Africa, South Korea, Spain, Sri Lanka, Sudan, Sweden, Switzerland, Taiwan, Tanzania, Thailand, Trinidad & Tobago, Turkey, Turkmenistan, Uganda, Ukraine, United Arab Emirates, United Kingdom, United States, Uruguay, Uzbekistan, Venezuela, Vietnam, Zambia, Zimbabwe)|
|Capsule; Oral; Orlistat 120 mg (USV-Corvette (US Vitamins Ltd))|
|Generic Xenical 120mg - 42 Capsule (USV-Corvette (US Vitamins Ltd))||$ 114.95|
|Generic Xenical 120mg - 84 Capsule (USV-Corvette (US Vitamins Ltd))||$ 199.95|
|Xenical 120 mg - 21 Tablets (USV-Corvette (US Vitamins Ltd))||$ 57.20|
|Xenical 120 mg x 4 x 21's (USV-Corvette (US Vitamins Ltd))|
|Xenical 120 mg x 21's (USV-Corvette (US Vitamins Ltd))||$ 22.81|
|Xenical 120 mg x 84's (USV-Corvette (US Vitamins Ltd))|
|Xenical 120 mg x 21 Tablet (USV-Corvette (US Vitamins Ltd))|
|Xenical 120 mg x 42's (USV-Corvette (US Vitamins Ltd))|
|Xenical 120 mg x 4 Blister x 21 Tablet (USV-Corvette (US Vitamins Ltd))|
|Xenical 120 mg Capsule (USV-Corvette (US Vitamins Ltd))||$ 0.83|
|XENICAL 120 MG CAPSULE 1 strip / 21 capsules each (USV-Corvette (US Vitamins Ltd))||$ 17.59|
|XENICAL cap 120 mg x 10's (USV-Corvette (US Vitamins Ltd))||$ 7.62|
|Xenical cap 120 mg 21's (USV-Corvette (US Vitamins Ltd))|
|Xenical Capsule, hard 120 mg (USV-Corvette (US Vitamins Ltd))|
|Xenical capsule 120 mg/1 (USV-Corvette (US Vitamins Ltd))|
|Xenical 120mg hard capsules (United Kingdom)|
|Xenical Bb Farma (Italy)|
|Xenical Bcnfarma (Spain)|
|Xenical D.A.C. (Iceland)|
|Xenical Dark Blue|
|Capsule; Oral; Orlistat 120 mg|
|Xenical Difarmed (Spain)|
|Xenical Generfarma (Spain)|
|Xenical Gervasi (Spain)|
|Xenical Programmi Sanitari (Italy)|
|Xenical 賽尼可 (Hongkong)|
|Xenical cap 120 mg 21's (Roche)|
|Xenical cap 120 mg 42's (Roche)|
|XTRA SLIM CAPSULE 1 strip / 10 capsules each (Medsea Healthcare Pvt Ltd)||$ 6.11|
|Zerofat 120mg CAP / 7 (Discovery (Mankind Pharmaceuticals Pvt. Ltd.))||$ 3.89|
|120 mg x 7's (Discovery (Mankind Pharmaceuticals Pvt. Ltd.))||$ 3.89|
|Zerofat 120 mg Capsule (Discovery (Mankind Pharmaceuticals Pvt. Ltd.))||$ 0.32|
- DailyMed. "ORLISTAT: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "orlistat". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "orlistat". http://www.drugbank.ca/drugs/DB01083 (accessed September 17, 2018).
ReviewsThe results of a survey conducted on ndrugs.com for Vyfat are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Vyfat. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
Consumer reported usefulNo survey data has been collected yet
Consumer reported price estimatesNo survey data has been collected yet
Consumer reported time for resultsNo survey data has been collected yet
Consumer reported ageNo survey data has been collected yet
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Information checked by Dr. Sachin Kumar, MD Pharmacology