Xianfengjiu Uses

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What is Xianfengjiu?

Xianfengjiu is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, Xianfengjiu will not work for colds, flu, or other virus infections.

Xianfengjiu is available only with your doctor's prescription.

Xianfengjiu indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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To reduce the development of drug-resistant bacteria and maintain the effectiveness of Xianfengjiu (Xianfengjiu hemihydrate) Tablets and Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) Capsules and other antibacterial drugs, Xianfengjiu (Xianfengjiu hemihydrate) Tablets and Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) is indicated for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:

Urinary tract infections caused by E. coli, P. mirabilis, and Klebsiella species.

Skin and skin structure infections caused by staphylococci and/or streptococci.

Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (Group A beta-hemolytic Streptococci).

Note: Only penicillin by the intramuscular route of administration has been shown to be effective in the prophylaxis of rheumatic fever. Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) is generally effective in the eradication of streptococci from the oropharynx. However, data establishing the efficacy of Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) for the prophylaxis of subsequent rheumatic fever are not available.

Note: Culture and susceptibility tests should be initiated prior to and during therapy.

Renal function studies should be performed when indicated.

How should I use Xianfengjiu?

Use Xianfengjiu suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Xianfengjiu suspension.

Uses of Xianfengjiu in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Pharyngitis and/or tonsillitis: Treatment of pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (group A beta-hemolytic streptococci).

Skin and skin structure infections: Treatment of skin and skin structure infections caused by staphylococci and/or streptococci.

Urinary tract infection: Treatment of urinary tract infections caused by Escherichia coli, Proteus mirabilis, and Klebsiella species.

Off Label Uses

Prosthetic joint infection with Staphylococci (oxacillin-susceptible)

Based on the Infectious Diseases Society of America (IDSA) guidelines for the management of prosthetic joint infection, Xianfengjiu is an effective and recommended agent for chronic oral antimicrobial suppression of prosthetic joint infection with Staphylococci (oxacillin-susceptible) after completion of parenteral therapy.

Xianfengjiu description

Xianfengjiu (Xianfengjiu monohydrate) is a semisynthetic cephalosporin antibiotic intended for oral administration. It is a white to yellowish-white crystalline powder. It is soluble in water and it is acid-stable.

It is 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[amino(4-hydroxy-phenyl)acetyl]amino]-3-methyl-8-oxo-,monohydrate, [6R-[6(α),7(β)(R*)]. It has the formula C16H17N3O5S·H2O and a molecular weight of 381.40.

Xianfengjiu dosage

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Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) is acid-stable and may be administered orally without regard to meals. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.

Adults

Urinary Tract Infections: For uncomplicated lower urinary tract infections (i.e., cystitis) the usual dosage is 1 or 2 g per day in single (q.d.) or divided doses (b.i.d).

For all other urinary tract infections the usual dosage is 2 g per day in divided doses (b.i.d).

Skin and Skin Structure Infections: For skin and skin structure infections the usual dosage is 1 g per day in single (q.d.) or divided doses (b.i.d).

Pharyngitis and Tonsillitis: Treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis - 1 g per day in single (q.d.) or divided doses (b.i.d) for 10 days.

Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) oral suspension may be more suitable for pediatric patients

Children

For urinary tract infections, the recommended daily dosage for children is 30 mg/kg/day in divided doses every 12 hours. For pharyngitis, tonsillitis, and impetigo, the recommended daily dosage for children is 30 mg/kg/day in a single dose or in equally divided doses every 12 hours. For other skin and skin structure infections, the recommended daily dosage is 30 mg/kg/day in equally divided doses every 12 hours. In the treatment of beta-hemolytic streptococcal infections, a therapeutic dosage of Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) should be administered for at least 10 days.

Renal Impairment

In patients with renal impairment, the dosage of Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) should be adjusted according to creatinine clearance rates to prevent drug accumulation. The following schedule is suggested. In adults, the initial dose is 1000 mg of Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) and the maintenance dose (based on the creatinine clearance rate [mL/min/1.73 M]) is 500 mg at the time intervals listed below.

Creatinine Clearances Dosage Interval
0 to 10 mL/min 36 hours
10 to 25 mL/min 24 hours
25 to 50 mL/min 12 hours

Patients with creatinine clearance rates over 50 mL/min may be treated as if they were patients having normal renal function

How supplied

Xianfengjiu tablets contain Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) hemihydrate equivalent to 1 gram of Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) and are supplied as follows:

Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) 1 gram Tablets: white, oblong, biconvex film-coated tablets, debossed on one side with ‘CF 512’ and scored on the other side.

(50s) NDC 63304-512-50

(100s) NDC 63304-512-01

(unit-dose 100s) NDC 63304-512-80

Xianfengjiu capsules contain Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) hemihydrate equivalent to 500 mg of Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) and are supplied as follows:

Xianfengjiu (Xianfengjiu (Xianfengjiu hemihydrate) hemihydrate) 500 mg Capsules: white opaque body and brown opaque cap imprinted with ‘C’ on the cap and ‘582’ on the body.

(50s) NDC 63304-582-50

(100s) NDC 63304-582-01

Dispense in a tight container as defined in the USP.

Store at 20 - 25° C (68 - 77° F)..Manufactured for: Ranbaxy Pharmaceuticals Inc. Jacksonville, FL 32216 USA by: Ranbaxy Laboratories Ltd. New Delhi - 110 019, India March 2007

FDA rev date: 3/2007

Xianfengjiu interactions

See also:
What other drugs will affect Xianfengjiu?

