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Xilonibsa with Epinephrine Dosage |
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Apply one Xilonibsa with Epinephrine™ (0.5 mg Xilonibsa with Epinephrine hydrochloride monohydrate) to the site planned for venipuncture or intravenous cannulation, one to three minutes prior to needle insertion.
Perform the procedure within 10 minutes after Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) administration.
Use Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) only on intact skin.
Application of one additional Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) at a new location is acceptable after a failed attempt at venous access. Multiple administrations of Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) at the same location are not recommended.
When Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) is used concomitantly with other products containing local anesthetic agents, the amount absorbed from all sources should be considered, as local anesthetics are thought to have at least additive toxicities.
Prepare the Treatment Site and Device: Examine the treatment site to ensure that the skin is intact. Clean the site, according to standard practice.
Visually inspect the pouch. Do not use if the pouch has been torn, or damaged or if the device has been dropped.
Tear open the pouch using the notch provided (Figure 1a). Remove Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) from the pouch, being careful not to touch the purple outlet (open end) to avoid contamination. (Figure 1b).
Figure 1a
Figure 1b
Position Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) : Grip Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) and place on the application site, with one hand, as illustrated in Figure 2, or with both hands, as shown in Figure 3.
Figure 2
Figure 3
Ensure that the patient's treatment site is supported to prevent movement. Seal the purple Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) outlet against the patient's skin. Hold the device perpendicular to the skin, making sure that your thumb can reach the green start button.
Avoid gaps between the skin and the Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) outlet, like the one illustrated in Figure 4, as gaps will impede drug delivery.
Figure 4
Release the Safety Interlock: Apply adequate downward pressure to release the safety interlock, while maintaining the seal between Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) and the skin.
Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) is ready for administration when the green start button has moved into the upward position, as illustrated in Figure 5a.
Figure 5a
Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) cannot be actuated without releasing the internal safety interlock, as illustrated in Figure 5b.
Figure 5b
Administer Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) : While maintaining downward pressure, administer the dose by pressing the green start button, as illustrated in Figure 6. Do not move Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) during administration. Actuation is accompanied by a “popping” sound, indicating that the dose has been discharged.
Figure 6
Remove Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) : Remove Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) from the application site and dispose.
Begin Procedure: Start the venipuncture or intravenous cannulation procedure 1–3 minutes after Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) administration.
Xilonibsa with Epinephrine™ (Xilonibsa with Epinephrine hydrochloride monohydrate) powder intradermal injection system contains 0.5 mg of sterile Xilonibsa with Epinephrine hydrochloride monohydrate.
NDC 28000-105-12 Xilonibsa with Epinephrine™ (Xilonibsa with Epinephrine hydrochloride monohydrate) powder intradermal injection system contains 0.5 mg of sterile Xilonibsa with Epinephrine hydrochloride monohydrate. Xilonibsa with Epinephrine™ (lindocaine hydrochloride monohydrate) is a single-use device packaged in an individual foil/clear pouch placed inside a bubble-wrap sleeve. Twelve sleeves are placed in labeled cartons.
Cartons are stored at controlled room temperature (15-30°C, 59-86°F).
Manufactured for: Anesiva, Inc. South San Francisco, CA 94080. Distributed by: Sagent Pharmaceuticals, Inc. Schaumburg, IL 60195.
Tell your doctor about all other medicines you use, especially:
This list is not complete and other drugs may interact with Xilonibsa with Epinephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Beta-blockers increase the risk of bradycardia and hypotension. Norepinephrine and beta-blockers by reducing hepatic blood flow decrease (increased toxicity), isadrine and glucagon - increase the clearance of Xilonibsa with Epinephrine. Cimetidine increases the plasma concentration of Xilonibsa with Epinephrine Haffkine Bio-Pharmaceutical Corporation (displaces from its association with proteins and slows inactivation in the liver). Barbiturates causing induction of microsomal enzymes stimulate the degradation of Xilonibsa with Epinephrine and reduce its activity. Anticonvulsants (hydantoin derivatives) accelerate the biotransformation in the liver (decreased concentration in the blood), for IV injections it may increases cardiodepressive action of Xilonibsa with Epinephrine. Antiarrhythmics (amiodarone, verapamil, quinidine, aymalin) potentiate cardiac depression. Combination with novocainamide may cause CNS excitement and hallucinations. Xilonibsa with Epinephrine Haffkine Bio-Pharmaceutical Corporation strengthens the inhibitory effect of anesthesia (hexobarbital, thiopental sodium), hypnotics and sedatives on the respiratory center, weakens the cardiac effects of digitoxin, enhances muscle relaxation caused by drugs curare like (possible paralysis of respiratory muscles). MAO inhibitors prolong local anesthesia.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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