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Positive direct Coombs' tests have been reported during treatment with the cephalosporin antibiotics. In hematologic studies or in transfusion cross-matching procedures when antiglobulin tests are performed on the minor side or in Coombs' testing of newborns whose mothers have received cephalosporin antibiotics before parturition, it should be recognized that a positive Coombs' test may be due to Xianfengjiu.

Xianfengjiu side effects

See also:
What are the possible side effects of Xianfengjiu?

Applies to Xianfengjiu: oral capsule, oral powder for suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by Xianfengjiu (the active ingredient contained in Xianfengjiu). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Xianfengjiu:

Rare

Incidence not known:

Minor Side Effects

Some of the side effects that can occur with Xianfengjiu may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Rare

Incidence not known:

Xianfengjiu contraindications

See also:
What is the most important information I should know about Xianfengjiu?

Do not take this medication if you are allergic to Xianfengjiu, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others.

Before taking this medication, tell your doctor if you are allergic to any drugs (especially penicillin). Also tell your doctor if you have kidney disease or a history of intestinal problems.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Xianfengjiu will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Active ingredient matches for Xianfengjiu:

Cefadroxil in China.


List of Xianfengjiu substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Wydrox Kid 250 mg Tablet (Vostok & Wilcure Remedies)$ 0.04
Xicef 125 mg Tablet (Alpic Remedies Ltd.)$ 0.04
XIL Kid 125 mg Tablet (Vega Pharma)$ 0.04
XYL 500 500 mg Tablet (Chemo Biological)$ 0.12
Yaricef 500 mg x 3 x 10's (Yarindo Farmatama)$ 24.55
Yaricef 250 mg/5 mL x 60 mL x 1's (Yarindo Farmatama)$ 5.95
ZADRO Liquid / 250mg per 5ml / 30ml units (FDC Limited)$ 0.36
ZADRO Capsule/ Tablet / 500mg / 10 units (FDC Limited)$ 0.59
ZADRO Dispersible Tablet / 250mg / 10 units (FDC Limited)$ 0.33
ZADRO Dispersible Tablet / 125mg / 10 units (FDC Limited)$ 0.18
ZADRO Drops / 100mg per ml / 10ml units (FDC Limited)$ 0.23
ZADRO Liquid / 125mg per 5ml / 30ml units (FDC Limited)$ 0.28
Zadro 125mg DT-TAB / 10 (FDC Limited)$ 0.17
Zadro 250mg DT-TAB / 10 (FDC Limited)$ 0.31
Zadro 500mg FC-TAB / 10 (FDC Limited)$ 0.58
Zadro 125mg D-SYR / 30ml (FDC Limited)$ 0.26
Zadro 250mg D-SYR / 30ml (FDC Limited)$ 0.34
Zadro 100mg/mL DPS / 10ml (FDC Limited)$ 0.23
125 mg x 10's (FDC Limited)$ 0.17
250 mg x 10's (FDC Limited)$ 0.31
500 mg x 10's (FDC Limited)$ 0.58
125 mg x 30ml (FDC Limited)$ 0.26
250 mg x 30ml (FDC Limited)$ 0.34
100 mg x 1 mL x 10ml (FDC Limited)$ 0.23
Zadro 500 mg Tablet (FDC Limited)$ 0.06
Zadro 10 ml Drop (FDC Limited)$ 0.02
ZADRO 100MG DROPS 1 packet / 10 ML drop each (FDC Limited)$ 0.26
ZADRO 250 MG SUSPENSION 1 bottle / 30 ML suspension each (FDC Limited)$ 0.38
ZADRO 250 MG TABLET 1 strip / 10 tablets each (FDC Limited)$ 0.34
ZADRO 500 MG TABLET 1 strip / 10 tablets each (FDC Limited)$ 0.63
ZADRO dispertab 125 mg x 10's (FDC Limited)$ 0.17
ZADRO dispertab 250 mg x 10's (FDC Limited)$ 0.31
ZADRO film-coated tab 500 mg x 10's (FDC Limited)$ 0.58
ZADRO dry syr 125 mg x 30ml (FDC Limited)$ 0.26
ZADRO dry syr 250 mg x 30ml (FDC Limited)$ 0.34
ZADRO oral drops 100 mg x 1 mL x 10ml (FDC Limited)$ 0.23
Zadro 125mg DT-TAB / 10 (FDC Limited)$ 0.17
Zadro 250mg DT-TAB / 10 (FDC Limited)$ 0.31
Zadro 500mg FC-TAB / 10 (FDC Limited)$ 0.58
Zadro 125mg D-SYR / 30ml (FDC Limited)$ 0.26
Zadro 250mg D-SYR / 30ml (FDC Limited)$ 0.34
Zadro 100mg/mL DPS / 10ml (FDC Limited)$ 0.23
Zadro CV DT 250+62.5 Tablet (Select (FDC Limited))$ 0.09
Zadro DT 250 mg Tablet (FDC Limited)$ 0.03

References

  1. DailyMed. "CEFADROXIL/CEFADROXIL HEMIHYDRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "cefadroxil". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "cefadroxil". http://www.drugbank.ca/drugs/DB01140 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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